All issues
Successor
Volume 17 (1967)
- Issue 4 Pages 499-
- Issue 3 Pages 333-
- Issue 2 Pages 143-
- Issue 1 Pages 1-
Volume 17, Issue 3
Displaying 1-18 of 18 articles from this issue
- |<
- <
- 1
- >
- >|
-
SETSUYA TAKEUCHI1967 Volume 17 Issue 3 Pages 333-339
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSAntidiabetic action of the mesoxalic acid was previously reported by Kobayashi et al. (1, 2) and mesoxalates were suggested to act on the mechanism of insulin release from the beta-cell in the pancreatic “Langerhans' islet” [Kobayashi and Ohashi (2)]. The effect of this drug was reported by Ohashi et al. (3) to be so weak that the elevation of insulin-like activity determined by rat-diaphragm method was evidenced only after the continuous infusion of a large dose into the pancreatico-duodenal artery in dogs. At the same time, however, it was suggested that the action of mesoxalates on the beta-cell would be pharmacologically pure and specific. Consequently, more active compounds related to mesoxalic acid, if discovered, are expected to be pharmacologically usefull for study on clinical control of diabetes mellitus as well as for investigation on mechanism of insulin secretion from the beta-cell. The present report describes the observations on the relationship between the mesoxalinic activities and the chemical structures of compounds.View full abstractDownload PDF (328K) -
IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYSKYO KAZIWARA, HAJIME YOKOTANI, YOSHIO IMAI, SHIGEO OGIWARA, YOSHITOMO ...1967 Volume 17 Issue 3 Pages 340-350
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIt has been demonstrated that cholestane-3β, 5α, 6β-triol (CT) and its derivatives show remarkably preventing effects on the development of the experimental hypercholesterolemia and atherosclerosis in cholesterol-fed-rabbits, rats and chickens, and that the compounds lower the elevated lipemia caused by oral administration of the vegetable oil in rats (1). Their effects on the metabolic fate of cholesterol have been investigated (2). The present experiments are the preclinical studies of the compounds including acute, subacute and chronic toxicities in mice, rats, dogs and monkeys.View full abstractDownload PDF (650K) -
SHIGENORI KAMIYA1967 Volume 17 Issue 3 Pages 351-363
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSAmong a series of clinically available psychopharmacological agents chlorpromazine is known to be effective against the reactive or neurotic depressive disorders with little effect on the endogenous depression, while imipramine is described to be very effective against the endogenous disorders by activating the psychic processes rather than by sedating. Therefore, the comparison of the pharmacological effects of both agents has been a matter of much concern. Domenjoz and Theobald (1) have found little difference in the anti-acetylcholine, anti-barium chloride and anti-serotonin potencies between imipramine and chlorpromazine using the isolated small intestine. However, relative anti-histamine potency appeared to depend upon the experimental preparations used. Chlorpromazine proved more potent against histamine on the isolated ileum, while imipramine was more potent in antagonizing the effects of histamine on the ear vessels of rabbits. Sigg (2) has reported that both agents prolong the barbiturate sleep and alcohol sedation and depress the motor activity in mice and the conditioned avoidance response in rats, though chlorpromazine is more potent than imipramine in all respects. Further, he has shown the difference between both agents in the peripheral effects; imipramine potentiates the contractile responses of the nictitating membrane of cats to stimulation of the cervical sympathetic nerve and to exogenously administered noradrenaline or serotonin, but chlorpromazine suppresses either response. He has also described the divergency in the effects of both agents on the pressor responses of dogs to noradrenaline. Thoenen et al. (3, 4) have shown the potentiating effect of imipramine on the contractile response and noradrenaline output of the isolated perfused spleen of cats to sympathetic stimulation, in contrast to the suppressing effect of chlorpromazine. Axelrod et al. (5, 6) have demonstrated that imipramine inhibits the uptake of tritiated noradrenaline in the brain of intact rats, while chlorpromazine does not. It is well known that the effects of imipramine and chlorpromazine on the spontaneous EEG coincide well; both agents produce the resting pattern intermingled with the spindle bursts. The depletion of monoamines in the brain by reserpine has widely been demonstrated in association with the simultaneous development of sedation. The antagonistic effect of imipramine against the depressed behavior caused by reserpine in the experimental animals has also been discussed in relation with the role of endogenous monoamines in the central nervous system. In the present experiments, the effects of imipramine and chlorpromazine on the cortical and hippocampal EEG were comparatively studied in the intact and reserpinized rabbits.View full abstractDownload PDF (760K) -
