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Volume 19, Issue 1
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[in Japanese]1978 Volume 19 Issue 1 Pages 1-8
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (622K)
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Yoshihisa WAKABAYASHI, Fumimaro TAKAKU1978 Volume 19 Issue 1 Pages 9-14
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThirteen cases of chronic myelogenous leukemia (CML) were treated with a new alkylating agent, Carboquone (2, 5, -bis (1-aziridinyl)-3-(2-carbamoyloxyethyl)-6-methyl-1, 4-benzoquinon), orally in 0.25∼1.5mg daily dosis.
Peripheral leucocyte counts were reduced in all cases to about 1.0×104/cmm. within 1-4 months after an administration. Peripheral myeloblasts disappeared gradually in parallel with the decrease in peripheral leucocyte counts. Other blood components were affected only slightly.
Carboquone was effective in reducing the degree of splenomegaly, but not enough in cases with large splenomegaly.
In our present series, side-effects by Carboquone administration were observed rather frequently such as gastrointestinal disorders, headache, and others. However there was no case who had to discontinue the administration of the drug because of these side-effects.
These results indicate that the effect of Carboquone in the treatment of CML was similar to that of Myleran 6 mg per day on reducing leucocyte counts, and to that of Myleran 2 mg per day on affecting to other blood components.
It is considered therefore, that Carboquone is a useful drug in the treatment of CML because of it's rather selective effect on leucocytes.View full abstractDownload PDF (420K) -
Makoto UTSUMI, Hiroshi OHTA, Kenichiro NAKAMURA, Akiyasu YASUMA, Izumi ...1978 Volume 19 Issue 1 Pages 15-21
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSLevels of each class of serum immunoglobulin were studied in 15 patients with aplastic anemia in order to clarify the immunologic capability of those patients. And the correlation between their levels and peripheral blood lymphocyte counts or degree of severity of aplastic anemia was also studied.
Peripheral blood lymphocyte counts with the mean of 1420±626/cmm (mean±1S. D.) were decreased below normal range. Levels of γ-globulin and Ig G were within normal range with the mean of 0.97±0.39g/dl and 1106±441 mg/dl respectively, though low levels of γ-globulin were detected in one third of patients. The mean value of IgA was within normal limits. Elevated IgM values were demonstrated with the mean of 170±78 mg/dl.
Peripheral blood lymphocyte counts were not significantly correlated with γ-globulin, IgG and IgA. Weak correlation was obtained between lymphocyte counts and IgM. No significant correlation was found between serum immunoglobulin values and peripheral blood B-lymphocyte counts or plasma cell counts in bone marrow. Degree of severity of aplastic anemia was not significantly correlated with peripheral blood lymphocyte counts and serum immunoglobulin levels.
Serial estimation of serum immunoglobulin in those patients revealed several types of change of immunoglobulin in the course of the disease…gradual increase, unchanged, increase following decrcase and decrease…but no correlation was obtained between such changes and prognosis.
Adrenocortical steroid caused transient decrease in serum immunoglobulin levels in about half patients, and so the patients with hypogammaglobulinemia, to whom steroid is administered, must be fully attended.View full abstractDownload PDF (521K) -
Matsuzo MATSUOKA, Shoji SHINADA, Isao KOBAYASHI, Masakazu ITO, Nobuo S ...1978 Volume 19 Issue 1 Pages 22-30
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSCoagulation test reagents obtained either from human placenta or from rabbit brain were used in prothrombin time (PT) and activated partial thromboplastin time (aPTT) procedures respectively.
(1) Fresh pooled oxalated plasma was assayed 10 times in PT and 8 times in aPTT. PT determined by 3 different lots of Activated Thromboplastin (Dade, rabbit) showed significant differences; whereas PT by Thromborel (Hoechst, human) indicated no variation. Likewise, aPTT by Activated Cephaloplastin (Dade, rabbit) indicated significant differences among lots; whereas aPTT by Pathromtin (Hoechst, human) did not.
(2) When PT of 21 oxalated plasmas with various diseases were compared, there was a high correlation (r=0.915); but when citrated plasmas were assayed, it was 0.732. PT of citrated plasma was shorter than PT of oxalated plasma by both reagents. Between PT of citrated plasma and of oxalated plasma, there was significantly better correlation (p<0.05) with Thromborel (r=0.906) than with Activated Thromboplastin (r=0.683). Therefore, oxalated plasma within 3 hours after drawing blood was used in this study.
(3) Some plasmas with PT less than 100% by Thromborel were assayed as more than 100% by Activated Thromboplastin. Plasmas from patients with liver cirrhosis or under warfarin therapy which showed low PT percent were added normal plasma at ratios 1/4, 2/4 and 3/4; their PT were assayed by both reagents respectively and compared with expected PT percent which were calculated. With Activated Thromboplastin, the correlation coeficient was 0.512; but with Thromborel it was 0.807, indicating that the latter offered more reliable PT results than the former (p<0.05).
