巻号一覧
33 巻 (1983)
- 6 号 p. 1111-
- 5 号 p. 915-
- 4 号 p. 717-
- 3 号 p. 503-
- 2 号 p. 267-
- 1 号 p. 1-
33 巻, 6 号
選択された号の論文の26件中1～26を表示しています
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Charles WAMBEBE1983 年 33 巻 6 号 p. 1111-1118
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe effects of gamma amino butyric acid (GABA), bicuculline and aminooxyacetic acid (AOAA) on nitrazepam-induced sleep were studied in young chicks. GABA (200-3200 mg/kg) induced a marked sedation in young chicks. It also potentiated nitrazepam (1.6 mg/kg)-induced sleep. Bicuculline (1.25-5.00 mg/kg) effectively antagonized nitrazepam-induced sleep. In addition, it effectively antagonized GABA (1600 mg/kg)-induced potentiation of nitrazepam sleep. AOAA (2.5-7.5 mg/kg) delayed the onset of nitrazepam sleep, but significantly prolonged its duration. Nitrazepam (1.6 mg/kg) synchronized the electroencephalogram (EEG) of the hyper-striatum, optic tectum and reticular formation. Similarly, the electromyograph (EMG) activity was markedly reduced. GABA (1600 mg/kg) synchronized the EEG of the hyperstriatum, optic tectum and reticular formation while the EMG activity was reduced. Administration of GABA (1600 mg/kg) into nitrazepam (1.6 mg/kg)-pretreated chicks induced desynchronization of the EEG of the hyperstriatum, while the EEG of the reticular formation was synchronized. In addition, the EMG activity was reduced. Bicuculline (5 mg/kg) activated the EEG of the hyperstriatum; this effect was antagonized by GABA (1600 mg/kg). Similarly, GABA (1600 mg/kg)-induced decrease in EMG activity, synchronization of the EEG of the optic tectum and reticular formation was antagonized by bicuculline. The present data suggest that GABA potentiated nitrazepam-induced behavioral and electroencephalographical sleep.抄録全体を表示PDF形式でダウンロード (382K) -
Motoki KOBAYASHI, Katsuya OHATA1983 年 33 巻 6 号 p. 1119-1126
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーA kinin (material c), which was different from kallidin, methionyl-lysylbradykinin (MLBK), bradykinin (BK) and neurotensin, released from rat plasma by the kinin-forming enzyme in rat stomach was pharmacologically compared with BK and histamine or serotonin (5-HT) in various in vitro and in vivo systems. Material c produced contraction of isolated rat uterus, rat fundic strip, isolated guinea-pig ileum and guinea-pig tracheal chain; increased the vascular permeability of guinea-pig skin to circulating Evans blue; and produced a fall in rabbit blood pressure. Such effects were also produced by BK, but both were clearly discriminated by their quantitatively different activities. Histamine was not effective on isolated rat uterus, isolated rat duodenum, rat fundic strip, and rabbit blood pressure; produced contraction of isolated guinea-pig ileum and guinea-pig tracheal chain; and increased the vascular permeability of guinea-pig skin; but these activities were quantitatively different from those of material c. The contraction of isolated guinea-pig ileum elicited by histamine was sustained until it was removed from the bath, but those provoked by material c and BK gradually faded. 5-HT was qualitatively different from material c and BK with respect to contracting isolated rat duodenum. 5-HT also produced contraction of isolated rat uterus and rat fundic strip and produced a fall in rabbit blood pressure, but these activities were quantitatively different from those of material c and BK. As mentioned above, material c was quantitatively and qualitatively different from histamine and 5-HT.抄録全体を表示PDF形式でダウンロード (361K) -
Hisashi KURIBARA, Sakutaro TADOKORO1983 年 33 巻 6 号 p. 1127-1133
