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Volume 8 (1967)
- Issue 6 Pages 613-
- Issue 5 Pages 527-
- Issue 4 Pages 425-
- Issue 3 Pages 277-
- Issue 2 Pages 73-
- Issue 1 Pages 1-
Volume 8, Issue 4
Displaying 1-11 of 11 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1967 Volume 8 Issue 4 Pages 425-431
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (621K)
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Atsushi KUBONOYA, Isamu UMEZAWA, Atsushi HONGO, Yutaka HASHIMOTO, Mich ...1967 Volume 8 Issue 4 Pages 432-436
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSTwenty-nine patients with arteriosclerosis were given six tablets of Streptokinase (Varidase Oral) daily. After four weeks of administration serum total cholesterol and β-lipoprotein decreased, the fibrinolytic activity increased and lipoprotein β/α ratio tended to normal, but no bleeding tendency was observed clinically.
Although plasma fibrinogen level was varied in clinical cases, it tended to decrease in the experiments using rabbits.View full abstractDownload PDF (377K) -
Takeo FUJIMOTO, Chizuru TSUBOI, Hiromichi TAKE, Sumio MIYAZAKI1967 Volume 8 Issue 4 Pages 437-444
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSTwelve episodes of meningeal involvement were observed in 9 infantile patients with acute leukemia and 10 episodes of intrathecal treatment of Methotrexate in 7 patients were described. Their significant symptoms were cranial and peripheral nervous dysfunction, including visual or autonomic system disturbances, cerebrospinal fluid abnormality, etc., for instanrce the cerebrospinal fluid showed higher pressure in 90%, pleocytosis in 100%, higher protein concentration in 64% and lower sugar value in 50% of patients.
These meningeal leukemic infiltration developed even during the bone marrow remission as well as during its relaps.
The intrathecal treatment of Methotrexate induced complete relief in 5, partial relief in 4 episodes, and nausea, vomiting and fever were recognized as side effects in two patients.View full abstractDownload PDF (917K) -
Hajime FUKUTA, Tatsunobu RIKIMARU, Susumu FUJINAGA, Ken-ichi HATTORI1967 Volume 8 Issue 4 Pages 445-454
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSIn an attempt to find out the most proper anticoagulant in blood cell counting, effects of several anticoagulants available at present time: oxalate, EDTA, heparin alone (Anticlot) and mixture of heparin and EDTA (Anticlot/ET) upon blood cells were evaluated from the view-points of quantitative and qualitative (morphologic) changes in the venous blood added with such anticoagulants observed after definite time intervals. Data of the capillary (ear-lobe) blood were used as control. Blood examination comprised hemoglobin, red blood cells, hematocrit, reticulocytes, white blood cells, platelets and leukocyte differentials on a blood smear. Examinees of each group were about 100 subjects.
1. Quantitative Studies:
Values of the anticoagulant-mixed venous blood were generally lower than those of the capillary blood. These differences, however, were statistically insignificant when oxalate, EDTA and Anticlot/ET were used as an anticoagulant. Values of the venous blood added with Anticlot were significantly lower than the control values.
Time course study revealed that no remarkable changes in hemoglobin, red blood cells, hematocrit and reticulocytes were seen as long as six hours after sampling with any kind of anticoagulants, whereas leukocytes decreased with the progression of time in all cases and platelet counts did not change in oxalated, EDTA- and Anticlot/ET-blood but Anticlot caused a remarkable decrease in platelets with the progression of time.
2. Qualitative Studies:
Morphological study revealed that several degenerative changes were seen in leukocytes on smears prepared from anticoagulated blood, most markedly from oxalated and most mildly from Anticlot/ET-blood. There was no remarkable change in red cells but a slight crenation after a long time. Platelets shrunk and were densely stained in oxalated, EDTA-, and Anticlot/ET-blood, whereas they were rather swollen with Anticlot with the time elapsed.
From the above-mentioned results it may be concluded that Anticlot/ET or EDTA is a most suitable anticoagulant for routine use when blood examination is done within two hours after sampling.View full abstractDownload PDF (951K) -
Tadashi KAWAI, Jutaro TADANO1967 Volume 8 Issue 4 Pages 455-462
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSA total of 33 cases of paraproteinemia, including 22 cases of G-myeloma, 6 cases of Amyeloma, 3 cases of Bence Jones proteinemia and 2 cases of macroglobulinemia, were studied. Relative viscosity of their sera was measured with Hess viscometer, and also reduced viscosity was obtained by calculation.
Approximately 30% of the cases of both G- and A-myeloma showed markedly increased serum viscosity. Two of the cases with G-myeloma showed the serum viscosity even higher than that of macroglobulnemia. Normal serum viscosity was obtained in 3 cases of Bence Jones proteinemia.
Serum viscosity was highly dependent upon the concentration of the paraproteins, but it varied among different cases.
Increased serum viscosity in multiple myeloma was confirmed to be due to abnormal tendency of paraprotein aggregation in vivo from the following facts: 1) marked inhibition of electrophoretic migration in agar gel, 2) formation of “wavy band” on cellulose acetate electrophoresis, 3) markedly increased intrinsic or reduced viscosity, and 4) the sedimentation constant of the paraprotein decreased significantly at pH 3.0, indicating the occurrence of molecular dissociation.
