Background and aims:
We have developed a Stress-free Therapy® device wherein “Pinpoint Plantar Long-wavelength Infrared Light Irradiation (PP-LILI)” increases peripheral-deep body temperature and blood flow volume and stabilizes blood pressure as well as significantly reduces stress hormones such as adrenocorticotrophic hormone and cortisol without using drugs. Moreover, we have found this therapy to significantly improve blood glucose and insulin resistance in patients with type 2 diabetes. Based on this background of clinical efficacy, we validated changes in cerebral blood flow in patients with metabolic cardiovascular disease and examined the efficacy of Stress-free Therapy® on cerebral blood flow as compared to that in healthy control subjects and placebo-treated patients.
Results:
The change in cerebral blood flow volume during 15-minute PP-LILI was 5.1 ± 1.8 mL/min in patients with metabolic cardiovascular disease, showing a significant increase (P<0.05) of 3.1 mL/min as compared with the mean blood flow value after resting for 15 minutes.
Conclusions:
Our results suggested Stress-free Therapy® to significantly increase cerebral blood flow, possibly leading to the prevention of metabolic cardiovascular disease.

抄録全体を表示

Background and aims: Pigmented lesions, e.g., senile lentigo and seborrheic keratosis are commonly seen in photodamaged skin in the Japanese general population. The use of the laser to treat such lesions is often painful, and intense pulsed light (IPL) systems have become widely used. Clearly demarcated pigmented lesions may be identified easily and treated with IPL. Less welldemarcated lesions, however, which are very difficult to identify or thick melanogesic lesions like seborrheic keratosis represent one of the most challenging conditions to be treated using IPL. This pilot study evaluated carbon suspension-assisted IPL treatment of such lesions.
Subjects and methods: Three female Japanese patients, Fitzpatrick skin type III-IV, comprised the subjects, aged 58, 78 and 85, with indistinct senile lentigines or thick seborrheic keratoses. The lesions were painted or demarcated with a carbon-based ink from a commercially-available Japanese writing instrument (Fude-pen^TM, Pentel, Japan) consisting of a brush-like pen nib with a refillable or replaceable ink reservoir, and then treated with a broadband (560 - 1200 nm) IPL system.
Results: The poorly-demarcated lesions were quickly and easily marked with the pen, and the IPL treatments were well-tolerated. All patients had good improvement in their painted pigmented lesions based on the overall evaluation, compared with unpainted ones. Side effects after treatment, such as hyperpigmentation, persistent erythema, and scarring, were minimal.
Conclusions: Topical carbon suspension-assisted IPL treatment could be a good option for patients with indistinct pigmented or thick melanogenesic lesions. Adverse reactions to this treatment were minimal and the results acceptable, though appropriate lesions need to be chosen carefully.

抄録全体を表示

Background and aims: The purpose of this study was to evaluate the bleaching efficiency of two different lasers (KTP and diode 810 nm) on teeth, randomly divided by means an Excel function (Microsoft Excel 2010 “Fx causale”) and stored in physiological solution, that were previously stained with different substances commonly considered as a cause of tooth discoloration, such as coffee, tea and red fruits and to investigate the role of laser irradiation in an experimental model, during the dental bleaching process.
Methods: Three groups of 45 bovine teeth were created and immersed for one week in a solution of tea, coffee or red fruits respectively. Each group was divided into three sub-groups of fifteen teeth. One was bleached with a 30% hydrogen peroxide gel for 30 min only as control, another 15 teeth group was bleached with the gel plus 810 nm diode laser irradiation and the last group was bleached with the gel plus KTP irradiation. The lasers were applied in three cycles of 30 sec each with a power of 1.5 W localized on a 10 mm spot on the teeth. The temperature of the gel was checked during the bleaching procedure using a thermometer and the colour of each tooth was measured by a spectrophotometer.
Results: Statistical analysis of the collected data was performed using Graph Pad Prism, version 6.01 software, Kruskal-Wallis test and Dunn's multiple comparison test and Mann-Whitney test. P value <0.0001 was considered extremely significant (***), P value between 0.001 to 0.01 very significant (**), P value between 0.01 to 0.05 significant (*) and P value >0.05 not significant (ns). By these tests diode laser was effective only at bleaching teeth stained with coffee meanwhile the KTP laser was efficient at bleaching teeth with coffee, tea and red fruits stains.
Conclusion: This study suggests that a relation between the laser wavelength and the type of staining on the dental enamel and the efficacy of the whitening treatment exists.