MASASHI SASA, YOSHIHISA NAKAI, SHUJI TAKAORI1967 Volume 17 Issue 3 Pages 364-380
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSPhysiological significance of the auditory cortex in the central nervous system was firstly investigated by Kornmüller (1), Bremer and Dow (2) and Ades et al. (3-5) using electrophysiological technique, and mapping of the primary (AI) and secondary areas (AII) of auditory cortex was introduced by Ades (4), Woolsey and Walzl (6) and Rose and Woolsey (7). The inferior colliculus, the largest relay nucleus in the specific auditory pathway, receives the afferent impulses from the ipsilateral and contralateral cochlear nuclei, superior olivary nuclei and lateral lemniscus, and projects the ascending fibers to the medial geniculate body of thalamus and the auditory cortex. There are another nonspecific projection system to the auditory cortex, which passes through the midbrain reticular formation and medial ascending route (8-12). Takaori et al. (13) have shown that electrical stimulation of the various areas of midbrain reticular formation inhibits or facilitates the evoked click responses in the auditory cortex and medial geniculate body but it does not affect the click responses in the inferior colliculus. Nakai et al. (14-16) have demonstrated that small doses of pentobarbital sodium, chloralose and chlorpromazine facilitate the click responses in the auditory cortex of cats but urethane and ethyl alcohol depress them in proportion to the doses. These findings are noteworthy, because the sites of action of the central depressants are different each other in the auditory system which has considerably complicated fiber connection. However, there are not enough informations about the mode of action of volatile anesthetics on the central auditory system. The present experiments are challenge to know the effects of inhalation of volatile anesthetics such as ether, chloroform, fluothane and nitrous oxide on the evoked potentials in the auditory cortex and inferior colliculus and the unitary discharges in the inferior colliculus caused by click stimulation in the encéphale isolé preparation of cats and to compare the action of the volatile anesthetics with that of barbiturate, chloralose, urethane and chlorpromazine reported previously (14-17).View full abstractDownload PDF (876K) -
KENZABURO TANABE1967 Volume 17 Issue 3 Pages 381-392
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESS5-n-Butyl-l-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP), a new antipyretic antiphlogistic agent, has been reported to differ from aminopyrine and phenylbutazone in lack of central convulsion in mice and rats as well as in mildness of the convulsion caused by the toxic doses in rabbits and dogs (1). Respiratory depression was the usual cause of death following excessive doses of BCP. The oral subchronic toxicity of BCP, aminopyrine and phenylbutazone in rats was reported by Okamoto (2) and Araki (3). According to their results, BCP in the daily doses above 800 mg/kg produced slight degeneration and destruction of the convoluted tubular epithels in the kidney, while phenylbutazone in the lesser doses resulted not only in the similar changes in the kidney, but also in obvious degeneration of the liver cells and the cardiac muscle fibers. The necessary prerequisite of a clinically available drug should be superiority of the main pharmacological effects and also minority of the side effects. During the toxicological studies of the anti phlogistics, the present author found that the lethal dose of BCP in the pregnant rats was markedly different from that in the non-pregnant ones. Therefore, attemt has been made in the present report whether the lethal response to the compound is conditioned by sex or gestation.View full abstractDownload PDF (989K) -
SHIRO SUZUKI, EIICHI OGAWA, KATSUHIRO SHIBATA, HIROSHI TSUZUKI1967 Volume 17 Issue 3 Pages 393-408
