For the purpose of elucidating the relation between serum Ca and vitamin B
1 in the body, the Ca content in serum of rabbits was reduced by inducing persistent hyper-or hypoglycemia or administering oxalic acid or acetic acid. Their subsequent total serum Ca, serum dialytic Ca, the drop number, the blood VB
1 content and the excretion of VB
1 in urine were measured. The serum Ca content and the VB
1 content in the body in some diseases and pregnancy were also determined. Furthermore Ca was administered to subjects suffering from Ca deficiency in serum or VB
1 deficiency and the subsequent VB
1 metabo lism was followed up. The results obtained were as follows:
1) Adiminution of serum Ca disturbs the metabolism of VB
1 in the body. Such a reduction of serum Ca content heightens the consumption of bodily VB
1 on the one hand, and on the other lowers the utilization of the vitamin in the body.
2) This disturbance of VB
1 metabolism caused by a diminition of serum Ca may be prevented or cured by administration of Ca An oral administration is more effective than otherwise.
3) Administration of VB
1 is effective in preventing the reduction of serum Ca content and causes its slight rise. Therefore, it may be concluded that the Ca content in serum and the VB
1 content in the body stand in mutual correlation.
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