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Volume 12 (1971)
- Issue 6 Pages 513-
- Issue 5 Pages 417-
- Issue 4 Pages 335-
- Issue 3 Pages 207-
- Issue 2 Pages 61-
- Issue 1 Pages 1-
Volume 12, Issue 4
Displaying 1-10 of 10 articles from this issue
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Koyo TAKEDA, Hiroshi OKUMURA, Hiroko NINOMIYA, Ryuichi YOKOHARI, Masah ...1971 Volume 12 Issue 4 Pages 335-352
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESS1). Clinical manifestations of essential cryoglobulinemia were surveyed in 25 cases appeared in literature including 3 cases of our own. Purpura was the symptom most frequently encountered (16 cases). Twelve cases had albuminuria. Other symptoms such as Raynaud's phenomenon, cutaneous ulceration, gangrene, cold urticaria, arthralgia were seen in 40 per cent or less.
2). Cryoglobulins might be classified into following 2 groups on the immunochemical basis: 1) single component cryoglobulins composed of exclusively one kind of monoclonal immunoglobulins (single class IgG, IgA or IgM) or light chains (kappa or lambda), 2) cryoglobulins of the mixed type constituted of more than one kind of globulins. The latter group also contains immunoglobulins without fail and an immunoglobulin (IgM, IgG or IgA) which reacts in cold with another constituent like antigen-antibody interaction is called “cryoprecipitating factor”.
3). Kappa type light chains seem to predominate over lambda type ones in monoclonal IgM cryoprecipitating factors from IgM-IgG mixed cryoglobulins. Of 25 typed cryoprecipitating macroglobulins of such origin in literature, 10 were polyclonal containing both kappa and lambda, 14 contained only kappa, and the remaining one only lambda light chains.
4). Clinical and pathological aspects of cryoglobulinemia in literature were surveyed. Physicochemical and immunological characteristics of cryoglobulins were also reviewed and discussed in relation to their possible role on pathogenesis of symptoms.View full abstractDownload PDF (1686K)
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Toru MASAOKA, Yoshihisa HASEGAWA, Junsuke YOSHITAKE, Yukio UEDA, Nobuy ...1971 Volume 12 Issue 4 Pages 353-360
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe present report deals with an adult case with acute lymphatic leukemia who showed a complete remission for seven years after one year treatment since the onset.
From the changes of leukemic cells in total circulating blood, an equation, log Z=K1t2+K2t+K3, was found to be applicable to a diminishing curve of leukemic cells; where Z stands for the total number of the leukemic cells in the peripheral blood, t for the time elapse after the onset, and K1, K2 and K3 for the constants.
The equation will lead one to obtain significant informations for the treatment of leukemia, e.g., the number of surviving leukemic cells and the time when the medication should be changed.View full abstractDownload PDF (763K) -
Ryuichi KAMIYAMA1971 Volume 12 Issue 4 Pages 361-366
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSAmong five patients of acute promyelocytic leukemia, fibrin-like inclusions, which composed of periodic cross bands with spacing of about 200 Å, were observed in the rough surfaced endoplasmic reticulum of leukemic cells. Moreover, Auer bodies were also seen electron microscopically, in the cases having these inclusions.
It will be necessary to clarify their biochemical character and function in relation to characteristic pathophysiology of acute promyelocytic leukemia, in future.View full abstractDownload PDF (1258K) -
Utako OKAMOTO, Masako MATSUMOTO1971 Volume 12 Issue 4 Pages 367-372
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSIt has been reported that two kinds of proactivators, large molecular and small molecular, are separated from human plasma through Sephadex gelfiltration. The large molecular proactivator mostly appeared in the fraction where fibrinogen was eluated, and it is difficult to separate fibrinogen and proactivator by using usual salting out and isoelectric precipitation methods. Then the question arises that large molecular proactivator may be the complex of fibrinogen and small molecular proactivator. In order to answer the question this experiment was undertaken.
