Recently, amebic liver abscess cases have been reported sporadically, showing the trend of increase in Japan. Main source of the infection is considered to be (1) so-called imported amebiasis by oversea travelers and refugees from the endemic areas and (2) native asymptomatic E. histolytica cyst passers in the community.
The present paper reports on a case of amebic liver abscess of 34-year-old male Vietnamese refugee. He came to Japan in May 1981, and was admitted to our hospital in July 1981 with symptoms of fever and right lateral chest pain. E. histolytica was not detected by fecal examinations, but abdominal echography revealed a mass echo, 10 cm in diameter, in the right lobe of the liver. The necrotic contents of the abscess pocket in liver were aspirated, and trophozoites of E. histolytica were demonstrated from the exhausted pus. Serameba® test showed positive reaction. He was discharged from the hospital after complete cure by the administration of metronidazole (2 g/day×10 days×2 courses).
For this occasion, Serameba® test was carried out on his 32 associates (21 male, 11 female), and only one serum (3.1%) showed positive reaction. Fortunately, neither abscess in liver nor E. histolytica in feces was found in this positive case.

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タイ国に自生するカキ科の植物Ma-Klua (Diospyros mollis) の抽出物に駆虫効果のあることは古くから分っているが, その生理・生化学的作用機序に関する研究は未だその報告をみない。筆者らはその予備的検討として, 小形条虫と広東住血線虫のフォスファターゼ活性, プロテアーゼ活性及びグルコースの吸収に対する本抽出物の影響をin vitroで調べた。インキュベーション溶液中に含まれる本抽出物 (0.05, 0.5mg/ml) は小形条虫ではフォスファターゼ活性 (pH 7.2-7.4) に影響がなかったが広東住血線虫のそれは低下した。両種虫体の基質ヘモグロビンに対するプロテアーゼ活性 (pH 3.7) は本抽出物 (0.1, 0.5, 1.0mg/ml) により阻害された。両種虫体によるグルコースの吸収 (pH 7.1-7.6) は本抽出物 (0.5, 1.0mg/ml) により抑えられた。これらの影響について, 他の研究者により報告された本抽出物の駆虫効果に関する形態学的検討結果と関連して論議した。

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