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Volume 25 (1975)
- Issue 6 Pages 621-
- Issue 5 Pages 493-
- Issue 4 Pages 359-
- Issue 3 Pages 223-
- Issue 2 Pages 85-
- Issue 1 Pages 1-
Volume 25, Issue 5
Displaying 1-19 of 19 articles from this issue
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Nobufumi ONO, Tatsuo FURUKAWA1975 Volume 25 Issue 5 Pages 493-499
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSReserpine injected intravenously during infusion with dopamine brought about sympathomimetic effects, but a second injection of reserpine after 120 minutes did not elicit such effects. This pressor effect was eliminated by phenoxybenzamine and this positive chronotropic effect by propranolol. Reserpine induced similar but weak sympathomimetic effects after cocaine, while it induced no changes in blood pressure and heart rate after infusion with noradrenaline. Meanwhile, pressor response to dopamine was potentiated 24 hours after reserpine and was further potentiated after additional infusion with noradrenaline. The sympathomimetic actions induced by the concurrent administration of reserpine and dopamine may be attributable to a facilitation of those indirect mechanisms, principally of endogenous catecholamine release.View full abstractDownload PDF (312K) -
Toshio YOSHIZAKI, Kanya TONDA, Takeshi KITAKAZE, Yasunao OGAWA1975 Volume 25 Issue 5 Pages 501-505
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSThe effects of 3-phenyl-5-(2-piperidinoethyl)-isoxazole citrate (31245) on blood glucose level and adrenaline release from the adrenal gland were studied in rats. Elevation of blood glucose was detected in intact and hypophysectomized rats, but not in adrenalectomized or adrenal-demedullated rats after s.c. injection of 31245. Increase of adrenaline release from the left adrenal after administration of 31245 was detected under pentobarbital anesthesia. In splanchnicotomized rats, no increase of adrenaline secretion was observed after administration of this compound. Pretreatment with 31245, 5 mg/kg i.v., prevented about 35 % of the adrenaline output caused by electrical stimulation of the splanchnic nerve, though it had no inhibitory effect on adrenaline secretion caused by histamine and bradykinin. From these results, it is concluded that hyperglycemia induced by 31245 is due to hypersecretion of adrenaline from the adrenal glands through excitation of the splanchnic nerves, though its direct action on the gland is an inhibitory effect on adrenaline release.View full abstractDownload PDF (213K) -
Tetsuyuki NASU, Yukio ISHIDA, Norimoto URAKAWA1975 Volume 25 Issue 5 Pages 507-514
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSSince the correlation between the K-induced contracture and the Ca move ment during the contracture in guinea-pig taenia coli has been clarified, the effects of caffeine were deemed worthy of investigation. The tonic contraction induced by 40 mM K disappeared within 5 min in the presence of caffeine above 7 mM. The in hibitory effect of caffeine was reversed by a high concentration of Ca added to the external medium. High-K added to the medium increased tissue Ca, Ca uptake and the size of cellular Ca fraction that did not exchange within 4 min (tightly bound fraction, TBF), and it decreased Ca efflux. An application of 7 mM caffeine to the muscle treated with high-K for 30 min restored all parameters to the control level. Further, caffeine had no effect on the developed tension of the glycerinated taenia induced by Ca, Mg and ATP. It was observed that 14C-caffeine entered the cell in the presence of high-K. From these data, it is suggested that caffeine inhibits high-K induced contracture by inhibiting Ca influx into the contractile mechanism.View full abstractDownload PDF (296K) -
Hiroyoshi HIDAKA, Fumiko SHOKA, Yoshio HASHIZUME, Nobutaka TAKEMOTO, M ...1975 Volume 25 Issue 5 Pages 515-524
