巻号一覧
31 巻 (1981)
- 6 号 p. 863-
- 5 号 p. 653-
- 4 号 p. 485-
- 3 号 p. 305-
- 2 号 p. 147-
- 1 号 p. 1-
31 巻, 5 号
選択された号の論文の30件中1～30を表示しています
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Yukiko SUZUKI, Kyoji TAGUCHI, Yukihiko HAGIWARA, Kazuyo KAJIYAMA, Taka ...1981 年 31 巻 5 号 p. 653-659
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEffects of desoxynupharidine hydrochloride (DN) on the central nervous system of cats were studied using electric physiological techniques. With regard to the EEG arousal responses, DN (1-3 mg/kg, i.v.) inhibited the responses induced by midbrain reticular formation and posterior hypothalamus (P-Hypo) stimulation. The threshold voltage of stimulation was elevated. DN decreased the amplitude of the augmenting response and the recruiting response induced by the stimulation of specific and non-specific pathways in the thalamus. As to the evoked potentials in the somatosensory area I, DN decreased the amplitude of the fast and late components. This compound slightly inhibited the monosynaptic and polysynaptic reflexes, in the spinal cats. With regard to autonomic responses on stimulation of the P-Hypo, DN decreased contractions in the nictitating membrane, the hypertensive action and the galvanic skin response. Our findings indicate that the inhibitory effects of DN on the central nervous system may be related to the brainstem reticular formation and the hypothalamus activating system, the non-specific pathway, the specific pathway and the limbic system etc., and may involve the central anti-adrenergic actions.抄録全体を表示PDF形式でダウンロード (388K) -
Hidehiko ABE, Nobukuni OGATA1981 年 31 巻 5 号 p. 661-675
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEpileptogenic action of penicillin (PC) was investigated in thin slices prepared from the guinea-pig hippocampus. Bath-applied PC (1.7 mM) provoked an epileptiform activity. A series of cellular events before during and after application of PC were shown by stable intracellular recording from the same neuron. The effect of PC became progressively pronounced when the temperature of the medium was raised from 30°C to 40°C. PC-induced epileptiform activity showed odd time courses, i.e., recurrent reduction during perfusion of PC and abrupt reversion during washing. Increased potassium concentration in the medium increased the rate of occurrence of the spontaneous epileptiform activity induced by PC. Removal of chloride from the medium converted the PC-induced epileptiform activity to clonic relapsing discharges. In the laminar field potential analysis, ‘sink’ for the epileptiform activities induced by PC appeared at a broad region of the middle and distal portions of the apical dendrite, whereas ‘sink’ for potentials considered to reflect mainly synaptic events appeared at a relatively restricted region of the proximal and middle portions of the apical dendrite. Together with other observations, these results led to the conclusion that not only the synaptic but also the non-synaptic process is involved in initiation of the epileptiform activity.抄録全体を表示PDF形式でダウンロード (799K) -
Katsuo TAKASHI, Tetsuro KUGA1981 年 31 巻 5 号 p. 677-688
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe role of brain monoamine systems in the jumping behavior induced by the combination of harmine and apomorphine was studied by using a MT pick-up to assess jumping behavior in rats. The jumping induced by the combination of harmine 10 mg/kg and apomorphine 2 mg/ kg was enhanced by pretreatment with p-chlorophenylalanine, methysergide and by treatment with clonidine, while, it was reduced by pretreatment with 5-hydroxytryptophan, haloperidol, perphenazine, α-methyl-p-tyrosine, chlorpromazine, phenoxybenzamine, phentolamine, atropine and pilocarpine. The combination of harmaline or harmane and apomorphine also induced jumping with the aid of p-chlorophenylalanine. The combination of benserazide, L-DOPA and harmine induced jumping similar to that induced by harmine and apomorphine. Despite pretreatment with p-chlorophenylalanine the combination of apomorphine and benzylhydrazine, iproniazid, tranylcypromine or pargyline failed to induce jumping. These results suggest that this jumping behavior is induced not by the monoamine oxidase inhibitory effect of harmine but probably by the specific central action of harmine and on condition that the dopaminergic system is activated. The activation of this system appears to be essential, the noradrenergic system plays a facilitatory role, the serotonergic system an inhibitory role and the cholinergic system probably a specific role.抄録全体を表示PDF形式でダウンロード (498K) -