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIt is well known that an excess or deficiency, as well as a metabolic disorder in trace elements, causes various disturbances in the body; and further that there are many metalloenzymes or metal-enzyme-complexes which contain these trace elements. In recent years with the advance in research methods, active attempts have been made to clarify the correlation between trace elements and those enzymes which require them as a cofactor. Regarding zinc and zinc metabolism, a review by Vallee (1) is well known among many reports from various workers. As to the correlation between zinc and carbonic anhydrase, Vallee et al. (2, 3) and Wolff (4) reported that in red blood cells, the zinc level is directly related to carbonic anhydrase activity and its content. In order to find a similar relation between 65Zn metabolism and carbonic anhydrase activity in the liver, the authors have made several researches both in tumor-bearing animals (5-7) and animals with abnormal endocrine milieu (8-10), but failed to obtain any definitive conclusion. Many studies have been made on zinc metabolism under various diseases, especially in hepatic disorders (4, 11, 12). Baxter and Smith (13) reported that administration of carbon tetrachloride into rats made no change in 65Zn uptake in their livers but decreased 54Mn uptake; and Smith et al. (14) reported that 28Mg uptake increased in similarly treated animals. Further, there have been many reports on change in iron metabolism and hepatic catalase activity in tumor-bearing animals. Also, the authors previously reported on the relation between 59Fe metabolism and catalase activity in liver of Ehrlich ascites cancer bearing mice (15). Similar reports were made on liver-damaged animals (16-24). Concerning the other metal metabolism, Thiers and Vallee (25), Thiers et al. (26) and Reynolds et al. (27) reported that the administration of carbon tetrachloride results in striking increase of calcium and decrease of potassium content of the mitochondria of rat liver as compared with normal mitochondria, and that the sodium concentration is elevated in all fractions obtained from the liver sample taken at 16 hours after carbon tetrachloride administration, the magnesium concentration is increased in the supernatant fraction, the zinc and manganese concentrations in whole liver and the subcellular fractions are virtually stable throughout the period of marked changes in calcium and potassium contents, iron is altered, being elevated in both mitochondria and microsomes at 40 hours after carbon tetrachloride administration (26). The present experiment investigates the relation between 65Zn metabolism and carbonic anhydrase activity and between 59Fe metabolism and catalase activity in animals treated with carbon tetrachloride or ethionine to cause hepatic disorder.View full abstractDownload PDF (1006K) -
R.P. KOHLI, T.K. GUPTA, SURENDRA S. PARMAR, R.G. ARORA1967 Volume 17 Issue 3 Pages 409-415
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSFacilitation of experimental convulsions by reserpine (1) which persisted for several days was found to correspond with depletion of brain amines including 5-hydroxytryptamine, adrenaline and noradrenaline. Decrease in the concentration of these amines was found to be responsible for such experimental convulsions. It has also been reported that inhibitors of the enzyme monoamine oxidase, responsible for the metabolism of biogenic amines, have pronounced anticonvulsant effect (2) presumably due to an increase in the concentration of brain amines. In the present study some quinazolone hydrazides (3) and quinazolone hydrazines (4) synthesized in this laboratory as monoamine oxidase inhibitors were tested for their ability to protect against convulsions produced in rats by subcutaneous injections of pentylenetetrazol. Attempts were made to investigate if the enzyme inhibition is related to anticonvulsant effects elicited by such 2, 3-disubstituted quinazolones which have been shown to possess pronounced hypnotic (5) and anticonvulsant properties (6).View full abstractDownload PDF (393K) -
SHIGERU TSUNOO, KAZUYOSHI HORISAKA, MASAOMI OKAGAWA, SADAKO TAKAHASHI, ...1967 Volume 17 Issue 3 Pages 416-424
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSEs ist heutezutage von allen Seiten in grösstem Umfange geltend gemacht worden, dass das Lebewesen seinen Ursprung von dem Meer genommen hat. Aus dem Urtier kam das Lebewesen in der zusammengesetzteren Gestalt nach und nach zum Vorschein. Bald ist irgend ein Tier abgestorben, bald in Ozean im Leben geblieben, indem irgend anderes Tier sich im Süsswasser oder auf dem Lande niedergelassen ist. Qualitativer Milieuwechsel gang mit unzähligen Umwandlungen der Lebensgewohnheiten fortwährend einher. Es stellt sich heraus, class die Muskulatur der Wirbeltiere verschiedene Dipeptide in reichlicher Menge charakteristischerweise enthält. Die Muskeln der Tiere von