The profile of Sephadex chromatography of the plasma from a congenital afibrinogenemia patient was compared with that from healthy person in fibrinolytic components. The result obtained showed that there was no qualitative difference between two plasma samples in plasminogen and proactivator. Besides, large molecular proactivator also appeared in the fraction where fibrinogen would apper if existed any. This clearly indicates that the large molecular proactivator is not the complex of fibrinogen and small molecular proactivator.View full abstractDownload PDF (472K) -
Fujio SAKO1971 Volume 12 Issue 4 Pages 373-382
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSOne hundred and seventy-seven patients (137 families) with hemophilia A and hemophilia B were seen during 12 years, 1959 through 1970, at the First Department of Internal Medicine, Nagoya University School of Medicine. Sixty-two among them, 52 hemophilia A (36 families) and 10 hemophilia B (10 families), were classified as mild hemophilia on the basis of mild hemorrhagic manifestation. Clinical and hemostatic studies were also carried out on those patients with moderate and severe forms.
Genetic studies revealed that, as in moderate and severe forms, about half of the patients with mild hemophilia were sporadic. Mild and moderate or severe forms of hemophilia were never seen together within a family. Onset of abnormal hemorrhage spread over a wide range of age. Majority of initial hemorrhage was post-traumatic and bleeding after tooth extraction followed in incidence as the first hemorrhagic manifestation. In subsequent course of mild hemophilia, most hemorrhage was also induced by some trauma and spontaneous bleeding was rare. Habitual bleeding was rarely encountered in mild hemophilia. Hemarthrosis was observed in about half of the cases although an incidence of limitation of joint movement remained low.
Whole blood clotting time was normal in half of the cases, and slightly prolonged less than 20 minutes in the rest of them. The activity of Factor VIII or Factor IX ranged from 1.2 to 50.0% of the normal control. TGT was abnormal in all the cases. Each one of tests such as whole blood clotting time, recalcification time, TST, and prothrombin consumption test was not sufficient individually to detect every single case of mild hemophilia. Prothrombin consumption test, however, could detect the mild hemostatic abnormality when combined with 2 or 3 of others.View full abstractDownload PDF (794K) -
Ichita AMAKI, Atsushi HORIUCHI, Michiya YAMAGUCHI, Yasuo NAGATA, Eikic ...1971 Volume 12 Issue 4 Pages 383-387
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSResults of treatment of malignant lymphoma with L-Asparaginase are reported. L-Asparaginase was given at the dosage of 200u/kg daily for from 10 to 14 days in four cases; three lymphosarcoma and one reticulum cell sarcoma.
In two cases corticosteroids were administered simultaneously combined with L-Asparaginase. A complete remission was obtained in one of three cases of lymphosarcoma who received initial treatment with L-Asparaginase. Other two cases who had been treated with one or more conventional chemotherapeutic agents before showed moderate clinical improvements. But one case of terminal stage of reticulum cell sarcoma developed no reaction.
Anorexia, nausea, somnolence and hypoproteinemia were the outstanding side effects of L-Asparaginase and hypolipemia, anemia, urticaria, depressed liver function and anaphylactic reaction were also observed.
Remission duration was relatively short to usually within three months.View full abstractDownload PDF (383K)
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Sumio MIYAZAKI, Takeo FUJIMOTO, Hiromichi TAKE1971 Volume 12 Issue 4 Pages 388-391
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe clinical courses of six boys with acute leukemia who developed leukemic infiltrations of the testes while the leukemia was in remission are described.
Two of them were assumed to have acute lymphoblastic leukemia, another three were acute stem cell leukemia and the other one was acute myeloblastic in type.
Clinically, four of them had only unilateral enlargement. Four of our six cases were treated with methotrexate. Orchiectomy was performed in the other two. Histologic section of the testes showed leukemic infiltrations. Two of them showed episodes of meningeal leukemia which successfully treated with intrathecal methotrexate.View full abstractDownload PDF (337K) -
Tetsuo AKIHAMA, Yasuyuki ENDO, Akira SHIBATA, Yoshiro TACHIBANA, Seiju ...1971 Volume 12 Issue 4 Pages 392-397
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 45-year old woman is described, who has first been suspected chronic lymphocytic leukemia but had, on laboratory studies, other features which were incompatible with chronic lymphocytic leukemia.
