In the Ist Report, the author stated that the liver function is expressed as the elimination quotient (E. Q.) of the bile acid, namely by D. E., R. E. and R. E./D. E., and when D. E.>3.0, R. E.<4.0, R. E./D. E.<1.0, the liver function is disturbed, and that the patients with liver disease had high positive results in this test paralleling those of some other liver function tests.
In the present study, this test was performed on the other various diseases, viz. 44 cases of pulmonary tuberculosis, 9 cases of gastrointestinal diseases (4 gastric cancer, 4 gastric and duodenal ulcer, 1 chronic gastritis), 6 cases of gallbladder diseases (cholelithiasis, cholecystopathia and cholecystectomized patients, 2 respectively), 9 cases of heart diseases (7 mitral failure, 1 aortic failure, 1 pericarditis), 8 cases of renal diseases (7 chronic nephritis, 1 nephrosclerosis), 7 cases of diabetes mellitus and 15 cases of other diseases. And then, by administration of various hepatotonic preparations such as V. B1, V. B2, V. K, glucuronic acid and methionine to these liver disturbed patients, their effects were observed on the point of this test. The results obtained are as follows:
1) In pulmonary tuberculosis, 70.4% of the total showed positive result in this test, and the more advanced the disease, the higher the positivity of the test and the stronger the disturbance of the liver.
2) In gastric cancer, gastric and duodenal ulcer, the positivity of this test was remarkably high.
3) In heart diseases, particularly with congestive hepatomegalia, this test showed sharply positive results.
4) In renal diseases, the elimination of the R-acid was very little and this test revealed serious disturbance of liver function.
5) In diabetes mellitus, either D. E. or R. E. tended to be high, which suggested particularly a changed metabolism of the bile acid in the liver.
6) In observing the effects of various hepatotonic preparations on the disturbances of the liver function by this test, methionine, glucuronic acid and V. B2 had clear hepatotonic action, but V. B1 and V. K had none.
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