Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Search
Advanced search
OR
Browse
Search
Volume 15, Issue 4
Displaying 1-10 of 10 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • Present Status and Some Characteristics of Infections in Acute Leukemia
    Masafumi KAWATO
    1974 Volume 15 Issue 4 Pages 359-366
    Published: 1974
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.15.359
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    The author studied the infections in 61 adult patients with acute leukemia admitted to the 2nd Tokyo National Hospital from May 1967 to September 1973.
    The results were as follow:
    1. Fifty-six of 61 patients had 151 febrile episodes during the course of leukemia.
    Infections were proved to be the cause of fever in 109 (72.2%) of febrile episodes.
    2. The kinds of infections, in order of frequency, were pneumonia, sepsis, urinary tract infections and skin infections.
    3. The identified organisms were gram-negative bacilli in most of the infections, and those avirulent organisms of ten caused fatal infections. Systemic fungus infections occurred in 4 of 61 patients.
    4. Eighty-three percent of infectious episodes occurred during induction or consolidation therapy of leukemia.
    5. The incidence of infectious episodes and fatality rate of infections increased with decreasing mature neutrophils.
    6. In some cases, immunological abnormalities were thought to be one of the causes of infections in acute leukemia.
    View full abstract
    Download PDF (611K)
  • Septicemia in Acute Leukemia
    Tetsuhei OGAWA
    1974 Volume 15 Issue 4 Pages 367-374
    Published: 1974
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.15.367
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    The clinical and microbiologic features of 67 episodes of septicemia occuring in patients with leukemia have been reviewed. Most were recieving induction therapy with antileukemic drugs, 74%, and/or antibiotics, 75%.
    Fourteen episodes of multiple organ septisemia occured in 5 patients.
    Septicemia due to pseudomonas spiecies had shown striking increse and klebsiellaenterobacter group had remained an important pathogen.
    Nine patients with pseudomonas septicemia recovered by the treatment with combination of gentamicin and carbenicillin or sulbenicillin. Four patients with klebsiella septicemia treated with a combination of gentamicin and cephalosporin recovered.
    View full abstract
    Download PDF (584K)
  • Pulmonary Infections of Leukemia
    Munetaka ISHIKAWA, Atsushi HORIUCHI
    1974 Volume 15 Issue 4 Pages 375-383
    Published: 1974
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.15.375
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    In patients with acute leukemia, infections commonly are localized in the lung, paticularly, pneumonia is quite often (62.9%) in stage of remission induction. Roentgenographic findings in early stage of pneumonia, diffuse granular or reticulo-granular pattern shows such as interstitial pneumonitis. Histologically, infection is occasionally different to recognize in patients with acute leukemia since the inflammatory response is altered and is characterized by a paucity of neutrophils. Accordingly, it is possible that a lesion resembling and identified as recent intra-alveolar hemorrhage or edema actually may have been the early stage of pneumonia.
    The fungal infections most frequently found in terminal stage were aspergillosis, candidiasis and mucormycosis. The incidence of these infections has been increasing in recent years.
    Tuberculosis, although not statistically increased in patients with leukemia, should always be considered in any patient with pulmonary infiltration.
    View full abstract
    Download PDF (1755K)
  • Chemotherapy of Acute Leukemia in a Bioclean System
    Tadaaki UETANI, Ryuzo OHNO, Kazumasa YAMADA
    1974 Volume 15 Issue 4 Pages 384-392
    Published: 1974
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.15.384
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    Fourteen patients with acute leukemia were treated in a bioclean isolator system devised by us. All patients had entire body cleaning with Chlorhexidine and i.v. antibiotics prior to the entry in the isolator and received nonabsorbable antibiotics and sterile food during the Study. Thirteen patients received combination chemotherapy for initial remission induction therapy. Eleven out of them achieved complete remission.
    The incidence of infection among the patients in the isolator was significantly reduced as compared to that of the patients treated in the open ward. Days febrile in the confinement was also greatly reduced. With granulocytes less than 100/cmm, patients spent febrile 16.1% of their total days of the induction period in the isolator, whereas spent febrile 31.3% of their total days of the induction period in the open ward.
    With granulocytes 100 to 500/cmm, patients spent febrile 8.2% in the isolator, whereas 15.2% in the open ward.
    Documented infections were observed in 2 patients treated in the isolator. Both were pneumonia, one caused by klebsiella and the other by E-coli. Those were presumed to be endogenous infections, judging from the spectrum of the cultured organisms prior to the development of the infections.
    Patients protection by isolation seems to offer important potential aids to intensive chemotherapy of acute leukemia.
    View full abstract
    Download PDF (705K)
  • [title in Japanese]
    [in Japanese], [in Japanese]
    1974 Volume 15 Issue 4 Pages 393-401
    Published: 1974
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.15.393
    JOURNAL RESTRICTED ACCESS
    Download PDF (640K)
  • Development of Procoagulant (tissue thromboplastin) Activity of Leukemic Cells in Acute Promyelocytic Leukemia
    Kiyoaki WATANABE, Kazuoki KONDO, Tetsuhei OGAWA, Mitsuto HASEGAWA, Ken ...
    1974 Volume 15 Issue 4 Pages 405-414
    Published: 1974
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.11406/rinketsu.15.405
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    Peripheral leukemic cells from a patient with acute promyelocytic leukemia (APL) were analysed for coagulant activity.
    Suspensions of leukocytes were prepared by a modification of the method of Böyum. Washed preparations were disrupted by freezing and thawing six times and homogenized by a Potter-Elvenhjem apparatus 0.34 M sucrose solution.
    Lysate of these leukemic cells significantly shortened the recalcification time and activated PTT in normal human plasma. Clot was formed in a time of 49 sec. when 0.1 ml of lysate (WBC: 150,000/mm3) was added into prothrombin time system, instead of tissue thromboplastin but not formed when it was added into thrombin time system instead of thrombin. These leukemic cells also shortened clotting time with factor VIII and factor IX deficient plasma, however not with factor II, factor V or factor VII complex deficient plasma. The activity was destroyed almost completely after heating for 120 min. at 56°C and 80°C.
    The results suggest that this procoagulant activity has a characteristics of tissue thromboplastin. Approximately 1.5×107 leukemic cells has a thromboplastic activity of 0.2 mg of rabbit lung tissue thromboplastin (Lyoplastin). Small amount of sodium heparin could inhibit this activity in vitro.
    No significant procoagulant activity was detectable in the leukemic cells from a patient witn AML or CML, or in normal leukocytes.
    These data suggest that leukemic cells of APL has a significant quantity of thromboplastic activity and could be involved in the pathogenesis of disseminated intravascular coagulation of this disease.
    View full abstract
    Download PDF (1007K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top