All G-myeloma cases showing significantly increased reduced viscosity had the paraproteins migrating at the slow-gamma area on filter paper electrophoresis. Thus, slow migrating IgGmyeloma proteins assumed to have significant tendency to show molecular aggregation and an increase in serum viscosity.View full abstractDownload PDF (812K) -
Mitsuyasu KAGAMI, Yasuhiko KAWAMOTO, Miharu MIYOSHI, Tomo-o WATANABE1967 Volume 8 Issue 4 Pages 463-469
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSThe authors have studied the in vitro and in vivo influences of Bothropase, an extract of the venom from Bothrops jararaca, on haemostatic mechanism.
In vitro studies: The undiluted Bothropase was found to have a thrombin-like activity corresponding to 0.6 NIH units per ml. Unlike thrombin it was not inactivated by heparin nor antithrombin in serum. Clotting activity of Bothropase was not absorbed on the fibrin clot.
The shortening of the recalcification time of the plasma by the addition of Bothropase could be explained entirely by its thrombin-like activity. The preparation had not any thromboplastin effect, since it was uncapable of correcting the poor prothrombin consumption of haemophilic or thrombocytopenic blood.
In vivo studies: On injecting one ml. of the preparation intravenously, there was no changes in platelet count, bleeding time, capillary fragility, prothrombin time and plasma fibrinogen level. Whereas, a slight but definite reduction in the prothrombin consumption, clot retraction and clot firmness were obsesved.
From the result of our observations, the clinical use of Bothropase as a clot-promoting agent seemed to be unsignificant.View full abstractDownload PDF (550K)
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Toshiyasu TSUKADA, Masaru SHIMIZU, Shiro MIWA, Ichitaro ASAI, Umeo ITO1967 Volume 8 Issue 4 Pages 470-480
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSA case of acquired primary sideroblastic anemia in a 63-year-old Japanese male was reported.
He was admitted to the Toranomon Hospital in March 1966, because of anemia. Peripheral blood showed moderate normochromic anemia with hypersideremia. Examination of bone marrow revealed normoblastic hyperplasia with partially defective hemoglobin formation. Sideroblasts were markedly increased, over half of them were ringed sideroblasts.
In electron-microscopic study, a large quantity of iron was demonstrated in swollen mitochondria surrounding nucleus of erythroblasts. Although the life-span of the patient's erythrocytes estimated by the radio-chromium method was moderately reduced, neither signs nor laboratory data suggesting a certain type of hemolytic anemias could be obtained.
Erythrocyte coproporphyrin content was normal, and the amount of erythrocyte protoporphyrin exceeded the normal. The results of ALA synthetase, ALA dehydrase and heme synthetase assays in erythroblasts all came out normal.
It was speculated that a disturbance in iron incorporation into heme in erythroblast mitochondria might be responsible for the cause of this type of anemia.View full abstractDownload PDF (1469K) -
Hiroshi MATSUO, Masaaki NAGATA, Tatsujiro GONDAIRA, Kinnojo IGUSHI, Yo ...1967 Volume 8 Issue 4 Pages 481-484
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSA case of acute myeloblastic leukemia in a 21-year-old male, initially treated mainly with 6-mercaptopurine (100 mg/day) and prednisolon (30 mg/day), showed a complete remission for 18 months on the drug regimen. Blood transfusions and large doses of prednisolon (300 mg/day) were dramatically effective for his second relapse, although the remission was shorter in duration (6 months).
He died of gastrointestinal bleeding in the third hospital admission after three years' successful treatment.View full abstractDownload PDF (315K) -
Tetsuhei OGAWA, Keisuke TOYAMA, Kin-ichi NAKAMURA, Mitsuto HASEGAWA1967 Volume 8 Issue 4 Pages 485-491
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSA 65 year-old male myeloma case with peculiar immunoglobulin findings is reported.
Serum electrophoresis revealed two compoments or spikes of K type gamma G myeloma protein. Bence Jones proteins in the urine consisted of type K and type L. The myeloma cells aspirated from the bone marrow were composed of two cell types on light- and electronmicroscopic observation; the one had chromatin-rich nucleus with a prominent nucleolus and parallel endoplasmic reticula, the other had scattered chromatin in nucleus and distended endoplasmic reticula.
It might be conceivable that these two types of cells could be compatible with two types of Bence Jones proteins.View full abstractDownload PDF (2193K) -
Shigeyuki OSAMURA, Kenjiro ITO, Sunao SATO, Keiichi MUROTA1967 Volume 8 Issue 4 Pages 492-498
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSA case of acute granulocytic leukemia of 28-year-old female in terminal stage was reported, which showed change of blood group. Her blood group was essentially B type. A part of her red cell was modified and reacted like O type in her terminal stage, where she was transfused B type red cell suspension. Pathogenesis was discussed.View full abstractDownload PDF (819K)
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1967 Volume 8 Issue 4 Pages 499-517
Published: 1967
Released on J-STAGE: October 20, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (1786K)
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