Eijiro TAGASHIRA, Tameo HIRAMORI, Tomoko URANO, Kenzo NAKAO, Saizo YAN ...1981 年 31 巻 5 号 p. 689-699
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーAntipsychotic agents which are considered to depressive to the central nervous system (CNS) but free of dependence liability were used in combination with barbiturates or tranquilizers to study the physical dependence liability in the so-enhanced CNS depression. In the study of physical dependence formation, when CNS depression was maintained in an enhanced state during the continuous application of the drug combinations, the withdrawal convulsions were enhanced in both frequency and severity. In the crossphysical dependence study, two-drug combinations, i.e., phenobarbital (PhB)-chloropromazine (CPZ), PhB-diphenhydramine (DPH) and nitrazepam-chlorprothixene, and 3-drug combinations, i.e., PhBCPZ-promethazine and PhB-CPZ-DPH were evaluated. The 2-drug combinations suppressed some of the withdrawal signs, but those at high dosages showed a tendency to aggravate the signs. The 3-drug combinations differed from the 2-drug combinations in that the suppression of withdrawal signs was synergistically enhanced and the barbital withdrawal signs were weak. In conclusion, when CNS depression with PhB was enhanced with combinations of dependence liability-free drugs the drug combinations enhanced withdrawal convulsions both in frequency and severity. The sedation enhanced by the combinations did not always parallel the suppression of barbital withdrawal.抄録全体を表示PDF形式でダウンロード (519K) -
Koji NISHIKORI, Toichi TAKENAKA, Hiroo MAENO1981 年 31 巻 5 号 p. 701-709
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーA new potent vasodilator, nicardipine hydrochloride inhibited oxytocin-induced contraction of rat uterus dose-dependently with an increase in the intracellular cyclic AMP level at the onset of relaxation. Dibutyryl cyclic AMP and papaverine, an inhibitor of cyclic AMP phosphodiesterase (PDEase), also inhibited the contraction. Nicardipine inhibited competitively PDEase in homogenates of rat uterus which exhibited apparently two Km values for cyclic AMP (3.6 μM and 67.3 μM) with the Ki of 5.3 μM and 13.2 μM, respectively, but had no effect on adenylate cyclase. Nicardipine enhanced calcium uptake by rat uterine microsomes, at concentrations which inhibited oxytocin-induced contraction in the same manner as cyclic AMP. The maximal stimulation by nicardipine of the microsomal calcium uptake was identical substantially to that by cyclic AMP, and both were not additive. Cyclic AMP was also accumulated during the uptake reaction in the presence of nicardipine. On the contrary, neither myosin ATPase nor microsomal Ca2+-dependent ATPase was inhibited directly by nicardipine. These results suggest that the inhibition of oxytocin-induced contraction of rat uterus by nicardipine may be due to an enhancement of microsomal calcium uptake, mediated by cyclic AMP accumulated through the inhibition of PDEase.抄録全体を表示PDF形式でダウンロード (472K) -
Haruo KOBAYASHI, Akira YUYAMA, Naonori MATSUSAKA, Kazu TAKENO, Iwao YA ...1981 年 31 巻 5 号 p. 711-718
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEffect of methylmercury chloride (MMC) on behavior was studied in male ICR-JCL mice. In order to clarify the causal relationship between the potent suppressing action of MMC on the central cholinergic system and toxic manifestations, behavioral changes induced by MMC were compared with those induced by the two reference drugs, hemicholinium-3 (HC-3) and 3'-chloro-4-stilbazole (CS; a potent choline acetyltransferase inhibitor). When administered intraperitoneally, daily in a dose of 5 mg Hg/kg/day, MMC caused a decrease in spontaneous motor activity, rotarod dysfunction, and hypothermia before an abrupt loss in body weight and the appearance of overt signs. These behavioral changes were similar to some extent to those induced by HC-3 or CS. A single intracerebral injection of HC-3 (51 or 100 μg/kg) caused hypothermia and rotarod dysfunction over a period of 40-250 min. A single intraperitoneal administration of CS (100 or 200 mg/kg) induced a decrease in spontaneous motor activity, hypothermia, and rotarod dysfunction over a period of 1-5 hours after injection. These results suggest that the prior toxic behavioral changes caused by MMC may be related to suppression of the cholinergic system.抄録全体を表示PDF形式でダウンロード (412K) -
