巻号一覧
52 巻 (1990)
- 4 号 p. 513-
- 3 号 p. 387-
- 2 号 p. 179-
- 1 号 p. 1-
52 巻, 4 号
選択された号の論文の17件中1～17を表示しています
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Mikio ITO, Takao TANAKA, Yoshio SUZUKI1990 年 52 巻 4 号 p. 513-521
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーIn the healing test of acetic acid ulcers in rats with limited food-intaketime, Z-1 03 given, p.o., at doses of 3 and 10 mg/kg, twice a day, for 14 consecutive days from the day after acetic acid injection not only reduced the size and depth of the ulcers, but also promoted the regeneration of the defective mucosa. In the hydrocortisone-induced relapse test of acetic acid ulcers in rats with limited food-intake-time, Z-103 given, p.o., twice a day, at doses of 3 and 10 mg/kg for 20 consecutive days from the 40th day after the acid injection strongly prevented the exfoliation of the regenerated mucosa. Cimetidine (100 mg/kg × 2/day, p.o.), like Z-103, showed a marked relapse-preventive action in addition to the healing-promoting action. However, it was more effective on the healing. Gefarnate (300 mg/kg × 2/day, p.o.) markedly reduced the size and depth of the ulcers and strongly prevented the steroid-induced relapse, but showed no apparent effect on the regeneration of the defective mucosa. These results suggest that Z-103 may be a new therapeutic agent sharing both healing-promoting and relapse-preventive actions on gastric ulcers.抄録全体を表示PDF形式でダウンロード (482K) -
Hiroshi SHIBATA, Itaru YAMAMOTO1990 年 52 巻 4 号 p. 523-532
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーEnhancement of interleukin 2 (IL 2) activity in the culture medium of splenocytes of BALB/c mice occurred if the cells were precultured before concanavalin A (Con A) and phytohemagglutinin stimulation. This enhancing effect was much greater in autoimmune NZB/W F1 mice than BALB/c mice, the induced high level of IL 2 being sustained for 11 days of culture. The continuously elevated IL 2 activity induced by precultivation was lowered by the addition of the intact normal thymocytes, but not by precultured or irradiated thymocytes. Lipopolysaccharide-induced anti-DNA antibody production in the precultured splenocytes of NZB/W F1 mice was higher than that in freshly prepared ones. Mitogen-induced proliferative responses in both freshly prepared thymocytes and splenocytes of BALB/c mice treated with hydrocortisone (HC) were significantly enhanced, although the number of splenocytes and the primary in vitro plaque-forming cell response to sheep erythrocytes were reduced. Con A-induced IL 2 elevation in the supernatant of splenocytes precultured before the antigen stimulation was potentiated in HC-treated mice. Similar results were obtained in splenocytes from BALB/c mice loaded with restraint stress. These findings suggest that disturbance of IL 2 metabolism might be involved in the pathogenesis of NZB/W F1 mice, and an increased level of glucocorticoids might lead to a condition in which the body becomes susceptible to the development of hyper-immune responses.抄録全体を表示PDF形式でダウンロード (593K) -
Wataru FUJII, Hisashi KURIBARA, Sakutaro TADOKORO1990 年 52 巻 4 号 p. 533-539
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーInteraction between methamphetamine (MAP; 1 and 2 mg/kg, s.c.) and scopolamine (SCP; 0.5 and 2 mg/kg, s.c.) was investigated by means of ambulatory activity in mice of the dd strain. The single administration of MAP and SCP increased the ambulatory activity in a dose-dependent manner. The repeated administration of SCP, 5 times at intervals of 3-4 days, elicited a tolerance to its ambulation-increasing effect. The SCP-experienced mice showed no marked change in their sensitivity to the ambulation-increasing effect of MAP. However, when MAP was additionally administered, these mice showed a reverse tolerance to MAP. Such repeated administration of MAP was effective for attenuating the SCP-tolerance. On the other hand, the repeated MAP administration produced not only reverse tolerance to MAP itself but also cross reverse tolerance to SCP. However, as observed in the drug-naive mice, the MAP-experienced mice also exhibited tolerance to the additionally administered SCP. The repeated SCP administration scarcely modified the acquired MAP-reverse tolerance. The present results suggest that a cross reverse tolerance from MAP to SCP, but not from SCP to MAP, is developed in this mouse strain. It is also suggested that the reverse tolerance to MAP and tolerance to SCP appear regardless of the pretreatment of SCP and MAP, respectively, and that the reverse tolerance to MAP is wellmaintained.抄録全体を表示PDF形式でダウンロード (350K) -
