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Volume 20, Issue 1
Displaying 1-14 of 14 articles from this issue
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Yoshiro NIITSU, Junichi KOSEKI, Naoki WATANABE, Shinobu OTSUKA, Ichiro ...1979 Volume 20 Issue 1 Pages 1-7
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSSerum ferritin concentration in normal subjects was measured with its relation to hemoglobin value and % transferrin saturation. There was a significant difference in mean values of serum ferritin concentration between male (117.2±62.3 ng/ml) and female (55.9±54.2 ng/ml).
Serum ferritin levels tend to increase with aging in both sexes. Quite abrupt increase in serum ferritin levels was observed in female after the age of late 40, indicative of menopause.
Abnormally low levels of serum ferritin were found in populations of apparently healthy subjects (11% of adolescent in female) whose hemoglobin values were within normal range. These subjects were considered to be in the state of latent iron defciency since serum ferritin levels are closely related to mobilizable iron store in the tissue.
5 out of 8 subjects with the latent iron defciency had impared activity of cytochrome-C oxidase in peripheral leucocytes and frequently complained of dizziness, easy fatigability and weakness. These complaints were effectively relieved by iron therapy.View full abstractDownload PDF (517K) -
Tadami NAGAO, Katsuto WATANABE, Mitsumoto KOMATSUDA, Shigeru ARIMORI1979 Volume 20 Issue 1 Pages 8-14
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThe changes of microbial burdens of 5 patients with acute leukemia were studied before, during and after protective isolation.
Under conventional ward, genus numbers of microbial burdens were decreased with the treatment of sterile foods and prophylactic oral and topical antibiotics. Genus numbers in the throat were decreased with sterile foods alone in 2 of 3 patients who were not treated with antibiotics. Under protective environments, genus and species numbers of microbial flora were decreased in the patients who were treated with antibiotics, but the numbers of the residual flora were rather increased. The changes in genus numbers of microbial flora were various in the patients who were not treated with antibiotics. In some patients, total number of fecal microbial flora was rather increased and many bacteria were found in the anus. All patients never developed infection during their stay in the protective environments.
From these bacteriological data, prophylactic methods of infection under protective isolation ward were discussed.View full abstractDownload PDF (529K) -
Hiroshi FUJII, Yukio YOSHIDA, Tsuyoshi IKAI, Kenji OGINO, Shigeru TAKE ...1979 Volume 20 Issue 1 Pages 15-24
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSSixty-one patients with hematopoietic disorders who were autopsied in Kyoto First Red Cross Hospital between 1968∼1977, have been retrospectively studied for Pneumocystis carinii infection using toluidine blue-O, Gomori's methenamine silver, and hematoxylin-eosin stains. Pneumocystis carinii infection was found in 14 patients of them: 6 of 22 cases of leukemia, 4 of 24 cases of malignant lymphoma, 2 of 7 cases of multiple myeloma, 2 of 6 cases of aplastic anemia and 0 of 2 cases of myelofibrosis. All patients but one had been treated with steroids, cytotoxic agents and/or irradiation. Two of the 14 positive cases had extensive infection with Pneumocystis carinii. Alveolar spaces were filled with clusters of organisms, and the surrounding tissue exhibited an interstitial pneumonitis. Other 4 cases had increasing number of organism with minimal inflammatory response in alveolar septa. Remaining 8 cases were few in number of the organism, and did not show any response.View full abstractDownload PDF (807K) -
Katsuhiro INOUE, Masanori SHIMOYAMA, Keisuke MINATO, Takeaki TAKENAKA, ...1979 Volume 20 Issue 1 Pages 25-32
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThe effects of leukapheresis and plateletpheresis on normal donors using Celltrifuge and Haemonetics Model 30 to obtain large quantities of granulocytes and platelets were investigated. The procedure to obtain granulocytes using Haemonetics were performed over a 2-hr period using 6% hydroxyethyl starch (M. W. 45×104, 20×104) and the donor received an intravenous injection of Solu-Cortef 100 or 200 mg before each procedure.
Changes in many laboratory data (less than 20% decrease) were observed. However, it was considered that they occurred due to hemodilution by saline infusion and plasma expansion by 6% HES. Except these minor changes, white blood cells and granulocytes increased significantly in donors with Solu-Cortef injection. About 20 to 30% decrease of platelet count was observed in donors with plateletpheresis. It was noteworthy that 29% decrease of serum inorganic phosphorus was appeared in 10 cases treated without 6% HES, while in 15 cases treated with 6% HES 50% decrease (P<0.01) was shown.