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSThe effect of picolinic acid derivatives, 5-butylpicolinic (fusaric) acid (FA), 5-(3', 4'-dibromobutyl)picolinic acid(Br2FA)and 5-(N-N-dimethyldithiocarbamoilmethyl) picolinic acid (YP-279) on dopamine β-hydroxylase in blood vessels in vivo was studied. Maximum inhibition of the conversion of 14C-dopamine (14C-DA) to 14C-norepinephrine 14C-NE) in rat aorta, mesenteric artery and renal artery was detected 30 min after FA and Br2FA (75 mg/kg) and 60 min after YP-279 (75 mg/kg). NE synthesis from 14C-DA returned to near control values by 6 hr in the blood vessels. NE levels of the aorta and mesenteric artery were significantly reduced by 30 to 50 % at 4 hr after Br2FA or FA (75 mg/kg). Dopamine β-hydroxylase (DBH) activity, using tyramine as substrate, in heart, aorta, mesenteric artery and renal artery was markedly reduced. The concentrations of FA, Br2FA and YP-279 in rat blood following a single i.p. injection of each drug increase rapidly, reaching highest values in 0 to 30 min and decreasing slowly to 0 after 6 hr. These compounds did not affect the uptake of 3H-NE into the rat heart. These three compounds were found to lower blood pressure effectively in normal Wistar rats (above 25 mg/kg).View full abstractDownload PDF (479K) -
Yoshio IWASAWA, Motoaki OHASHI, Shiro YAMAMURA, Seiichi SAITO, Akio KI ...1975 Volume 25 Issue 5 Pages 525-533
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSIn order to clarify whether or not trimetoquinol (TMQ) and isoproterenol (ISO) interact with the same receptor, the pA2 values of propranolol (PR) and certain trimethoxybenzene derivatives were measured, using isolated guinea pig tracheal chains. Each of PR, mescaline (MES) and its derivatives gave almost the same pA2 values for TMQ and ISO. Introduction of an alkyl group into the N atom of MES increased the affinity to the receptor in the order of methyl and isopropyl as well as the structure-activity relationship of catecholamines, while that of hydroxyl group in the β-position of the side chain decreased pA2 values. The slopes of the regression lines for anti-TMQ action of MES derivatives as well as PR were almost one, but those for their anti-ISO action were less than 0.3. 3, 4, 5-Trimethoxyaniline and 3, 4, 5-trimethoxy-benzoic acid had little activity as β-blocking agents. These results suggest the possibility that TMQ and ISO would interact with the same receptor sites. The importance of the trimethoxybenzene and the phenethylamine moieties in the MES-derivatives for anti-TMQ action is discussed.View full abstractDownload PDF (401K) -
Tetsuyuki NASU, Yukio ISHIDA1975 Volume 25 Issue 5 Pages 535-540
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSCa sensitivity and energy dependence in the contractile proteins of the glycerinated taenia coli of guinea pig were studied. Above 1×10-7M Ca caused contraction in muscle which had been immersed in glycerol solution for 7 days in the presence of 5 mM Mg-ATP. Muscles which had been immersed in glycerol for 30 days had a higher Ca sensitivity than ones in glycerol for 7 days. When AMP or ADP (5, 10 mM) in place of ATP was added in the presence of 1×10-6 M Ca and Mg (5, 10 mM), there was no contraction. Increasing the concentration of the same molar ratio of Mg-ATP from 1 to 20 mM in the presence of 1×10-6M Ca, the tension increased according to the Mg-ATP concentration. However, increase in Mg or ATP only in the presence of 1×10-6M Ca did not increase the tension. In conclusion, the three factors of Ca, Mg and ATP are essential for the activation of the contractile elements of glycerinated taenia. It is also suggested that the tension development in glycerinated taenia is controlled by the concentration of Ca and Mg-ATP complexes in intracellular fluid.View full abstractDownload PDF (212K) -
Hisashi KURIBARA, Kiyoko OKUIZUMI, Sakutaro TADOKORO1975 Volume 25 Issue 5 Pages 541-548
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSSystematic research was performed on the acquisition of free-operant (Sidman-type) avoidance response, which is widely used for the study of psychotropic drugs, with the following results: When the training session was fixed at 2 hours once daily, shock-shock (S-S) interval at 5 seconds, and response-shock (R-S) interval variable-20, 30 and 60 seconds, the acquisition speed of the response was almost constant independent of the R-S interval, about 6 sessions being always required. When the S-S and R-S intervals were constantly 5 and 30 seconds, respectively and the length of one session was varying-1, 2 and 4 hours, the behavioral baseline was established after about 6 sessions independently of the length of the session. Thus the cumulative time for the acquisition was shortest when one session was 1 hour long, and longest when it was 4 hours long. There was a linear relation with negative inclination between the logarithm of mean numbers of shock delivered per session and the number of sessions. In rapid and exact training of animals for the evaluation of drug effects, one session of an hour per day is adequate. In the evaluation of drug effects on the acquisition process, observation of the shift in logarithmic value of shocks delivered is recommended.View full abstractDownload PDF (340K) -
