巻号一覧
34 巻 (1984)
- 4 号 p. 367-
- 3 号 p. 269-
- 2 号 p. 131-
- 1 号 p. 1-
34 巻, 3 号
選択された号の論文の14件中1～14を表示しています
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Yasuyuki NAKAMURA, Yasuyuki SHIRAKI, Hiroyuki NABATA, Kazushige SAKAI1984 年 34 巻 3 号 p. 269-276
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe effects of nicorandil (NCR) on tracheal and vascular smooth muscle in the dog were compared with those of nitroglycerin (NTG) in in vitro and in vivo preparations. In the isolated tracheal strip and coronary artery preparations contracted with KCI (30 mM), the ability of NCR to relax these muscles and arteries by 50% was 1/10-1/15 as potent as NTG. I n blood-perfused tracheal preparations, single doses of NCR and NTG injected into the tracheal artery produced dose-related decreases in the intraluminal pressure (ILP) of the trachea (relaxation) and increases in the tracheal blood flow (TBF). When the potency of NCR relative to that of NTG was compared on the basis of doses decreasing the ILP and increasing the TBF by 50%, NCR was 822 times less potent than NTG in producing tracheal relaxation and 572 times less potent in producing tracheal vasodilation. The effects of NCR on the ILP and TBF were not antagonized by propranolol. In non-perfused tracheal preparations, the two drugs administered i.v. elicited the effects in a similar dose-dependent mariner: decreases in systemic blood pressure (SBP), left ventricular systolic pressure (LVP), pressure-rate product (PRP), femoral vascular resistance (FVR), and ILP and increases in heart rate (HR) and LVdP/dt max. The results show that NCR has a potent bronchodilating action and that its pharmacological profile is somewhat similar to NTG.抄録全体を表示PDF形式でダウンロード (562K) -
Yutaka MATSUOKA, Masafumi SAKUMA, Tsutomu URUNO, Kazuhiko KUBOTA1984 年 34 巻 3 号 p. 277-287
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーCharacteristics of the analgesic action of phenylethylamine derivatives, amphetamine, phenylethylamine (PEA), hydroxyphenylethylamine (OHPEA) and hydroxyphenylalanine (OHF), were examined. Pain threshold of mice was measured by using the hot plate method. OHPEA (50 mg/kg), amphetamine (0.5-8 mg/kg) or PEA (50 mg/kg) produced an analgesic effect in the absence of MAO inhibitor, and the analgesia was reversed by naloxone (5 mg/kg) or reserpine (2 mg/kg×2). Ten mg/kg of PEA, 250 mg/kg of OHF and 10 mg/kg of OHPEA could not produce detectable analgesia, but they revealed analgesic activity when mice were pretreated with pargyline (100 mg/kg). Analgesia induced by a combined use of PEA, OHF or OHPEA with pargyline was inhibited by naloxone or p-chlorophenylalanine (PCPA), an inhibitor of serotonin synthesis. Amphetamine-induced analgesia was also blocked by PCPA. Analgesia induced by PEA or OHPEA was blocked by methysergide (2 mg/kg). From the above findings, it was concluded that PEA, OHPEA, OHF and amphetamine possess similar characteristics in their analgesic action, and their analgesic actions involve the participation of endogenous serotonin and endogenous opioid peptides.抄録全体を表示PDF形式でダウンロード (816K) -
Saizo YANAURA, Hideaki FUJIKURA, Tomokazu HOSOKAWA, Harumi KITAGAWA, J ...1984 年 34 巻 3 号 p. 289-298
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe antitussive effect of the new compound 1, 2, 3, 4a, 9b-hexahydro-8, 9b-dimethyl-4-[3-(4-methyl-piperazine-1-yl) propionamide] dibenzofuran-3-one dihydrochloride (RU-20201) was investigated in dogs and guinea pigs, including its sites of action. The antitussive effect of RU-20201 was about 1/10 as potent as that of codeine phosphate in dogs with the puncture electrode-induced cough (PEC) method and about 1/12 and 1/4 as potent as that of codeine phosphate in guinea pigs with the PEC and chemical stimulation methods, respectively. When RU-20201 was administered in a dose range of 1 to 10 mg into the vertebral artery toward the brain in lightly anesthetized dogs, no antitussive effect was observed against the coughing elicited by electrical stimulation of the central cut end of the superior laryngeal nerve. However, a stimulative effect on respiration, especially on respiratory rate occurred. The peripheral effect of RU-20201 on the cough was investigated using the in situ upper trachea perfusion preparation which allows a direct drug administration to the local site around the tracheal mucosa, this site being electrically stimulated to induce coughing. A close i.a. infusion of RU-20201 in doses of 1 and 3 mg/min into the tracheal vascular bed for 5 min inhibited the cough response elicited by mucosal stimulation. The above findings suggest that RU-20201 has a significant antitussive activity, the site of action being probably, at least, at the cough receptor level.抄録全体を表示PDF形式でダウンロード (731K) -
Haruhiko SHINOZAKI, Michiko ISHIDA1984 年 34 巻 3 号 p. 299-306