Shoichi UEDA, Keiichi IKEGAMI, Ken-ichi YONEMURA, Matao SAKANASHI1981 年 31 巻 5 号 p. 719-723
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーExperiments were designed to investigate generation of automaticity of isolated human renal arteries induced by administration of potassium in vitro. Helical strips of human renal arteries showed marked oscillations in the potassium-induced contractions which persisted for 2 hr. Indomethacin and aspirin dose-dependently inhibited these oscillations. Tranylcypromine and mepacrine also had an inhibitory action on the oscillations of the strips induced by potassium. In the strips which reached a steady state 2 hr after administration of potassium, phospholipase A2 and bradykinin produced marked oscillations. Our results indicate that human renal arteries can generate automaticity in the contractions induced by potassium, and that such automaticity may be related to the biosynthesis of prostaglandins.抄録全体を表示PDF形式でダウンロード (225K) -
Hidehiko WATANABE, Yasuyuki FURUKAWA, Kazuhiko IWATSUKI, Shigetoshi CH ...1981 年 31 巻 5 号 p. 725-730
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEffects of nicardipine, a newly synthesized dihydropyridine vasodilator exhibiting cyclic phosphodiesterase inhibitory properties, were studied in the isolated canine atrium which was cross-perfused with blood from a donor dog. When nicardipine (1.0-10 μg/kg) was administered intravenously to the donor dog, the systemic blood pressure decreased and the heart rate did not significantly change. However, the contraction and beat rate of the isolated atrium were only slightly decreased. At larger doses (30-100 μg/kg, i.v.), the systemic blood pressure fell markedly and was usually accompanied by marked bradycardia, which was greater than that of the isolated atrium. Nicardipine injected into the sinus node artery of the isolated atrium caused dose-related negative chronotropic and inotropic effects which were less pronounced than those of verapamil. In contrast, papaverine increased right atrial rate and contractile force. Nicardipine similarly to verapamil and unlike manganese ion caused greater inhibition of the right atrial contraction at higher than lower pacing frequencies. From these results, it is concluded that nicardipine may produce predominantly cardiac depressant properties as a calcium antagonistic, and that such may not be related to phosphodiesterase inhibition in cardiac tissues.抄録全体を表示PDF形式でダウンロード (268K) -
Toshihiro TOKUDOME, Norio TAIRA1981 年 31 巻 5 号 p. 731-736
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーIn vitro experiments were carried out on strips of the dog saphenous vein to characterize β-adrenoceptors mediating relaxation. Four β-adrenoceptor agonists, isoproterenol, salbutamol, procaterol and α-(3, 4, 5-trimethoxyphenethylaminomethyl)-3, 4-dihydroxybenzylalcohol hydrochloride (T-1583), all produced concentration-dependent relaxation of venous strips contracted by 10-6 M methoxamine. These four drugs behaved as full agonists. In producing venous relaxation, procaterol was about 2.5 times more potent, and salbutamol and T-1583 were 7 and 98 times less potent than isoproterenol, on a molar basis. The concentrationrelaxation response curves to the four agonists were shifted in a parallel way to the right by (t-butyl-amino-3-ol-2-propyl)oximino-9 fluorene hydrochloride (IPS 339), a selective β2-adrenoceptor antagonist, and by practolol. However, pA2-values for IPS 339 against the four agonists were all nearly 11.0, whereas those for practolol were all nearly 5.7. We conclude that β-adrenoceptors in the dog saphenous vein mediating relaxation are predominantly of the β2 type.抄録全体を表示PDF形式でダウンロード (329K) -
Nobuo HAYASHI, Hiroyasu KINEMUCHI, Kazuya KAMIJO1981 年 31 巻 5 号 p. 737-746
