巻号一覧
23 巻 (1973)
- 6 号 p. 753-
- 5 号 p. 599-
- 4 号 p. 431-
- 3 号 p. 277-
- 2 号 p. 129-
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23 巻, 3 号
選択された号の論文の20件中1～20を表示しています
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K.N. GARG, S. SHARAN1973 年 23 巻 3 号 p. 277-280
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーMany cases of alcohol induced hypoglycemic states have been reported from various parts of the world. Hypoglycemia after alcohol in diabetics was also reported by several investigators. While non-diabetic drinkers need not worry about hypoglycemia, insulin dependent diabetics have much cause for concern. If confused after drinking alcohol, they may either take an over-dose of insulin or may miss meals. In the present study it has been shown that the animals not having adequate food intake after insulin and ethanol showed a severe degree of hypoglycemia. It is likely that alcohol per se directly interferes with the blood glucose regulating mechanism when taken concurrently with insulin, this condition producing central nervous system damage. For this reason, diabetics should be made aware of this before they are allowed to consume alcohol.抄録全体を表示PDF形式でダウンロード (152K) -
[I] THE EFFECT OF HYDROXY BIS-[2-(P-CHLOROPHENOXY)-ISOBUTYRIC ACID] ALUMINIUM ON LIPID METABOLISM IN NORMAL RATSTakako TOMITA, Reiko TAKESHITA, Toshiyuki NAGAKURA, Eiichi HAYASHI1973 年 23 巻 3 号 p. 281-287
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe hypolipidemic effect of alfibrate has been studied in normocholesterolemic rats with clofibrate as a reference. At the dosage of 150 mg/kg, 29% increase of liver weight was observed in the alfibrate group and 87% increase in the clofibrate group. Daily administration of alfibrate (150 mg/kg) produced a significant decrease in serum cholesterol (5%) and triglycerides (15%), and liver cholesterol (12%) and triglycerides (23%) with no change in phospholipids and free fatty acids. Like clofibrate, alfibrate exerted a greater effect on lowering the triglyceride level than cholesterol in normocholesterolemic rats. The liver glycogen concentration and glucose tolerance in the alfibrate group were similar to that of control.抄録全体を表示PDF形式でダウンロード (281K) -
[II] THE EFFECT OF HYDROXY BIS-[2-(P-CHLOROPHENOXY) ISOBUTYRIC ACID] ALUMINIUM ON LIPID METABOLISM IN HYPERCHOLESTEROLEMIC RATSTakako TOMITA, Yasuko YAMAMURA, Toshiyuki NAGAKURA, Eiichi HAYASHI1973 年 23 巻 3 号 p. 289-298
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe effect of alfibrate on the lipid metabolism in serum and liver was studied in the rats maintained on a cholesterol diet with simultaneous oral administration of alfibrate (150-900 mg/kg, daily) for two weeks. Clofibrate was used as a reference. The growth in alfibrate group was less inhibited than in clofibrate group and the increase in liver weight was 7% for alfibrate and 39% for clofibrate at 150 mg/kg dosage. Alfibrate inhibited the elevation of serum cholesterol by 60-67%, which is almost the same level of inhibition as for clofibrate. About 70% of inhibition in serum β-lipoprotein level, 36-58% decrease in the ratio of total cholesterol to phospholipids and a significant decrease in the ratio of free to esterified cholesterol were observed in alfibrate treated rats. About 15-23 % inhibition in serum triglycerides and almost the same level of inhibition in serum phospholipids was observed, the rate of inhibition by alfibrate being less than that by clofibrate. Alfibrate administration produced no significant change in liver cholesterol concentration in the hypercholesterolemic rats, but caused a 40-50% decrease on liver triglyceride and free fatty acid concentration, and 9 and 22% increase in phospholipid concentration at low and high dosages respectively. Any detectable change in total lipid concentration on liver, brain, kidneys, testes and the weight of epididymal fat tissues was not observed with alfibrate administration. Palmitic acid in cholesterol ester fraction of both liver and serum was decreased significantly, and in general, oleic acid tended to increase with alfibrate.抄録全体を表示PDF形式でダウンロード (393K) -
Akira UENO1973 年 23 巻 3 号 p. 299-306
