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Volume 26, Issue 4
Displaying 1-4 of 4 articles from this issue
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GOTTHARD F. SCHETTLER, P. DIETER LANG1977 Volume 26 Issue 4 Pages 197-203
Published: 1977
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSDietary factors are at least in part responsible for the high mortality on coronary heart disease in Europe and the United States. The fatty acid composition of adipose tissue, reflecting mainly the intake of dietary fat, may be of value in assessing the risk for coronary heart disease.
In a comparative study of the Japanese and the American, two populations with an extremely different incidence of coronary heart disease, the American had significantly more lauric, myristic, palmitic, stearic and oleic and less palmitoleic and linoleic acids.
In an autopsy study on the American, the degree of pathologically graded coronary arteriosclerosis correlated positively with age and relative body weight, and negatively with lauric and stearic acids.
In a diet-controlled clinical study in two groups of the German, one with and one without coronary heart disease, only stearic acid in adipose tissue showed a significant difference between both groups, its proportion being lower in patients with coronary heart disease. Although stearic acid, to-gether with age, discriminated significantly between the two groups studied, the proportion of stearic acid in a single subject does not predict with rea-sonable certainty the presence or absence of coronary heart disease.
The role of stearic acid in atherogenesis has to await further clarifica-tion.View full abstractDownload PDF (1513K) -
GOTTHARD F. SCHETTLER, P. DIETER LANG1977 Volume 26 Issue 4 Pages 205-211
Published: 1977
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSFatty streaks of human aortas, studied by electron microscopy, showed lipid inclusions to be inside foam cells. Solid, ring and vacuolar inclusions were most frequent. Others were of reticular, laminar and lysosome-like appearance or showed a central core with a clear zone around. Intermediate forms were frequent. The differences in morphological appearance may be due to differences in lipid composition or may reflect some interference of the processing of the tissue.
Isolated lipid inclusions, examined by polarizing microscopy, were found to be present as a mixture of anisotropic and isotropic inclusions (84% and 16%, respectively, at 22°C). With increasing temperature, more anisotropic inclusions became isotropic. Anisotropic forms were more frequent in younger individuals and early lesions, thus possibly representing the initial form.
Lipid inclusions accounted for approximately 50% of the lipid in the lesion. In contrast to the lesion residue, they consisted by 95% of cholesterol ester with minor amounts of free cholesterol, phospholipids and triglycerides. Major fatty acids esterified with cholesterol were oleic and linoleic acids (50% and 15%, respectively). Since the lipid composition of the lesion residue was identical with that of normal, undiseased intima, the results did not contradict with the possibility that fatty streaks could undergo complete regression.View full abstractDownload PDF (6331K) -
YASUO IKEDA1977 Volume 26 Issue 4 Pages 213-222
Published: 1977
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSEffects of Ibuprofen, a non-steroidal anti-inflammatory drug, on platelet function were studied. Similar to aspirin, Ibuprofen inhibited both platelet release reaction and aggregation in vitro. However, the alteration of platelet function induced by the administration of a therapeutic dose of Ibuprofen in vivo was observed after 2 hours of its administration and disappeared usually within 24 hours. Aspirin-induced changes in platelet function have been known to continue as long as 7 days after a single dosage of aspirin. Prolongation of bleeding time was also noted with Ibuprofen. The platelet dysfunction thus induced by Ibuprofen was easily restored by washing the platelets in vitro, while aspirin-induced one remained unchanged by the same procedure. These results may suggest that Ibuprofen is responsible for easy bruises in its users and the mechanism by which induces the platelet dys-function is somewhat different from that by aspirin.View full abstractDownload PDF (554K) -
HARUHIKO SAKURAI, YUKIO SEKI1977 Volume 26 Issue 4 Pages 223-233
Published: 1977
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSRecords of blood pressure and body weight of CS2 workers were analyzed in relation to the levels of CS2 exposure at a Japanese rayon-producing fac-tory. A cohort of 46 CS2 workers who had later been transferred to non-CS2 jobs showed first a statistically significant rise, which was then followed by two consecutive episodes of statistically significant falls in systolic blood pressure. These episodes corresponded precisely to the initial increase in CS2 concentration at workplaces due to the increased output of thicker threads, the subsequent decrease in concentration due to the improvement of the working environment and finally to the transfer of most of the members of the cohort to non-CS2 jobs. Body weight also revealed statistically significant changes corresponding to the changes in CS2 levels. Time-weighted average CS2 con-centration of 329 air samples taken at the breathing zones of three spinners was 17.4 ppm in 1972. It is concluded that CS2 causes mild and reversible hypertension and that the CS2 concentrations of 15-20 ppm may not be com-pletely safe when the exposure of workers is continuous throughout their workdays.View full abstractDownload PDF (573K)
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