The leukapheresis and plateletpheresis using Celltrifuge, or Haemonetics have been shown without severe side-effects. Numbness in lips (11.2%) and extremities (6.2%) was observed in the Haemonetics procedure.View full abstractDownload PDF (582K)
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Mutsuko KONNO, Takuji SATO, Chikara MIKUNI, Noboru YAMANAKA, Hirofumi ...1979 Volume 20 Issue 1 Pages 33-39
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSSix children with B-cell type acute lymphocytic leukemia were studied on their chinical pictures and cytologic and ultrastructural features.
All the 6 cases were boys under 5 years of age. Most of them bad sever anemia (Hb less than 6 g/100ml), massive bone marrow infiltration and marked hepatosplenomegaly.
The leukemic cells were reactive to anti-human B lymphocyte serum in all cases, but in two of them had no other marker such as a complement receptor or sIg.
All of them were easily induced to complete remission with prednisone with or without vincristine or 6 MP. Two cases without both complement receptor and sIg had a better prognosis than those with a complement receptor or sIg.View full abstractDownload PDF (714K) -
Koichi FURUKAWA, Yasumitsu NAKAIDE, Masao TANAKA, Mineya TANAKA, Yoshi ...1979 Volume 20 Issue 1 Pages 40-48
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 37-year-old female of acquired hemolytic anemia with negative Coombs test was reported. She was admitted to our hospital on September 2, 1977, with the symptoms of anemia which had occurred in the first trimester of her first pregnancy.
She was markedly anemic and jaundiced. Peripheral blood examination revealed RBC 109×104/mm3, Hb 3.5g/dl and reticulocyte 14.6%. The sternal marrow showed a marked erythroid hyperplasia.
Although a diagnosis of autoimmune hemolytic anemia was suspected, repeated Coombs tests were negative. In the peripheral blood film, rosette formation of autologous red cells around neutrophils and erythrophagocytosis by neutrophils were detected. These rosette formation and erythrophagocytosis were never found in lymphocytes, nor in monocytes. The same phenomenon was observed in the peripheral blood smear of the male infant who was delivered on November 2, 1977.
The rosette formation was found in 70 to 90% of neutrophils when blood was incubated for 2 hours, and not affected by anticoagulants and temperature of the incubation. On the other hand, erythrophagocytosis was more frequently detected in heparinized blood film than in EDTA-anticoagulated blood smear, especially when incubated at 25°C.
From study of transmission electron microscopy, this rosette resembled Fc rosette of lymphocyte. The relationship between rosette formation, erythrophagocytosis and hemolytic anemia was discussed.View full abstractDownload PDF (1030K) -
Hideo ENOKIHARA, Kenji SAITO, Sakae HAZAMA, Koji HIROSE, [in Japanese] ...1979 Volume 20 Issue 1 Pages 49-55
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 16-year-old girl was admitted to our hospital because of arthralgia in four extremitres since three months. About four years before admission, she had had Hodgkin's disease in a left cervical region and received radiotherapy (2,000 R) with a complete remission. Nine days after the admission, she suddenly complained of low back pain. Seven days later, there appeared motor weakness and hypesthesia below the level of 11th thoracic vertebra, followed by complete paralysis. Myelography demonstrated a epidural tumor at the level of ninth thoracic vertebra. Laminectomy was performed and histopathological findings of the tumor established a relapse of Hodgkin's disease. At this time, she had no lymphadenopathy but slight splenomegaly. She was diagnosed as having stage III involvement. She was given radiotherapy with 3,500 rads to the field where the epidural tumor was present, and chemotherapy with a combination of COPP. The disease relapsed in the left cervical lymph node one month after the completion of six courses of COPP therapy. She was given a combination chemotherapy including Adriamycin, to which she responded well. The neurological symptoms improved remarkably soon after the laminectomy, and disappeard completely after about one year. Thirty months after the laminectomy, she has no findings suggestive of relapse. Treatment for Hodgkin's lymphoma of the spinal epidural space was discussed. The importance of an adequate irradiation dose for radiotherapy of Hodgkin's lymphoma was also stressed.View full abstractDownload PDF (918K) -
Teruhito KOGA, Akira KANETO, Yutaka SHIMOKAWA, Kyuichi TANIKAWA, Masah ...1979 Volume 20 Issue 1 Pages 56-62
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThis is the report of three cases with malignant lymphoma and allied disorder in a family, derived from Goto island of Nagasaki prefecture.
Case 1: A 61 year-old female, dwelling in Chiba prefecture, was diagnosed as reticulum cell sarcoma in April 1973 and died in 8 months.