Amphibien aufwärts enthalten fast gewisse Dipeptide. Was die Muskeln der Fische anbetrifft, enthalten dieselben von Bonitfisch and Thunfisch u.a. (1-3) Anserin, Aalmuskeln (3-5) hohe Mengen Carnosin, aber es hat sich dadurch gekennzeichnet, dass andere Fische Dipeptide nur in kleinem Masse oder kaum enthalten. Abgesehen von Walen (6, 7), zum Säugetier gehörig, und von Seeschlangen (8), zum Reptil gehörig, kommt es uns vor, als ob die Tiere, welche gewisse Dipeptide in den Muskeln enthalten, ihr ganzes Leben hindurch vornehmlich auf dem Lande leben. Um Anhalt für eine physiologische Wirkung von diesen Dipeptiden zu finden, wurden in hiesigem Institut ihre pharmakologischen Untersuchungen und die über ihre Verteilung im tierischen Organismus dauernd durchgeführt. Darauf wurden die Wirkungen des Carnosins und seiner Methylverbindungen, Anserins and Ophidins, auf die Herztätigkeit, den Blutdruck und die Atmung in situ sowie auf das isoliertes Herz am Kaninchen untersucht. Dabei bestand kein Unterschied der Wirkungen in drei Dipeptiden (9, 10). Auch Einflüsse der hochgereinigten Dipeptide auf Darm and Uterus wurden am Kaninchen und Meerschweinchen untersucht. Diese Dipeptide zeigten die histaminähnlichen Wirkungen, aber wirkten weit weniger als Histamin. Auch bedeutender Unterschied in ihren Wirkungen konnte nicht nachgewiesen werden. Es hat sich auch herausgestellt, dass Ophidin sich in den Muskeln von Schlangen findet, welche sich nicht nur auf dem Lande, sondern auch im Meer halten (8). Es ist vor allem sehr interessant, dass Ophidin, welches bis jetzt nur aus den Schlangenmuskeln abgetrennt wurde, auch aus anderen Geweben ausser Muskeln isoliert wurde. Nämlich konnte Ophidin von uns (6, 11) aus gefrorenem Walpankreas und Walmuskel dargestellt werden. Aber wir durften durch vergleichende Untersuchungen über Histidin and Histidindipeptide in Muskelextrakten von Fischen auf die Korrelationsbeziehung zwischen ihrem anatomisch Gemeinsamen und der Art der Histidindipeptide einigermassen schliessen (3). In vorliegenden Versuchen haben wir das Vorkommen der Histidindipeptide in Muskulatur und Gesamthirn von Callorhinus ursinus, Phoca richardii pribilofensis und Mirounga angustirostris, zur Ordnung Carnivora und Unterordnung Pinnipedia gehörig, untersucht.View full abstractDownload PDF (571K) -
SHIGERU TSUNOO, KAZUYOSHI HORISAKA, TADAYUKI YAMBE, SADAKO TAKAHASHI, ...1967 Volume 17 Issue 3 Pages 425-434
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSVersuche zur Klärung der Frage, ob inwiefern Carnosin, Homocarnosin and Methylverbindungen des ersteren (Anserin and Ophidin), β-Alanin oder γ-Aminobuttersäure als die ω-Aminosäure mit Histidin in Form des Dipeptides verknüpft, an den physiologischen und pharmakologischen Wirkungen im Organismus selbst beteiligt sind, wurden von uns dauernd ausführlich angestellt. Eine Mitteilung von Abraham und anderen (1961) (1), dass γ-Aminobutyrylhistidin (Homocarnosin) auch in den Skelettmuskeln und im Herzmuskel der Ratte neu gebildet werden konnte, wenn abgestillte Ratte 3 Wochen lang durch Caseinfutter mit Zusatz von γ-Aminobuttersäure ernährt wird, ist für uns interessant. Dieses Homocarnosin wurde erstmals aus Rinderhirn (2) isoliert, und es liess sich kurz darauf feststellen, dass Homocarnosin im Hirn der verschiedenen Wirbeltiere in den unterschiedlichen Konzentrationen enthalten ist, aber in Muskeln (3) nicht. Unter Benutzung der aus Pektoralmuskulatur dargestellten Synthetase von Carnosin und Anserin wurden betreffende Dipeptide in vitro aus den Baustoffen derselben, Histidin, 1-Methylhistidin, β-Alanin and anderen ähnlichen Aminosäuren, respektive gebildet (4-6). Diesmal sind wir auf die Frage der Neubildung dieser Dipeptide im Hühnerorganismus eingegangen.View full abstractDownload PDF (575K) -
K.N. DHAWAN, B.N. DHAWAN, G.P. GUPTA1967 Volume 17 Issue 3 Pages 435-438
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSGaddum and Hameed (1) were first to suggest that 5-hydroxytryptamine (5-HT) produces some of its effects by acting on specific receptors. Gaddum and Picarelli (2) established that the guinea pig ileum contains two types of 5-HT receptors, each being blocked by a separate set of blocking agents. The “nervous receptors” (M-receptors) were blocked by morphine, atropine, cocaine and methadone; the other type, the “smooth muscle receptors” (D-receptors) were blocked by dibenzyline, dihydroergotamine and 5-benzyloxygramine. Since then the nature of 5-HT receptors in various organs of the body has been worked out. However, studies on the nature of 5-HT receptors and the effect of various antagonists on the effects of 5-HT in the central nervous system are few. In the present study an attempt has been made to work out the nature of the receptors involved in the central hypotensive response of 5-HT administered in the lateral cerebral ventricle of dogs (3). A preliminary report of this work has already been published (4).View full abstractDownload PDF (220K) -