On examination of the peripheral blood smears, atypical lymphoid cells predominated. The histologic pictures of lymph nodes were strikingly different from those of chronic lymphcytic leukemia.
On the culture studies, the percentage of lymphocytes which showed blastoid transformation was 77.5% with phytohemagglutinin (PHA) and 76% without PHA. An additional finding was an elevated EB virus antibody titers in the patient's sera. These observations suggest that the case we presented is probably a new entity.View full abstractDownload PDF (715K) -
Koichi HARA, Hirokuni TAGUCHI, Koji KANBARA, Hiroo YOSHIOKA, Shigeru A ...1971 Volume 12 Issue 4 Pages 398-404
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA case of megaloblastic anemia induced by pregnancy was reported. She became anemia three months after her first delivery. She was treated at first with iron and vitamin B12 without any effect. She had a macrocytic hyperchromic anemia on admission. Leukopenia and thrombopenia also existed. Examination revealed that serum folic acid level was 1.2 mμg/ml and vitamin B12 level was 875 μμg/ml. LDH was 1660 unit.
Megaloblasts and large metamyelocytes were detected in the bone marrow. Folic acid absorption test by 3H-folic acid was 57%. Schilling test was 23.5%. These examinations show that this anemia was folic acid deficiency anemia induced by pregnancy.
Though the increased demand of folic acid during pregnancy is the primary cause of this anemia, malnutrition, lactation and fever were the factors which promoted folic acid deficiency.
After admission, her anemia was recovered itself without any folic acid administration.
The importance of nutrition, lactation and fever for the pathogenesis of megaloblastic anemia of pregnancy was discussed by quoting literatures. The relationship of estrogen and malabsorption of folic acid to the anemia was also discussed.View full abstractDownload PDF (511K) -
Yamao ADACHI, Shimpei FURUSAWA, Hideo SHISHIDO, Takeo NOMURA, Masafumi ...1971 Volume 12 Issue 4 Pages 405-411
Published: 1971
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 60-year-old man was referred to the Tokyo Medical and Dental University on August 26, 1970 from a local hospital where he had been given adrenocortical steroid with the diagnosis of chronic lymphocytic leukemia.
Physical examination on admission showed a mild lymphadenopathy and moderate hepatosplenomegaly. Blood study revealed a marked leukocytosis of 249,000/cmm with 91.5% small lymphocytic cells and 2.0% large blastic cells. Morphology of the small cells, depression of the PHA-induced blastoid transformation, abnormalities in serum proteins such as decreased IgA and positive cryoglobulin and negative Mantoux reaction were all consistent with chronic lymphocytic leukemia. On the other hand, approximately 30% of the marrow cells was large blasts and 60% was small lymphocytes. The lymphnode biopsy revealed a moderate infiltration of large blasts without any features of chronic lymphocytic leukemia. Cytochemial and electronmicroscopic findings of the blasts were compatible with acute lymphoblastic leukemia. Furthermore, there was no transition between the two types of cells. Thus, a diagnosis of “mixed leukemia” was made, the term being used in the sense of independent occurrence of two types of leukemia in one subject.
The patient developed septicemia due to Pseudomonas on the 10th hospital day, which was followed by agranulocytosis. The infection was successfully treated by antibiotics, and remission of acute lymphoblastic leukemia ensued, whereas hematological findings of chronic lymphocytic leukemia persisted. He was transferred to the local hospital a month later where the same therapeutice regimen consisting of adrenocortical steroid and cyclophosphamide was given. The patient died suddenly in the beginning of November, 1970 while in remission so long as acute lymphoblastic leukemia was concerned. Autopsy was not performed and the major origin of cells of chronic lymphocytic leukemia remained undetermined.View full abstractDownload PDF (875K)
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