The purpose of the present paper is to report comparative observation of the variation on the level of potassium and inorganic phosphate in the plasma and urine of healthy and alloxan-diabetic animals by the administration of hexoses.
Glucose, fructose and galactose were administered to normal and alloxan-diabetic dogs at a ratio of 2g and to rabbits at a ratio of 1, 5g per kilo. in a 20% solution intravenously. Duplicate analyses were made for the total sugar and the substances given, and for potassium and inorganic phosphate in the plasma and urine.
The results of analyses showed as follows:
1) In the healthy dog and rabbit group, the ratio of utilization of those substances was ordinarily greatest in the case of glucose, less in fructose and least of all in galactose,
2) In the alloxan-diabetic animal group, the ratio of utilization of those substances was greatest in fructose, less in glucose and least of all in galactose ordinarily.
3) In the healthy animal group, the administration of hexoses produced a decrease in the concentration of potassium and inorganic phosphate in the plasma, and in the excretion rate of potassium and inorganic phosphate in the urine, although those decreases, expressed as a percentage of the orginal, were greatest in glucose, less in fructose and least of all in galactose.
4) In an alloxan-diabetic dog group, the administrtaion of hexoses produced a decrease in the concentration of inorganic phosphate in the plasma, although this decrease was smaller than that produced similarly in a normal dog group, but such administration did not change the concentration of potassium in plasma except in fructose. In an alloxan-diabetic rabbit group, the excretion rate of potassium and inorganic phosphate in urine showed no decrease except in fructose.
5) It seems to the worker that the decrease of potassium and inorganic phosphate in the plasma and urine vary in proportion to the ratio of utilization of those hexoses.
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