Journal of the Mass Spectrometry Society of Japan

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Mass Spectra of 7-Substituted Indolizidin-7-ol Derivatives

Hidetoshi Fujiwara, Akira Kato

1987 Volume 35 Issue 6 Pages 335-341
Published: 1987
Released on J-STAGE: May 01, 2007

DOIhttps://doi.org/10.5702/massspec.35.335

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Mass spectra and IKE spectra of a series of 7-substituted indolizidin-7-ol derivatives were measured by electron impact ionization, and their characteristic fragmentation patterns were discussed. The configurations of the epimers could be distinguished by the relative intensity of the peak at m/z 140 in the electron ionization mass spectra and by characteristic peaks corresponding to eliminations of H₂O and alkyl substituents in the IKE spectra.

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Estimation of Relative Sensitivities of Amino Acids by Selected Ion Monitoring GC/MS Analysis

Asao Murai, Yoko Takeuchi, Kazuo Hirayama

1987 Volume 35 Issue 6 Pages 343-348
Published: 1987
Released on J-STAGE: May 01, 2007

DOIhttps://doi.org/10.5702/massspec.35.343

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A linear correlation between the sensitivity and the product of the intensity of monitored fragment ion, molecular weight and molar refraction of an amino acid was found in the selected ion monotoring GC/MS analysis for three kinds of derivatives of amino acids. Using this relationship, it is possible to estimate a relative sensitivity of amino acid derivative by selected ion monitoring GC/MS analysis.

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Application of Molecular-Secondary Ion Mass Spectrometry for Drug Metabolism Studies (III) Analysis of Metal Containing Drugs by SIMS and TLC/SIMS

Haruo Iwabuchi, Hisomu Nagashima, Kan-ichi Nakamura

1987 Volume 35 Issue 6 Pages 349-355
Published: 1987
Released on J-STAGE: May 01, 2007

DOIhttps://doi.org/10.5702/massspec.35.349

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The mass spectra of metal containing nonvolatile drugs and related compounds; i.e. cisplatin (Pt), transplatin (Pt), nitroprusside (Fe), cyanocobalamin (Co), mercurochrome (Hg), and chlorophyll b (Mg), were measured by molecular-secondary ion mass spectrometry (SIMS) directly coupled with thin-layer chromatography (TLC).
Characterisitic positive or negative quasi-molecular ions were obtained sensitively in each metal containing compound by the addition of most suitable liquid matrix.

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Personal Mass Spectral Data Base in Floppy Disk System: III. Correlations between Mass Spectra and Unsaturation in C_nH_lO₁ compounds

Yasuji Koyama, Kogoro Maeda

1987 Volume 35 Issue 6 Pages 357-373
Published: 1987
Released on J-STAGE: May 01, 2007

DOIhttps://doi.org/10.5702/massspec.35.357

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A personal mass spectral data base has been constructed for 2281 C_nH_lO₁ compounds through the extraction from EPA/NIH MSDB.
Base peak distributions were examined for the data base and found almost the same as that of the hydrocarbon compounds, except for the several base peak values such as m/z 31, 45, 59, 73, 87 and others, which are all characteristic base peaks for alcohols and ethers.
It was also found that a clear correlation does exist between the structures (m-value) and the m/z values having their intensities higher than 10% of that of the base peaks when the C_nH_lO₁ compounds were represented as C_nH_2n-mO₁.
Each base peak has usually the largest population at a specific m-value and then the base peak can be classified to several groups according to the same specific m-values. Furthermore, chemical formula for the base peak ions in this grouping were inferred to be C_nH_l⁺, but not C_nH_lO₁⁺, when m^* in C_nH_2n-m^*O₁ is equated to m-4 in case of m≧2.

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