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Volume 9, Issue 2
Displaying 1-10 of 10 articles from this issue
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ATSUSHI SEKIYA, ZENGO KANDA, KAZUYUKI KATAYAMA, MINORU IIDA1960 Volume 9 Issue 2 Pages 91-99
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSDigitalinum verum is a cardiac glycoside which was discovered at first by Kiliani (1) in digitalis seeds. Its pharmacological action was inves.igated by Fromherz (2), Chen (3) and one of the authors (4). Rec intly Okano et al. (5) produced 16-acetyl digitalinum verum (16AD) by partial acetylation of digitalinum verum (Fig. 1). This glycoside is highly soluble in water though parent compound, digitalinum verum is not. We used various animals to study the pharmacological action of this substance, and found that it was a much more potent and rapid ac ing compound than its parent.View full abstractDownload PDF (280K) -
PART 1: EFFECTS OF EXOGENOUS GLUCURONIC ACID UPON THE ANALGESIA DUE TO MORPHINE IN MICESEIJI OTOBE1960 Volume 9 Issue 2 Pages 100-104
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSDownload PDF (210K) -
PART 2: INFLUENCE OF EXOGENOUS GLUCURONIC ACID UPON THE EXCRETION OF FREE AND BOUND MORPHINE IN URINE OF RABBITSSEIJI OTOBE1960 Volume 9 Issue 2 Pages 105-108
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSIt has been already reported by the author (1) that exogenous glucuronic acid should be utilized for the conjugation with morphine in animal body. In order to prove this fact directly, the author measured the amount of free and bound morphine excreted into the urine of the animal after morphine only or morphine and sodium glucuronate (or glucuronolactone) has been administered.View full abstractDownload PDF (143K) -
TATSURO SHIGEI, KOROKU HASHIMOTO1960 Volume 9 Issue 2 Pages 109-122
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSRecently, there has been much discussion about a hypothesis that there are two kinds of experimental heart failures, namely the one caused by impaired utilization of energy and the other by impaired libera, ion of energy (1-5). Spontaneous failure and many druginduced failures belong to the former group, and such failures induced by metabolic inhibitors belong to the latter. It was pointed out that, in general, cardiac glycosides are effec, ive in the first group of failures, but not in the second, suggesting that the mechanisms of failure are different from each other. In the present study, the authors reinvestigated this problem systematically, using dog's heart-lung preparation.View full abstractDownload PDF (549K) -
MAKOTO HAYASHI1960 Volume 9 Issue 2 Pages 123-129
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSDownload PDF (258K) -
NORIMOTO URAKAWA, TAKEHIKO DEGUCHI, YOSHIO OHKUBO1960 Volume 9 Issue 2 Pages 130-136
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSMaltoxin, an amine obtained from brew malt rootlet, has been reported to have a strong contrac ile effect on the frog rec us muscle (1).
Crystalline powder of maltoxin hydrochloride was isolated from the crude component, and was found to produce a peripheral paralysis in the frog. This peripheral action of maltoxin was revealed to be an effect on the neuromuscular junction. In the present paper the effect of maltoxin on the nerve-sartorius and the rec us muscle preparations of the frog is described.View full abstractDownload PDF (277K) -
REPORT 2: ACTIVATION OF NONSPECIFIC CHOLINESTERASE BY POLYHYDRIC ALCOHOISYOSHIMI HAGIWARA1960 Volume 9 Issue 2 Pages 137-149
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSPreviously (1), I have reported on the kinetical property of benzoylcholinesterase (BzChE) and on the influence of anti-chol ineste rase (anti-ChE) on BzChE using guinea pig liver, and found that BzChE is an entirely different enzyme from the nonspecific ChE enzymologically.
During the course of the previous experiments I have found that propylene glycol (P.G.), ethylene glycol (E.G.) and polyethylene glycol (PE. G.) activated nonspecific ChE, but inhibited BzChE.
