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Volume 15, Issue 7
Displaying 1-11 of 11 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1974 Volume 15 Issue 7 Pages 732-738
Published: 1974
Released on J-STAGE: October 31, 2008
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1974 Volume 15 Issue 7 Pages 739-746
Published: 1974
Released on J-STAGE: October 31, 2008
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1974 Volume 15 Issue 7 Pages 747-755
Published: 1974
Released on J-STAGE: October 31, 2008
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Akira B. MIURA, Akira SHIBATA, Tetsuo AKIHAMA, Yasuyuki ENDO, Yasuko S ...1974 Volume 15 Issue 7 Pages 756-763
Published: 1974
Released on J-STAGE: October 31, 2008
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Hajime OKITA, Kazuhiko ITO, Yoshinori TAKETOMI, Kingo FUJIMURA, Atushi ...1974 Volume 15 Issue 7 Pages 764-773
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe clinical and pathological findings of 4 patient with leukemia, that is, 3 cases of acute lymphocytic leukemia and one case of chronic granulocytic leukemia, who showed especially atypical type of interstitial pneumonia, probably caused following the administration of antileukemic drugs, and resulted in death following the extremely rapid downhill course.
It was the clinical characteristic features that the signs in each case began with high fever ranging 38°C to 40°C of several days durations before the abnormal findings of the chest X-ray appeared, and that sudden deaths occured in a week against the treatment with various antibiotics, followed with poor physical symptoms of respiratorysystem such as rales, cough and sputum.
The characteristic histopathological features were the edematous and fibrous thickning of alveolar wall, exudation of hyalinous or fibrinous substances into the alveolar cavities and the atypical changes of the alveolar and bronchial epithelia. There were no findings which were suggestive of viral, fungal or pneumocystiscarini infections.
Consequently, it appears most likely that the vascular injuries due to the antileukemic drugs might play a most important role for inducing these pulmonary lesions. As the possibillity that the drug allergy may take a part in this pathogenesis, it was discussed that the further investigation will be awaited.View full abstractDownload PDF (1942K) -
—Assessed by Modified Bioassay Method—Katsutoshi TAKADA, Toshiyuki NODA, Mizuho ASAKAWA, Masahiko YAMAMOTO, ...1974 Volume 15 Issue 7 Pages 774-779
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThis report deals with the modified bioassay method of measuring erythropoietin (EPO) using polycythemic mice and the correlation between EPO level and hemoglobin concentration in patients with and without anemia. The results were as follows.
(1) Polycythemic mice for the sensitive bioassay of erythropoietin was easily available by being fed at one half atmospheric pressure for a week.
(2) In patients with iron deficiency, posthemorrhagic and hemolytic anemia, EPO level which well correlates with the degree of anemia turned out to be a good index of hematopoiesis.
(3) In patients with aplastic anemia, hyperthyroidism and secondary polycythemia, no correlation was found between EPO level and Hb concentration and EPO level was high compared with Hb concentration. In patients with uremia, hypothyroidism and collagen disease, EPO level was low in comparison with Hb concentration.View full abstractDownload PDF (447K)
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Norio HIRABAYASHI, Gen ITO, Masanori KURASHINA, Harumitsu MIZUNO, Nobo ...1974 Volume 15 Issue 7 Pages 780-789
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSAn autopsy case of histiocytic medullary reticulosis (HMR) in a seventeen-old girl, clinically characterized by fever, jaundice, hemorrhagic diathesis, hepatosplenomegaly, impaired liver function and pancytopenia, was described. A small number of atypical cells, some of which showed erythrophagocytosis, were seen in the smears of peripheral blood and bone marrow. Electron microscopic examination of these cells allowed for their categorization as histiocytes of varying maturity, because of their overt phagocytotic properties and of the presence of pseudopodal extensions, pinocytotic vesicles and phagocytotic vacuoles. She went very rapidly downhill to death eleven days after onset.