(4) Because it had a more distinct end point and longer assay times between dilutions, Pathromtin was the reagent of choice in single intrinsic factor assays, especially for Factor VIII.View full abstractDownload PDF (649K)
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Kenji SAITO, Hideo ENOKIHARA, Koji HIROSE, Hideaki KOMATSU, Shimpei FU ...1978 Volume 19 Issue 1 Pages 31-38
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 63-year-old woman with chronic idiopathic neutropenia had repeated febrile episodes but her clinical course had been benign. The in vitro soft agar culture of bone marrow cells revealed normal to slightly increased incidence of neutrophilic colony forming cells (CFC) and a slight increase in absolute numbers of neutrophilic CFC. The levels of colony stimulating factor in serum were increased, and colony inhibiting activity in serum and marrow plasma was within normal limits. The liquid culture of bone marrow cells showed normal proliferation and maturation of neutrophil series. These findings, in addition to normal levels of serum muramidase and vitamin B12 binding capacity, suggested that neutropenia in this patient was due to increased destruction rather than decreased production of neutrophils. Although classical tests for the detection of antineutrophil antibodies were all negative, partial response to corticosteroid therapy suggested that our case might belong to the group of immuneneutropenias.View full abstractDownload PDF (599K) -
Tsutomu ABE, Yoshinori TAKETOMI, Kingo FUJIMURA, Kosuke OKADA, Atsushi ...1978 Volume 19 Issue 1 Pages 39-45
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSAn autopsy case of Ewing's sarcoma was reported. The patient, 13-year-old female, was admitted to the Pediatric Department of Municipal Hospital on October 3, 1974, because of lumbago and back pain. A diagnosis of acute leukemia was suspectable from the findings of bone marrow in which abnormal cells were found in 84% of the nucleated cells. Examination of the peripheral blood disclosed anemia, leukocytosis with a few immature granular cells and accelerated blood sedimentation rate. She had been induced to a remission for two months after treatment with cyclophosphamide, vincristine, Ara-C, and prednisolone until April 4, 1975 when she was admitted to the Hiroshima University Hospital because the symptoms had relapsed. She was treated again with COAP therapy without clinical responses and expired on June 4, 1975. Autopsy study revealed disseminated metastasis of tumors in the liver, spleen, kidneys, heart, lungs, lymphnodes and bone marrow. In abnormal cells, many PAS-positive granules were demonstrated histochemically and the diagnosis of Ewing's sarcoma was made. Electron microscopic findings of intercellular desmosome and intracellular glycogen granules of these cells also confirmed the diagnosis.View full abstractDownload PDF (909K) -
Hiroko HIRAI, Masanori ETO, Sinpei FURUSAWA, Ryuuiti KAMIYAMA, Keniti ...1978 Volume 19 Issue 1 Pages 46-52
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThis patient is a 19-year-old man. On admission, January 1972, there were no enlarged liver, spleen and lymph nodes, and 6.4g/dl of Hb, 2.35×106 of RBC, 48×103 of platelet, and 16.8×103 of WBC. The differential count showed 84% atypical immature cells. Bone marrow findings showed 800×103 of NCC with 0% megakaryocyte, and 99% abnormal immature cells. Wright stains showed basophilic granules in these abnormal cells. These granules gave a positive reaction to peroxidase, Sudan Black B., PAS, and metachromasia with toluidine blue. An electron microscopic study characteristically showed 0.5∼1.0μm basophilic granules surrounded by a layer of limiting membrane, and filled with fine granules, 25∼30nm in diameter. The patient showed partial remission by COAP and VEMP therapies, but died of cerebromeningeal bleeding in the terminal stage, fourteen months after the initial diagnosis. Autopsy showed marked infiltration of the leukemic cells in the bone marrow, spleen and liver.View full abstractDownload PDF (907K) -
Teizo KABASHIMA, Michio NIIMI, Kan HASEGAWA, Koji NISHIYA, Katsuaki KO ...1978 Volume 19 Issue 1 Pages 53-61
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA case of hyperthyroidism associated with microangiopathic hemolytic anemia (MHA) is reported.
Patient was 32-year-old male who had anemia and jaundice of 7 months' duration. Hematological examination on admission revealed that patient had Coombs negative hemolytic anemia, many fragmented red cells in his peripheral blood and thrombocytopenia. There were slight decrease of fibrinogen (176mg/dl) and coagulation Factor V (50 per cent) but FDP was normal. Diagnosis of MHA was made but no underlying disease which might cause MHA was found at this stage. Initial trial with Aspirin and Dipyridamol failed to improve patient's hemolysis.
After the admission patient showed increasing signs of thyrotoxicosis and small diffuse enlargement of the thyroid gland was found on the 70 th hospital day. Thyroid function tests showed the presence of hyperthyroidism. Immediately the treatment of hyperthyroidism was started with Propylthiouracil (PTU) 300 mg per day. There was improvement of hemolytic anemia and thrombocytopenia along with the decrease of serum thyroid hormones. After the administration of PTU for 15 weeks, hemolytic findings and thrombocytopenia disappeared and fragmented red cells decreased to less than one per cent. Discontinuation of PTU caused prompt elevation of serum triiodothyronine and reappearance of hemolysis and thrombocytopenia.
These findings and clinical course strongly suggested that hyperthyroidism was the cause of the MHA of this patient.View full abstractDownload PDF (721K)
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