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Volume 35, Issue 3
Displaying 1-6 of 6 articles from this issue
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Roy Ashikari, Patrick L. Molt1986 Volume 35 Issue 3 Pages 151-161
Published: 1986
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSBreast cancer is one of the most common malignancies among women in the United States. Based on 1, 150 cases operated by the author, 56% of all operable breast cancers were treated either by radical mastectomy or extended mastectomy and 44% were treated by modified mastectomy during the 5 year period from 1974-1978. However, in 1985, 20% of the patients were treated by partial mas-tectomy and radical mastectomy was performed on only 5% and the rest were treated by modified radical mastectomy. These changes in the treatment of breast cancer are now being seen throughout the United States.
Adjuvant chemotherapy treatment has been routinely given patients in the United States who have metastases to the regional lymph nodes for the past 10 years. Currently, CMF or CMFVP combinations of chemotherapy are the most commonly used for 9 or 12 month's duration. Some institutions use anti-estrogen (tamoxifen) as adjuvant treatment for the patient who has an estrogen receptor positive tumor. Conservative treatment of breast cancer will probably increase to 25-30% of primary breast cancers in the near future in the United States, but treatment should be determined individually.View full abstractDownload PDF (2303K) -
Kyoh-Ichi Takahashi1986 Volume 35 Issue 3 Pages 162-179
Published: 1986
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSIn order to reveal the characteristics of ion channels, the in situ rods of the frog retina were stimulated by intracellular current injection. Transient depolar-izations were observed not only at the onset of the application of the depolarizing current, but also at the termination of the hyperpolarizing current. Experiments in perfusate containing ion channel blockers, Co2+ and TEA, revealed that the both depolarizations were attributed to the activation of the voltage-dependent Ca2+ current, and appeared transient being counteracted by hyperpolarization due to the voltage-dependent or the Ca2+-dependent K+ current. In addition, Cs' ap-plication eliminated a negative transient response produced at the onset of the hyperpolarizing current, suggesting that it was attributed to the h current. All the ion channels observed in in situ frog rods were identical to those found in enzymatically isolated sa!amander rods, indicating that the cell dissociation procedures did not affect the rod membrane properties. In addition, taking into account the direction of the stimulus current and the rectification of the rod cell membrane, the active site for producing the Ca2+ response was not restricted solely to the rod terminal, but the inner segment also could produce Ca2+ response.View full abstractDownload PDF (579K) -
Tsutomu Sakuta, Satoru Saito, Hiro Kanai, Joji Inomata1986 Volume 35 Issue 3 Pages 180-187
Published: 1986
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSThe present paper investigates the differences in the way the mothers' foster-ing attitudes influence the personality of boys and girls. A questionnaire survey was carried out for a total of 423 mother-three year o!d child couples. The survey revealed the following results. 1) Both boys' and girls' personalities cor-relate with their mothers' fostering attitudes (p<0.05). 2) Boys' personalities are more significantly influenced than girls' by their mothers' fostering attitudes. 3) Correlation between the child's personality and his mother's attitudes was higher for boys than girls in the following items; 1. tendency towards discord between parents, 2. contradiction, 3. tendency to give in to the child's demands, 4. active rejection, 5. severity. These items are arranged in order of the amount of difference. 4) There was a higher correlation between girls' personalities and the maternal attitudes when those were 1. passive rejection and, 2. expection.
It appeared that boys were influenced to a greater extent by their mothers' fostering attitudes than girls were.View full abstractDownload PDF (281K) -
with special reference to the effect on cell cycle progressionMasato Fujii, Yukio Inuyama, Juichi Tanaka, Tetsuro Takaoka, Hyonosuke ...1986 Volume 35 Issue 3 Pages 188-197
Published: 1986
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSThe synergistic effect mechanism of Cisplatin (CDDP) and Peplomycin (PEP) therapy was studied in terms of its effect on cell-cycle progression.
Based on the clinical dosing schedule that CDDP administration was followed by PEP after a 48 hours interval, the combination chemotherapy of CDDP and PEP was performed on Ehrlich ascites carcinoma. As a result, a significant synergistic effect was obtained.
After a single administration of CDDP, cell accumulation was first observed in the S phase. After 48 hours, cells accumulated in the G2-M phase, but it was reversible and the original pattern restored 96 hours after the administration. After a single administration of PEP, cell accumulation in the G2-M phase was observed, but it also was reversible and the original pattern restored 48 hours after the administration. On the contrary, irreversible response of a DNA pattern was observed after the combination of CDDP and PEP. The occurrence of debris and decrease in cell number may suggest an induction of intense cytotoxic reaction.
One possible mechanism of the synergistic effect of the sequential combination of CDDP and PEP is as follows. Cell accumulation in the G2-M phase is most significant 48 hours after CDDP administration, and PEP, with preferential cytocidal effect on the cells in the G2-M phase, may exert its cytocidal effect more efficiently when it is timely administered. This mechanism may explain the excellent clinical efficacy obtained by combination chemotherapy in which CDDP was administered prior to PEP.View full abstractDownload PDF (344K) -
Satoru Shima1986 Volume 35 Issue 3 Pages 198-202
Published: 1986
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSFifty-six depressed patients were administered sulpiride. No significant cor-relation was found between plasma levels of sulpiride and clinical responses. Basal 3-methoxy-4-hydroxyphenylglycol and dopamine-β-hydroxylase levels failed to predict the therapeutic effect.View full abstractDownload PDF (203K) -
Satoru Shima, Toshinori Kitamura, Yoshikazu Takahashi, Masahiro Asai1986 Volume 35 Issue 3 Pages 203-207
Published: 1986
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSOf twenty-two female in-patients with DSM-III schizophrenic disorder ad-ministered the dexamethasone suppression test, 5 failed to suppress cortisol. A significant positive correlation was obtained between postdexamethasone cortisol levels and the severity of negative symptoms.View full abstractDownload PDF (215K)
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