Hiroshi AZUMA, Norio FUNAYAMA, Takeshi KUBOTA, Masayuki ISHIKAWA1990 年 52 巻 4 号 p. 541-552
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーThe present experiments were carried out to determine the regrowth of endothelial cells (EC) after balloon denudation of the rabbit carotid artery and the changes in responsiveness of the artery with regenerated EC. Scanning electron microscopic findings revealed that 28.8% of the luminal surface was covered with regenerated EC at week 1. The regrowth of EC proceeded progressively, and a full lining was achieved at week 6. Regenerated EC were morphologically different from native ones; they were elongated (weeks 1 and 2) and irregularly oriented (weeks 4 and 6), and their numbers had significantly increased. Light microscopy revealed the intimal thickening and proliferation of smooth muscle cells. No accumulation of lipids in the vascular wall could be detected at any observation time. The experiments in an organ bath demonstrated that the altered appearance of EC was accompanied by depressed endothelium-dependent relaxations to acetylcholine, ADP and A23187. However, sodium nitroprusside-induced relaxation and contractile responses to noradrenaline, serotonin and histamine remained unchanged in the normal and denuded preparations, indicating that the dysfunction of the endothelium occurs at a time when the ability of the underlying vascular smooth muscle to relax or contract was unchanged. In addition, it is suggested that the impairment of the endothelium-dependent relaxation may be partly due to impairment of the synthesis and/or release of endothelium-derived relaxing factor(s) in EC.抄録全体を表示PDF形式でダウンロード (855K) -
Akira KARASAWA, Kazuhiro KUBO1990 年 52 巻 4 号 p. 553-562
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーRenal failure was produced in rats by unilateral clamping of the left renal artery for 60 min, followed by reperfusion and contralateral nephrectomy. Prophylactic administrations of benidipine (10, 30 μg/kg, i.v.) significantly ameliorated the development of renal failure as estimated by histological examination as well as by the measurements of serum creatinine and blood urea nitrogen. ATP content of the ischemic kidney dropped immediately after renal ischemia, and this decline persisted for more than 48 hr after reperfusion. The content of lipid peroxide in the kidney was increased 15 min after reperfusion following renal ischemia. Calcium content of the kidney progressively increased after reperfusion and reached the peak level 24 hr after reperfusion, whereas calcium content scarecely changed during 60 min of renal ischemia. The decline of ATP, the lipid peroxidation, and the increase in calcium content of the kidney observed after reperfusion were significantly inhibited by pretreatment of the rats with benidipine (30 μg/kg, i.v.). These results suggest that lipid peroxidation and Ca-overload play causative roles in the pathogenesis of acute ischemic renal failure and that benidipine protects the ischemic kidney by inhibiting these deteriorating consequences.抄録全体を表示PDF形式でダウンロード (766K) -
Takayuki TANI, Yoshiya HORIGUCHI1990 年 52 巻 4 号 p. 563-572
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーThis investigation examined the effect of formaldehyde (HCHO) on cardiac function in in vitro cardiac preparations and in situ hearts of guinea pigs and rabbits. Though HCHO (0.2-4 mg/kg, i.v.) produced noticeable bradycardiac and negative inotropic responses in anesthetized guinea pigs and rabbits, the responses to HCHO were far less in isolated guinea pig auricles and perfused hearts (Langendorff's preparations). The inhibitory responses to HCHO in the isolated auricles and perfused hearts were obtained at concentrations 200-400 times and 4-8 times higher than the blood concentrations attained in anesthetized animals, respectively. The responses in the isolated preparations were not significantly affected by propranolol. The bradycardiac response to the intravenously administered HCHO in anesthetized animals was not significantly affected by atropine or vagotomy, but was markedly attenuated by propranolol, reserpine or surgical denervation of the heart. These results indicate that the direct action of HCHO on the heart plays only a small role in the negative chronotropic response to HCHO in anesthetized animals. Furthermore, the negative chronotropic effect of HCHO in animals seems to be caused mainly by the inhibition of sympathetic nervous activity through the central nervous system.抄録全体を表示PDF形式でダウンロード (453K) -
