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Volume 14, Issue 11
Displaying 1-9 of 9 articles from this issue
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Yasunari NAKATA, Shigeru ARIMORI, Shinya TADA, Hidehiro KOBASHI1973 Volume 14 Issue 11 Pages 1075-1079
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe thymic hyperplasia was determined using pneumomediastinography in patients with idiopathic aplastic anemia in previous report.
Further evaluation of thymic functions of aplastic anemia patients was done in this paper estimating sheep red blood cell rosette-forming cell (SRBC-RFC) and surface immunoglobulin bearing cell (SIBC) in peripheral lymphocytes. The SRBC-RFC in peripheral lymphocytes of patients with aplastic anemia increased their percentages as well as their absolute numbers in unit volume than those of healthy subjects (p<0.001). Decreased absolute numbers of SIBC in peripheral lymphocytes of patients with aplastic anemia was observed in spite of their normal ranges of SIBC percentages. Both evidence indicated that the patients with aplastic anemia seemed to have a thymic hyperfunction.
In comparison with laboratory examinations and the populations of SRBC-RFC in the patients with aplastic anemia, only the tuberculin skin reaction had a good correlation against SRBC-RFC percentage among erythrocyte sedimentation rate, peripheral blood pictures, serum iron level, serum gamma-globulin level, CRP, RA factor, antinuclear antibody and tuberculin skin reaction.
Further elucidation of relationship between thymic hyperfunction and bone marrow suppression is going under way.View full abstractDownload PDF (418K) -
Nobuyuki TAGUCHI, Kimiko NISHIJIMA1973 Volume 14 Issue 11 Pages 1080-1085
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA total of 50 patients—17 with acute myeloblastic leukemia (AML), 11 with poorly differentiated AML, 3 with acute lymphoblastic leukemia and 19 with acute unclassified leukemia—have been studied in order to evaluate the therapeutic effectiveness of periodic consolidation courses in maintenance of remission.
Consolidation courses were administered to 31 patients (consolidation group) and the other patients were observed as a control group.
Consolidation courses were instituted every three months with VCR 1.5 mg/m2/w on days 1 and 8, MTX 15 mg/m2 twice a week, 6-MP 60 mg/m2/day for 7 days and Prednisolone 40 mg/m2/day for 7 days orally, or with combination of VCR, 6-MP and Prednisolone for 7 or 14 days.
In consolidation group, the average hematological remission duration was 14.2 months and the averaga survival was 25.4 months. The average hematological remission duration was four times as long as a control group.
Drug toxicity due to consolidation courses included leukopenia, thrombocytopenia, diminution of serum IgG and IgA and mild local infections.
This method has proved in our experience to prolong considerably the remission duration of acute leukemia in children.View full abstractDownload PDF (462K) -
Tadaaki UETANI, Fujio SAKO, Kazuo IMAMURA, Masami HIRANO, Kuniyuki IMA ...1973 Volume 14 Issue 11 Pages 1086-1094
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThirty eight cases with acute leukemia were treated with consolidation therapy immediately after obtaining complete remission and intensification therapy during cyclic maintenance therapy.
The median duration of complete remission for this group was 16 1/3 months and the median survival was 18 2/3 months, whereas 8 and 16 2/3 months for cyclic maintenance therapy only, 4 2/3 and 10 1/3 months for 6MP maintenance therapy and 2 and 8 1/3 months for non-maintenance therapy respectively.
Differences of complete remission length between each of the four groups are statistically significant, whereas that of survival time between consolidation-intensification with cyclic therapy and cyclic therapy only is not significant, but 16 cases in the former group are still alive.
Side effects of consolidation and intensification therapy include nausea, vomiting, epilation, paresthesia and liver function abnormalities. Fever above 38°C was noted during the time of leukopenia after 28 courses of the treatment out of 109.
Eleven cases of hepatitis, 6 cases of pneumonia, one case of exacerbation of pulmonary tuberculosis and 3 cases of herpes zoster were major complications because of which the maintenance therapy had to be interrupted. Almost all of these complications were observed, except for herpes zoster, soon after consolidation treatment that was given following remission induction.
Eight cases (23%) had meningeal infiltration of leukemia during the maintenance therapy prior to hematologic relapse.
It is concluded that intensification and consolidation therapy coupled with cyclic maintenance therapy seem worth-while in prolongation of duration of remission and survival time of patients with acute leukemia.View full abstractDownload PDF (697K)
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Masashige TSUKADA, Atsushi KOMIYAMA1973 Volume 14 Issue 11 Pages 1095-1101
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSAn 1 9/12-year-old girl with Down's syndrome was admitted because of fever, anemia, bleeding tendency and hepatosplenomegaly. Promyelocytes were predominant in circulating blood and especially in bone marrow. Her clinical course was characterized by rapid dowhill course against treatments, marked bleeding tendency with hypofibrinogenemia and little acceleration of erythrocyte sedimentation rates. She was diagnosed as acute promyelocytic leukemia with Down's syndrome.
