Ischemic change on E.C.G. was found in postalimentary lipemia in coronary sclerotic patients. It is interesting to note the ischemic change was readily reversible with heparin administration. So it would be reasonable to consider that oxygen supply to heart muscle is affected by change of plasma lipid level. In order to clarify the mechanism of appearance of the ischemic change on E.C.G. during postalimentary lipemia, 100 gm of raw-cream was given to patients with coronary sclerosis and Pao₂ was measured before and after fat intake. Pao₂ was found to be decreased during the period of 4 hours after fat intake and then restored to the fasting level in 30 minutes after heparin injection. From these results, it has been suggested that oxygen diffusion in the lung and oxygen transport to the heart muscle were impaired by fat loading.

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One case of chronic chylopericardium of a 10-year-old boy with chylosanguineous pericardial fluid was demonstrated. It has been proved that there exists the communication between thoracic duct and pericardial space by demonstrating the deposition of the contrast material into the pericardial sac on lymphangiogram, although it has not been ascertained yet by operative procedure. At the same time, an abnormal visualization of the lymphatic channels has been found in upper mediastinum which led us to suspect the lymphangioma. It is suggested that the oral loading of fat and the RIHSA infusion in pericardial space are useful methods for knowing the anastomotic connections of pericardial sac. In addition, review of the 9 cases of chylopericardium reported in English was presented.

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In order to study the distribution of the blood flow in diseased human kidney, ¹³³xenon clearance curves were obtained from the patients with chronic renal disease and hypertension. The results obtained from the <133>xenon clearance curves were compared with those determined by the dye dilution method. Materials and Methods Observations were made in 34 kidneys of the patients including 21 chronic glomerulonephritis, 8 essential hypertension, 4 chronic pyelonephritis and I suspected polyarteritis nodosa. Through the catheter inserted into one renal artery, 1-5 mci of ¹³³xenon dissolved in isotonic saline was injected and the clearance curve of ¹³³xenon from the kidney was monitored externally by a scintillation probe positioned perpendicularly to the back for 30 to 45 minutes. The output of the probe was led to a ratemeter and thence to a printer. The counts per second were plotted against time on semilogarithm graph and the curves were analyzed graphically into several exponential components. The flow per unit mass of tissue (flow rate) and the percentage of the total renal blood flow (flow ratio) for each of these components were calculated. In 10 patients dye dilution curves were recorded and analyzed by the method introduced by TAKEUCHI and ISHIKAWA. The relationships between the results derived from ¹³³xenon clearance curves recorded for 30 minutes and the values of blood urea nitrogen, RBF calculated from C_CPH (RBF_PAH), C_thio and of maximal urinary osmolality determined on Fishberg's concentration test were studied. Results The clearance curves of ¹³³xenon recorded for 45 minutes were all resolved into 4 components, while 3 components were recognized in the curves recorded for 30 minutes. In the kidneys with normal function, the mean values of the flow rate and the flow ratio in component I and III calculated from the 30 minutes curves coincided closely with those of component I and IV obtained from the 45 minutes curves, respectively. The mean value of the flow rate of component II in the 30 minutes curves was similar to the average of those of component II and III in the 45 minutes curves. Analyzing in the same curves, statistically significant correlations were observed between the values of component I and III from the 30 minutes record and those of component I and IV from the 45 minutes record, respectively. Also, there was significant correlation between component II from the 30 minutes record and the average of component II and III from the 45 minutes record in the flow ratio but not in the flow rate.

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