Masakatsu TAKAHASHI, Toshihiko SENDA, Hiroshi KANETO1990 年 52 巻 4 号 p. 573-578
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーThe action mechanism for the production of spinal analgesia of KK-3, tyrosyl-N-methyl-γ-aminobutylyl-phenylalaninol, was examined by the tail pinch and tail flick methods. Intrathecal KK-3, 2.5, 5 and 10 nmol/mouse, dosedependently produced an analgesic effect in both methods. In the tail pinch method, the analgesia was suppressed by 2 mg/kg but not by 1 mg/kg of naloxone; however, the analgesic effect was significantly antagonized by 1 and 2 mg/kg Mr2266, a κ-antagonist. Meanwhile, both naloxone and Mr2266 failed to block the analgesic effect of KK-3 in the tail flick test. Intrathecal capsaicin, 0.3, 3 and 15 nmol/mouse, also produced a dose-dependent analgesic effect in the tail flick test, whereas no appreciable analgesia could be found in the tail pinch test. Neither naloxone nor Mr2266 blocked the analgesic effect of capsaicin. The results indicate that KK-3 may possess two separate pharmacological mechanisms for the production of analgesic effects on the spinal level: one is the depletion of substance P following its release from the spinal cord, and the other is the mediation through κ-opioid receptors.抄録全体を表示PDF形式でダウンロード (273K) -
Salivary Peptide P-C Modulates Both Insulin and Glucagon Release from Isolated Perfused Rat PancreasMasayasu KIMURA, Noboru NAKASHIMA, Ikuko KIMURA1990 年 52 巻 4 号 p. 579-585
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーThe effect of salivary peptide P-C, saliva-derived peptide on glucose-induced insulin release was studied using perfused rat pancreas. Salivary peptide P-C (194 nM) remarkably potentiated glucose (8.3 and 16.7 mM)-induced insulin release, whereas the same concentration suppressed arginine (10 mM)-induced glucagon release. Both effects of salivary peptide P-C occurred in a concentration-dependent manner. These findings suggest that salivary peptide P-C may modulate both the levels of insulin and glucagon in vivo.抄録全体を表示PDF形式でダウンロード (334K) -
Kouji MORIKAWA, Miki FUKUOKA, Masato KAKIUCHI, Hideo KATO, Yasuo ITO, ...1990 年 52 巻 4 号 p. 587-595
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーIntravesical instillation of xylene (30-50%) produced detrusor hyperreflexia characterized by a decrease in both the bladder capacity (time to micturition in the cystometrogram) and the urine volume in conscious rats placed in a restraining cage. At this time, the bladder tissue showed evidence of experimental cystitis with degradation of the epithelium and edema and hemorrhage in the submucosa, and a slight increase in the content of prostaglandin E2, which stimulates directly and/or indirectly capsaicin-sensitive sensory fibers. In addition, the bladder exhibited high amplitude spontaneous activity, but the bladder contractions induced by acetylcholine, substance P, prostaglandin E2 and capsaicin were not changed following intravesical instillation of xylene. In these hyperreflexic rats, atropine suppressed the amplitude of the micturition contraction and morphine increased the bladder capacity at similar doses as in sham-treated rats, while thiopental and indomethacin increased the bladder capacity at lower doses than in sham-treated rats. These findings indicated that intravesical instillation of xylene had produced detrusor hyperreflexia in conscious rats, and that the detrusor hyperreflexia is thought to be a useful model for evaluating the effect of a newly-developed agent on bladder function.抄録全体を表示PDF形式でダウンロード (562K) -
Yoshihisa KITAMURA, Shiho HAYASHI, Yasuyuki NOMURA1990 年 52 巻 4 号 p. 597-607