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe effect of Tris (hydroxymethyl) aminomethane on mitochondria monoamine oxidase (MAO) activity in dog brain and liver and in human placenta was studied and the results obtained were compared with results on dog serum amine oxidase. With benzylamine as substrate, Tris did not inhibit mitochondrial MAO activity in these preparations, whereas it inhibited amine oxidase activity in a serum preparation. However, with tyramine, 5-hydroxytryptamine or β-phenylethylamine as substrate, Tris inhibited MAO activity in all these preparations and its mode of inhibition was found to be non-competitive and reversible. The inhibition by Tris of MAO activity in these preparations was not due to decrease in the extent of extraction of aldehydes produced during the enzyme reaction. Moreover, increase in the oxygen tension did not change the extent of inhibition of MAO activity by Tris. From these results, it is concluded that with benzylamine as substrate, there is a remarkable difference in the effects of Tris on amine oxidase activity in mitochondrial and serum preparations. This difference in the inhibitions of mitochondria and serum is discussed.抄録全体を表示PDF形式でダウンロード (521K) -
Haruo OHNISHI, Hiroshi KOSUZUME, Kazuo YAMAGUCHI, Masatsugu OHKURA, Ma ...1981 年 31 巻 5 号 p. 747-756
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーAnti-inflammatory properties of a newly synthetized compound, 6-chloro-4-oxyimino-1-phenyl-1, 2, 3, 4-tetrahydroquinoline (M-7074), have been investigated. Anti-edema activities of M-7074 were more potent than those of phenylbutazone in carrageenin, bradykinin and mustard edema tests in rats. M-7074 showed an inhibitory effect on adjuvant arthritis, especially on the secondary inflammatory lesions in rats. Inhibitory effect of M-7074 on cotton-pellet granuloma formation was all but equal to that of phenylbutazone in rats. M-7074 also showed inhibitory effects on ultraviolet erythema in guinea-pigs and increased vascular permeability in mice, moderate analgesic activity in rats and mice, and antipyretic activity in rats. Furthermore, inhibitory effects of M-7074 on prostaglandin biosynthesis in guinea-pig lung homogenate and arachidonic acid-induced aggregation of rabbit platelets were fairly equal to those of indomethacin. However, M-7074 showed no effect on humoral nor cellular immunity in mice. M-7074 possessed no ulcerogenic activity in rats and mice, and LD50 value of M-7074 was 8.01 g/kg, p.o. in mice. These data indicate that M-7074 is a novel anti-inflammatory agent with large margin of safety.抄録全体を表示PDF形式でダウンロード (472K) -
Katsuo KOIKE, Issei TAKAYANAGI1981 年 31 巻 5 号 p. 757-762
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEffects of papaverine and cyclic AMP on Ca-uptake by the microsomal fraction from rat uterus were studied. Papaverine (3×10-5 M) potentiated Ca-uptake by the microsomal fraction in the presence of potassium oxalate. However, cyclic AMP and MIX (3-isobutyl-1-methylxanthine; 1 mM), a potent phosphodiesterase inhibitor, did not influence Ca-uptake by the microsomal fraction in the presence of potassium oxalate. Cyclic AMP in concentrations of 10-8 to 10-4 M did not influence Ca-uptake by the microsomal fraction in the presence of potassium oxalate. In the absence of potassium oxalate, papaverine and Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride), a nonspecific smooth muscle relaxant, inhibited Ca-uptake by the microsomal fraction and cyclic AMP had no influence on this uptake. These results suggest that papaverine potentiated Ca-uptake by membranes such as sarcoplasmic reticulum, in the presence of potassium oxalate and inhibited Ca-uptake by the plasma membrane-derived vesicles in the absence of potassium oxalate. These results suggest that relaxation of smooth muscle by papaverine is related to a cyclic AMP-independent mechanism as well as to a mechanism mediated via cyclic AMP.抄録全体を表示PDF形式でダウンロード (317K) -
Toru EGASHIRA, Yasumitsu YAMANAKA1981 年 31 巻 5 号 p. 763-770
