Journal of the Mass Spectrometry Society of Japan
Online ISSN : 1880-4225
Print ISSN : 1340-8097
ISSN-L : 1340-8097
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Volume 37, Issue 1
Displaying 1-5 of 5 articles from this issue
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REGULAR PAPERS
  • An Attempt for the Precise Isotope Analysis: Modification of a Compact Type Mass Spectrometer.
    Noriko Torigoye, Hiroshi Nishimura, Masako Shima
    1989 Volume 37 Issue 1 Pages 33-60
    Published: 1989
    Released on J-STAGE: May 01, 2007
    DOIhttps://doi.org/10.5702/massspec.37.33
    JOURNAL FREE ACCESS
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    A compact virtual image double focusing mass spectrometer was adopted for the precise isotope analysis with surface ionization ion source. A interface with 16-bit DA converter was set into the computer for automatic control of magnetic field. This new system enabled to measure isotopic ratios by peak hopping method. To obtain high precision, the digital voltmeter under computer control was introduced for collecting data and processing them successively.
    The flatness of the peak top and the stability of the magnetic field during the single run were checked and found to be satisfactory. For the test of the measuring system, the isotopic ratios of K, Rb and Sr were measured using shelf reagents. It was concluded that (1) by the Faraday collector, the isotopic ratio could be measured with the precision better than 0.01% when the ion currents for both isotopes were higher than 10-11A, (2) for the isotope less abundant than 10-4, the precision achieved a few percent by Faraday collector with ion current of 10-15A, while the precision was within 1% by SEM collector with ion current of 10-17A. The performance of the mass spectrometer was found to be satisfactory to measure isotopic ratios with a high precision.
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  • Mass Spectra of Indole-2-carboxylic Acid Derivatives
    Yasuo Shida, Takanobu Maejima, Toyozo Takada, Mitsuo Akiba
    1989 Volume 37 Issue 1 Pages 61-67
    Published: 1989
    Released on J-STAGE: May 01, 2007
    DOIhttps://doi.org/10.5702/massspec.37.61
    JOURNAL FREE ACCESS
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    The mass spectra of indole-2-carboxylic acid derivatives were investigated. In particular, indole-2-carboxylic acid with good leaving groups were noted to undergo thermal rearrangement in the ion source of the mass spectrometer to form a ketene and a ketene-dimer.
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  • Atmospheric Pressure Spray Mass Spectra of Thermolabile and Nonvolatile Compounds
    Minoru Sakairi, Hideki Kambara
    1989 Volume 37 Issue 1 Pages 69-78
    Published: 1989
    Released on J-STAGE: May 01, 2007
    DOIhttps://doi.org/10.5702/massspec.37.69
    JOURNAL FREE ACCESS
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    Atmospheric pressure spray (APS) mass spectra of thermolabile and nonvolatile compounds such as saccharides, glycosides, peptides, phospholipids and glycolipids are presented. The APS method can produce intense protonated and/or cationized molecules such as (M+H)+, (M+Na)+ and (M+K)+ for these compounds without any buffers or external ion sources, unlike other ionization methods. The APS method combined with a collision-induced dissociation technique can provide significant fragment ions, which are very useful for structural elucidation.
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  • Direct Analysis of Urines of Newborn Babys by Liquid Ionization Mass Spectrometry
    Yukio Yokoyama, Hiroaki Kakinuma, Masahiko Tsuchiya
    1989 Volume 37 Issue 1 Pages 79-90
    Published: 1989
    Released on J-STAGE: May 01, 2007
    DOIhttps://doi.org/10.5702/massspec.37.79
    JOURNAL FREE ACCESS
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    Liquid ionization (LI) mass spectrometry, providing mostly MH+ ions of components in a solution, was applied to screening inborn errors of metabolism using urines of newborn babys without any pretreatment.
    Urinary samples of healthy babys exhibited MH+ ions of urea at m/z 61 and of creatinine at m/z 114 and their related ions at m/z 121, 174, 181, 227, and so on. In contrast, the patient's urines exhibited abnormally abundant peaks of components, such as amino acids and/or organic acids, due to the errors of metabolism. All urines of babys suffering from phenyl-ketonuria clearly showed the peak at m/z 166 corresponding to phenylalanine as far as examined. Some of the other peaks at m/z 90, 104, 116, 130, 136, 141, 146, 154, 247, were observed in the mass spectra in common. The peaks assumed to be amino acids (m/z 76, 90, 104, 116, 146) were also observed in the mass spectrum of hypertyrosinemia, which is one of inborn disorders in amino acid metabolism. In the case of glycerol kinase deficiency, the peaks of glycerol (m/z 93) and 3-hydroxybutanoic acid (m/z 105) were clearly exhibited in the mass spectrum, where ammonium adduct ions with them were also observed at m/z 110 and 122 of rather intense peaks than that of MH+ ions. In the case of methylmalonic acidemia, methyl-malonic acid (m/z 119) was rather concentrated in the urine, but weakly observed by means of the direct measurement.
    Clear distinction was found between the mass spectra of normal and abnormal urines, although the direct analysis of urines provided rather weak peaks for organic acids. LI-MS is considered to be useful for analysis of biomedical samples like urine.
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