Medical Mycology Journal
Online ISSN : 2186-165X
Print ISSN : 2185-6486
ISSN-L : 2185-6486
最新号
選択された号の論文の5件中1~5を表示しています
Original Article
  • A Case Report
    Chiaki Takahashi, Ryohei Asakura, Ayaka Chaya, Michi Ota, Kazutoshi Ha ...
    2024 年 65 巻 1 号 p. 1-5
    発行日: 2024/01/31
    公開日: 2024/02/29
    ジャーナル フリー
    Microsporum canis is a type of dermatophyte that causes zoonotic dermatophytosis in cats and dogs. We report three cases of tinea corporis due to M. canis from a single household with a domestic cat as a pet. The cases included a woman in her thirties (mother), a girl in her teens (older sister), and a girl in her teens (younger sister). Following sudden hair loss in the domestic cat, annular erythema with pruritus and scales appeared on the face, neck, and limbs of the older sister, younger sister, and mother, sequentially; they subsequently visited our hospital. Potassium hydroxide direct microscopy revealed filamentous fungi on all three women. In addition, short-haired colonies with a white to yellowish-white color and extending in a radial manner were found in cultures using a flat plate agar medium. A slide culture with the same medium indicated pointed spindle-shaped macroconidia with 7-8 septa. Therefore, the cases were diagnosed as tinea corporis due to M. canis. Genetic analysis of the cells of the cat and the mother, older sister, and younger sister using multilocus microsatellite typing (MLMT) indicated that all cases were classified into the same genotype, suggesting that the transmission route of these cases was familial. Here, we show that MLMT is useful in identifying the infection route in cases of tinea corporis due to M. canis.
Review
  • Yasuhiko Matsumoto, Shintaro Eshima, Sanae Kurakado, Takashi Sugita
    2024 年 65 巻 1 号 p. 7-12
    発行日: 2024/01/31
    公開日: 2024/02/29
    ジャーナル フリー
    Experimental animal models are necessary for research on infectious diseases. Generally, mammalian animals, such as mice, are used for infection experiments. However, there are ethical issues associated with conducting infection experiments in mammals. This has made it difficult to perform infection experiments with a large number of individuals. The invertebrate silkworm, Bombyx mori, is gaining attention as a model animal for infection experiments, and silkworm infection models with various pathogens have been established. This review provides information on the use of silkworm infection models for fungal infection research and evaluation of in vivo biofilm formation by pathogenic fungi using a novel silkworm experimental system. Various silkworm infection models with pathogenic fungi have been used for the development of antifungal drugs and the identification of fungal virulence-related genes. Furthermore, a catheter-material-inserted silkworm infection model was established to evaluate biofilm formation in vivo. Silkworm infection models have contributed to research on fungal infections.
Short Reports
  • Takuya Fujiwara, Megumi Itoh, Naoya Matsumoto, Yusuke Koshizaki, Syunp ...
    2024 年 65 巻 1 号 p. 13-15
    発行日: 2024/01/31
    公開日: 2024/02/29
    ジャーナル フリー
    電子付録
    In this study, we analyzed Aspergillus fumigatus short tandem repeat patterns of 106 strains isolated from the outdoor air, clinical specimens, and king penguins (Aptenodytes patagonicus) with aspergillosis in Japan, and compared them with those of 668 strains from AfumID (including six isolates from Japan). The results showed that the isolates were classified into three major groups. Group II contained most of the azole-resistant strains with 34- and 46-bp tandem repeats in cyp51A promoter. As in our previous study, OKH50 and Env1 strains were classified in Group II. Most of the azole-susceptible strains obtained in Japan were classified in Group III.
  • A Case Report
    Yukiro Matsumoto, Sayuka Arakawa, Ken Sadahira, Tomotaka Sato, Kazuto ...
    2024 年 65 巻 1 号 p. 17-21
    発行日: 2024/01/31
    公開日: 2024/02/29
    ジャーナル フリー
    Disseminated trichosporonosis is a rare fungal infection whose risk factors are hematological malignancies and neutropenia. Recently, breakthrough Trichosporon infections after administration of micafungin, the first-line systemic antifungal agent in compromised hosts, have been widely recognized. A man in his seventies about 1 month into chemotherapy for acute megakaryoblastic leukemia presented with a worsening fever and dyspnea. The patient was being administered with empirical micafungin therapy for suspected candidiasis. As the symptoms progressed, scattered erythema appeared on the trunk, some with a dark red vesicle at the center. Blood cultures identified Trichosporon asahii, as did the specimen of the skin biopsy. On the basis also of the presence of pneumonia on chest computed tomography, we confirmed the diagnosis of disseminated trichosporonosis and changed the antifungal agent from micafungin to voriconazole. Blood culture turned out to be negative 1 month after administrating voriconazole. However, the patient died of the leukemia. Our review of previous reports on cutaneous manifestations of disseminated trichosporonosis revealed that despite their morphological diversity, erythema with a red papule or vesicle at the center, implying necrosis, was also observed in previous cases. Our case report suggests that dermatologists should be aware of skin manifestations of disseminated trichosporonosis after micafungin administration, especially in cases of hematological malignancies.
  • Norihito Fukada, Hisashi Kobayashi, Manabu Nakazono, Keita Ohyachi, Ak ...
    2024 年 65 巻 1 号 p. 23-26
    発行日: 2024/01/31
    公開日: 2024/02/29
    ジャーナル フリー
    A Filipino woman in her forties had facial erythema that was being self-treated with over-the-counter (OTC) drugs purchased outside of Japan. The drugs included clobetasol propionate, antibiotic, and antifungal components. Her facial erythema symptoms were worse during summertime. KOH direct examination of annular erythema was positive for fungal hyphae and negative for Demodex folliculorum. Fungal culture revealed Trichophyton indotineae based on internal transcribed spacer sequence analysis. Minimal inhibitory concentration for terbinafine was 0.06 µg/mL. We made a diagnosis of tinea faciei with steroid rosacea. We treated the patient with oral itraconazole. Physicians should be aware of increasing T. indotineae infections and increasing self-medication using topical OTC steroids combined with antifungals and antibiotics not only in India but also among foreign people living in other countries such as Japan.
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