Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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Volume 16, Issue 5
Displaying 1-7 of 7 articles from this issue
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  • Chromosome Aberrations of Acute Leukemia Patients in Pre-and Post-Treatment
    Nanao KAMADA, Nobuo OGUMA, Motoko MIKAMI, Ryuji TANAKA, Yukifumi ISHII ...
    1975 Volume 16 Issue 5 Pages 505-512
    Published: 1975
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.16.505
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    Hematological and cytogenetical studies on bone marrow cells were performed in 101 adults with acute leukemia, 58 (57.4%) of whom had abnormal karyotypes in their leukemic cells prior to treatment. In granulocytic leukemia non random distribution of chromosomal abnormalities were observed; C+, D+, E+, G- abnormalities which were probably due to translocation of C gruop chromosome to the long arm of G chromosome, t (Cq-: Gq+), were significantly more frequent than expected. All patients with these translocation had low neutrophil alkaline phosphatase activity and characteristic findings in blood pictures and survival time.
    Repeated examinations of chromosomes were also performed in 32 patients. When the condition of patients with abnormal karyotypes turned to those of complete or incomplete remission by effective treatment, most of the bone marrow cells showed normal karyotypes or co-existence with small percentage of abnormal karyotypes. Cases without responce to leukemic therapy had persistent abnormal karyotypes. It seems that chromosome analyses during the course of the disease give some informations about the judgement of remission and guide for the leukemia therapy.
    The discussion was made on the frequency of chromosme abnormalities in acute leukemia, possible non random abnormalities of chromosomes in acute granulocytic leukemia and fairly weak relationship between chromosome aberrations and survival time.
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  • Serum and Urinary Phosphorus During Therapy of Childhood Leukemia
    Yukiko TSUNEMATSU, Ryo KOIDE
    1975 Volume 16 Issue 5 Pages 513-521
    Published: 1975
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.16.513
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    Severe hyperphosphatemia and hypocalcemia were observed in two cases of acute myeloblastic leukemia associated with hyperuricemic nephropathy. Hyperkalemia was also detected in the first case before the elevation of blood urea nitrogen.
    These findings may be explained as a consequence of increased endogenous phosphorus and potassium load resulting from destruction of blast cells. These phenomena are analogous in their pathophysiology to hyperuricemia which results from the metabolism of purines released from cell breakdown. Hyperphosphatemia and hyperkalemia seemed to be aggravated by the hyperuricemic nephropathy which disturbed urinary excretion of phosphorus and potassium. A large amount of phosphorus was excreted in urine during therapy in the absence of renal failure.
    In contrast to these findings, marked hypophosphatemia and hypophosphaturia were observed in the terminal stage after withdrawal of antileukemic agents. This could be possibly explained by mobilization of phosphorus into rapidly proliferating malignant cells.
    Measurement of the urinary phosphorus may be useful to evaluate the effects of antileukemic agents.
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  • Clinical Effects of Intravenously Administered Dextrin Citrato-Iron (III) Complex “Ferricon”
    Hiroya KAWAGOE
    1975 Volume 16 Issue 5 Pages 522-529
    Published: 1975
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.16.522
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    Ferrokinetic studies with 59Fe-labelled dextrin citrato-iron (III) complex (Ferricon) were performed in anemic rabbits due to bleeding and acute liver damaged rabbits due to carbon tetrachloride administration. In the anemic rabbits, labelled Ferricon was rapidly disappeared from the circulating plasma, red blood cell utilization of 59Fe increased than normal control. On the other hand in the liver damaged rabbits, the disappearance rate was slow and 59Fe utilization into hemopoiesis was decreased.
    Ferricon was administered intravenously to 8 cases of iron deficiency anemia in gastroenteropathy or after gastrectomy. The red blood cells, hemoglobin and hematocrit levels were increased after reticulocyte crisis in all cases. Ferrokinetics with 59Fe labelled Ferricon was studied on a case of iron deficiency anemia after gastrectomy, the iron was incorporated relatively slow and continuously into red blood cells. These results showed that Ferricon had a continuous effect for hemopoiesis and little side effects. The indication for clinical use and other favorable effects were also discussed.
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  • A Case of Consumption Coagulopathy Due to Atrial Giant Thrombus
    —Detection of thrombus by scintillation camera using fibrinogen labelled with 125I, 131I and Warfarin-Aspirin combination therapy—
    Shojiro IKEMATSU, Izumi TAKEUCHI, Ohki ITOH, Tomohiro SAMORI, Takashi ...
    1975 Volume 16 Issue 5 Pages 530-536
    Published: 1975
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.16.530
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    It has been reported in previous papers that a giant thrombus could be found out in mitral valve failure, especially in mitral stenosis.
    In this paper, by the use of a scintillation camera with 125I-fibrinogen and 131I-fibrinogen the authors demonstrated a giant thrombus in the left atrial area of a patient indicating the laboratory findings of consumption coagulopathy with mitral setnosis and insufficiency, and, furthermore, we tried to administer aspirin together with warfarin for anticoagulant therapy, because of the wide fluctuation of coagulation factors during the administration of warfarin alone. As the results of this trial, the patient took into a favorable turn in the laboratory findings and clinical status of consumption coagulopathy.
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  • A Case of Cyclic Neutropenia
    Mitsuaki TAJIRI, Ken ISHIDA, Shigemi ARIYAMA, Kunio ARIYOSHI, Koji NAK ...
    1975 Volume 16 Issue 5 Pages 537-542
    Published: 1975
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.16.537
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    A 20-year-old female suffering from cyclic neutropenia was studied from the viewpoint of daily complete peripheral blood counts, serial bone marrow examinations, marrow reserve test and serum lysozyme determinations. Daily peripheral blood counts revealed periodic fluctuations of 21 days intervals. Bone marrow examinations, marrow reserve test and serum lysozyme measurements suggested periodic failure of marrow production rather than peripheral destruction.
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