The involvement of the
MET5 gene in virulence of
Cryptococcus neoformans was examined using the silkworm
Bombyx mori infection model. In the virulence assay, the
met5Δ mutant showed virulence not significantly different from the wild-type strain, suggesting that the
MET5 gene is not essential for full virulence of
C. neoformans. The effect of silkworm hemolymph on the survival of the
met5Δ mutant was also tested. The
C. neoformans met5Δ strain incubated in the silkworm hemolymph for five days remained viable, suggesting that silkworm hemolymph supports survival of the
met5Δ strain.
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