Case 2: A 32 year-old male who was the first son of case 3 and living with her in Fukuoka prefecture, was diagnosed as chronic lymphocytic leukemia of T-cell type in December 1973 and died in 20 months.
Case 3: A 62 year-old female who was younger sister of case 1, was diagnosed as reticulum cell sarcoma in December 1976 and died in 3 months.
It is interesting to note that similar manifestations such as lymphoadenopathy, hepatosplenomegaly and infiltration into the skin and the marrow were found in all these cases. Furthermore, they all had repeating respiratory infections from youth, and the cause of death was pulmonary infections in all cases.
Familial and genetic factors among these cases were discussed.View full abstractDownload PDF (1130K) -
Hisashi SAKAMAKI, Yamao ADACHI, Yasushi KUYAMA, Kiyoshi HIROTA, Mikio ...1979 Volume 20 Issue 1 Pages 63-68
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 42-year-old female who has handled organic solvents in a plastic sign board factory for 2 and a half years, was given Thiamphenicol (1.5 gm/day for 3 days) by her family doctor because of common cold. About 2 and a half months later, jaundice and general malaise developed and she was admitted to Bokuto Metropolitan Hospital on July 28, 1976.
Laboratory findings were following: GOT 1145 U, GPT 858 U, LDH 355 U, Al-P 126 mu/ml, HB antigen negative, HB antibody negative, Hb. 11.6 g/dl, WBC 2,700/cmm, Platelet 22.8×104/cmm. Coagulation test was normal.
She made a favorable recovery from hepatitis since the middle of August when she began to suffer from gingival bleeding and high fever. Severe pancytopenia (WBC 1,000/cmm, Hb. 8.4 g/dl, Retic. 0%, Platelet. 0.8×104) and hypoplastic marrow were noticed. After some blood cultures, which yielded E. Coli, Predonisolone 60 mg/day, CB-PC 21 gm/day and Gentamicin 120 mg/day were administered from 20th of August. She died on 4th of September because of septicemia.
Autopsy findings revealed fatty marrow, rather healed hepatitis and generalized candidiasis. Thiamphenicol is believed never to raise irreversible aplastic anemia, but this case is thought to be very similar to that of chloramphenicol-hepatitis-aplastic anemia syndrome. The relationship between thiamphenicol, benzol, hepatitis and aplastic anemia was discussed.View full abstractDownload PDF (496K) -
Keisuke TOYAMA, Hiromichi SUZUKI, Masao KIKUCHI, Kazuaki HANAOKA1979 Volume 20 Issue 1 Pages 69-76
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 58-year-old female was first seen at the Keio University Hospital because of anemia. On admission she had petechiae over her whole body and no hepatosplenomegaly. Blood examination revealed pancytopenia and absence of poikilocytosis. There were numerous erythroblasts with positive PAS stain in peripheral blood and some of them were megaloblastoid. These cells were also found in the hypoplastic bone marrow. Because of the normal level of serum vitamin B12, chromosome aberration and absence of Ph1 chromosome, a diagnosis of DiGuglielmo syndrome was made. The patient died on her 52th hospital day without any antileukemic treatment. Autopsy revealed prominent myelofibrosis and neoplastic cell infiltration in various organs. This case showed many clinical and pathological findings similar to acute myelofibrosis such as pancytopenia, absence of splenomegaly and prominent myelofibrosis. However, many reports concerning acute myelofibrosis stressed on the absence of the invasion of neoplastic cells into other organs and tissues. Myeloproliferative disorders proposed by Dameshek included many clinical entities such as hypoplastic leukemia, myelofibrosis, DiGuglielmo syndrome and sideroblastic anemia, etc. Thus, it is conceived that myeloproliferative disorders could be overlapped each other.View full abstractDownload PDF (753K) -
Mitsunori SAITO, Yoko SHINOHARA, Takuo HIROTSU, Jun-ichi AKATSUKA, Tos ...1979 Volume 20 Issue 1 Pages 77-81
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA case of acute hemolytic anemia with G 6 PD Canton was reported. He was 2 years and 4 months old on admission, and had the complaint of pallor and abdominal pain. The laboratory examination revealed severe anemia and hemosiderinuria. Coombs test was negative. Autohemolysis test showed Dacie type I. Heinz body formation test with acetylphenylhydrazine and glutathione stability test were abnormal. The activity of G 6 PD of the patient's erythrocytes was shown to be about 13% of the control value. He had recovered rapidly with blood transfusion and steroid hormone, and has been free from hemolytic episodes after discharge.View full abstractDownload PDF (375K) -
Akira KANETO, Masakazu MOTOKAWA, Teruhito KOGA, Yutaka SHIMOKAWA, Kyui ...1979 Volume 20 Issue 1 Pages 82-89
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA family of new G 6 PD variant associated with chronic nonspherocytic hemolytic anemia was reported.