YONG-JA YOH1967 Volume 17 Issue 3 Pages 439-449
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSAlthough the oral and parenteral administration of n-butylbiguanide in rabbits produces a hyperglycemic or hypoglycemic effect depending on the dose, the compound causes only a hypoglycemic response in normal as well as alloxan-diabetic rats (1). Clinical studies show a high incidence of gastrointestinal distress in patients as a remarkable side effect of the orally administered n-butylbiguanide (2). However, no pathohistological change in the gastrointestinal tract has been observed in rats after receiving the various doses of the compound for 6 months (1). Therefore, the anorexia and diarrhea of the diabetic patients treated with this compound are assumed to be functional in origin. Experimental studies on the distribution of hypoglycemic biguanides-14C by Kaneko (2), Wick et al. (3), Cohen et al. (4) and Beckmann (5) are consistent with each other in that biguanides distribute extensively to the gastrointestinal tract. The present experiments were designed to know the distribution of n-butylbiguanide-14C in tissues and the nature of urinary metabolites in mice.View full abstractDownload PDF (607K) -
TOMIO SEGAWA, MICHIO KOJIMA, HIROSHI TAKAGI1967 Volume 17 Issue 3 Pages 450-464
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIt seems to be a general phenomenon in the neuromuscular junction that the response to single shocks following the tetanic stimulation of the motor nerve is regularly potentiated than the pre-tetanic one for a limited time. This phenomenon, the post-tetanic potentiation (PTP), has been shown to occur at a large number of synapses (1): the neuromuscular junction, the spinal cord, the autonomic ganglia, the hippocampus, the amygdala, the globus pallidus, and the sensory systems. The hypotheses explaining a mechanism of PTP in the neuromuscular junction have been introduced by many investigators. These are classified as follows: (a) PTP is attributed to a post-tetanic increase in transmitter release per nerve stimulation from the motor nerve terminals (2-4). (b) PTP is due to a temporal summation of the post-tetanic repetitive activity which is generated in the motor nerve terminals and is transmitted to the muscles (5-7). (c) Swelling of the pre-synaptic terminals following an application of tetanus causes a facilitated synaptic transmission, which is a cause of PTP (8). (d) PTP is explained in terms of a post-tetanic increase in the external potassium ion concentration because an increase in the potassium ion produces effects similar to those produced by tetanus (9-11). (e) PTP is accounted for by the change occurred in the muscle contractile mechanism or the increased contractile strenght of the muscle fibers (12, 13). Although no direct evidences have been obtained to explain the mechanism of PTP, many investigators have favoured the hypothesis that PTP is accounted for by the acceleration of the transmission mechanism in the pre-synaptic terminals. The prupose of the present experiments is to investigate effects of changes in temperature and ionic environment on PTP in the isolated rat phrenic nerve-diaphragm preparation, which may throw some light upon an elucidation of the mechanism of PTP. A preliminary report has been published in This Journal (14).View full abstractDownload PDF (1018K) -
TOMIO SEGAWA, MICHIO KOJIMA, HIROSHI TAKAGI1967 Volume 17 Issue 3 Pages 465-474
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSThe phenomenon of the post-tetanic potentiation (PTP) has been reported to occur in the neuromuscular junction, which generally refers to a long lasting increased response following the tetanic stimulation (1-5). There are considerable divergences of opinions with respect to a mechanism of PTP, which have been briefly reviewed in the previous paper (6). However, it seems to us that a generally accepted view for it is that PTP is explained in terms of the potentiation of transmitter release per nerve stimulation following the tetanic stimulation. This potentiation have been attributed to an increase in the amplitude of the pre-synaptic spike potential due to hyperpolarization of the nerve terminals (7), mobilization of transmitter (3), an intracellular accumulation of the sodium ion in the nerve terminals (8) and some change in the ionized calcium at a membrane site important