Masaru KAWAKAMI, Eiichi MORISHIGE, Shoichi MATSUMURA, Hiroshi TAKEDA1975 Volume 25 Issue 5 Pages 549-561
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSThe antiarrhythmic effect of aprindine was compared with those of lidocaine and propranolol on several ventricular arrhythmias—epinephrine arrhythmias in cats, ouabain arrhythmias in cats and guinea pigs, ischemic ventricular arrhythmias in coronary-ligated Beagle dogs. Antiarrhythmic effects of aprindine and lidocaine were observed both in ouabain and ischemic arrhythmias, but not in epinephrine arrhythmias. While propranolol had a strong antiarrhythmic effect against epinephrine and ouabain arrhythmias, it did not increase sinus beats in ischemic arrhythmias. Marked anti-arrhythmic effects of aprindine in ischemic arrhythmias were observed in dogs using either single intravenous administration (4 mg, kg) or intravenous infusion (200 μg/kg/min, 2 mg/kg). Antiarrhythmic activity of aprindine is considered to be about twice as strong as that of lidocaine, but lidocaine is less toxic in experimental animals.View full abstractDownload PDF (506K) -
Mitsugu HACHISU, Shigeo YAMADA1975 Volume 25 Issue 5 Pages 563-572
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSThe local anesthetic activities of 1-(morpholino or piperidino)-2-propanol derivatives were investigated. These activities were observed with nerve trunk anesthesia, rabbit's corneal anesthesia and intradermal injection anesthesia. Among these propanol derivatives, No. 24 and No. 25 which possess thioether-type sulfur were the most active and the effective potency was enhanced by increasing the dissociation constant (pKa) value in a series of the compounds. Effects on cat spinal reflex were also observed. These propanol derivatives revealed no selective depression of presynaptic depression or depression of the potential of monosynaptic reflex (MSR) and polysynaptic reflex (PSR). Procaine and lidocaine had similar actions. Effects on axonal membrane potential and interaction of the calcium on these derivatives were also investigated. These derivatives decreased the action potential without altering the resting membrane potential and when antagonized with calcium, sciatic nerve action potential was decreased. Procaine and lidocaine also showed the same results.View full abstractDownload PDF (403K) -
Kazushige SAKAI, Michitaka AKIMA, Shigeru SUGANO, Yasuyuki SHIRAKI1975 Volume 25 Issue 5 Pages 573-581
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSDirect perfusion of the sinus node artery under a constant pressure of 100 mmHg was carried out in vagotomized dogs. “Selective” injection of L-3-methoxy-ω-(1-hydroxy-l-phenylisopropylamino) propiophenone hydrochloride (oxyfedrine) into the sinus node artery induced three types of chronotropic response; a pronounced sinus tachycardia, an initial bradycardia followed by sustained tachycardia, or a definite sinus bradycardia alone. The paradoxical sinus bradycardia induced by oxyfedrine was more pronounced at higher doses of the compound, whereas it was never produced by the injection of isoproterenol. The oxyfedrine-induced sinus tachycardia, which occurred even in reserpinized preparations, was not suppressed by the treatment with tetrodotoxin, hexamethonium or bretylium, but it was selectively inhibited by propranolol. Atropine, tetrodotoxin or hexamethonium did not prevent the occurrence of sinus bradycardia induced by oxyfedrine, and physostigmine failed to enhance the response. The present study indicates that the oxyfedrine-induced tachycardia is mediated mainly by a direct stimulating action on adrenergic β-receptors, while the bradycardia appears to be induced by a direct depressant action on the S-A node.View full abstractDownload PDF (381K) -
Shuji TSUDA, Norimoto URAKAWA, Yukio SAITO, Jun-ichi FUKAMI1975 Volume 25 Issue 5 Pages 583-590