抄録全体を表示

Background: In our activity in the Ambulance Service of Bucharest Municipality during March 2002 - March 2003 we studied a casuistry of patients who had fallen in a coma of varying degrees. To aid better understanding of coma, the concept of “pre-coma stage” or diencephalic “0 stage ” was introduced. This concept complements the Arseni classification already used in medical practice, because some doctors alternatively use the term of “inaugural coma” for the same condition that we call diencephalic “0 stage”. In the median hypothalamus and on the retino-hypothalamic path (SCN - AN) optical waves are transmitted, probably in the near infrared spectral range (800-1000 nm). These waves would constitute a means of transmitting information about the infradian biorhythm of coordination (frequencies below 1 cycle/28 hours), essential for the modulation and pre-processing of the consciousness and wakefulness, a fact which has already been demonstrated in animals.
Methods: The current work is based on observations made on a group of 51 patients with the precoma and coma conditions, and on a thorough study of the specialized (especially Romanian) literature. Also, we used validated scientific proof of torture in conditions of lack of light.
Results: We found a perfect interpenetration between the ARAS and the following two complementary subsystems: 1. The hypothalamic suprachiasmatic nucleus, that has the role of coordinating the periodicity of some biological functions depending on the circadian rhythm; and 2. The main photoperiodic organ, the pineal gland (epiphysis), which together with the ARAS has a role in the photoperiodicity modulation of some biological functions during the state of vigilance.
Conclusion: From the above mentioned one may conclude that the consciousness condition is the unitary result of action of all human brain systems and especially sub-systems, which are controlled and led by a psycho-neurological process of integration at the cortex level. “Everyone knows what the consciousness is, until one tries to define it” (William James: The Stream of Consciousness”, 1892).

抄録全体を表示

Background and aims: Despite modern advances in the prevention of dental caries and increased understanding of the importance of maintaining the natural primary dentition, many teeth are still lost prematurely. This can lead to malocclusion with aesthetic, phonetic and functional problems that may be transient or permanent. Therefore, maintaining the integrity and health of the oral tissues is the primary objective of pulp treatment. Pulpotomy has remained an acceptable and mainstay treatment in preserving the vitality of primary tooth and prolonging its life till the permanent successor erupts. Various materials and techniques are available for pulpotomy on primary molars; all with some advantages and disadvantages. The present study was carried out on 45 primary molars to evaluate and compare the clinical and radiographic success of diode laser, electrosurgical and ferric sulfate pulpotomy over a period of 9 months.
Materials (Subjects) and Methods: The forty five primary molars were randomly and equally divided into three treatment groups which were as follows: Group A: 15 primary molars treated with 15.5% Ferric sulfate Group B: 15 primary molars treated with electrosurgical unit and Group C: 15 primary molars treated with diode laser. All teeth in three categories were followed up clinically and radiographically at 1, 3, 6 and 9 months post treatment and the findings were recorded on the prepared proforma
Results: Clinically, 86.6% success rate was found in ferric sulfate group whereas 100% success rate was found in electrosurgical and diode laser groups. Radiographically, 80% success rate was found in all the three groups at the end of 9 months with internal resorption being the most common cause of failure after pulpotomy.
Conclusions: Thus, electrosurgery and diode lasers appear to be acceptable alternative to pharmacotherapeutic pulpotomy agents.

抄録全体を表示

Background: Tremendous advances have been made in the medical application of the laser in the past few decades. Many diseases in the dermatological field are now indications for laser treatment that qualify for reimbursement by many national health insurance systems. Among laser types, the carbon dioxide (CO₂) laser remains an important system for the dermatologist.
Rationale: The lasers used in photosurgery have wavelengths that differ according to their intended use and are of various types, but the CO₂ laser is one of the most widely used lasers in the dermatology field. With its wavelength in the mid-infrared at 10,600 nm, CO₂ laser energy is wellabsorbed in water. As skin contains a very high water percentage, this makes the CO₂ laser ideal for precise, safe ablation with good hemostasis. In addition to its efficacy in ablating benign raised lesions, the CO₂ laser has been reported to be effective in the field of esthetic dermatology in the revision of acne scars as well as in photorejuvenation. With the addition of fractionation of the beam of energy into myriad microbeams, the fractional CO₂ laser has offered a bridge between the frankly full ablative indications and the nonablative skin rejuvenation systems of the 2000s in the rejuvenation of photoaged skin on and off the face.
Conclusions: The CO₂ laser remains an efficient, precise and safe system for the dermatologist. Technological advances in CO₂ laser construction have meant smaller spot sizes and greater precision for laser surgery, and more flexibility in tip sizes and protocols for fractional CO₂ laser treatment. The range of dermatological applications of the CO₂ laser is expected to continue to increase in the future.

抄録全体を表示