巻号一覧
35 巻 (1984)
- 4 号 p. 339-
- 3 号 p. 203-
- 2 号 p. 79-
- 1 号 p. 1-
35 巻, 1 号
選択された号の論文の11件中1～11を表示しています
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Masako MORIKAWA, Takashi KOJIMA, Michiko INOUE, Minoru TSUBOI1984 年 35 巻 1 号 p. 1-7
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe effect of aspirin on the prostacyclin (PGI2) production of rat aorta was investigated, and the influence of sex hormones on the effect of aspirin was studied by the treatments of hormone administration, ovariectomy and castration. There was no significant sex difference in the arterial production of PGI2 between male and female rats. However, the PGI2 production was decreased with aspirin treatment, and the effect of aspirin was more efficient in male rats. The inhibitory effect of aspirin was reduced in the rats treated with estradiol and the castrated male rats, but it was potentiated in the rats treated with testosterone and the ovariectomized female rats. These results suggest that sex hormones may regulate the effect of aspirin on the PGI2 production in the aorta.抄録全体を表示PDF形式でダウンロード (496K) -
Haruo TAKEMURA1984 年 35 巻 1 号 p. 9-17
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe effect of carbachol (CCh) on isoproterenol (ISP)-induced amylase release was investigated using isolated rat parotid cells. CCh (1-100 μM) inhibited ISP (1 μM)-induced amylase release in a dose-dependent manner, whereas CCh alone had a slightly increasing effect on amylase release. Both inhibitory and stimulatory effects of CCh were blocked by atropine (10 μM), and they also disappeared in Ca-free (1 mM EGTA) medium. CCh (10 μM) did not change cyclic AMP levels induced by ISP (1 μM), but significantly inhibited dibutyryl cyclic AMP (1 μM)-induced amylase release. CCh and ISP increased 45Ca2+ uptake in 30 min. Furthermore, 45Ca2+ uptake in the presence of CCh plus ISP increased almost additively. These increasing effects of CCh were abolished by atropine. Calcium ionophore A23187 (10 μM) inhibited ISP-induced amylase release to the level of the release by A23187 alone and considerably increased 45Ca2+ uptake . CCh increased both control and ISP-stimulated effluxes of 45Ca2+ in Ca-free (1 mM EGTA) medium from parotid cells. These results suggest that CCh produces a potent increase in Ca2+ influx from the extracellular medium into parotid cells, and this increase may result in a higher level of cytosolic free Ca2+ which inhibits the ISP-induced amylase release.抄録全体を表示PDF形式でダウンロード (641K) -
Shiro ISHIKAWA1984 年 35 巻 1 号 p. 19-25
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーEffects of a newly synthesized alpha-adrenoceptor blocking agent, 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-(1H, 3H)-quinazoline-2, 4-dione monochloride (SGB1534), on the electrical and mechanical properties of smooth muscles of guinea-pig mesenteric artery and on the electrical properties of smooth muscles of rat tail artery were investigated. SGB1534 (10-10 M-10-5 M) did not modify the membrane potential and ionic conductance of the membrane in guinea-pig mesenteric artery, but this agent did inhibit depolarizations induced by noradrenaline, phenylephrine, or histamine with similar potencies. This agent inhibited serotonin-induced depolarization, but with a weak potency. In rat tail artery, the noradrenaline-induced depolarization (10-5 M) was inhibited by yohimbine (5×10-7 M), but not by SGB1534 (10-6 M). SGB1534 (10-6 M) did not modify the amplitude of excitatory junction potentials (e.j.ps), the facilitation process or spike potential evoked by perivascular nerve stimulation in the mesenteric artery. Noradrenaline, phenylephrine or histamine evoked the contraction in guinea-pig mesenteric artery, and this contraction was inhibited by SGB1534 (over 10-10 M). The serotonin-induced contraction was inhibited by higher concentrations of SGB1534 (over 10-6 M). The concentration of SGB1534 required to inhibit the contractions evoked by these amines was much higher than that required to inhibit the depolarizations. SGB1534 (<10-6 M) had no effect on the excess K-induced depolarization and contraction. These results indicate that SGB1534 possesses the property of an alpha1-but not alpha2-adrenoceptor blocking agent. In addition, this agent possesses a histaminergic receptor blocking action and a weak serotonergic receptor blocking action.抄録全体を表示PDF形式でダウンロード (498K) -
