The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 1, Issue 4
Displaying 1-5 of 5 articles from this issue
  • EXPERIMENTAL OBSERVATIONS ON HUMAN EYE-BALL
    KEN KATO
    1952 Volume 1 Issue 4 Pages 251-268
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • DAIZO USHIBA, BUJIRO KITASATO
    1952 Volume 1 Issue 4 Pages 269-281
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The mutabile type variation (Murase) described here represents a particular phenomenon which is observed in many strains of E. coli, Salmonellae, and Shigellae. Typical features of the mutabile variant (M) are connected with changes of colonial appearance and morphology under influence of galactose (or lactose, raffinose).
    Influences of galactose on these variants have been discussed in this report. It has been revealed that galactose inhibits the growth of M cells and gives an in-hibitory effect on their oxidation of certain amino acids. Detailed studies on mechanism of this effect are required in the future.
    Daughter cells, on the other hand, show characteristics resistant to this galactose effect, though they are still not able to utilize galactose.
    Other phenomena of daughter cell formations including B. coli mutabile of Massini, which was definitely distinguished from the variation mentioned here, have been discussed in relation with the sugar used in the medium.
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  • BUNYA NAKAMURA, NOBUO KAGA
    1952 Volume 1 Issue 4 Pages 283-297
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    We have examined the production of diphtheria antitoxin in guinea pigs, which were infected experimentally with the Gravis and Mitis type strains of Coryne-bacterium diphtheriae. The infection was attained by inoculation the conjunctiva palpebre according to Bessau-Bormann's method. The results obtained are sum-marized as follows:
    1. No production of diphtheria antitoxin was noticed in the serum of the guinea pigs after their primary infection with the Gravis type strain.
    2. When the guinea pigs were re-infected with the same Gravis type strains, all of the cases in which the interval between the primary inoculation and the secondary inoculation was 90 days, produced noticeable diphtheria antitoxin in the serum. The interval being 15 or 30 days the antitoxin production was noticed in most cases.
    3. The diphtheria antitoxin was produced relatively rapidly after the secon-dary inoculation.
    4. The diphtheria antitoxin production was neither related to the lokal symp-toms nor to the period during which the diphtheria bacilli was demonstrated posi-tively, but was only due to re-infection, to our belief.
    5. The amount of this antitoxin attains its peak rapidly, and thereafter tends to maintain this level.
    6. In experiments with the Mitis type strains no diphtheria antitoxin produc-tion was noticed even after the secondary inoculation.
    7. In cross-experiments with the Gravis type strains, the strains used in the primary inoculation and the secondary inoculation being changed, the diphtheria antitoxin was produced rapidly in the serum either after the secondary inoculation or the third inoculation.
    8. In experiments with several different strains of the Mitis type, no antitoxin production was noticed even after the secondary inoculation.
    9. After the secondary inoculation with Mitis type strain, following the primary inoculation with the Gravis type strain, production of diphtheria antitoxin was noticed in some cases.
    10. After the secondary inoculation with the Gravis type strains, following the primary inoculation with the Mitis type strains, no production of diphtheria antitoxin was noticeable.
    It is considered, to our belief, that these results gives a definite answer to one of our unsolved problems that why the diphtheria antitoxin production are in-creased only in certain cases after the healing of diphtheria. Moreover, in natural healing of diphtheria, it is understood that the diphtheria antitoxin production in the serum is not closely related to the healing mechanism of diphtheria.
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  • MITSUTO HASEGAWA, YOSHIO ASANO, HIROSHI HOSHINO, KENJI SAITO, TATSUO K ...
    1952 Volume 1 Issue 4 Pages 299-311
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • I. EXPERIMENTAL AMOEBIC LIVER ABSCESS IN RATS
    BUYU YOSHIMURA
    1952 Volume 1 Issue 4 Pages 313-321
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Download PDF (487K)
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