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe relation between precursors and restoration of A-form MAO activity in rat liver after administration of clorgyline to rats was investigated by measuring the rates of recovery of A-form MAO activity after treatment with the inhibitor. The half-lives of mitochondrial and microsomal A-form MAO were estimated as 3.5 and 2.0 days, respectively. MAO activity and the amount of MAO molecules were completely restored within 14 days. However the values attained did not exceed the control values in a period of 14 days. Clorgyline plus cycloheximide or chloramphenicol did not prevent the recovery of MAO activity in the microsomes, but did not delay the appearance of enzyme activity in the mitochondria. A and B-form-like MAO were also observed in the microsomal and supernatant fractions, with clorgyline as inhibitor. These results suggest that the microsomal enzyme is a precursor of the mitochondrial enzyme, that the levels of A-form and B-form MAO are regulated genetically, and that the two forms of MAO may be synthesized separately.抄録全体を表示PDF形式でダウンロード (401K) -
Misako HORI, Tsugutaka ITO, Masanao SHIMIZU1981 年 31 巻 5 号 p. 771-779
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe experiments were performed electroencephalographically on gallamine-immobilized cats with the thalamic foci induced by application of tungstic acid gel (gel). The gel (50 μl) applied to n. centralis lateralis (CL) caused generalized seizure (GS) with high frequency components triggered by slow wave, and GS recurred with a regular interictal period. The application to n. centralis medialis or n. medialis dorsalis did not induce recurring GS, indicating the heterogeneity in the epileptogenesis of the thalamus. The GS induced by the gel application to the CL was of thalamic origin. Anticonvulsants used were found to prolong the interictal period of the GS, without modifying its duration. There was a difference between the drugs effective against grand mal and petit mal epilepsies in that the prolongation by the former drugs, diphenylhydantoin and phenobarbital, was more pronounced at low doses than that by the latter drugs, trimethadione and dipropylacetate. These results suggest that the gel-induced epileptic model with thalamic foci is useful for analyzing the pathophysiological process of epilepsy and for evaluating the drugs effective against grand mal epilepsy.抄録全体を表示PDF形式でダウンロード (418K) -
Shigeru KIGOSHI1981 年 31 巻 5 号 p. 781-785
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe effect of pentazocine, a non-narcotic analgesic, on Ehrlich ascites tumor cells was examined in vitro and in vivo. To test the in vitro effect of pentazocine, Ehrlich tumor cells suspended in Hanks balanced salt solution (BSS, pH 7.4) supplemented with 2% bovine albumin were incubated with various concentrations of the drug (0.10-1.0 mM) at 37°C for 120 min. After incubation, the tumor cells in BSS were inoculated subcutaneously into the right flank of mice (106 cells/mouse). All mice given the tumor cells incubated alone developed solid tumor. However, no tumor growth was observed in groups of mice given the tumor cells pretreated with 0.3 or 1.0 mM pentazocine. The in vivo effect of pentazocine was then examined against Ehrlich ascites carcinoma in mice. Mice inoculated intraperitoneally with Ehrlich tumor cells in BSS (2×106 cells/mouse) were given various doses of pentazocine (20-80 mg/kg/day) intraperitoneally once a day for 5 successive days. The average survival time in a group of mice given the tumor cells alone was about 19 days, and the survival time was about 29 days in a group of animals, treated with pentazocine in a dose of 80 mg/kg/day (p<0.01).抄録全体を表示PDF形式でダウンロード (242K) -
Minoru INABA, Kunie KAMATA, Momoko KAMIDE1981 年 31 巻 5 号 p. 787-793
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーAdrenocortical functions of adrenal-demedullated rats (ADMX rats) and peripherally chemical-sympathectomized ADMX rats were studied by examining changes in the levels of serum and adrenal corticosteroids (CS). Resting levels of serum and adrenal CS were not influenced by adrenal-demedullation and peripheral chemical-sympathectomy with 6-hydroxydopamine. Diurnal variation in serum CS concentration was also unchanged, suggesting that peripheral adrenergic systems do not influence the basal function of hypothalamo-pituitary-adrenocortical axis. Exposure of ADMX rats to the stressful stimuli, however, resulted in lowered adrenocortical response with a lesser increase in serum CS concentration, while