Mayumi MORI, Hiromi TSUSHIMA, Tomohiro MATSUDA1984 年 35 巻 1 号 p. 27-36
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe effect of oxotremorine, a muscarinic agonist, on urine outflow compared with the effects of other cholinergic agonists and inhibitory effects of cholinergic antagonists upon the cholinergic actions were studied by microinjecting drugs stereotaxically, unilaterally into the supraoptic (SON) or paraventricular nuclei (PVN) in the hypothalamus of the rat which was loaded with water and anesthetized with ethanol. Oxotremorine decreased the urine outflow in dose-and time-dependent manners when microinjected into these nuclei. The median effective doses (ED50) were approx. 0.3 and 0.2 nmol in SON and PVN, respectively, being much less than ED50 values for nicotine. The time course of the antidiuretic effects was relatively slow, with the minimal urine outflow at approx. 30 min and the duration of one or longer hours. The antidiuretic effects of oxotremorine in these nuclei as well as the effects of acetylcholine and nicotine were completely blocked by pretreatment with atropine. The pretreatment with hexamethonium inhibited partially the effects of nicotine, but was unable to inhibit the effects of oxotremorine and acetylcholine. The data suggest that the antidiuretic effects of cholinergic agonists in SON and PVN are predominantly mediated through a muscarinic type of acetylcholine receptor. A possible mechanism for the anti-diuretic effects is discussed.抄録全体を表示PDF形式でダウンロード (690K) -
Makoto MURAMATSU, Makoto TANAKA, Atsuko FUJITA, Susumu OTOMO, Hironaka ...1984 年 35 巻 1 号 p. 37-46
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe characteristics of the time-dependency of nonsteroidal antiinflammatory drugs (NSAIDs) and their active sites in inhibiting cyclooxygenase activity were investigated using bovine seminal vesicle microsomal fraction. The Hill's coefficients of the inhibition curve of most NSAIDs were approximately 1.0, except for some drugs which had Hill's coefficients that were obviously more than 1.0. The values for indomethacin, diclofenac and flurbiprofen were approximately 1.5, 1.7 and 2.0, respectively. A time-dependent cyclooxygenase inhibiting effect was observed only with the NSAIDs in the group which had Hill's coefficients that were significantly more than 1.0. A time-dependent increase in inhibiting activity of these drugs was observed by the change in the inhibition curve. Time-dependently, the Hill's coefficient of the curve of the NSAIDs approached 1.0 from more than 1.0. With this change, the shift of the curve to the left was also observed time-dependently. These changes in the curve were no longer seen when the Hill's coefficient dropped to 1.0. These time-dependent effects were protected by salicylic acid, which did not have any effect on cyclooxygenase activity in vitro, in a dose-dependent manner. These results suggested that the two classes of NSAIDs, time-dependent and non-time-dependent, are clearly differentiated by the slope of the inhibition curve of NSAIDs. Furthermore, the present results indicate that the degree of time-dependence of the NSAIDs depends on the Hill's coefficient of the inhibition curve, and the value is important for the potency of the cyclooxygenase inhibition, in addition to the affinity for the catalytic site of the enzyme.抄録全体を表示PDF形式でダウンロード (661K) -
Toshio SUWA, Michiko NAKAZIMA, Ayako SHINOZAKI, Kazuaki KYOGOKU, Yo MO ...1984 年 35 巻 1 号 p. 47-53
