Various destruction in the tubero-mamillary region in hypothalamus induced hypertension and hypotension, on which etiological hormonal and neural factors were investigated pathologically, chemically and electrophysiologically, and the chronic effects of the lesions on blood pressure were compared with the acute effects of hypothalamic stimulation and destruction. The results provided the evidences that these hyper- and hypotensions were both classified into two main categories; adrenogenic and nonadrenogenic (perhaps neurogenic and partly thyroidgenic), and hypothalamic contribution to blood pressure regulation through nervous and endocrine systems was discussed in relation to the detailed localization of hypo-thalamic lesions.

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The correlation between the continuity grade of the cerebral blood flow pattern (blood flow pattern in internal carotid artery) by ultrasonic Doppler technique during life and the severity of the cerebral arteriosclerosis (intracerebral arteriolosclerosis and extracerebral atherosclerosis) in the same subject was investigated. The correlation between the continuity grade of the cerebral blood flow pattern and the severity of the cerebral arteriosclerosis is much more significant. The result suggests that the ultrasonic Doppler technique is useful for the quantitative detection of cerebral arteriosclerosis, i.e., anticipation of the cerebral vascular accidents. However, the consideration for several factors affecting the cerebral blood flow patterns are essential in application of the method.

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A more accurate observation of retina and vessels was made by the fluorescence angiograms than the ones made by ophthalmoscope and routine color photography. The method proved to be the most effective in detecting the soft exudates caused by increase in permeability and damage of arteriole walls. The soft exudates revealed by this method occur in many hypertensive patients with abnormal ECG. No conspicuous difference was observed in the measurement of the caliber of artery and vein of a normal person either by color or fluorescein photography. The differences however, become greater as copper wire artery and silver wire artery. Observation was also made on fluorescein photographs at the time of blood pressure raised by means of cold pressure and intravenous injection of methoxamine and also at the time of blood pressure lowered by means of sodium nitrite treatment.

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A case of lymphosarcoma which was primarily manifested as cardiac tamponade, and congestive heart failure is presented. Irradiation caused dramatic recovery and later the patient succumbed due to systemic dissemination. The primary site was undetermined at autopsy. A discussion of primary cardiac malignant lymphoma versus secondary one is given with re-view of the literature.

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There are so many lead systems of vector-cardiography and their loops vary so much from each other that a great deal of inconvenience arises in the clinical use of vectorcardio-gram (VCG). In order to remove this inconvenience, the author worked out a mutual transformation theory of VCGS based on BURGER'S conception of lead vector to acquire a transformation equation by which a VCG of any lead system could be transformed into a VCG of any other lead system. Mutual Transformarion Theory of VCG When lead vectors of two lead systems A and B are represented by Ai and Bj respectively, the following equation can be induced according to the general principles of vector: A_i=Σ^^3__(j=1)(A←B)<ij>_Bi ( 1 ) The i is 1, 2 or 3 ; A₁ corresponds to the lead vector A^^→_x, A^^→₂ to the one A^^→_y, and A^^→₃ to the one A^^→_z. The same is the case with j. The (A←B)_ij is transformation coefficient. Equation ( 1 ) holds good whether A^^→_i; and B^^→_j are orthogonal or oblique respectively. If we get the scalar product of the heart vector H^^→_t at a given moment by the lead vec-tor A^^→_i, there follows the equation below: H^^→_t·A^^→_i=Σ^^3__(j=1)(A←B)_ijH^^→_t·B^^→_j (2) H^^→_t·A^^→_i according to the definition of lead vector, represents the potential differences of the scalar electrocardiograms (SECGs) of Lead System A at a given moment, and so is replaced with VA_it· In the same way, H^^→_t·B^^→_j is replaced with VB_it· Thus, the following equation results from Equation (2) : VA_it=Σ^^3__(j=1)(A←B) _ijVB_<jt&ge; ( 3 ) The transformation coefficients being computable from SECGs, it is prossible to transform the SECGS of Lead System B into that of Lead System A by using Equation (3). When the electric action of the heart is assumed to be caused by an electric dipole, Equation (3) holds good generally.

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Previously KATUNUMA has shown that GOT from pig liver consists of two types of isozyme, the one being localized in cell supernatant (GOTs) and the other in mitocondria(GOTM), and subsequently purified them to almost single protein. Using the technique of colum chromatographic separation, the author elucidated the changes of GOT-isozyme and effects of some medicines on the enzymatic activity in infarcted heart muscles togather with subsequent changes of pattern of ECG in experimental infarction in order to develop the way to their clinical application. Method of the Experiment Experimental myocardial infarction was made by ligating the coronary artery of dogs at the circumflex branch of the left coronary artery. The direct ECG were recorded before or twenty-four hours after occlusion respectively. The dogs were sacrificed for the enzymatic assay. Furthermore, in order to determine the effect of some medicines, medicines were injected intravenously before or immediately after the ligation of coronary artery. Dogs were killed and the removed heart muscle was divided into the infarcted portion and non-infarcted portion. The isozymic activity were measured on the materials obtained from each portion. HUZlNO-KATUNUMA'S method was employed for the separation and the measurement of the isozymic activity. Results 1. GOT-isozyme in Normal Heart Muscles: The ratio of the activity of GOTS to GOTM in normal heart muscles was about 4 to I on the average. 2. Twenty-four Hours after Occlusion: 1) Control groups without medicines The average ratio of the activity of GOTS to GOTM in the non-infarcted portion were almost the same value as that in the normal heart muscles. The average activity of GOTS in the infarcted portion decreased about 70 per cent compared with that in the non-infarcted portion. 2) The effect of some medicines on the GOT-isozymes in the infarcted portion a) Control group (physiological saline solution) The rates of decrease of GOTS were 62.8 per cent and 73.6 per cent respectively, and, in comparison with the control group to which no medicines were administered, any difference could not be observed.

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A girl of thirteen years was admitted to Iwate Medical University Hospital on December 22th, 1956, complaining of palpitation by physical exertion since childhood. She had a splendid physique and was well-nourished, and didn't have any acquired diseases at that time. But her heart had a shape of dextrocardia on chest x-ray film, and it had been recognized on physical and x-ray examinations that she had heterotaxia of abdominal organon. Marked systolic murmur was heard on the right sternal line in the IIIrd intercostal space. The right and left heart catheterization had revealed VSD and ASD. The right and left heart catheterization and the cineangiocardiography suggested strongly mirror image dextrocardia. Nevertheless in ECG, P waves in I, aVL and left precordial leads were positive with a P-R interval of 0.19 second, and P waves in aVR, V4R, V5R, and V6R were negative. So they didn't coincide with the ordinary ECG-criteria of mirror image dextrocardia. But mirror image dextrocardia, as well as VSD and foramen ovale, were made sure by operation. Namely the P wave pattern above mentioned was proved to represent left atrial rhythm. Also "dome and dart" type P waves were seen m V2. So this left atrial rhythm was fit for the lst type, according to the classification of M. MIRROWSKI. After operation, pacemaker wandering between sinus node and left atrium was seen without artificial procedures. In sinus rhythm, P waves in I, aVL and left precodial leads were negative with a P-R interval of 0.20 second and P waves in aVR, V4R, V5R and V6R were positive. Compression on eyeballs or carotid sinus failed to change the position of pacemaker. But posture change from supine to erect position converted left atrial rhythm to sinus rhythm.

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