peripheral chemical-sympathectomy of ADMX rats with 6-hydroxydopamine or guanethidine caused a significant enhancement of adrenocortical response to the stress with elevation of the serum CS concentrations. These findings suggest that increased peripheral adrenergic activity may suppress the activation of the hypothalamo-pituitary-adrenocortical system as the animals were exposed to the stressful stimuli. Adrenal-clemedullation produced no increase in spleen weight while chemical-sympathectomy by peripheral administration of 6-hydroxydopamine did produce a significant increase in the weight of this organ. Histological features following chemical-sympathectomy are described.抄録全体を表示PDF形式でダウンロード (613K) -
Tadashi FUJITA, Yohko FUJIMOTO1981 年 31 巻 5 号 p. 795-800
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEffect of various diuretics on lipid peroxidation in rat kidney cortical mitochondria and in the supernatant (11, 000xg) was studied. Mersalyl (mercurial diuretic) markedly stimulated the lipid peroxidation in mitochondria and in the supernatant at a concentration of 1 mM, and metolazone (sulfonamide derivative, 1 mM) stimulated only that in the supernatant. Mersalyl-induced lipid peroxidation was markedly inhibited by several classical radical scavengers such as sodium diethyldithiocarbamate, 2, 6-di-tert-butyl phenol and N, N'-diphenyl-p-phenylenediamine, but metolazone-induced lipid peroxidation was not inhibited by these scavengers. The addition of superoxide dismutase to the reaction mixture inhibited the mersalyl-induced lipid peroxidation, but did not inhibit the peroxidation by metolazone or ascorbate. These results suggest that lipid peroxidation by mersalyl is mediated by free radicals or superoxide anion, which were probably produced by mersalyl, and the mercurial diuretics-induced nephrotoxicity may be due to the lipid peroxidation in the kidney.抄録全体を表示PDF形式でダウンロード (302K) -
Hitoshi ISHIDA, Masashi SASA, Shuji TAKAORI, Hajime ISHIDA1981 年 31 巻 5 号 p. 801-807
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーEffects of harmaline on excitability of crayfish giant axon in relation to effects on Na, K-ATPase activity were investigated and the findings were compared with relative data on ouabain. Exposure of the axon to harmaline in doses over 0.5 mM resulted in a dose-dependent reduction of the action potential. Harmaline of 2.5 mM produced a complete blockade of the action potential with a slight decrease in the resting membrane potential (5.7 mV), but no alterations of Na, K-ATPase activity. In contrast, ouabain (5 mM) produced a more pronounced decrease in the resting membrane potential (10.6 mV) and also a partial reduction in the action potential, while a significant decrease in Na, K-ATPase activity was obtained. Increasing the membrane potential to the initial level resulted in a partial recovery (46%) of the rising rate (dV/dt) of action potential. The dV/dt was exponentially decreased when the resting potential was reduced with application of KCl solution over 8 mV. These results suggest that harmaline externally applied produces a decrease in sodium conductance without affecting Na, K-ATPase activity, while ouabain inhibits Na, K-ATPase activity and, to lesser extent, decreases in sodium conductance.抄録全体を表示PDF形式でダウンロード (292K) -
Norihisa INAZU, Hiroshi KOGO, Yoshio AIZAWA1981 年 31 巻 5 号 p. 809-813
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe role of uterine tissue in the changes of rat ovarian prostaglandin (PG) content was investigated. PGE and PGF levels in rat ovary were decreased to about one-fourth of control levels by hysterectomy, when the contents were determined on the day of estrus 4 days after surgery. Both the PGE and PGF contents in diestrous ovary 10 to 14 days after hysterectomy tended to be decreased, as compared with those in intact control (diestrus), but no significant difference was observed. Administration of estradiol to hysterectomized rats on the day of diestrus increased neither PGE nor PGF levels. Also with the administration of pregnant mare serum gonadotropin, no increase in the PG contents was seen in the ovary of hysterectomized rats. The incorporation of 3H-arachidonic acid into the 3H-PGE and 3H-PGF fractions, expressed in terms of the organ, was much greater in the uterus than in the ovary. The incorporation of 3H-arachidonic acid into the 3H-PGE and 3H-PGF fractions in the ovary was higher on the day of estrus than on the day of diestrus. These results strongly suggest that the changes in the PG content in rat ovary may be regulated, at least in part, by uterine tissue.抄録全体を表示PDF形式でダウンロード (270K) -