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSIn an attempt to elucidate the regulation mechanism of respiration in the smooth muscle cell, we investigated the roles of nicotinamide-adenine dinucleotide (NAD), adenosine diphosphate (ADP) and Ca++ in the muscle respiration using the tissues and subcellular fractions from guinea pig taenia coli. The tension in the strips of taenia coli increased with a concomitant increase in O2 consumption in high-K medium (40 mM K) containing 2.5 mM Ca. 10-3 M amytal and 10-5 M ouabain decreased the high-K induced tension and O2 consumption of the muscle. 10-4 M 2, 4-dinitrophenol (DNP) relieved the decreased respiration induced by ouabain, but not that with amytal. From these data it is suggested that NADH-linked respiration plays an important role in the respiration of the muscle. Ca++ in concentrations ranging from 0.5 to 2.5 mM in the high-K medium resulted in an increase in tension and in O2 consumption progressively. In spectrophotometric observations of subcellular fractions of the taenia coli, ADP increased in absorbance change at 340 mμ. Such occurred in mitochondrial fractions and was initiated by the addition of NADH. Therefore it is deduced that the increase in ADP level of the cytoplasm is primarily due to a contraction triggered by Ca++ thus stimulating respiration. On the other hand, at 0.1 mM of Ca++ concentration, the muscle strip increased O2 consumption without tension development in high-K medium. In the spectrophotometric observations, Ca++ and Sr++ increased the absorbance change in the homogenate and in the mitochondrial fraction. Hence, it seems that one part of the Ca++ entering into the smooth muscle treated with the high-K increased O2 consumption in mitochondria independent of an increase in muscle tension. From these results it is concluded that NADH-linked respiration plays an important role in the smooth muscle respiration in high-K medium and that ADP and Ca++ also play a role in regulating respiration.View full abstractDownload PDF (336K) -
Yoko NAKASHIMA, Hiroo SANADA, Ryokuero SUZUE, Shoji KAWADA1975 Volume 25 Issue 5 Pages 591-597
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSThe action of prostaglandin E1 on tyrosine hydroxylase activity in adrenal slices of guinea pig was studied. The activity of tyrosine hydroxylase was decreased by the incubation of adrenal slices with prostaglandin E1 at concentrations beyond 2 μg per ml for 2 hours. The activity of tyrosine hydroxylase was stimulated by dibutyryl adenosine 3', 5'-monophosphate in slices of guinea pig adrenal glands. Incubation of adrenal slices with the combination of PGE1 and DBc-AMP led to a tyrosine hydroxylase activity higher than that with PGE1 alone, but not as great as DBc-AMP alone. It was suggested that PGE1 inhibited the enzyme activity independently of the cyclic AMP level. Other prostaglandins such as PGA1 and PGB1 were deficient to the extent that the tyrosine hydroxylase activity was decreased. PGE1 inhibited the enzyme activity much to the same extent seen with protein synthesis inhibitors such as cycloheximide and actinomycin D. However, PGE1 did not influence the incorporation of L-leucine-14C into acid insoluble protein. The studies reported here showed that PGE1 inhibited the synthesis of tyrosine hydroxylase.View full abstractDownload PDF (296K) -
Issei MATSUBARA, Shoichi IMAI1975 Volume 25 Issue 5 Pages 599-601
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSDownload PDF (127K) -
Ken KADOTA, Mitsuhiro NAGATA1975 Volume 25 Issue 5 Pages 602-605
Published: 1975
Released on J-STAGE: December 19, 2006
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Kazuo WATANABE, Hiroshi Y. WATANABE, Yoshiaki GOTO, Nobuyuki YAMAMOTO, ...1975 Volume 25 Issue 5 Pages 605-607
Published: 1975
Released on J-STAGE: December 19, 2006
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Susumu OKABE, Koji TAKEUCHI, Keijiro TAKAGI, Madoka SHIBATA1975 Volume 25 Issue 5 Pages 608-609
Published: 1975
Released on J-STAGE: December 19, 2006
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Yasuo ENDO, Yasumi OGURA1975 Volume 25 Issue 5 Pages 610-612
Published: 1975
Released on J-STAGE: December 19, 2006
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Tomio SEGAWA, Kyoko SAKAMOTO, Fumiko NAITOH1975 Volume 25 Issue 5 Pages 612-615
Published: 1975
Released on J-STAGE: December 19, 2006
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Kazuo HASEGAWA1975 Volume 25 Issue 5 Pages 616-619
Published: 1975
Released on J-STAGE: December 19, 2006
JOURNAL FREE ACCESSDownload PDF (194K)
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