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーEffects of antipsychotic drugs, chlorpromazine, haloperidol and tetrabenazine, on lever-press avoidance responses under Sidman avoidance (response-shock interval=30 sec and shock-shock interval=5 sec) and discriminated avoidance (intertrial interval=25 sec and warning duration=5 sec) situations in male mice of the dd strain were investigated. The results were compared with those in male rats of the Wistar strain. All the drugs tested were administered s.c., and the avoidance responses of the mice and rats were observed for 1 hr after each administration. Chlorpromazine, haloperidol and tetrabenazine suppressed the avoidance responses of the mice and rats in a dose-dependent manner. The susceptibilities of the mice to these drugs were calculated to be 1/5-1/6 as low as those of the rats. However, the potencies of the avoidance-suppressing effects of chlorpromazine, haloperidol and tetrabenazine were estimated to be 1 :20:1.3 and 1 :18:1.4 by the Sidman avoidance responses in the mice and rats, respectively, and 1 :18:1.1 by the discriminated avoidance responses in both the mice and rats. These results suggest that the conditioned lever-press avoidance responses in mice, as well as those in rats, are applicable for the evaluation of antipsychotic drugs.抄録全体を表示PDF形式でダウンロード (345K) -
Mitsuo OHASHI, Issei TAKAYANAGI1983 年 33 巻 6 号 p. 1135-1144
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe effects of D 600, Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride) and papaverine on CaCl2-, KCl- and histamine-induced contractile responses of isolated rabbit basilar artery, aorta, taenia coli and tracheal smooth muscle were compared with each other. D 600 reduced CaCl2-induced maximal responses in basilar artery and aorta, and parallelly shifted the concentration-response curves for CaCl2 to the right in taenia coli and trachea. D 600 also reduced histamine-induced maximal contractions in basilar artery and taenia coll. These reductions were not reversed by increasing CaCl2 concentration in bathing fluids. High concentration of D 600 parallelly shifted the concentration-response curve for histamine to the right in aorta. Like D 600, Aspaminol, a nonspecific smooth muscle relaxant, parallelly shifted the concentration-response curve for histamine in aorta. Papaverine parallelly shifted the concentration-response curve for CaCl2 in taenia coli and reduced the maximal responses in other tissues. Papaverine also reduced histamine-induced maximal responses in basilar artery, aorta and taenia coll. Influences of these smooth muscle relaxants on histamine-induced contraction in Ca-free buffer solution and on KCl-induced contraction in normal and high Ca (Ca: 12.5 mM) buffer solution were also studied. From the results obtained in this study, the effects of smooth muscle relaxants are considered to vary with the type of smooth muscle or the condition eliciting contraction, and the possible mechanisms of the contractions were discussed.抄録全体を表示PDF形式でダウンロード (517K) -
Mikio ITO, Hisaharu YAMADA, Kyoko OKAMOTO, Yoshio SUZUKI1983 年 33 巻 6 号 p. 1145-1154
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーAn experimental model of crescentic type nephritis was established by immunizing rats that had been given at i.v. nephritogenic dose (0.4 ml/animal) of rabbit anti-rat glomerular basement membrane (GBM) serum [anti-GBM serum] with 5 mg of rabbit γ-globulin in Freund's complete adjuvant, and the process of nephritis was investigated by means of biochemical, histopathological and immunopathological analyses. Rats treated with anti-GBM serum and then with rabbit γ-globulin (group II) showed significantly high levels or a tendency for high levels of urinary protein content, N-acetyl-β-glucosaminidase activity and plasmin-like activity from the 20th day to the 40th day observations after the induction of nephritis, when compared to rats given anti-GBM serum alone (group I). On the 40th day, plasma urea nitrogen, cholesterol and fibrinogen levels were significantly higher in group II than in group I. Glomerular histopathological examination on the 40th day revealed that the incidence and the degree of severity of crescent formation, adhesion of capillary walls to Bowman's capsule and fibrinoid degeneration were remarkably greater in group II than in group I. However, no significant difference was seen between both groups on the thickening of capillary walls and mesangial proliferation. Linear deposits of rabbit IgG and rat IgG along the capillary walls as well as fibrinogen-reactive material deposits in Bowman's capsular spaces were observed by the immunofluorescence technique in both groups. The deposition of fibrinogen-reactive materials was considerably greater in group II than in group I. Moreover, the deposition of rat IgG was slightly greater in group 11. These results suggest that the nephritis of group II closely resembles rapidly progessive glomerulonephritis in humans and thus seems to be an adequate experimental model for screening beneficial drugs on this type of nephritis.抄録全体を表示PDF形式でダウンロード (547K) -
