All issues
Volume 46, Issue 7
Displaying 1-13 of 13 articles from this issue
- |<
- <
- 1
- >
- >|
-
Ko MAYAMA, Shinobu TSUZUKI, Masao SETO2005 Volume 46 Issue 7 Pages 479-485
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSt(11;18)(q21;q21) is a specific chromosomal aberration in mucosa-associated lymphoid tissue (MALT) lymphoma, and produces chimeric transcript Apoptosis Inhibitor 2 (API2)-MALT1. Although it is known that API2 has an antiapoptotic effect, it is still unclear whether this also applies to API2-MALT1. To investigate its effects against various apoptotic stimuli, API2-MALT1 was expressed by means of retroviral infection on the epithelial cell line HeLa and the murine Pro-B cell line Ba/F3. On both these cell lines, API2-MALT1 was found to cause a significant reduction in UV-induced apoptosis. The apoptosis induced by doxorubicin was also inhibited by API2-MALT1, but not that induced by IL-3 withdrawal from Ba/F3. These findings suggest that API2-MALT1 has an antiapoptotic effect on both epithelial and lymphoid cells and that this effect depends on the apoptotic stimulus.View full abstractDownload PDF (882K)
-
Makiko TAKIZAWA, Takafumi MATSUSHIMA, Akihiko YOKOHAMA, Hiroshi HANDA, ...2005 Volume 46 Issue 7 Pages 486-491
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 53 year-old male visited our hospital for evaluation of his leukocytosis, which was first diagnosed more than 6 years previously. He was asymptomatic and there were no remarkable findings on physical and laboratory examinations except for the lymphocytosis. Abnormal lymphocytes with deep folded nuclei were seen on light microscopy, whose phenotype was CD3+, CD4-, CD8-, CD7-, CD16-, CD56-, CD45RO+ and CD45RA-. Electron microscopy revealed ‘cerebriform nuclei’ which were characteristic of Sézary cells. Adult T cell leukemia (ATL) and Sézary syndrome (SS) were ruled out because of the negative HTLV-1 test and the absence of skin lesions, respectively. T-prolymphocytic leukemia (T-PLL), which is characterized by a marked increase in leukocytes having a CD7-phenotype and a progressive fatal course, was also excluded. Recently, the TCL1 onco-protein has been shown to be overexpressed in progressive T-PLL but not in other mature T cell leukemias including Sézary syndrome. Peripheral mononuclear cells in the present patient did not overexpress TCL1. In its morphology and phenotypes, our case resembled ‘Sézary cell leukemia (SCL)’ but the clinical course was much more indolent. This case did not match any of the mature T cell leukemias defined in the WHO classification.View full abstractDownload PDF (982K) -
Miki ANDO, Yasushi ISOBE, Makoto SASAKI, Koichi SUGIMOTO, Jun ANDO, Ka ...2005 Volume 46 Issue 7 Pages 492-495
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 59-year-old woman with goiter complained of nausea, vomiting and weight loss in April 2000. She underwent an endoscopic examination and was admitted to our hospital because gastric biopsy specimens revealed that she had diffuse large B-cell lymphoma. A thyroid biopsy also detected the diffuse infiltration of lymphoma cells, which were positive for CD19, CD20, CD38 and HLA-DR. Although the cells expressed surface immunoglobulin α chain, they lacked expressions of the κ and λ light chains. Chromosomal analysis of the thyroid cells showed 47, XX, t(2;3)(q31;q13), +3, t(8;22)(q24;q11). After five courses of biweekly CHOP chemotherapy, she received autologous peripheral blood stem cell transplantation in October 2000. Currently, she has maintained complete remission for more than 4 years.View full abstractDownload PDF (962K) -
Hideyuki KOHARAZAWA, Satoshi YAMAJI, Hirotaka TAKASAKI, Maki TAKABAYAS ...2005 Volume 46 Issue 7 Pages 496-500
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 31-year-old man was diagnosed as having cutaneous T-cell lymphoma in January 1994. He received an allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling donor in May 1995, because of refractoriness to chemotherapy. The patient had been treated with immunosuppressants including prednisolone and cyclosporin A for chronic graft-versus-host disease (GVHD) of the extensive type following acute GVHD. Five years after the BMT, he developed moderately differentiated squamous cell carcinoma (SCC) on the mandibular gingival mucosa and underwent surgical resection. Furthermore, 6 years after the BMT well differentiated SCC developed on his palate and was resected. Concurrently, he was diagnosed as having esophageal cancer (poorly differentiated SCC) and underwent a subtotal esophagotomy. One year later he had a recurrence of the esophageal cancer with dysphagia and was treated with radiation and chemotherapy. He remains free of triple cancer and lymphoma. It is suggested that total body irradiation, immunosuppressants, and chronic GVHD are associated with a risk of secondary malignancies following allogeneic BMT. These factors might have contributed to the onset of triple cancer in our patient.View full abstractDownload PDF (954K) -
Kazuyoshi ISHII, Yoshihisa YAMAMOTO, Shosaku NOMURA2005 Volume 46 Issue 7 Pages 501-506