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーEffects of 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate (WEB 1881 FU), a novel pyrrolidinone nootropic, on acetylcholine (ACh) receptors and adrenoceptors were investigated using crude membranes of the rat brain. The affinity order of WEB 1881 FU was: M1-muscarinic (m) ACh receptor>M2-mACh receptor>α2-adrenoceptor>β-adrenoceptor>α1-adrenoceptor>nicotinic ACh receptor. The WEB 1881 FU-competition curve for [3H]pirenzepine binding in hippocampal membranes was rightward-shifted by GTPγS; such behavior was also observed in the case of oxotremorine but not with scopolamine. The effects of long-term administration of WEB 1881 FU (30 mg/kg/day, i.p.) for 21 days resulted in a significant decrease in the Bmax of [3H]quinuclidinyl benzilate binding in the cerebral cortex, hippocampus and striatum. In addition, the Bmax of [3H]pirenzepine binding to hippocampal and striatal membranes and that of [3H]AF-DX 116 binding to cerebellar membranes were significantly decreased as well. From these results, WEB 1881 FU seems to act on M1-mACh receptors, and its long-term administration probably induces the down-regulation of mACh receptors, mainly M1-mACh receptors in the hippocampus and striatum and M2-mACh receptors in the cerebellum.抄録全体を表示PDF形式でダウンロード (559K) -
Yutaka GOMITA, Yasuyuki ICHIMARU, Minehiro MORIYAMA, Katsushi FURUNO, ...1990 年 52 巻 4 号 p. 609-619
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーEffects of HR-592 on various behaviors were investigated in rats and mice. 1) HR-592 at doses of 10-100 mg/kg, p.o., and chlorpromazine at doses of 2.5-20 mg/kg, p.o., suppressed dose-dependently spontaneous activities of mice. 2) In the mice treated with HR-592, 10 and 30 mg/kg, p.o., and with chlorpromazine, 1.25-5 mg/kg, p.o., the durations of loss of the righting reflex induced by thiopentalNa were extended in a dose-dependent manner. 3) In the mice and rats when HR-592 was administered at doses of 3-100 mg/kg, p.o., catalepsy was induced in a dose-dependent manner. 4) The incidence of catalepsy induced by haloperidol in mice was reduced dose-dependently after HR-592 administration (10-100 mg/ kg, p.o.). 5) Dose-dependent suppressions of the slant of screen at which the mice slipped down were observed by HR-592 at 3-100 mg/kg, p.o., and chlorpromazine at 5-20 mg/kg, p.o. 6) The rotarod performance in mice was suppressed dose-dependently by HR-592, 3-100 mg/kg, p.o., and chlorpromazine, 5-20 mg/ kg, p.o. 7) HR-592 at doses of 0.3-3 mg/kg, i.p., suppressed dose-dependently the turning behavior induced by methamphetamine in unilateral substantia nigralesioned rats. From these results and our previous data, it is considered that HR592 has pharmacological properties as a major tranquilizer, although its behavioral effect is slightly weaker than that of chlorpromazine. Furthermore, these results imply that HR-592 has anti-cataleptogenic activity and might thereby alleviate the adverse effect of neuroleptics such as haloperidol.抄録全体を表示PDF形式でダウンロード (513K) -
Yasuo TAKEHANA, Shuichiro HAMANO, Shinji KIKUCHI, Hidetada KOMATSU, Ta ...1990 年 52 巻 4 号 p. 621-630
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーWe studied a role of TXA2 in the development of PAF-induced nonspecific airway hyperresponsiveness in guinea pigs using a TXA2 synthetase inhibitor (OKY-046·HCI) and a stable TXA2 mimetic agent (STA2). Inhalation of PAF (1 μg/ml) and STA2 (1 or 10 ng/ml) increased the airway response to acetylcholine (ACh), histamine, leukotriene D4 and electrical vagal stimulation. Intraduodenal administration (i.d.) of OKY-046·HCI (100 mg/kg) inhibited PAF-induced airway hyperresponsiveness. However, OKY-046·HCI (30 mg/kg, i.v.) did not suppress STA2-induced airway hyperresponsiveness. Neither hexamethonium (1 mg/ kg, i.v.) nor hemicholinium-3(10 mg/kg, i.v.) prevented the increase in the airway response to ACh after inhalation of PAF and STA2. In the presence of atropine (0.5 mg/kg, i.p.), PAF-induced airway hyperresponsiveness to histamine did not change. OKY-046·HCI (100 mg/kg, i.d.) inhibited the increase in ACh (10-8 M)-induced 45Ca uptake into the lung tissue from PAF-inhalated guinea pigs. Inhalation of STA2 increased the number (Bmax) of muscarinic and H1-histaminergic receptors in the lung tissue from guinea pigs, but no changes were found on β-adrenoceptors. These results suggest that TXA2 should act on the smooth muscle cells or alter functions of muscarinic and H1-histaminergic receptors, except β-adrenoceptors, and then increase the membrane permeability to extracellular Ca2+. We also assume that OKY-046·HCI can inhibit PAF-induced nonspecific airway hyperresponsiveness by suppressing the generation of TXA2.抄録全体を表示PDF形式でダウンロード (515K) -