Hiroshi OZAKI, Junya TOMONO, Hiromi NAGASE, Norimoto URAKAWA1983 年 33 巻 6 号 p. 1155-1162
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe mode of action of palytoxin (PTX) on the contractile responses and ion movements in guinea-pig aorta was investigated. PTX (10-8 M) induced a contraction with a latency period of 0.5-1 min, and it reached maximum after about 20 min. This contraction was not affected by phentolamine (10-6 M). The contraction induced by PTX was rapidly abolished by removal of external Ca. Readdition of Ca restored the contraction. Verapamil, which markedly antagonized the contraction induced by some depolarizing agents (K, Ba and tetraethylammonium), decreased the rate of rise of the PTX-induced contraction, but did not affect the sustained tension level. Removal of external Na markedly inhibited the contraction induced by PTX (10-10-10-8 M), while it had no effect on the contraction induced by histamine (10-7-10-5 M). PTX rapidly decreased tissue K content with a similar time course to that of the increase in tension. Ouabain (10-4 M) also caused contraction and decreased tissue K content in the muscle, but the rate of these changes was much slower than the PTX-induced ones. PTX increased cellular 45Ca content in normal solution, but not in Na deficient solution. These results suggest that the PTX-induced contraction in guinea-pig aorta is due to an increase in membrane Na permeability.抄録全体を表示PDF形式でダウンロード (432K) -
Kazuo WATANABE, Hiroshi WATANABE, Yoshiaki GOTO, Masao SHIMIZU, Masaki ...1983 年 33 巻 6 号 p. 1163-1169
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーInfluences of γ-butyrolactone (GBL) on GABA agonists-induced gastric acid secretion were studied in anesthetized rats. GBL potentiated the effect of GABA and GABA agonists on gastric acid secretion, and γ-hydroxybutyric acid, a metabolite of GBL, tended to enhance the effect of GABA. However, GBL did not influence 2-deoxy-D-glucose or bethanechol-stimulated acid secretion. A benzodiazepine, diazepam, also increased the secretagogue action of baclofen. A GABA antagonist, bicuculline, but not picrotoxin, inhibited the acid secretion stimulated by the combination of GBL and GABA or muscimol. Aminooxyacetic acid, an inhibitor of GABA transaminase, potentiated the effect of GABA. Dopamine receptor agonists and antagonist did not modify the effect of GABA. Neither GABA mimetic action of GBL nor its influences on the dopaminergic system are involved in the effect of the compound on gastric acid secretion. Although the possibility that GBL inhibits GABA degradation is not excluded, the compound appears to increase the sensitivity of GABA receptor to GABA mimetics in the gastric acid secretion.抄録全体を表示PDF形式でダウンロード (326K) -
Hideo NAKAMURA, Masanao SHIMIZU1983 年 33 巻 6 号 p. 1171-1176
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe physical dependence potential of meprobamate (MPB) was compared with that of phenobarbital (PHB) and codeine (COD) to ascertain whether MPB produces definite physical dependence in the rat. Rats were treated orally with MPB (maintenance dosage=800 mg/kg×2/day), PHB (100×2) or COD (50×2) twice a day (10:00 a.m. and 5:00 p.m.) for a total of 21 days; the treatment was ceased for 3 days after administration for 7 days, and the last dosing was performed on day 27. During intoxication and after the withdrawal, the M PB treated rats exhibited behaviour and withdrawal signs similar to those seen in the PHB treated rats, but not the COD treated rats. After withdrawal of drugs, definite weight loss was observed in all the rats given drugs, and the recovery of the MPB and PHB treated rats was clearly later than that of the COD treated rats. A long-lasting increase in rectal temperature was observed after the with-drawal in the MPB and PHB treated rats; a decrease was seen in the COD treated rats. From these results, it is concluded that definite physical dependence on MPB, similar to that on PHB but different from that on COD, was developed after repeated oral administration for a total of 21 days in the rat.抄録全体を表示PDF形式でダウンロード (333K) -