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーEffects of vecuronium bromide, an analog of pancuronium, on the cholinergic and glutamatergic neuromuscular junction were investigated. Vecuronium depressed the postsynaptic response of the frog end-plate at lower concentrations than 10-6 g/ml without affecting the presynaptic events. Vecuronium decreased the amplitude of the double ACh potential, but the second potential was more markedly reduced than the first. In analogy with d-tubocurarine, this suggests that vecuronium may act in part as an open channel blocker at the frog end-plate. Vecuronium depressed both the glutamate response and the excitatory junctional potential at the crayfish neuromuscular junction, although high concentrations were required. The drug increased the decay rate of extracellularly recorded excitatory junctional potentials at the crayfish neuromuscular junction. The reduction of the crayfish synaptic response caused by vecuronium can be explained by the open channel blocking action at this functional site. The problem that cholinergic antagonists possess a property of channel blocking at the other transmitter system was discussed.抄録全体を表示PDF形式でダウンロード (639K) -
Masahiko OGIHARA, Yukiko TOKUMITSU, Michio UI1984 年 34 巻 3 号 p. 307-311
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーWe studied the influence of prolonged starvation on carbohydrate metabolism in streptozotocin-diabetic rats compared with normal rats. In streptozotocin (STZ)-diabetic rats, the plasma glucose concentration decreased gradually during prolonged starvation, while it did not change in normal rats. In normal rats, glycogen depletion in the liver occurred within 24 hr of starvation, while in STZ-diabetic rats, glycogen content did not change even after 72 hr of starvation. Impaired glucose tolerance and glycogen deposition in response to oral administration of glucose were observed in STZ-diabetic rats compared with normal animals. STZ-diabetic animals generally had lower glycogen synthase and phosphorylase activities compared with normal rats during starvation. In normal animals, there is a significant correlation between the plasma concentration of free fatty acids and 3-hydroxybutyrate. On the basis of these findings, metabolic alterations in chemically-induced diabetic animals were discussed.抄録全体を表示PDF形式でダウンロード (391K) -
Masahiko OGIHARA, Michio UI1984 年 34 巻 3 号 p. 313-318
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーEffect of somatostatin on liver glycogen metabolism and lipid metabolism were studied in rats in vivo. Somatostatin infused at a rate of 100 ng/min/100 g wt. into the femoral vein resulted in a marked decrease in the blood glucose concentration. The content of glycogen in the liver and the concentration of insulin in the portal vein were also decreased during somatostatin infusion. Glucose was infused at a constant rate of 1.25 mg/min/100g wt. in combination with somatostatin to prevent the somatostatin-induced hypoglycemia. Under this condition, significant increase in liver glycogen was observed without significant changes in the blood glucose level. The liver glycogen synthase activity did not change significantly during infusion of somatostatin and/or glucose. In contrast, the glycogen phosphorylase activity was markedly inhibited by infusion of somatostatin plus glucose. Liver glycogen phosphorylase was inversely correlated with the blood glucose level. However, there was no correlation between the phosphorylase activity and blood glucose concentration during somatostatin infusion. Infusion of somatostatin alone caused an increase in the blood free fatty acid and a marked decrease in the blood ketone bodies. Glucose-induced decrease in the blood free fatty acids and ketone bodies were partially overcome by the simultaneous infusion of somatostatin. On the basis of these findings, possible physiological roles of somatostatin in regulation of carbohydrate metabolism were discussed.抄録全体を表示PDF形式でダウンロード (490K) -
Tsutomu SUZUKI, Toshio YOSHII, Saizo YANAURA1984 年 34 巻 3 号 p. 319-325
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe drug-admixed food method was applied to ICR strain mice for studying development of physical dependence on morphine. Mice were treated with morphine-admixed food of increasing concentration (1, 2 and 3 mg/g food) every third day for 9 days. During the treatment, the mice did not show any signs of toxicity. Plasma and brain morphine levels were quantitatively related to the morphine concentration in drug-admixed food. The plasma morphine level showed a circadian rhythm, and the level was higher than 0.15 μg/ml throughout the day. The morphine-treated mice manifested body weight loss, diarrhea and ptosis from 4 hr after morphine withdrawal and showed maximum body weight loss at 12 hr. In the naloxone-precipitated test, jumping and body shakes were observed in mice treated with morphine-admixed food (2 mg/g food) at least for 1 day. Moreover, in mice treated with morphine (2 mg/g food) for 3 days, marked jumping and body shakes and some writhing were observed after naloxone administration. These results suggest that the drug-admixed food method has advantages of easily and rapidly inducing the physical dependence on morphine in mice without causing toxicity and death.抄録全体を表示PDF形式でダウンロード (510K) -