Ultrastructual findings of promyelocytes were as follows;
1. The cytoplasm had enlarged granular endoplasmic reticulum, which contained materials with positive peroxidase activities, Showing reticular appearance, partially sack-like or irregularly lamellar structure.
2. There were two types of granules, large and small ones, found mostly around a Golgi apparatus. The large granules revealed positive peroxidase activities and the small ones negative activities. The similar structure to Auer's body was demonstrated in some of the large granules.View full abstractDownload PDF (1159K) -
Yoshiaki NAKANO, Kazumi SAMPI, Yoichi GOCHO, Satoshi KATAYAMA, Ichiro ...1973 Volume 14 Issue 11 Pages 1102-1108
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 32-year-old male was admitted to our clinic in Apr. 1971, because of pallor and weakness of one month duration.
Physical examination showed severe anemia and slight jaundice without hepatosplenomegaly. The hematologic studies revealed anemia and thrombocytopenia with 24% erythroblasts and 12% myeloblasts in peripheral blood. Bone marrow was hypercellular with erythroid hyperplasia including megaloblastoid cells and multinucleated erythroblasts.
Cytogenetic studies of bone marrow cells showed karyotypic abnormality including marker chromosome in all cells observed.
Serum Vitamin B12 of this patient was 380 pg/ml and intramuscular administration of Vitamin B12 did not change his bone marrow picture.
Following blood transfusions of 1400 ml, the myeloblast in the bone marrow and peripheral blood began to increase in number, terminating in acute myeloblastic leukemia.
The alteration of erythropoiesis by blood transfusions in erythroleukemia was discussed.View full abstractDownload PDF (807K) -
Yukihiro SAKURAI, Isamu NAKAO1973 Volume 14 Issue 11 Pages 1109-1113
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 42 year old male was admitted after diagnosis of CML on July, 1969. He received Myleran therapy for three months and was discharged in remission state.
The chromosomal number of bone marrow cells and cells from peripheral blood revealed eudiploidy, on the other hand, Ph1 chromosome was shown positive result of 100% at start of initial therapy. Two years later, he readmitted on July, 1971, because of blastic crisis occured. The Karyotypes have changed hypodiploidy (45), and C monosomy has been observed in 60% of marrow cells. He has had three times partial remissioas by means of the therapy with Prednisolone, 6MP-Riboside, Ara-C, Vincristine and Carbazilquinone. He died of cerebral hemorrhage on Jan, 1972.
The C monosomy-changed cells were observed in 100% at second relapse on Aug, 1971.
Canellos et al,6) have reported on relationship between hypodiploid cell line and response to therapy with Prednisolone and Vincristine.
This case has obtained relative good response not only to Prednisolone and Vincristine, but also 6MP-Riboside, Ara-C and Carbazilquinone in acute blastic crisis, whereas the survival time has confined within seven months.View full abstractDownload PDF (564K) -
Katsumi NAKAMURA, Takeaki SUOU, Tsukasa ITAKURA, Atsuko IMAI, Kuni ISH ...1973 Volume 14 Issue 11 Pages 1114-1119
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA case of congenital factor XIII deficiency in a 12-year-old boy is described. The bleeding episode was started with umbilical bleeding and persisted as hemorrhagic disorder associated with slow wound healing.
All usual clotting tests were normal except for a small amplitude and a rapid reduction of amplitude in the thrombelastogram. Diagnosis was established by the clot solubility test, the monoiodoacetate (MIA) tolerance test and the quantitative test with antifactor XIII serum.
In the family history, his parents were cousins, whose plasma factor XIII levels were reduced, and a cousin of maternal grandmother was a bleeder.
The transfusions of Cohn fraction I, fibrinogen and purified factor XIII preparations were evaluated.View full abstractDownload PDF (570K) -
Hiromu OKADA, Toranosuke ISHIMARU1973 Volume 14 Issue 11 Pages 1120-1125
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSTwo instances of leukemia in siblings which occurred in two families are reported. One patient had microcephalia in addition to acute granulocytic leukemia. The parents were first cousins. Both mothers of the involved siblings had histories of early entry into Hiroshima City after the atomic bomb explosion and prior to their marriages. While a probable role of consanguineous marriage on the occurrence of familial leukemia is supported by previously reported studies, a leukemogenic effect of parental exposure to atomic bomb radiation has not been shown.View full abstractDownload PDF (736K)
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1973 Volume 14 Issue 11 Pages 1126-1131
Published: 1973
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (535K)
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