Hiroaki ARAKI, Hironaka AIHARA, Shigenori WATANABE, Tsuneyuki YAMAMOTO ...1983 年 33 巻 6 号 p. 1177-1182
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe role of the brain monoamines in the development of hippocampal kindling was studied. Reserpine markedly facilitated the formation of hippocampal kindling. The high amplitude spike waves in the amygdala and reticular formation appeared earlier in the reserpine treated rats than in the saline injected rats. α-Methyl-p-tyrosine did not have any effect on the formation of hippocampal kindling. Systemic injection of p-chlorophenylalanine and intraventricular injection of 5, 7-dihydroxytryptamine also did not have any effect on the formation of hippocampal kindling. Progressive changes of afterdischarge elicited by hippocampal stimulation in the α-methyl-p-tyrosine, p-chlorophenylalanine and 5, 7-dihydroxytryptamine treated rats are the same as those in the saline injected rats. These results indicate that the decrease in both catecholamines and serotonin levels caused a marked facilitation of the hippocampal kindling formation, but the separate decrease in either catecholamines or serotonin did not produce a significant effect.抄録全体を表示PDF形式でダウンロード (311K) -
William K. RIKER, Brian R. APATOFF, Kazuhiko SASAKI1983 年 33 巻 6 号 p. 1183-1189
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThis study aimed to define the complete concentration-effect relationship for anticurare effects of 3, 4-diaminopyridine (3, 4-DAP) in the isolated sympathetic ganglion of the bullfrog. Synaptic transmission was monitored by extracellular and intracellular recordings of the postganglionic response to preganglionic stimulation. A previous study showed that in the bullfrog sympathetic ganglion 3, 4-DAP caused stimulus-bound repetitive postganglionic responses (SBR) to each single preganglionic stimulus. The concentration-effect relationship for 3, 4-DAP-induced SBR was bell-shaped, and the descending limb of the curve reflected progressive suppression of SBR while normal synaptic transmission was maintained. In the present study a detailed concentration-effect analysis of 3, 4-DAP's anticurare action also resulted in a bell-shaped curve nearly congruent with that for SBR. SBR and anticurare effects of 3, 4-DAP therefore occupy a common concentration-effect domain, and this suggests that a common mechanism (increased transmitter release) may account for both effects.抄録全体を表示PDF形式でダウンロード (416K) -
Shigetoshi CHIBA, Miyoharu KOBAYASHI, Masahiro SHIMOTORI1983 年 33 巻 6 号 p. 1191-1197
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe effects of a large amount of adenosine and ATP (100 to 3000 μg) were investigated on sinus rate and developed tension, using the isolated dog atrium which was perfused with arterial blood from a heparinized donor dog. Each of the substances used for study was administered into the cannulated sinus node artery of the isolated atrium. Adenosine caused monophasic negative chronotropic and inotropic effects in a doserelated manner. However, ATP induced two-peaked positive chronotropic phases during a long-lasting negative chronotropic phase, i.e., initially, brief positive (t-1) effects and secondarily, relatively longer positive chronotropic (t-2) effects. These responses were repetitively induced during the experiment. The t-1 and t-2 were not influenced by treatment with propranolol which significantly blocked the positive chronotropic effect of norepinephrine. Aminophylline treatment significantly suppressed t-2 but not t-1. Quinidine (100-1000 μg) did not affect either the t-1 or t-2. It is suggested that ATP-induced tachycardia in the dog is partially due to activation of the P1-purinoceptors named by Burnstock.抄録全体を表示PDF形式でダウンロード (310K) -