The pathological examination showed generalized proliferation of histiocytic series in the lymph nodes, liver, spleen and bone marrow. Essentially medullary proliferations of these cells in lymph nodes was noted as a characteristic topographical picture. The nature of the case was considered as a malignant neoplastic disease because of the marked proliferation of atypical cells and of the absence of old infectious focus. Pertinent literatures were reviewed mainly from the histopathological point of view. The characteristic histopathological appearances of HMR and the nosological differentiation of presented case from the other neoplastic diseases of reticuloendothelial system were discussed.View full abstractDownload PDF (1667K) -
Toshiro NAGASAWA, Kenjiro TANOUE, Yasusuke ONOZAWA, Takashi NAKAJIMA, ...1974 Volume 15 Issue 7 Pages 790-794
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 32-year-old female with acute leukemia is presented where peritoneal leukemia developed during hematological remission. The patient responded excellently to vincristine and was apparently in remission 4 weeks after initiation of the induction therapy, when the signs of meningeal leukemia were noted. Meningeal leukemia was successfully treated with intrathecal methotrexate, which, however, resulted in a severe depression of the bone marrow lasting for approximately 3 weeks. Following the recovery from aplasia, consolidation was attempted with intravenous vincristine and intrathecal methotrexate. During the consolidation therapy a very rapid accumulation of ascites occured, which contained numerous leukemic cells. Although intraperitoneal methotrexate caused a marked decrease in the quantiy of ascites as well as the leukemic cell count in ascites, the patient died of sepsis due to E. coli 2 weeks after ascites had been first noted. Leukemic cells were not seen in the peripheral blood during the episode of peritoneal leukemia. Autopsy revealed a striking thickening of the peritoneum which consisted of massive infiltration of leukemic cells. In contrast, little infiltration of leukemic cells was detected in the bone marrow, spleen, lymph nodes or liver.View full abstractDownload PDF (640K) -
Jun OKAMURA, Yasushi OSHIMA, Takashi HOSOYAMADA, Takeo FUJIMOTO, Hirom ...1974 Volume 15 Issue 7 Pages 795-803
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 7 year-old girl was admitted because of chronic diarrhea, short stature and frequent febrile episodes.
On physical examination, telangiectatic erythema were noted on the face and chest. Laboratory findings showed abnormal lactose tolerance test and low level of serum immunoglobulin A and M. Chromosome analysis revealed an increase of chromosomal rearrangement including Quadriradial configuration and dicentric incidence chromosomes. She was suspected to have ‘Bloom's syndrome’.
A diagnosis of lactase deficiency was also established by the peroral small-bowel biopsy which showed markedly decreased lactase activity.
Therapeutic trial of lactase resulted in dramatic improvement of diarrhea, but she readmitted with cough and high fever five months later. A biopsy of the left supraclavicular lymphnode showed the histology of Hodgkin's disease. She was treated with radiation and chemotherapy but she died two months later.
Relation between Bloom's syndrome and malignancy is discussed.View full abstractDownload PDF (1552K) -
Shusuke MATSUYAMA, Saburo ONISHI, Kiyozumi OSADA1974 Volume 15 Issue 7 Pages 804-811
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSLong term survival of acute leukemia has been made possible by the recent advances in chemotherapeutic agents and general managements.
From 1963 to 1971 we treated 78 cases of acute leukemia in childhood; 8 cases of acute lymphoblastic leukemia (ALL), 16 cases of peroxydase-negative cells of acute myeloblastic leukemia (AML), 19 cases of peroxydase-positive cells of AML, 8 of acute promyelocytic leukemia and 27 of acute stem cell leukemia. Eight cases of acute promyelocytic leukemia were excluded in this study, for no cases were survived for more 2 years.
Fifty-six remissions were induced and 21 patients survived for more than 2 years. Forty per cent of cases of ALL and peroxydase-negative cells of AML are included in this group. Remission rate was low in patients under 1 year and the highest rate of more 2-year-suruival was seen in patients between ages of 6 and 10 years. Fourteen of these 21 long survivors had 60 relapses and 11 them died. Meningeal lekemia occurred in 33 per cent of 56 patients in whom remission were induced and in 42 per cent of patients with survival period of more than 2 years.
No correlation was seen between long term survival and clinical features and peripheral blood analyses.View full abstractDownload PDF (680K) -
Tatsuhito TONOOKA, Takeo TAKEDA, Yoshio HATAE, Nobuko AKINO1974 Volume 15 Issue 7 Pages 812-818
Published: 1974
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSAcute promyelocytic leukemia (APL) is known to be a severe hemorragic disorder, which is probably due to increased fibrinolytic activity, or to D. I. C. There are a few reports suggesting the presence of thromboplastin-like materials in the promyelocytic cells, and this may induce D. I. C.
Recently we had a case of typical APL. Laboratory tests revealed hypofibrinogenemia, thrombocytopenia, moderate titer of F. D. P., prolongation of prothrombin time and serial thrombin time, and presence of a number of promyelocytic cells in bone marrow.
By combined administration of prednisolone, vincristine sulfate, daunorubicin, and other drugs, a complete remission was obtained.
After 3 months, patient relapsed and we studied thromboplastic activity of APL cell extracts.
The method of estimating thromboplastic activity of tumor cell extracts is as follows.
White blood cells consisting of more than 90% of promyelocytic cells were obtained by venipuncture and bone marrow puncture. To remove blood coagulation factors and thrombocytes, leukemic cells were cultured for 2∼5 days. Cultured cells and medium harvested were used for study. Results were as follows.
1) Recalcification time of normal and hemophilic plasma was more accelerated by the extracts of APL cells than that of control cells (ALL, AML or nomal leukocytes).
2) Medium harvested after APL cell culture did not accelerate recalcification time of normal plasma.
These evidences seemed to suggest that promyelocytic cells of APL contain a large amount of thromboplastin-like materials.View full abstractDownload PDF (813K)
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