Toru EGASHIRA, Toshinori YAMAMOTO, Yasumitsu YAMANAKA1984 年 34 巻 3 号 p. 327-334
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe multiplicity of monoamine oxidase (MAO) in monkey brain was studied by comparing the relationship between the selective substrates of MAO and the pH-activity curves obtained using these substrates. When mitochondrial and A-form MAO were used as the enzyme preparations with serotonin (5-HT) and norepinephrine (NE), preferential substrates for A-form MAO, the pH optima were 8.8 and 7.8 with 5-HT and 8.5 and 7.2 with NE. These substrates were also oxidized by B-form MAO after changing the pH of the incubation medium (shift to alkaline); these pH optima were 9.0 and 8.2, respectively. When common substrates of MAO were used (tyramine, octopamine, dopamine and tryptamine), the pH activity curves obtained were all broad and bell-shaped with pH optima for the 3 species of enzyme (mitochondria, A-form and B-form MAO) at 8.0, 7.8, and 8.0 with tyramine; 8.3, 7.5, and 8.5 with octopamine; 7.8, 7.5, and 8.5 with dopamine; and 8.0, 8.3, and 6.9 with tryptamine, respectively. The pH optima were 6.6 with β-phenylethylamine (β-PEA) and 9.0 with benzylamine, preferential substrates for B-form MAO, for either mitochondria or B-form MAO. The Km values obtained for tryptamine and β-PEA were lower than those for the other substrates of MAO, regardless of the enzyme preparations. The Km and Vmax values of both forms MAO for 5-HT and NE were similar to those of the A-form MAO. The differences in the Km and Vmax values of the A-form MAO and B-form MAO for common substrates were comparable. Tyramine, octopamine and dopamine were substrates for both forms MAO, with only a slight preference for B-form MAO over A-form MAO. However, tryptamine may be deaminated predominantly by A-form MAO.抄録全体を表示PDF形式でダウンロード (634K) -
Toshiro AMAMOTO, Tadayasu OKAZAKI, Toshi KOMURASAKI, Kiyoshi OGUMA, Ma ...1984 年 34 巻 3 号 p. 335-342
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーEp-1, L-trans-Dicyclohexyl epoxysuccinate, is a synthetic and specific inhibitor of thiol proteases. The effects cf this inhibitor on some immunological parameters were examined in normal and immunity-impaired mice and rats. In the cultures of splenocytes obtained from the mice treated with Ep-1, it enhanced the lymphocyte blast transformation induced by both suboptimal and optimal concentrations of concanavalin A (Con A) arid Lens culinaris (LC) . The in vivo administration of Ep-1 caused a depression of the plaque forming cells (PFC) for sheep red blood cell (SRBC) and enhanced the delayed-type hypersensitivity (DTH) for bovine serum albumin (BSA) as well as mixed lymphocytes cultures (MLC). Furthermore, Ep-1 demonstrated a preventive effect on adjuvant arthritic rats. The relevance of immunological regulation and the mode of action of Ep-1 as a thiol protease inhibitor are discussed in these findings.抄録全体を表示PDF形式でダウンロード (581K) -
Fumihiko KINEKAWA, Seiichi KOMORI, Hidenori OHASHI1984 年 34 巻 3 号 p. 343-352
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーMuscarinic, cholinergic depression of adrenergic excitatory transmission was investigated by the microelectrode method in isolated dog retractor penis muscle. Electrical stimulation of the intramural nerves with single or repetitive stimuli elicited adrenergic contractions and excitatory junction potentials (e.j.p.s). The mechanical response and e.j.p. were suppressed by physostigmine (5×10-7 g/ml) and carbachol (up to 5×10-8 g/ml) without changing the sensitivity of the muscle to noradrenaline and muscle membrane resistance measured by electrotonic potentials. Atropine reversed the drug-induced attenuation of these responses, but atropine itself had no effect on them. Carbachol at 5×10-8 g/ml, where the e.j.p. was blocked, caused a depolarization of the muscle membrane (less than 5 mV), whereas the same extent of depolarization produced by high K solution resulted in only a small decrease in e.j.p. amplitude. These results suggest that excitatory adrenergic transmission in the dog retractor penis muscle is depressed prejunctionally by a cholinergic mechanism.抄録全体を表示PDF形式でダウンロード (793K) -
J.R. VEDASIROMONI, D.K. GANGULY1984 年 34 巻 3 号 p. 353-355
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (223K) -
Atsushi MIYAMOTO, Hideyo OHSHIKA1984 年 34 巻 3 号 p. 356-358
発行日: 1984年
公開日: 2006/11/07
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Fujiko SANAE, Kenichi MIYAMOTO, Ryozo KOSHIURA1984 年 34 巻 3 号 p. 359-362
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (243K) -
Mitsuo EGAWA, Masayuki MITSUKA, Kohei UMEZU, Akihiro TOBE1984 年 34 巻 3 号 p. 363-365
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (206K)
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