Takafumi ITAMI, Seizaburo KANOH1983 年 33 巻 6 号 p. 1199-1204
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーOur previous paper reported that the fetotoxic effects of aspirin (ASA) were enhanced by bacterial endotoxin (LPS), and the effects of ASA were attributed to its major metabolite, salicylic acid (SA), as indicated by high SA concentrations in fetus and placenta. In order to clarify the mechanisms of the enhancement by LPS, serum total protein, albumin and free fatty acid (FFA) levels and SA-binding capacity of serum protein were investigated in pregnant rats. The following results were obtained: 1) FFA levels increased steadily after day 16 of pregnancy, and SA-binding capacity of serum protein decreased gradually after day 18, as the pregnancy proceeded to full term. 2) LPS injection decreased total protein and albumin levels in normal and starved rats on day 15 of pregnancy. 3) Starvation and/or LPS injection potentiated the increase of FFA level and reduced significantly SA-binding capacity of serum protein in the rats on day 1 5 of pregnancy. 4) Serum protein showing low SA-binding capacity from LPS-treated rats recovered normal SA-binding capacity when FFA was removed from serum protein by charcoal treatment. These data suggested the decrease of the SA-protein binding in serum by the increased level of FFA, an inhibitor of the binding, and the decreased level of albumin as a possible mechanism for the potentiation of the fetotoxicities of ASA by LPS.抄録全体を表示PDF形式でダウンロード (331K) -
Hiroshi MORI, Ichiro NAKATOMI, Yuzuru KATO, Akihide KODA1983 年 33 巻 6 号 p. 1205-1214
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーAuthors have previously shown that α-mercaptopropionylglycine (α-MPG) and sodium dipropylacetate (DPA) facilitate immunity as well as host-mediated antitumor activity. In this study, we found that a compound related to α-MPG and DPA, (2-n-propyl-n-pentanoyl)glycine (KN-539), inhibited the growth of E.L.4 lymphosarcoma transplanted in C57BL/6 mice and further investigated the anti-tumor effects of 1-(4-carboxy-n-neptyl)-5-FU (KN-826) and 1-(4-carboxymethylaminocarbonyl-n-heptyl)-5-FU (KN-827), in which DPA and KN-539 were combined, respectively, to 5-fluorouracil (5-FU). KN-827 showed stronger anti-tumor activity than KN-826, and it was also effective with oral administration. Although KN-827 demonstrated anti-tumor activity two to three times weaker than N1-(2-tetrahydrofuryl)-5-FU (FT-207), KN-827 did not reduce the blood leukocyte count and the number of spleen cells. Furthermore, KN-827 stimulated the production of the hemolytic plaque forming cell (HPFC) in the spleen of mice immunized with sheep-erythrocytes. In contrast, FT-207 and 5-FU obviously reduced not only HPFC-production but also the number of spleen cells.抄録全体を表示PDF形式でダウンロード (458K) -
Hiroichi NAGAI, Teiji IWAMOTO, Takeshi NISHIYORI, Tamotsu TAKIZAWA, Hi ...1983 年 33 巻 6 号 p. 1215-1223
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーEffects of 2-methyl-3-piperidino-β-propionaphtone hydrochloride (KZ-111), 3-isobutyryl-2-isopropylpyrazolo-[1, 5-a]pyridine (KC-404) and FPL-55712 on experimental allergic reactions were investigated. Homologous passive cutaneous anaphylaxis (PCA) in rats was clearly inhibited by oral and intravenous administrations of KC-404 and KZ-111. FPL-55712 inhibited the PCA reaction only by intravenous injection, but not by oral administration. Maximum inhibition of the PICA reaction by KC-404 and KZ-111 was obtained by administration of these agents 2 hr prior to challenge. The immunological release of histamine from sensitized rat peritoneal mast cells was inhibited by KZ-111 at a concentration of 10-4 g/ml. KC-404 and FPL-55712 did not inhibit the immunological release of histamine. All three compounds had no effect on the release of histamine from rat peritoneal mast cells and on the generation of SRS from rat polymorphonuclear leucocytes by calcium ionophore A23187. KC-404 and KZ-111 produced a downward displacement of the maximum without a parallel shift in LTD4 induced concentration-response curves of guinea pig ileal and tracheal smooth muscle at concentrations between 10-6 and 10-5 g/ml. FPL-55712 