Rinsho Ketsueki

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A series of Banti's syndrome was subjected to perform liver, spleen and bone marrow needle biopsies. Each specimen was studied by means of morphological observations as well as enzymological and isotopic examinations.
Of several enzymatic activities, the succinic dehydrogenase activity of the liver and spleen was found to be decreased with progress of clinical course. Urea cycle enzymes of the liver—e.g. arginase, ornithine transcarbamylase and arginine synthetase—which were measured before and two months after splenectomy showed no significant change in their activities. Concerning the distribution of incorporated C¹⁴-formate in the each fraction of bone marrow cells, the rates of incorporation into the grass protein fraction (GPF) and serine-glycine fraction were found to be within normal range while the rate of incorporation into the RNA fraction was accelerated and deviated from the normal range.
In order to confirm the existence of the splenic humoral effect upon the liver, serum obtained from the patients with Banti's syndrome was added to the normal human liver slice, taken from a person having identical hemotype, and the incorporation of C¹⁴-formate into the GPF fraction was observed. Normal human serum was subjected to the control study. The degree of the humoral effect was expressed by the comparative ratio of incorporation with the patient's serum against that of with normal serum. Similar experiments were also carried out on the every elements of nucleated cells obtained by bone marrow aspiration.
The humoral effect upon the liver observed at the step of GPF demonstrated a tendency of inhibition in every clinical stages of the Banti's syndrome. However, no difference was observed in the inhibitory effect between the splenic venous blood and peripheral blood of the same patient. On the contrary, the humoral factor in every clinical stages of Banti's syndrome gave an accelerative effect on the bone marrow cells at the step of GPF, while the serum obtained from patients with aplastic anemia showed inhibitory effect. However, the conspicuous accelerative effect of serum always decreased down to the normal range following splenectomy in Banti's syndrome.

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