Cytogenetic and clinical features are presented in a 8-month-old female infant with many clinical symptoms compatible with Down's syndrome. Leucocyte samples from this patient show 46 chromosomes. Karyotype analysis has revealed that one of the G chromosomes is missing, with the occurrence of an extra chromosome which apparently corresponds in size to the D chromosomes and carries a satellite. A tandem G/G translocation is most plausible to interpret the chromosome abnormality of this patient. The chromosomes of the parents are apparently normal.
Area 17 projects fibers to the main laminae and NIC of the dorsal lateral geniculate nucleus in a topical manner mediolaterally and also anteroposteriorly. The most caudal (posteroinferior) part of area 17 is connected with the pars dorsalis of the dorsal nucleus. Area 18 gives rise to fibers that pass between NIM and lamina A into the dorsolateral part of NIM, the medial part of NIC and the medial ends of laminae A and A1. These projections are organized in the anteroposterior dimension. Area 19 projects fibers to the major part of NIM, except in its most ventral and dorsolateral parts, and to the medialmost parts of NIC and lamina B. The majority of these fibers run along the medial aspect of NIM to enter it. The topical organization of projections from area 19 to the dorsal nucleus appears to exist in the anteroposterior direction. It is emphasized that parts of area 19 in the medial cortex also send fibers to NIM. The ventral lateral geniculate nucleus receives projections from areas 17 and 19. Most of area 18 sends no fibers to the ventral nucleus.
Heparin interacts, in aqueous solution at room temperature, with positively charged substances such as toluidine blue, albumin, and sodium ion to form a complex. The interaction belongs to a reversible semipolar (or ionic) bond reaction. It is uggested that heparin possesses a cation-exchange behavior.