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーPhysiological significance of shortened action potential on the negative inotropic action of acetylcholine was studied in isolated atria of guinea pigs from the aspect of drug-antagonism at the configuration of the transmembrane action potential. A series of agents which cause prolongation of duration in action potential and without marked effects on the contractility such as o-benzoyl thiamine, E-10, quinidine and diphenhydramine were used as antagonists to observe the effect of acetylcholine in shortening the duration of action potential. Additional applications of these antagonists to the atria during exposure to acetylcholine recovered to the normal state, both the shortened action potential as well as the suppressed contractility. The results herein clearly indicate that the negative inotropic action of acetylcholine is dependent on the shorter duration of depolarization.抄録全体を表示PDF形式でダウンロード (249K) -
Mitsuyoshi NAKASHIMA, Hiromichi TSURU, Tatsuro SHIGEI1973 年 23 巻 3 号 p. 307-312
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーMethoxamine showed positive inotropic and chronotropic actions in the rat atria. These actions were blocked by phentolamine, but not by propranolol. PTU treatment sensitized the animals to the positive inotropic and chronotropic actions of methoxamine. These results verify the findings of previous research that there are α adrenergic receptors in rat atria, that stimulation of these receptors shows positive inotropic and chronotropic action and that a receptors are sensitized by PTU treatment.抄録全体を表示PDF形式でダウンロード (183K) -
4TH REPORT: ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN CODEINE ADDICTED RATSIchiro YANO, Yasusuke MASUDA, Hitoo NISHINO, Hiroyuki YAMAMOTO, Tadash ...1973 年 23 巻 3 号 p. 313-319
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーInfluence of codeine on the fine structure of mitochondria in the cells of zona fasciculata of rat adrenal cortex was studied electronmicroscopically. By the administration of codeine in a dose of 40 mg/kg, the number of intramitochondrial vesicles was decreased, the change being diminished during repeated administration of the drug. Withdrawal of codeine reproduced an extensive transformation, while with a re-injection of the drug, a prompt restoration to the pretreated structure was observed. The feasibility of utilizing this transformation as an index of physical dependence liability has been discussed.抄録全体を表示PDF形式でダウンロード (1319K) -
V. ANTIARRHYTHMIC ACTIONSKenji YAMADA, Takashi SHIMAMURA, Hiromichi NAKAJIMA1973 年 23 巻 3 号 p. 321-328
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe effect of CRD-401 on several types of experimentally induced arrhythmias in guinea-pigs and dogs and the antagonistic effect against isoproterenol in the isolated atrium of guinea-pig were studied and compared with quinidine and propranolol. In epinephrine-induced arrhythmias of guinea-pigs, propranolol had a notable but brief depressive effect, which was observed only 5 min after administration of the drug. Although the potency of CRD-401 was weaker than that of propranolol in these arrhythmias, the effect persisted for more than 35 min after administration. In ouabain-induced arrhythmias of guinea-pigs, CRD-401 and propranolol showed similar depressive effects. Quinidine had little effect on both epinephrine- and ouabain-induced arrhythmias. Both CRD-401 and propranolol failed to reverse the arrhythmias produced by two-stage coronary artery ligation. Propranolol showed a competitive antagonism against the positive chronotropic effect of isoproterenol, while CRD-401 revealed a non-competitive β-blocking action. Quinidine produced no blocking effect in the present experiments.抄録全体を表示PDF形式でダウンロード (268K) -
Shigetoshi CHIBA, Hiroo HASHIMOTO, Koroku HASHIMOTO1973 年 23 巻 3 号 p. 329-335
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe relative potency of chronotropic effects of dopamine (DA), l-norepinephrine (NE), l-epinephrine (EP), l-isoproterenol (ISO) and tyramine (TY) was determined by direct application into the sinus node artery of the in situ canine heart (n=10), which was treated with atropine. The order of potencies of chronotropic effect of these amines was ISO>NE=EP>DA≥TY. The ratio of doses required to produce 50% increase in sinus rate was ISO: NE: EP: DA: TY=1/30: 1: 1: 10: 10. At any dose level for inducing the same grade of sinus acceleration, the duration of action of NE and EP was almost equal and short, while that of ISO was usually longer. The duration of action of DA was short at a lower dose level but became equal to ISO with a medium dose. At a larger dose to produce a maximum response, DA acted longer than ISO, which indicates direct effect of DA with induction of indirect effect of catecholamine release. This suggest a tyramine-like action of DA.抄録全体を表示PDF形式でダウンロード (279K) -
