Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Search
Advanced search
OR
Browse
Search
Volume 47, Issue 10
Displaying 1-11 of 11 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Picture in Clinical Hematology
The 46th Annual Meeting of the Japanese Society of Clinical Hematology
Special Award Received Lecture
Review
Clinical Study
Case Reports
  • Acute lymphoblastic leukemia presenting with calcineurin-inhibitor induced pain syndrome after a second allogeneic bone marrow transplantation
    Shuichiro TAKASHIMA, Akihiko NUMATA, Toshihiro MIYAMOTO, Tsuyoshi SHIR ...
    2006 Volume 47 Issue 10 Pages 1372-1376
    Published: January 30, 2006
    Released on J-STAGE: March 14, 2008
    DOIhttps://doi.org/10.11406/rinketsu.47.1372
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    A 42-year-old woman was referred to us for the treatment of relapsed Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL), which had been maintained in complete remission for seven years after an allogeneic bone marrow transplantation (allo-BMT) from an unrelated donor. She received remission-reinduction chemotherapy combined with imatinib mesylate. After the documentation of the molecular remission of Ph+ALL, she underwent the second allo-BMT from another unrelated donor. GVHD prophylaxis consisted of tacrolimus (TAC) and short-term methotrexate. On day 21, she suddenly suffered from an intermittent severe, cramp-like pain in the right lower limb. The typical pain profile and exclusion of other causative diseases suggested calcineurin-inhibitor induced pain syndrome (CIPS) as a possible cause of pain. The pain was gradually relieved after discontinuation of TAC and administration of several analgesic drugs. CIPS is rarely seen following allogeneic stem cell transplantation (allo-SCT); only three cases have been so far reported to our knowledge. Thus, physicians should be alert to this complication in patients receiving allo-SCT.
    View full abstract
    Download PDF (646K)
  • Type 1 hyper-IgM syndrome diagnosed in a 28-year-old patient with recurrent infections since childhood
    Michiaki KOIKE, Kazuo OSHIMI, Kazunaga AGEMATU, Takeshi FUTANI
    2006 Volume 47 Issue 10 Pages 1377-1380
    Published: January 30, 2006
    Released on J-STAGE: March 14, 2008
    DOIhttps://doi.org/10.11406/rinketsu.47.1377
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    We report a male patient who was diagnosed as having hyper-IgM syndrome at the age of 28 years old. The patient had a history of recurrent infectious diseases since childhood such as bronchitis and otitis media, with decreased and increased levels of serum IgG and IgM, respectively. Genomic analysis of the CD40 ligand gene revealed deletion of six nucleotides from 475 to 480 followed by a T to A change at 481. These findings were compatible with the diagnosis of type 1 hyper-IgM syndrome. Bearing in mind the fact that only 20% of such patients survive over the age of 25, this patient is considered to be a rare case who was not actually diagnosed as having this disease until 28 years old.
    View full abstract
    Download PDF (838K)
  • A neuron specific enolase-producing multiple myeloma
    Junko JIMBO, Kazuya SATO, Katsuya IKUTA, Junki INAMURA, Takaaki HOSOKI ...
    2006 Volume 47 Issue 10 Pages 1381-1386
    Published: January 30, 2006
    Released on J-STAGE: March 14, 2008
    DOIhttps://doi.org/10.11406/rinketsu.47.1381
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    A 53-year-old woman was admitted to our hospital with left chest-wall pain. Computed tomography scans showed a homogenous mass on the left chest-wall with pleural effusion. Laboratory data showed anemia, hypercalcemia, and high levels of serum IgG. An IgG-λ monoclonal protein was detected with serum immunoelectrophoresis. In addition, the serum level of neuron specific enolase (NSE) was elevated. A chest-wall tumor biopsy and a bone marrow aspiration revealed diffuse proliferation of atypical plasma cells, which were positive for cytoplasmic CD38 and IgG-λ. The patient was diagnosed as having IgG-λ type multiple myeloma with a chest-wall plasmacytoma. Immunostaining revealed diffuse NSE staining in the cytoplasm of the atypical plasma cells. These findings suggested that the myeloma cells produced NSE. The left chest-wall tumor and bone marrow myeloma cells disappeared following several courses of chemotherapy and radiotherapy and the serum levels of IgG and NSE also normalized. No recurrence of the multiple myeloma was seen after an autologous peripheral blood stem cell transplantation. This is the second report of an NSE-producing multiple myeloma. Interestingly, our case has similar clinical phenotypes with the previously reported case, such as chest-wall plasmacytoma, pleural effusion and hypercalcemia.
    View full abstract
    Download PDF (1569K)
  • Successful salvage therapy with cladribine and rituximab for a patient with a relapsed Asian variant of intravascular large B-cell lymphoma
    Akane TSUJIMURA, Koichi MIYAMURA, Yachiyo KUWATSUKA, Yoshihiro INAMOTO ...
    2006 Volume 47 Issue 10 Pages 1387-1392
    Published: January 30, 2006
    Released on J-STAGE: March 14, 2008
    DOIhttps://doi.org/10.11406/rinketsu.47.1387
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    The Asian variant of intravascular large B-cell lymphoma (AIVL) is a rare aggressive lymphoma characterized by various clinical symptoms, hemophagocytic syndrome and predominant growth within vessels. We present a 73-year-old man with relapsed AIVL who had been treated with six courses of CHOP regimen. A half year later, he presented with high fever, sweat, dementia and hepatosplenomegaly without lymphadenopathy. A bone marrow biopsy showed prominent hemophagocytosis and immunological staining disclosed an augmented intrasinusal pattern of atypical large lymphocytes characteristic of the CD20+ and CD5+ phenotypes. As salvage therapy, CND-R (rituximab, cladribine, mitoxantrone, dexamethasone) was performed, and the clinical symptoms immediately and dramatically improved. Subsequently, CND-R therapy was repeated every 4 weeks. No serious adverse events were observed with the exception of grade 4 neutropenia and grade 3 thrombocytopenia. After completion of the fifth course, a bone marrow biopsy pathologically confirmed complete remission, leading to termination of this therapy. The patient has remained in remission for more than 15 months. CND-R therapy, which is effective for indolent lymphoma, may be one of the candidates in salvage therapy for relapsed AIVL.
    View full abstract
    Download PDF (693K)
A Short Report
  • Multiple myeloma presenting as cavernous sinus syndrome
    Takuya MIYAZAKI, Jun TAGUCHI, Takashi OBANA, Satoshi YAMAJI, Hideyuki ...
    2006 Volume 47 Issue 10 Pages 1393-1395
    Published: January 30, 2006
    Released on J-STAGE: March 14, 2008
    DOIhttps://doi.org/10.11406/rinketsu.47.1393
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    We report on a 70-year-old male who developed cavernous sinus syndrome as the initial symptom of multiple myeloma. He was admitted with diplopia and ptosis in October 2004. The diagnosis of multiple myeloma and cavernous sinus syndrome due to a gross mass at the sinus base were made. Cerebral computed tomography revealed that the lesion occupied the sphenoid sinus and involved the oculomoter nerve. He underwent local irradiation of the mass followed by systemic chemotherapy. The symptoms caused by the mass disappeared after the treatment. Clinicians need to be aware of the rare manifestation of multiple myeloma.
    View full abstract
    Download PDF (728K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top