This paper deals with the mechanism of their action and the enzymological characteristics of BzChE.View full abstractDownload PDF (324K) -
KEIJI NAKAMURA, KIRO SHIMAMOTO1960 Volume 9 Issue 2 Pages 150-158
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSBein (1) was the first to describe that the administration of reserpine potentia!ed the pressor responses of the experimental animals to adrenaline and noradrenaline. The discharge of the catecholamines from the adrenal glands and from the other sympathetic structures such as the heart, liver, spleen and hypothalamus have been shown by Holzbauer and Vogt (2), Carlsson and Hillarp (3), Shore et al. (4) and others (5-8). Although the animals which have received reserpine, did not exhibit very obvious signs of an increased sympathetic activity such as would be expected during a discharge of adrenal medullary amines, Everett et al. (9) showed that the mice revealed a transient phase of piloerection, Kuschke and Franz (10) demonstrated a hyperglycemic effect in the rabbi. Rises of blood pressure in the rat and the spinal dog, the contraction of the denervated nicti!ating membrane in the cat have been reported following the injection of reserpine by de Jongh and van Proosdij-Hartzema (11) and Maxwell et al. (12). Torii (13) also showed that the carotid injection of reserpine (0.1 mg/kg) to intact rabbit or the intravenous injection of reserpine (1 to 3 mg/kg) to the iproniazid-trested rabbit induced increased spontaneous movements and the signs of the increased sympathetic ac!ivi'y. Within 30 minutes after the intravenous injection of reserpine the pressor responses of the animal to stimulation of the thalamic and hypothalamic nuclei had been rather potentiated. Burn et al. (14, 15) confirmed that the contract ive response of the spiral strips of the thoracic aor, a of the reserpinized rabbit to adrenaline and -noradrenaline was much sensitive than that of the normal one and that the contractive responses of the nictitating membrane of the cat to the same amines were also potentiated by the successive dose of reserpine.
Burn and Rand (14) discussed the mechanism of the supersensitivity of these structures by reserpine concluding that the depletion of the catecholaminestin the tissues by reserpine might be responsible. It would be expected to elucidate the mechanism of reserpine hypersensitivity to catecholamines by studying the effect of reserpine on the responses of the normal and denervated nictiating membranes to sympathomimetic stimuli. The effect of reserpine on the membranes was also, compared with those of the denervation, cocainization, ephedrinization, iproniazidizatitn and noradrenaline infusion.View full abstractDownload PDF (427K) -
REPORT 2: p-METHYLPHENYL HYDRAZINE, A POTENT AND SELECTIVE MONOAMINE OXIDASE INHIBITORAKIRA ARAI1960 Volume 9 Issue 2 Pages 159-168
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSMonoamine oxidase (MAO) plays an important role in the inactivation of monoamines in body, such as serotonin, adrenaline and noradrenaline.
Many hydrazines and hydrazides that had been synthesized for antituberculous activity in 1952 were re-examined as possible MAO inhibitors by Zeller and his collaborators (1, 2). They reported that 1-isonicotinyl-2-isopropyl hydrazine (IIH, Marsilid, Iproniazid) was a potent, relatively selective and irreversible inhibitor of MAO, whereas its close analogue isonicotinic acid hydrazide (INH, Rimifon, Isoniazid) was not, but inhibited diamine oxidase (DAO) selectively. This difference permitted the investigation of the physiological function of these enzymes (3, 4). By their extensive studies on MAO inhibitors (5), they found that alkyl hydrazines and benzyl hydrazine displayed more potent inhibition on MAO. Recently, Horita (6) reported that β-phenylisopropyl hydrazine (PIH) caused a potent and prolonged inhibition on MAO.
In the present paper, the inhibitory effects of INH derivatives and hydrayine derivatives on MAO and DAO were compared and found that p-methylphenyl hydrazine (MPH) showed a selective and more potent inhibition on MAO.View full abstractDownload PDF (365K) -
RYO ITO, MASAO MATSUDA, KOZO AOKI1960 Volume 9 Issue 2 Pages 169-173
Published: 1960
Released on J-STAGE: February 09, 2007
JOURNAL FREE ACCESSThere have been several reports on the action of tannic acid upon red blood cells (1, 2). The present paper is concerned with observations indicating that tannic acid acts upon mammalian red blood cells, rendering them resistant to streptolysin-S, an oxygens'able hemolysin of Streptococcus pyogenes (3, 4), in such a manner that the lost susceptibility of the tanned cells can be readily restored by treating them with certain proteins.View full abstractDownload PDF (181K)
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