at a concentration of 10-6 g/ml produced a parallel shift of LTD4 induced concentration-response curves to the right in both smooth muscle preparations. The 50% inhibitory concentration to the contraction by LTD4 of each of the three compounds is lower than those of other agonists, histamine, PGF2α and BaCl2. KC-404 and KZ-111 inhibited CaCl2-induced contraction in K+-depolarized ileal smooth muscle, but FPL-55712 had no effect on the CaCl2-induced contraction. All three compounds inhibited the Schultz-Dale reaction in guinea pig trachea. Respiratory disorder in guinea pig experimental asthma was inhibited by oral administration of KC-404 and KZ-111, but not by FPL-55712.抄録全体を表示PDF形式でダウンロード (436K) -
Shigenobu SHIBATA, Shyh Yuh LIOU, Showa UEKI1983 年 33 巻 6 号 p. 1225-1231
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーInfluences of amino acids and monoamines on the single unit discharges of the suprachiasmatic nucleus (SCN) were investigated using hypothalamic slice preparations. lontophoretic application of GABA inhibited 90% and taurine inhibited 40% of SCN neurons, while glycine inhibited only 4%. L-glutamate excited about 50% of the neurons. Serotonin, noradrenaline and dopamine inhibited 30, 22 and 26% of the SCN neurons, respectively. Amino acid effects were observed equally in both the ventrolateral part of the SCN and the remaining part of it, while monoamine effects were observed preferentially in the ventrolateral part of the SCN where the optic fibers and serotonin nerves terminated. These results suggest that amino acids and monoamines modulate the neuronal activity of the SCN through their direct effects.抄録全体を表示PDF形式でダウンロード (383K) -
Eiichiro OKABE, Kazuo TODOKI, Chisato ODAJIMA, Haruo ITO1983 年 33 巻 6 号 p. 1233-1239
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーEffect of free radicals on microvascular dimensions was studied in anesthetized cat intestinal mesentery. Generation of free radicals by xanthine oxidase, acting on endogenous substrates (e.g., xanthine, hypoxanthine), produced sustained vasodilation at pH 7.4 or at pH 6.6. These effects were reversed by superoxide dismutase (SOD), a superoxide radical (·O2-) scavenger, at pH 7.4, and by SOD plus hydroxyl radical (·OH) scavenger d-mannitol at pH 6.6. These findings suggest that the sustained vasodilation is caused by ·O2- and by ·OH derived from ·O2- at low pH.抄録全体を表示PDF形式でダウンロード (374K) -
Masayoshi GOTO, Hideki ONO, Kinzo MATSUMOTO, Mitsuru KONDO, Hideomi FU ...1983 年 33 巻 6 号 p. 1241-1246
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーWhether or not zopiclone, a new sleep-inducing drug, exerted a similar effect to that of benzodiazepines was examined. The drug inhibited crossed extensor reflexes in chicks and augmented the dorsal root-dorsal root reflexes in rats without affecting the mono- and polysynaptic reflexes. The site of its action was considered to be located in the spinal cord since the effect on the dorsal root reflex was observed also in the spinal rats. Zopiclone selectively reduced the phasic responses of anemic decerebrate rigidity like benzodiazepines in rats. Despite the structural difference from the benzodiazepines, zopiclone dose-dependently inhibited [3H]flunitrazepam binding in rat brain membranes, although the potency was weaker. These results suggested that zopiclone exerts CNS actions via benzodiazepine receptors.抄録全体を表示PDF形式でダウンロード (310K) -
Michio KURACHI, Keiko YOSHIHARA, Hironaka AIHARA1983 年 33 巻 6 号 p. 1247-1254
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThe effect of taurine on depolarizing responses to L-glutamate (L-glu) was examined in isolated frog spinal cord using the sucrose gap method. Taurine (1 mM) reduced L-glu-induced depolarization in ventral and dorsal roots, even when calcium ion was deleted from or EGTA was added to the perfusate. GABA (1 mM) showed little or no effect on the L-glu response. A log dose-depolarization curve for L-glu was found to be shifted by taurine (1 mM) to the right in a non-parallel fashion. Strychnine blocked the taurine effect completely, while picrotoxin produced a partial reduction, and bicuculline exhibited no blockade at all. The depolarizations by 3-types of excitatory amino acids were also inhibited by taurine in the following order: N-methyl-D, L-aspartate >kainate>quisqualate. These results suggest a possibility that taurine but not GABA inhibits the depolarization mediated by excitatory amino acid receptors, and this may explain, in part, the inhibitory action of taurine in the central nervous system.抄録全体を表示PDF形式でダウンロード (411K) -