Proband is a 17-year-old male who was admitted to Kurume University Hospital in September 1977 because of continuous jaundice during over one year.
On physical examination, the patient had jaundice and slight splenomegaly. Laboratory studies revealed RBC 368×104/cmm, Hb 14.0 g/dl, Ht 41%, reticulocyte count 6.5%, serum bilirubin 3.0 mg/dl (indirect bilirubin 1.9 mg/dl) and 51Cr-labeled red cell half-life 9 days. Abnormal hemoglobin was not detected.
G 6 PD activity was very low (0.8% of normal mean) with reduced GSH in red cells and abnormal GSH stability test (-82%). Other characteristics of G 6 PD in this case were disclosed electrophoretically slow-moving, normal Km G 6 P, normal Km NADP, low Ki NADPH, normal utilization of 2-deoxy-G 6 P and deamino-NADP, marked heat instability and a biphasic PH curve.
Hence, this case can be classified as Class 1 because of severe enzyme deficiency associated with chronic hemolytic anemia. The seven hitherto reported variants are similar to this case in electrophoretically slow-moving with normal Km G 6 P. However, these variants are clearly different from this case with the other biochemical characteristics of G 6 PD.
Consequently, the G 6 PD in this case may be regarded as a hitherto unreported variant and this variant was designated as G 6 PD Kurume.
Family study showed that the eldest brother and the youngest brother had the same abnormality as that of the proband. One of his sister, the mother, the maternal grand mother and one of his aunts were found to be heterozygous for G 6 PD deficient gene.View full abstractDownload PDF (547K) -
—Serum Methotrexate Level and Safty Administration—Kuniaki SASAKI, Takeo FUJIMOTO, Nagahide GOYA1979 Volume 20 Issue 1 Pages 90-96
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 11 year-old girl with non-Hodgkin's lymphoma, stage IIE, who achieved complete remission brought by treatment with weekly massive dose methotrexate (MTX) with citrovorum factor (CF) rescue was reported.
The dosage of methotrexate was escalated 50mg/kg, 75 mg/kg, and 100 mg/kg in a week. Citrovorum factor followed 3 hour later of MTX completion for 72 hours.
MTX concentrations of serum, urine, and cerebrospinal fluid were determined with enzyme kinetic method. At the termination of drug infusion, serum ranged between 2.3×10-4M and 3.2×10-4M of methotrexate with drug dosage of 50-100 mg/kg respectively. Urinary excretion within 24 hour ranged between 40.7 and 65.6% of the adminstered dose. Above 10-6M of MTX was detectable in the cerebrospinal fluid at the termination of drug infusion.
During these treatment, hydration and urinary alkalinization were performend for prevention of clinical toxicities. There is no severe clinical toxicities including myelosuppression, renal insufficiency, liver dysfunction, and manifestation of digestive system.
The patient remains in complete remission under the maintenance of cyclic high-dose MTX (q 12 week) therapy for 14 months.View full abstractDownload PDF (496K) -
Pyong-Young KIM, Junko ETO, Tetsuro TANAKA, Toshitake ISHII, Nobuyoshi ...1979 Volume 20 Issue 1 Pages 97-103
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSAn autopsy case of unusual complications of a maliguant fibrous histiocytoma arising in the jejunum and massive ascites due to leukemic infiltrations in the peritoneal cavity in a child with acute lymphoblastic leukemia in bone marrow remission is reported.
Histologically this jejunal tumor showed exuberant inflammatory reactions unassociated with tumor necrosis besides of a hallmark of a fibrous histiocytoma, and clinically the patient had persistent fever of unknown origin for over eight months period. This paper concerns an additional case of the inflammatory fibrous histiocytoma as a second malignant neoplasm. Its association with acute lymphoblastic leukemia appears to be the first instance, and the same etiologic factors or a stem-cell abnormality might be possible underlfiing cause of these two tumors, are discussed.
The patient responded well to the chemotherapy, but died of the progressive leukemic infiltrations in the peritoneneum while being in bone marrow remission. To our knowledge the complication of ascites due to leukemic infiltrations while the bone marrow remission appears to be the first documented instance.View full abstractDownload PDF (688K)
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