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 33-years-old man was diagnosed as having undifferentiated carcinoma presenting with right neck lymphadenopathy in December 2000. He obtained complete remission (CR) following chemotherapy, radiation and lymphadenectomy on the right neck. He had multiple para-aorta lymphadenopathy and splenomegaly in December 2001. An open-abdominal lymph node biopsy was performed from which a diagnosis of anaplastic large cell lymphoma was made. CR was achieved with biweekly CHOP, however, the patient suffered from a relapse twice. He underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-matched sister while in non-CR in November 2002. Engraftment was achieved on day 14, and at the same time, complete chimerism was confirmed. Acute grade III graft-versus-host disease (GVHD) developed and was controlled with cyclosporine A and prednisolone. Extensive chronic GVHD was subsequently observed and required systemic immunosuppression. His condition returned to CR after the PBSCT and he sustained complete chimerism. He suddenly died of fulminant thrombotic microangiopathy seven months after the PBSCT. The tumor cells were ALK-positive, CD30-negative and JH rearrangement was detected, and were therefore classified as diffuse large B-cell lymphoma with expression of ALK according to the WHO classification, though they differed from this subtype in some points. Although this case was refractory for chemotherapy with a complex karyotype, the graft-versus-lymphoma effect might have contributed to the sustained CR following the PBSCT.View full abstractDownload PDF (974K) -
Toyotaka IGUCHI, Masahiro KIZAKI, Asako KURAUCHI, Takahiro YANO, Yasuo ...2005 Volume 46 Issue 7 Pages 507-512
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 59-year-old man was referred to our hospital for the evaluation of pain on exertion of the right arm. X-ray examination showed a humeral tumor, and a tumorectomy was subsequently performed. The histological analysis showed necrotic tissue with no malignant cells. Serum protein electrophoresis yielded a small amount of M proteins without monoclonality of immunoglobulins. The bone survey in the whole body showed lucency of the right humerus, vertebra, ribs, left femur, skull, and right scapla. During outpatient clinic observation, a computed tomography scan of the pelvis showed a painless large tumor in the gluteus, appearing as an amyloidoma. Soft tissue amyloidoma occur very rarely, and so we here report a case of a soft tissue amyloidoma in the gluteus with review of the literatures.View full abstractDownload PDF (1056K) -
Masao HAGIHARA, Shigeki WATANABE, Kosuke TSUBOI, Takahiro SUYAMA, Koji ...2005 Volume 46 Issue 7 Pages 513-516
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 29-year-old woman was diagnosed as having Evans syndrome in 2002 and underwent a splenectomy for the refractory status of the disorder in May 2004. One and a half months after the operation, her platelet count again decreased due to relapse, and she was then prescribed with high dose dexamethasone (38 mg/day×4 days). Five days after the medication, she complained of a severe headache and then fell into coma, even though her platelet count had risen to 8×104/mm3. Computer tomography scan of the brain showed severe edema with a massive hemorrhage in left temporooccipital lobe, which was compatible with cerebral transverse sinus thrombosis. After resection of the damaged brain, her level of consciousness gradually recovered, although visual disturbance and moderate hemiplegia remained. This is the fourth case of idiopathic thrombocytopenic purpura which was complicated with sinus thrombosis in the literature.View full abstractDownload PDF (809K) -
Keiki KAWAKAMI, Ryugo ITO, Yasuyuki WATANABE, Tomoko GOTO2005 Volume 46 Issue 7 Pages 517-521
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 65-year-old male had a two-month history of fever and fatigue. He had been receiving low dose MTX administration for about 2 years for rheumatoid arthritis. The blood chemistry findings showed elevated liver function including lactic dehydrogenase (LDH) levels. The quantified serum EBV-DNA level was 200 copies/105 peripheral blood mononuclear cells. Computed tomographic scan demonstrated splenomegaly and intraperitoneal mass lesions. One of the masses was biopsied. Some tumor cells showed a large Hodgkin cell-like appearance. These were CD3e-, CD20+, CD30+, CD15-, LMP1+, EBNA2-, EBER-ISH+ without imbalance of the κ/λ ratio. A diagnosis of MTX-associated B-lymphoproliferative disorder was made. Although the patient's fever subsided and the serum LDH levels were normalized after withdrawal of the MTX, the masses showed almost no change. Therefore, we administered rituximab weekly for a total of four doses, resulting in normalization of the serum EBV-DNA load and serum CD4/CD8 ratio. The masses persisted, however, so we carried out eight courses of R-CHOP therapy, which induced complete response without any episode of serious infection.View full abstractDownload PDF (969K) -
