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Volume 47 (1999)
- Issue 6 Pages 319-
- Issue 5 Pages 289-
- Issue 4 Pages 251-
- Issue 3 Pages 97-
- Issue 2 Pages 67-
- Issue 1 Pages 2-
Volume 47, Issue 4
Displaying 1-4 of 4 articles from this issue
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REVIEW
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Koichi FUKASE1999 Volume 47 Issue 4 Pages 251-269
Published: 1999
Released on J-STAGE: October 16, 2007
JOURNAL FREE ACCESSThis review describes the recent progress of combinatorial chemistry for drug discovery. Application of combinatorial chemistry is also described to functional studies of biologically active natural products including our studies of bacterial glycoconjugate lipid A. Lipid A analogs were synthesized via a new divergent synthetic route in order to clarify the biological importance of acyl groups. The number and chain length of the fatty acyl groups proved to have crucial influence on the biological activity. The present divergent route opens an efficient way toward the synthesis of lipid A libraries.View full abstractDownload PDF (1767K)
REGULAR PAPERS
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Tsutomu ABURA, Tsuyoshi FUKUO, Satoshi SHINODA, Hiroshi TSUKUBE, Ryuic ...1999 Volume 47 Issue 4 Pages 270-273
Published: 1999
Released on J-STAGE: October 16, 2007
JOURNAL FREE ACCESSComplex formations of a quaternary tetrapyridinium macrocycle (Cpy4Br4) with anionic species, mono-, di-, tri-carboxylic acids, adenocine 5′-triphosphate (ATP), diphosphate (ADP), and monophosphate (AMP) were observed in a neutral pH region. Electrospray ionization mass spectrometry (ESI-MS) was used to study reactivity and selectivity of the complex formations between the Cpy4 cation and the guest anions.View full abstractDownload PDF (506K) -
Kozo MATSUMOTO, Shigeki HABAUE, Hiroharu AJIRO, Yoshio OKAMOTO1999 Volume 47 Issue 4 Pages 274-280
Published: 1999
Released on J-STAGE: October 16, 2007
JOURNAL FREE ACCESSA TLC-MALDI/TOFMS system is developed for rapid identification of compounds in a mixture produced in an organic synthetic chemistry. Styrene oligomer is used as a test sample for obtaining the optimum experimental conditions. This system may be applied successfully to rapid identification of a new synthesized compound.View full abstractDownload PDF (398K)
COMMENTARY
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Daisuke NOHARA1999 Volume 47 Issue 4 Pages 281-286
Published: 1999
Released on J-STAGE: October 16, 2007
JOURNAL FREE ACCESSIn mass spectrometry, electrospray ionization (ESI) method made it possible to measure the molecular weight of biopolymer accurately by producing multiply charged ions of the target molecule from the solution phase. Moreover, due to the softness of this method, the molecular weight of aggregates formed by noncovalent interactions can be measured. This article explains the applicability of ESI method to measurement of the micelle weight and the method of analysis of observed results.View full abstractDownload PDF (446K)
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