(II) SUBCELLULAR DISTRIBUTION OF SPECIFICALLY BOUND DIBENAMINEMasaatsu UCHIDA, Keijiro TAKAGI1973 年 23 巻 3 号 p. 337-347
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーBy means of differential centrifugation and density gradient separation, fractionation of histamine receptors of cat small intestinal smooth muscle was undertaken. The radioactivity differences were investigated between the muscle labeled with radioactive dibenamine under drug protection and the muscle without the protective drug. The fraction was obtained in which specifically labeled histamine receptors were concentrated. The specificity of the fraction was proved by examining the pattern of distribution of radioactivity differences in subcellular fractions of the muscle protected with specific drugs (diphenhydramine, chlorpheniramine and histamine) or with non-specific drugs (aniline, phenethylamine and benzylamine). The labeled components were of high molecular weight and degradated to smaller molecules by solubilization of the fraction with Triton X-100. A good correlation was found between radioactivity differences and pharmacological observations.抄録全体を表示PDF形式でダウンロード (410K) -
J.P. BARTHWAL, T.K. GUPTA, M.L. GUPTA, K.P. BHARGAVA1973 年 23 巻 3 号 p. 349-354
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe effect of diethylstilboestrol (DES; 0.5 mg/100 g) and progesterone (2.5 mg/100 g) was studied on the catecholamine content of adrenals and uteri of seven day ovariectomized albino rats. The agents were administered i.p. on alternate days for one week and the tissue catecholamine content was determined spectrophotofluorometrically. DES treatment increased the total adrenaline contents of adrenals and uterus. On the other hand progesterone caused a decrease in the level of catecholamines in both the tissues. These findings are discussed in relation to the actions of female sex hormones on cardiovascular and genital systems.抄録全体を表示PDF形式でダウンロード (245K) -
Jiro NAKANO, Arthur V. PRANCAN, Nemat H. MORSY1973 年 23 巻 3 号 p. 355-361
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe metabolic degradation of PGE, was studied by the incubation of 3H-PGE1 with rat and dog plasma and thoracic lymph and the homogenates of various rat and dog tissues. It was observed that rat and dog plasma metabolize very little PGE1 even when incubated for one hr. Very little metabolic degradation of PGE1 was found by dog thoracic lymph. In contrast, rat and dog lung and kidney metabolize PGE1 very rapidly, and approx. 95% of PGE1 was converted to a less polar metabolite within 20 min of incubation. The metabolic degradation of PGE, was also rapid in the homogenates of rat stomach and jejunum, but the velocity of this reaction in these homogenates was slower than that in the rat or dog lung and kidney homogenates.抄録全体を表示PDF形式でダウンロード (263K) -
P.N. SAXENA, M.B.L. JOHRI1973 年 23 巻 3 号 p. 363-371
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe antagonistic activity of eighteen phenothiazine derivatives against the neurohumors histamine, ACh, NA and 5-HT was studied in vitro and compared with accepted specific antagonists, viz., diphenhydramine, atropine, tubocurarine, phenoxybenzamine and LSD-25. The phenothiazines exhibited a dual antagonism (competitive and non-competitive) against histamine and muscarinic action of ACh. Many of them appeared more potent and more specific on histamine receptors than on ACh receptors while several others did not discriminate between the two receptor types. The phenothiazines showed a non-competitive antagonism against ACh (nicotinic action), NA and 5-HT. The activity against ACh (nicotinic action) was low while that against 5-HT was moderate. The α-adrenergic blocking activity was not shared by all the derivatives and some even potentiated the NA response. Only atropine and tubocurarine exhibited a pure competitive antagonism over a wide concentration range on the muscarinic and nicotinic receptors, respectively. Phenoxybenzamine possessed the widest spectrum of activity, antagonizing all the neuro humors. 5-HT receptors showed the maximum susceptibility to blockade, reacting to all the phenothiazines and reference antagonists.抄録全体を表示PDF形式でダウンロード (430K) -