Yuichi ONODA, Mine TAKIDO, Tetsuo MAGARIBUCHI, Hajime TAMAKI1990 年 52 巻 4 号 p. 631-638
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーEffects of TA-2711 on gastric mucosal lesions induced by various necrotizing agents and several defensive factors of gastric mucosa were investigated in rats. Oral administration of TA-2711 at 12.5 to 200 mg/kg prevented the formation of gastric mucosal lesions induced by 99.5% ethanol, 0.6 N HCI, 0.2 N NaOH and boiling water with ED50 values of 24, 58, 16 and 101 mg/kg, respectively. Oral TA-2711 at 100 mg/kg increased the gastric mucosal prostaglandin E2 (PGE2) level without any change in transmucosal potential difference. A sustained decrease in gastric mucosal blood flow produced by intragastric administration of 99.5% ethanol was inhibited by oral TA-2711 (50, 100 mg/kg) and 16, 16-dimethyl PGE2 (10 μg/kg). The effect of TA-2711 on ethanol-induced decrease in blood flow was suppressed by indomethacin (10 mg/kg, s.c.). Oral TA-2711 (25-100 mg/kg) dose-dependently increased the amount of mucus adherent to the gastric mucosa. In addition, gastric HCO3- secretion was increased by intragastric TA2711 at 2.5 and 5.0 mg/ml. These results suggest that TA-2711 enhances gastric mucosal resistance by increasing mucus and HCO3- secretion and by maintaining mucosal blood flow, and protects the gastric mucosa against various irritants. The effects of TA-2711 appear to be mediated by mucosal prostaglandins such as PGE2.抄録全体を表示PDF形式でダウンロード (480K) -
Miwa MISAWA, Yoshinori TAKAHASHI, Tomokazu HOSOKAWA, Saizo YANAURA1990 年 52 巻 4 号 p. 639-642
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーWe investigated the involvement of inhibitory innervation in reflex tracheal dilatation (RTD) induced by inflating the lungs in dogs. RTD was inhibited about 50% by 100 μg propranolol injected into the cranial thyroid artery, but was unaffected by adrenalectomy. Residual RTD under β-blockade was abolished by sections of both the bilateral superior laryngeal nerves and spinal cord at the C1 level. These findings suggest that RID may be mediated by adrenergic innervation and partly by nonadrenergic inhibitory innervation.抄録全体を表示PDF形式でダウンロード (228K) -
Kaoru OHNO, Shinichi NAKAMURA, Yoshio GOSHIMA, Yoshimi MISU1990 年 52 巻 4 号 p. 643-646
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーEffects of carteolol on norepinephrine (NE) release were studied at 2 Hz mainly in rat hypothalamic slices. Isoproterenol at 1 and 10 nM concentrationdependently facilitated NE release. Isoproterenol (10 nM)-induced facilitation was antagonized by 1 and 10 nM dl-carteolol, but not antagonized by 1 nM d-carteolol. dl-Carteolol alone at 1 nM to 10 μM did not inhibit NE release. In brainstem slices, 10 nM isoproterenol also facilitated NE release, and this facilitation tended to be antagonized by 1 nM dl-carteolol. Nanomolar concentrations of carteolol stereoselectively antagonized isoproterenol-induced facilitation of NE release via presynaptic β-adrenoceptors in rat hypothalamic slices.抄録全体を表示PDF形式でダウンロード (200K) -
Yoshio TSUCHIYA, Tomokazu HOSOKAWA, Yutaka KASUYA1990 年 52 巻 4 号 p. 647-651
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーThe neuromodulatory action of histamine was investigated in isolated canine trachea. Histamine potentiated the tracheal contraction induced by electrical field stimulation (EFS). The ACh release induced by EFS was potentiated by histamine. The potentiating effect was blocked by chlorpheniramine. These findings suggest that histamine potentiates the neurally mediated tracheal contraction and the potentiating effect may be related in part to the acceleration of the prejunctional release of ACh, which may be mediated by H1-receptors.抄録全体を表示PDF形式でダウンロード (233K) -
Masaaki ISHIKAWA, Yoshio TAKAYANAGI, Ken-ichi SASAKI1990 年 52 巻 4 号 p. 652-655
発行日: 1990年
公開日: 2006/08/25
ジャーナル フリーPretreatment of buthionine sulfoximine (500 mg/kg, i.p., BSO), a potent glutathione-depleting agent, markedly increased the lethality and nephrotoxicity of cisplatin. These results suggest that a reactive electrophilic intermediate may be involved in the mechanism of cisplatin nephrotoxicity and moreover, that renal glutathione may play a protective role against cisplatin-induced nephrotoxicity.抄録全体を表示PDF形式でダウンロード (243K)
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