Tsutomu IRIKURA, Takashi HIRAYAMA, Fukutaro TAGA1981 年 31 巻 5 号 p. 815-822
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe mode of action of nefopam, a novel analgesic, on the splanchnic afferent pathway was investigated using electrophysiological methods. Nefopam (2.5 and 5.0 mg/kg, i.v.) caused arousal patterns in spontaneous rabbit EEG. In intact cats, nefopam (1.0, 2.5 and 5.0 mg/kg, i.v.) suppressed the evoked potentials recorded from the posterior sigmoid gyrus of the cortex, N. ventralis posterolateralis and N. centralis medialis of the thalamus and the ventrolateral funiculus of the spinal cord following splanchnic nerve stimulation without inhibiting potentials in the thalamocortical pathways. These depressant effects were not antagonized by a narcotic antagonist, levallorphan (0.5 mg/kg, i.v.). The inhibitory effect of nefopam on the spinal potential evoked by splanchnic nerve stimulation was not observed in spinal cats (C1-C2 transection) and pentobarbitalanesthetized cats. These results suggest that nefopam may inhibit the splanchnic afferent pathways in the spinal cord by reinforcing descending inhibitory systems originating in the supra-spinal structure, in a manner which differs from that seen with morphine.抄録全体を表示PDF形式でダウンロード (379K) -
Junichiro AONO, Michitaka AKIMA, Kazushige SAKAI1981 年 31 巻 5 号 p. 823-830
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーThe effects of a newly developed nicotinamide derivative, N-(2-hydroxyethyl)nicotinamide nitrate (SG-75, Nicorandil), were examined in an experimental model of angina pectoris, utilizing methacholine-induced ECG changes as main parameter in intact anesthetized rats. The right carotid artery was exposed and through it a special cannula was inserted to a point near the right and left coronary ostium. Such a device made it possible to inject drugs more selectively into the coronary artery. Single intra-aortic injections of 4 to 8 μg of methacholine caused a transient elevation of the ST segment and T wave of the electrocardiogram (ECG). SG-75 (3 mg/kg i.v. or 10 mg/kg p.o.) prevented these changes in the ECG, while a potent vasodilator, papaverine, failed to do so. In the isolated, donor-perfused rat heart, SG-75 (1-30 μg) injected into the coronary perfusion system caused dose-dependent vasodilation, while 0.1-0.8 μg acetylcholine as well as methacholine produced marked vasoconstriction. SG-75 (10 mg/kg) administered orally to the donor rat inhibited the coronary vasoconstriction produced by the cholinomimetic drugs, whereas papaverine (30 μg La.) failed to prevent it. The inhibitory effects of SG-75 on methacholine-induced ECG changes in intact rats seemed to be due to its spasmolytic action.抄録全体を表示PDF形式でダウンロード (406K) -
Issei TAKAYANAGI, Tetsuhiro HISAYAMA, Takeshi KOTSUGAI1981 年 31 巻 5 号 p. 831-834
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (194K) -
Isamu OKUNO, Kiyohisa UCHIDA, Masumi KADOWAKI, Akira AKAHORI1981 年 31 巻 5 号 p. 835-838
発行日: 1981年
公開日: 2006/11/07
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Takao KUBO, Yoshimi MISU1981 年 31 巻 5 号 p. 839-841
発行日: 1981年
公開日: 2006/11/07
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Kazuhide YOSHIDA, Yuzuru KATO, Hiroo IMURA1981 年 31 巻 5 号 p. 842-844
発行日: 1981年
公開日: 2006/11/07
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Yoshiteru HARADA, Kunio TANAKA, Makoto KATORI1981 年 31 巻 5 号 p. 845-848
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (227K) -
Kazuo NAKAGAWA, Masukichiro ASAMI1981 年 31 巻 5 号 p. 849-851
発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (164K) -
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発行日: 1981年
公開日: 2006/11/07
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発行日: 1981年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (198K) -
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発行日: 1981年
公開日: 2006/11/07
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