Masahiro NISHIBORI, Kiyomi SAEKI1983 年 33 巻 6 号 p. 1255-1261
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーHistamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its “receptors” on the mast cell surface or some steps in the DSCG action.抄録全体を表示PDF形式でダウンロード (375K) -
Nobuhiro INATOMI, Yoshitaka MAKI1983 年 33 巻 6 号 p. 1263-1270
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーThis study deals with the action in anesthetized dogs of prostaglandin E2 and F2α given into the celiac artery and the femoral vein on gastric mucosal blood flow and on gastric mucosal damage induced by aspirin. In the non-stimulated stomach, infusion of prostaglandin E2 or F2α into the celiac artery resulted in a marked increase in mucosal blood flow and a sustained decrease, respectively. In contrast, an infusion of prostaglandin E2 into the femoral vein produced a decrease in mucosal blood flow, whereas prostaglandin F2α produced a biphasic response: a transient increase followed by a decrease. It was observed that intravenously infused prostaglandin E2, while reducing mucosal blood flow, significantly diminished mucosal lesions, altered transmucosal potential differences and H+ back-diffusion induced by a topical application of aspirin. The findings indicate that the action of prostaglandins on gastric mucosal blood flow alters depending on the route of administration and that prostaglandins seem to exert gastric cytoprotection through mechanisms other than an increase in mucosal blood flow.抄録全体を表示PDF形式でダウンロード (475K) -
Ikuko KIMURA, Hiroshi KATOH, Masayasu KIMURA1983 年 33 巻 6 号 p. 1271-1278
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーCa spike suppressions induced by isoproterenol (IsP) and a β2-agonist, 5-hydroxymethyl-6-hydroxy-2-isopropylamino-1, 2, 3, 4-tetrahydronaphthalene-1-ol (AA497), were investigated in the presence of butoxamine or practolol. The relaxations were isotonically recorded, and the Ca spike frequency was recorded using the single sucrose gap method. IsP-induced relaxation was not inhibited by butoxamine (Butox, 0.16 μM), but was inhibited by practolol (Prac, 0.188 μM). In 24 mM K+-Krebs' solution, AA497 caused relaxation in a lower dose range and suppressed to a small extent the Ca spike frequency in a higher dose range, as was observed for IsP-induced curves of log dose-spike frequency and log dose-relaxation. In normal K+-Krebs' solution, both IsP and AA497 greatly suppressed the Ca spike frequency. IsP (1.21 μM)-induced suppression of the Ca spike frequency was blocked by Prac (113 μM), and it was blocked by Butox (96 μM) to a greater extent. AA497-induced suppression of the spikes was not blocked by Prac (37.6 μM), but completely blocked by Butox (32 μM). These selective inhibitory effects of butoxamine on AA497-induced and IsP-induced Ca spike suppression demonstrate that in the adrenergic β-receptor-mediated process in taenia coli, β2-mechanisms are more closely related to the Ca spike suppression than the β1-mechanisms are.抄録全体を表示PDF形式でダウンロード (382K) -
Eiko TOIBANA, Ryoji OHNISHI, Yohko FUJIMOTO, Tadashi FUJITA1983 年 33 巻 6 号 p. 1279-1281
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (137K) -
Hiromichi NAKAJIMA, Kunio NOSAKA1983 年 33 巻 6 号 p. 1282-1285
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (181K) -
Kazuki MATSUNAGA, Akio MATSUURA, Saburo MATSUDA, Motohiko UEDA1983 年 33 巻 6 号 p. 1286-1288
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (162K) -
Krishnaswami RAMABADRAN1983 年 33 巻 6 号 p. 1289-1292
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (194K) -
Fukio KONNO, Issei TAKAYANAGI, Masaaki HIROBE1983 年 33 巻 6 号 p. 1293-1295
発行日: 1983年
公開日: 2006/11/07
ジャーナル フリーPDF形式でダウンロード (140K)
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