Among the causes of death by diabetes mellitus in recent years, vascular disturbrance has been increased and especially, diabetic nephropathy has drawn our attention. Studies on this diabetic nephropathy have been done on various aspects. However, most of them were based on the examinations at resting state. Therefore, the author examined the reactivity of renal circulation and electrolyte metabolism against stress produced by inhalation of low oxygen gas on patients with diabetes mellitus. Method and Meterials Method The standard renal clearance methods were employed simultaneously while 10 per cent O
2 inhalation was carried out. Before and after the low oxygen gas inhalation, determinations of renal circulation and electrolyte metabolism. Materials 41 patients with diabetes mellitus, age from 18 to 78, 24 men and 17 women. The subjects were classified as follow: (i) Existence of urine protein. (ii) Existence of urine sugar. (iii) Blood sugar: (a) under 139 mg/dl, (b) over 140 mg/dl: (vi). Blood pressure: (a) Normal type, systolic pressure under 149 mmHg and diastolic pressure under 89 mmHg, (b) Old age type, systolic pressure under 149 mmHg and diastolic pressure over 90 mmHg systolic pressure, over 150 mmHg and diastolic pressure under 89 mmHg, (c) Essential type, systolic pressure over l 50 mmHg and diastolic pressure over 90 mmHg; (v) Eye ground: (a) normal group, under KW I, (b) Abnormal group, over KW II; (vi) Duration (a) under 5 years, (b) over 5 years; (vii) Age: (a) under 39 years old, (b) 40 to 59 years old, (c) over 60 years old; (viii) Renal blood flow in the resting state: (a) over 760 cc/min, (b) 759 cc/min-480 cc/min, (c) under 479 cc/min. Result and Comments A. In room air inhalation. (1) Renal circulation. RBF of patients with diabetes mellitus, as compared with normal adults, has shown slightly low in general. In the study of this decrease of renal circulation by classification of clinical symptoms, it was proved with the abnormal eye ground group and the group of patients with diabetes mellitus over 5 years.
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