in transmitter release (9, 10). On the other hand there are many p a pers (11-17) dealing with pharmacological properties of the pre-synaptic terminals. Langley and Kato (18), later Masland and Wigton (19), found that curare, at a dose not enough to block the neuromuscular transmission, abolished both the twitch tension and the nerve repetitive discharge produced by administrations of ChE inhibitors. Recently Standaert (15, 16) has reported that a dose of d-tubocurarine or succinylcholine, having no appreciable effects on the twitch tension, abolished the post-tetanic repetitive activity in the cat soleus nerve which is a nerve phenomenon. In the present experiments in order to elucidate the mechanism of PTP effects of anticholinergic drugs on PTP were examined, especially, at a dose having no appreciable effects on the pre-tetanic twitch tension. A preliminary report of some parts of the present experiments has been published in This journal (20).View full abstractDownload PDF (584K) -
REPORT I: COMPARISON OF PHARMACOLOGICAL ACTIVITIES OF PIPERIDINE WITH THOSE OF OTHER AMINESYOSHITOSHI KASÉ, TAKESHI MIYATA, TOMOKAZU YUIZONO1967 Volume 17 Issue 3 Pages 475-490
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIn a study of structure-activity relationship in antitussive agents, a working hypothesis has been presented that introduction of piperidino group into a compound showing any actions on the central nervous system, can produce antitussive activity if the activity has been latent, or strengthen it if such activity is already manifest (1, 2). In order to clarify this mechanism, piperidino and other alicyclic amino compounds such as pyrrolidino, morpholino and piperazino, and aliphatic amino compounds such as n-amylamino, iso-amylamino, diethylamino, and dimethylamino compounds possessing the same residues were synthesized and the following pharmacological activities of those compounds have been investigated: Toxicity, analgesia, local anesthetic action, potentiation and prolongation of anesthetic action, respiratory depressant action in vivo, inhibitions of succinic dehydrogenase and respiration of brain tissue. However, any significant differences have not been found between the pharmacological properties of piperidino compounds and those of other alicyclic and aliphatic amino compounds. Therefore, piperidine from which piperidino group originated has been compared with other alicyclic and aliphatic amines such as pyrrolidine, morpholine, piperazine, amylamines, diethylamine and so forth, from which the corresponding amino groups originated, in order to find a clue to differentiate pharmacological properties between the two. Having compared the peripheral and central actions of alicyclic amines, especially piperidine with those of aliphatic amines, the authors found that there were fundamental differences between the two, that piperidine in alicyclic amines had pronounced actions similar to nicotine, and that pyrrolidine also had almost the same pharmacological activities as those of piperidine, while aliphatic amines never showed such pharmacological actions. Since piperidine, possessing nicotinic properties, has been said to be one of normal constituents in human urine (3, 4) and mammalian brain (5), it seems to be of great interest to study the physiological role of piperidine in the living body. It has been seemed to the authors that piperidine might be an endogenous synaptotropic agent as Euler (6) had stated before, serving some neural function in the regulation of behavior. The more so, after the authors had found its cholinergic and synaptotropic properties in the central nervous system (this finding will be shown in the succeeding report in the near feature). The present paper deals with experimental observations, giving priority to piperidine, on the peripheral actions of alicyclic and aliphatic amines and shows a conspicuous pharmacological activity of piperidine among the amines used.View full abstractDownload PDF (993K) -
SUKEHIRO CHIBA, YOSHIAKI SAJI, YUJI TAKEO, TOHORU YUI, YOSHITOMO ARAMA ...1967 Volume 17 Issue 3 Pages 491-492
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (119K) -
NORIMOTO URAKAWA, MIYOSHI IKEDA, YUKIO SAITO, YUTAKA SAKAI1967 Volume 17 Issue 3 Pages 493-494
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (131K) -
MASAO TADOKORO, ISAO YAMAGUCHI, AKIYOSHI SUZUKI, FUMINORI SAKAI1967 Volume 17 Issue 3 Pages 494-495
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (127K) -
HIDEAKI KARAKI, MIYOSHI IKEDA, NORIMOTO URAKAWA1967 Volume 17 Issue 3 Pages 496-497
Published: September 01, 1967
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (108K)
- |<
- <
- 1
- >
- >|