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーThe gastric cytoprotective action of SU-88, an anti-ulcer agent, was studied in rats. SU-88 dose-dependently prevented the formation of gastric lesions induced by absolute ethanol as observed by PGE2. The efficacy of SU-88 when given i.p. was more potent than the p.o. administration. Indomethacin (5 mg/kg, p.o.) given 30 min prior to SU-88 dosing blocked this protective effect, whereas it was not affected when indomethacin was given 30 min after the SU-88 dosing. Cimetidine, on the other hand, failed to exert a protective effect against the ethanol-induced lesions and caused a significant increase in the lesions induced by 0.6N HCI. Pretreatment with SU-88 prior to cimetidine resulted in a marked reduction in the lesions. SU-88 was found to increase the synthesis of gastric glycoproteins and to prevent the reduction of glycoprotein synthesis caused by the administration of absolute ethanol. However, no increase in the synthesis was observed 5 min after the SU-88 dosing, although the lesion was significantly suppressed at that time. These findings indicate that SU-88 possesses a cytoprotective effect and that this effect seems to be mediated by the increase in endogenous PG.抄録全体を表示PDF形式でダウンロード (515K) -
Hiroichi NAGAI, Hiroaki YAMADA, Naosuke MATSUURA, Naoki INAGAKI, Tsuka ...1984 年 35 巻 1 号 p. 55-60
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーEffect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice was studied. Employed models are nephrotoxic serum (NTS) nephritis in ddY or A/He mice, rabbit IgG (RGG) accelerated NTS nephritis in ddY mice and spontaneous nephritis in (NZB × NZW) F1 mice. The severity of nephritis was evaluated by measuring proteinuria and serological parameters and examining renal tissue by light microscopy. Therapy with FUT-175 clearly prevented the pathological changes of proteinuria and serological parameters in all four nephritis models. By contrast, treatment hardly affected histopathological changes of the kidney in any of the models. Cyclophosphamide used as a comparative drug showed more clearly remission of the onset and development of NTS nephritis and RGG accelerated NTS nephritis in ddY mice by means of the changes of urinary and selorogical parameters. These evidences suggest that FUT-175 shows beneficial effects on the nephritis in either normal or complement deficient mice.抄録全体を表示PDF形式でダウンロード (550K) -
Masayasu KIMURA, Ikuko KIMURA, Hiroshi NOJIMA, Kazuyoshi TAKAHASHI, To ...1984 年 35 巻 1 号 p. 61-66
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーA new monoterpene, paeoniflorigenone (PFG) (100-900 μg/ml), which was isolated from paeony roots and identified chemically, suppressed both indirectly and directly stimulated muscle twitchings of frog sciatic nerve-sartorius muscle preparation, and it indirectly stimulated muscle twitchings of phrenic nerve-diaphragm muscle preparations. The suppression effect by PFG (300 μg/ml) on twitching was not reversed by neostigmine (60 μg/ml) and was restored by washing out of PFG. PFG (150 μg/ml) depolarized the diaphragm muscle membranes by 10 mV and did not change the electrotonic potentials. PFG (100 μg/ml) inhibited weakly acetylcholine (5 μg/ml)-induced slow contractions. These results demonstrated that PFG is a depolarizing neuromuscular blocking agent, being similar to succinylcholine, except that PFG did not produce any contraction, but succinylcholine did.抄録全体を表示PDF形式でダウンロード (410K) -
Hiroaki ARAKI, Kazuaki KAWASHIMA, Hironaka AIHARA1984 年 35 巻 1 号 p. 67-72
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーA single administration of tricyclic antidepressants reduced the duration of the immobility in the behavioral despair test. The escape-directed behavior of tricyclic antidepressant-treated rats was observed in a cylinder partially filled with water. In contrast, although methamphetamine also reduced the duration of the immobility, an increase in the general motor activity was shown in methamphetamine-treated rats. Tricyclic antidepressants injected into the medial amygdaloid nucleus, not into the nucleus accumbens, suppressed the duration of the immobility. Methamphetamine completely suppressed the duration of the immobility not only when injected into the medial amygdaloid nucleus, but also when injected into the nucleus accumbens. The present results suggest that in the rat behavioral despair test, the medial amygdaloid nucleus may play an important role in the selective reductive effect on the duration of the immobility.抄録全体を表示PDF形式でダウンロード (415K) -
Shigenobu SHIBATA, Hiroshi NAKANISHI, Showa UEKI1984 年 35 巻 1 号 p. 73-75
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (216K) -
Takashi TANIGUCHI1984 年 35 巻 1 号 p. 76-78
発行日: 1984年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (196K)
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