Hiroshi HAMAKAWA, Takeshi SHIMIZU, Noboru TODA1973 年 23 巻 3 号 p. 373-379
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーRabbit left atria were driven electrically at frequencies from 6 to 240/min or higher. The contractile tension-frequency curve was significantly moved upward by phenylephrine (10-6 and 10-5 M). The positive inotropic effect was not influenced by propranolol but was markedly attenuated by phentolamine. Theophylline in a concentration (10-4 M) sufficient to potentiate the effect of isoproterenol did not alter the positive inotropic effect of phenylephrine. Cardiac excitability studied in preparations driven at high frequencies was reduced by phenylephrine, the effect being inhibited by phentolamine and potentiated by propranolol. The excitability was enhanced by isoproterenol. Theophylline potentiated the effect of isoproterenol but inhibited the effect of phenylephrine in a high concentration (10-5 M). It may be concluded that an enhancement of the contractile force by stimulation of myocardial alpha-receptors is not due to increased formation of cyclic AMP. Theophylline does not appear to change the effect of alpha-receptor stimulation on cardiac excitability but rather to unmask the effect of beta-receptor stimulation when high concentrations of phenylephrine are applied.抄録全体を表示PDF形式でダウンロード (279K) -
Takashi OCHIAI, Masaki HORI, Yoshio KOWA1973 年 23 巻 3 号 p. 381-390
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーPharmacological effects of HQ-275 on CCl4-liver injury have been investigated, and the results compared with those of rats treated with CCl4 plus HQ-275 with those of normal rats and only CCl4-treated rats. In the excretion test of biliary flow, bilirubin, solid contents and B•S•P, rats treated with CCl4, alone or with CCl4, plus HQ-275 showed less excretion than those of normal rats, and the differences among these three categories were not significant. HQ-275 revealed a potent recovery process from the liver damage caused by CCl4, in both histological and biological levels. Changes of Na+ and K+ in bile, water content of liver and body temp. were recognized among the three groups. It can be concluded from over-all results that there may be some differences between structural and functional recovery processes from CCl4-hepatotoxicity.抄録全体を表示PDF形式でダウンロード (529K) -
Hajime TAMAKI, Tomihiro IKEO, Shoichi HARIGAYA, Hiromichi NAKAJIMA1973 年 23 巻 3 号 p. 391-400
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーEffects of 1, 1-dimethyl-5-methoxy-3-(dithien-2-ylmethylene) piperidinium bromide (SA-504) on the motility of gastrointestinal tract and of the urinary bladder were examined in cats. The inhibitory activity of SA-504 on the spontaneous motility of the stomach brought about by i.v. injection was nearly equal to that of hyoscine-N-butylbromide (HB), but approx. one-fourth of atropine sulfate (Atr). Intragastric administration of either SA-504 or HB produced obvious inhibition on the spontaneous motility of the stomach, while their potencies were less than one-tenth of Atr. The spasmolytic activity of SA-504 on the stomach contraction induced by vagal stimulation was almost equal to that of HB and approx. one-fourth that of Atr. In contrast to the effect on spontaneous motility of the stomach, all these compounds exhibited a somewhat weaker inhibitory action on the contraction of the stomach induced by stimulation. Both SA-504 and HB exhibited more potent inhibition on spontaneous movements of the jejunum and the sphincter of Oddi than on the stomach. On the contrary, the inhibitory potencies of Atr on the jejunum and the sphincter of Oddi did not differ much from those observed in the stomach. The inhibitory effects of these compounds on the contraction of the colon induced by pelvic nerve stimulation was similar to that in the case of stomach