Noriko DOKI, Takumi HOSHINO, Hiroyuki IRISAWA, Tohru SAKURA, Shuichi M ...2005 Volume 46 Issue 7 Pages 522-526
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 47-year-old male had symptoms of coughing and with fever and was admitted to our hospital where tests revealed he had anemia and thrombocytopenia. Following the results obtained from a bone marrow aspiration, he was diagnosed as having acute myeloid leukemia (AML). A chest radiograph and a CT scan demonstrated nodular shadows and pleural exudate in both lungs. We suspected atypical pneumonia, or fungal pneumonia, and he was subsequently given antibiotics and antifungal agents, which were, however, ineffective. On the third day after admission, he was put on mechanical ventilation, and a bronchoalveolar lavage examination revealed no germs. His respiration, however, progressively worsened and he died on the twelfth day after admission. Although the autopsy findings revealed no infectious lesions in his lungs, a PAS-positive intra-alveolar eosinophilic material, which was positive for surfactant apoprotein A staining, was present. As a result of the autopsy findings, a diagnosis of secondary pulmonary alveolar proteinosis (PAP) associated with AML was made. Among the reported cases of PAP in hematological malignancy, there has not been one case detected at the time AML was diagnosed. If there is evidence of an unknown cause of lung infiltration when AML is diagnosed, attention should be paid to the possibility of the presence of PAP.View full abstractDownload PDF (828K) -
Kaori OKAMURA, Tetsusuke IKEDA, Yasuhito SHIMAKURA, Fumiaki YOSHIBA, K ...2005 Volume 46 Issue 7 Pages 527-531
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 34-year-old female was referred to our hospital for the evaluation of atypical lymphocytosis. Leukocyte count at diagnosis was 17,900/μl with 58% atypical lymphocytes having a convoluted nucleus and prominent nucleoli. Because the leukocyte count increased to 43,600/μl, the patient was treated with 2'deoxycoformycin followed by CHOP combination chemotherapy. However, both treatments failed to achieve remission. We planned an allogeneic bone marrow transplantation from an HLA-matched unrelated donor. The patient was treated with Ara-C and etoposide before conditioning to decrease the high leukemia burden. After administration of total body irradiation (12 Gy in six fractions) and cyclophosphamide (total dose of 120 mg/kg) unmanipulated marrow cells were infused. Under prevention of GVHD by CsA and short-term MTX, leukocyte engraft was prompt at day 16, and acute GVHD grade II was observed. Because 9.4% of residual recipient type T-cells was seen with STR analysis on day 22, we decreased the dose of CsA. After the occurrence of mild acute GVHD, the residual T-cell number decreased. The patient is still in complete remission for up to 22 months after BMT. We conclude that allogeneic SCT is effective for the treatment of T-PLL.View full abstractDownload PDF (896K) -
Takatsune SHIMIZU, Yoshitaka MIYAKAWA, Takayuki MITSUHASHI, Tsunayuki ...2005 Volume 46 Issue 7 Pages 532-535
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSWe experienced a 85-year-old female patient with granulocytosis, which occurred after the bacterial pneumonia. The white blood cell counts remained high between 30,000/μl and 120,000/μl for around one year. As the serum G-CSF level was within the normal range and there were no tumors on CT scan images, the existence of G-CSF-producing solid tumors was unlikely. Bone marrow examination revealed hypercellularity without excess of blasts and hiatus leukemia, accompanied by mild dysplasia in myeloid cells and megakaryocytes. No chromosomal abnormalities in bone marrow samples were seen with G-banding and multi-color FISH methods. Major/minor BCR-ABL fusion genes were negative by RT-PCR. As previously reported by several investigators, we often experience difficulties in distinguishing atypical CML from CNL and CMML. In this report, we discussed how to diagnose the cause of granulocytosis based on a literature review.View full abstractDownload PDF (888K)
-
Naoki WAKIMOTO, Motohiro MISUMI, Tomoya MAEDA, Tsuneyuki SHIMADA, Dais ...2005 Volume 46 Issue 7 Pages 536-538
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 61-year-old man with primary macroglobulinemia (PMG) had been followed without any treatment as he had no apparent manifestations. After 1 year and 3 months, he was admitted to our hospital with a fever. No signs or symptoms of infection and no progressive increase of serum IgM levels was observed. Non-Hodgkin's lymphoma was not additionally found. Fever without infection, elevated serum LDH level and further enlargement of the spleen compelled us to diagnose his condition as deterioration of the PMG. An immediate fall in his temperature and serum IgM levels was observed after CHOP therapy. Effective therapy must be discussed in the deterioration of this type of disease.View full abstractDownload PDF (375K)
-
2005 Volume 46 Issue 7 Pages 539-550
Published: 2005
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (884K)
- |<
- <
- 1
- >
- >|