All issues
Volume 16, Issue 9
Displaying 1-8 of 8 articles from this issue
- |<
- <
- 1
- >
- >|
-
[in Japanese]1975 Volume 16 Issue 9 Pages 839-849
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (1226K)
-
Toshiro NAKAGAWA, Junichi YATA, Kentaro NAKAYAMA1975 Volume 16 Issue 9 Pages 850-858
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSPeripheral blood lymphocytes from 14 healthy children and from 28 patients with primary aplastic anemia were examined for the presence of surface markers (E rosettes, EAC rosettes and Sm-Ig), and for the in vitro response to mitogens (Phytohemagglutinin: PHA and Lipopolysaccharide: LPS).
Absolute number of rosette forming cells (RFC) was increased in 50% of nontreated patients group, but decreased in the patients treated with adrenocortical steroids (ACS). Absolute number of complement receptor lymphocytes (CRL) was almost normal in non-treated patients group, but decrease was observed in 50% of the cases treated with ACS. Surface immunoglobulin bearing lymphocyte frequency was decreased remarkably in both non-, and ACS-treated group.
PHA responsiveness of the peripheral blood lymphocytes from patients was within normal range, while response to LPS was slightly or moderately decreased.
Frequency of CRL in bone marrow blood lymphocytes from 10 cases of aplastic anemia did not differ from control subjects. While, percentage of RFC was very much increased (mean 34.2%).
The observation that some defects of B cell differentiation and high frequency of RFC in bone marrow blood may be pathognomonic should be further elaborated.View full abstractDownload PDF (690K) -
Nobuhiro OTA, Shozo INOUE, Michiharu SASAKI, Nanao KAMADA, Hajime OKIT ...1975 Volume 16 Issue 9 Pages 859-867
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSTwo patients with acute myelocytic leukemia who were a 58 years old male and a 59 years old female and both had low neutrophil alkaline phosphatase activity and the translocation between C and G group chromosomes in bone marrow cells, and one male patient with acute lymphocytic leukemia were presented. The percentage of patients with leukemia and coexistent primary cancer was found to be 0.56—0.64 from the analysis of patients found in Japanese literatures, which seems to be lower than the incidence in the reports from U.S.A.
The possible factors which might induce the difference in the incidence between two countries, as well as the carcinogenesis in patients with acute myelocytic leukemia and coexistent stomach cancer were discussed.View full abstractDownload PDF (1016K) -
Mine HARADA, Toshitaka OMURA, Kunimi TANAKA, Kenichi HATTORI1975 Volume 16 Issue 9 Pages 868-874
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSTo evaluate cell-mediated immunity in aplastic anemia, tuberculin test, both nonimmune and active rosette formation of the peripheral blood lymphocytes, in vitro PHA stimulation of lymphocytes and a serum factor inhibiting PHA responsiveness were studied in 18 patients including a case with pure red cell aplasia.
Both percentage and total count of lymphocytes forming non-immune and active rosettes were a little lower in patients than in normal subjects, but there was no significant decrease in aplastic anemia (P>0.2). Although three patients subjected to long-term corticosteroid therapy were found to be negative to tuberculin test and abnormally low in active rosette formation, significant correlation was not observed between rosette formation and type or severity of the disease.
Peripheral blood lymphocytes showed almost normal reactivity to PHA stimulation, and an inhibitory factor for PHA responsiveness was not detected in the sera of 7 patients tested so far.
From these findings it may be concluded that cell-mediated immunity in aplastic anemia is kept mostly normal.View full abstractDownload PDF (598K)
-
Hiroko HIRAI, Atuko YAMAGISI, Akie KAWAGUTI, Kiiti ITO, Masayosi TAKAH ...1975 Volume 16 Issue 9 Pages 875-880
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe present report deals with a case of multiple myeloma with pleural effusion in which pathological plasmacytes and M-protein were shown. A 70-year-old woman was admitted to our hospital with the chief complaint of serious anemia in March 1974. Hematological examination on admission revealed 5.6 g/100 ml of hemoglobin and 2,130,000/cmm of erythrocytes. Examination of the bone marrow showed 55% of pathological plasmacytes. A test for Bence Jones protein in the urine was negative. The erythrocyte sedimentation rate was 167 mm/hr, while the serum total protein was 10 Gm/100 ml, Monoclonal pattern was observed in γ-globulin area and light chain type was K. Osteoporosis was observed throughout the body. Since her symptoms were improved by the therapy with cyclophosphamide, β-methazone and anabolic hormone, she was discharged on May 20, 1974. Two months later, however, she was readmitted with the complaints of chest pain and malaise. Soon afterwards, the right hydrothorax was developed. A lot of myeloma cells and M-protein were revealed in the pleural fluid. The patient died under general malaise on October 23, 1974. The autopsy was refused.View full abstractDownload PDF (649K) -
Masayo NISHI, Toshihiko KOHAMA, Kyoichi INOUE, Hiroshi SASAKI, Fumihir ...1975 Volume 16 Issue 9 Pages 881-886
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 31-year-old male was admitted because of nausea, nasal bleeding. Promyelocytes were predominant in circulating blood and especially bone marrow. The coagulation study revealed a marked bleeding tendency with hypofibrinogenemia, high titer of fibrinogen degradation products. He was treated with quadruple combination therapy of daunorubicin, cytosine arabinoside, 6-MP and prednisolone. After combination therapy, his peripheral leukocyte counts were reduced from the level of 1,300/cmm. down to 200/cmm., and the nucleated marrow cell counts were reduced from 68.5×104/cmm. to 0.22×104/cmm. Consequently he combined a klebsiella pneumonia, and recieved bone marrow transfusion (total nucleated marrow cell counts were 6.4×109) from identical twins. The consolidation therapy was attempted with intravenous daunorubicin and oral 6-MP.
He is doing well and the duration of his complete remission is 22 months.View full abstractDownload PDF (652K) -
Kazuo TAKEUCHI, Motoharu KIMOTO, Hisomu YAMAGUCHI, Ichitaro ASAI, Tosh ...1975 Volume 16 Issue 9 Pages 887-895
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSCase 1. M. A., 16-year-old schoolboy passed a temporary dark urine after an exercise of “fumikomi (a special step)” of “kendo (Japanese fencing)” on April 27, 1974. After the same episodes on two occasions he was admitted on July 5, 1974.
Case 2. K. W., 19-year-old male student passed dark urine as in Case 1 after a severe exercise of “fumikomi” of “kendo” without any subjective complaints. He was admitted on January 6, 1975 for further examinations.
On admission both cases showed no abnormalities in physical examinations and laboratory findings, including peripheral blood, bone marrow aspirates, urinalysis, blood chemistry and serological examinations.
A transitory hemoglobinuria was proved after an exercise of “fumikomi” for one to two hours and simultaneous increase in serum LDH level (especially Fraction I) was observed. Shortening of RBC life span was not proved after exercise. Mechanical fragility of the erythrocytes was normal and there was no change in enzyme activity of the erythrocytes after exercise.View full abstractDownload PDF (719K)
-
1975 Volume 16 Issue 9 Pages 896-911
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (1558K)
- |<
- <
- 1
- >
- >|