contraction induced by vagal stimulation. Inhibition of SA-504 on the spontaneous motility of the urinary bladder was weak and hardly any effect was observed even at a dose inhibiting the gastric motility. HB inhibited the motility of the urinary bladder under the influence of the same dose as that reduced the gastric motility. On the other hand, a significant effect was observed with Air, the activity of which was as strong as on the motility of the stomach. Blockade by these compounds of the contraction of the urinary bladder induced by pelvic nerve stimulation required much higher doses than those required for reduction of spontaneous movements of the bladder. Among the compounds tested, the activity of Atr on the contraction of the urinary bladder was the weakest.抄録全体を表示PDF形式でダウンロード (345K) -
Seiichi NURIMOTO1973 年 23 巻 3 号 p. 401-408
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe single dose suppression test was applied to estimating addiction liability of compounds in rats. Morphine at a dose of 50 mg/kg was chronically administered twice daily for more than 12 weeks, and the body wt. loss following morphine withdrawal was measured for 24 hr as a parameter of abstinence syndrome. A test compound was administered to the morphine withdrawn rats and physical dependence liability was determined from the increase in body wt. The results of narcotic analgesics in this method coincided well with those seen in monkeys, however, rats appeared to be particularly sensitive to morphine-like narcotics. Narcotic antagonists, nalorphine and pentazocine, produced a severe abstinence syndrome, and antipyretics, tranquilizers, hypnotics and anti histaminics had no influence on body wt. loss in the morphine addicted rats. Thus, the single dose suppression test in rats can be useful in detecting physical dependence liability of new compounds, especially morphine-like analgesics.抄録全体を表示PDF形式でダウンロード (303K) -
S. BALA, P.L. SHARMA, K.N. GARG1973 年 23 巻 3 号 p. 409-413
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe pressor activity of graded doses and an infusion of angiotensin was studied in 9 normal and 9 cirrhotic rats. No significant difference (P>0.05) in the mean pressor response to angiotensin was found. The results have been discussed herein.抄録全体を表示PDF形式でダウンロード (282K) -
Shigetoshi SUZUKI, Tetsuo SATOH1973 年 23 巻 3 号 p. 415-419
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーA single oral dose (15 mg/kg body wt.) of Ochratoxin A caused a depletion of hepatic glycogen level and an elevation in the cardiac glycogen level in both intact and adrenalectomized rats. When tested in adrenalectomized rats under pretreatment of hydrocortisone, Ochratoxin A showed similar effects on hepatic glycogen level as was seen in intact rats. These changes in hepatic glycogen levels of Ochratoxin A treated rats may be attributed to interference with endocrine balance.抄録全体を表示PDF形式でダウンロード (183K) -
Chiaki KAMEI, Kyoichi SHIMOMURA, Showa UEKI1973 年 23 巻 3 号 p. 421-426
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーThe significance of the naloxone-induced jumping response in predicting the physical dependence capacity of morphine-like analgesics was investigated in mice treated with morphine, morphine-6-glucuronide and pentazocine. The jumping response was induced by naloxone in mice chronically treated with morphine and morphine-6-glucuronide, but its development is not necessarily related to the number or frequency of drug injections, and it was also observed even after a single dose of the drugs. The jumping was not precipitated in mice chronically treated with pentazocine. The naloxone-induced jumping response in mice treated with morphine was not masked by morphine, but was markedly suppressed by chlordiazepoxide, diazepam, methamphetamine, delta-9-tetrahydrocannabinol and diphenylhydantoin. It is concluded that the naloxone-induced jumping response is not a specific abstinence phenomenon in mice treated with morphine-like analgesics, although it may be used for a first screening test to estimate a physical dependence capacity.抄録全体を表示PDF形式でダウンロード (219K) -
N.K. KHANNA, B.R. MADAN1973 年 23 巻 3 号 p. 427-429
発行日: 1973年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (140K)
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