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Volume 11, Issue 3
Displaying 1-10 of 10 articles from this issue
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A NEW POTENT INHIBITOR OF THE FIBRINOLYSISSHOSUKE OKAMOTO, UTAKO OKAMOTO1962 Volume 11 Issue 3 Pages 105-115
Published: 1962
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) A new potent inhibitor of the fibrinolytic system was found. Its chemical name was 1-(aminomethyl)-cyclohexane-4-carboxylic acid and abbrevi-ated as AMCHA in our laboratories.
2) The inhibitory effect of AMCHA in vitro was far more potent than that of EACA when examined by the fibrinolytic system.
3) The inhibitory effect of AMCHA given to rabbits intravenously or orally was also more potent than that of EACA when the effect was examined by the streptokinase activation test of blood samples taken at various intervals.
4) Reversal by AMCHA of the accelerated fibrinolysis in circulatory blood produced in rabbits by streptokinase was demonstrated.View full abstractDownload PDF (641K) -
SUSUMU OSHIBA, SHOSUKE OKAMOTO1962 Volume 11 Issue 3 Pages 117-125
Published: 1962
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) Effect of AMCHA upon fibrinolysis, caseinolysis and TAMe esterolysis with plasmin was examined and compared with that of EACA. It is evident that AMCHA has inhibitory activity upon fibrinolysis with plasmin but not caseinolysis and TAMe esterolysis, and the inhibitory activity of AMCHA is approximately 5 times greater than EACA.
2) Inhibitory activity of AMCHA upon activation process of plasminogen was suggested.
3) Enhancing effect of AMCHA and EACA upon fibrinolysis with plasmin and the difference of the action of AMCHA and EACA between the effect upon fibrinolysis with plasmin and caseinolysis or TAMe esterolysis were discussed.View full abstractDownload PDF (434K) -
HITOSHI HATANO, KAZUYA YAMAMOTO, NAMIO KONO, KIICHI USUI1962 Volume 11 Issue 3 Pages 127-130
Published: 1962
Released on J-STAGE: March 27, 2009
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PRELIMINARY REPORTYUICHIRO GOTO, KEIICHI MURAKAMI, KOSUKE MORI, TOYOZO AIZAWA1962 Volume 11 Issue 3 Pages 131-134
Published: 1962
Released on J-STAGE: March 27, 2009
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CLINICAL USE OF ε-AMINOCAPROIC ACID AND AMCHA ON GLAUCOMAYASUO UEMURA, TETSUO SHIMAZAKI, SHINOBU AKIYA, ITSURO HATA1962 Volume 11 Issue 3 Pages 135-143
Published: 1962
Released on J-STAGE: March 27, 2009
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HIROSHI MIHARA, MASAMITSU TAKATAMA, YOJI YOSHIDA, HISASHI MIHARA1962 Volume 11 Issue 3 Pages 145-155
Published: 1962
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) In cases with cerebral hemorrhage, blood plasmin activity was elevated within 24 hours after the attack, but it tended to fall after 2 weeks.
2) In cases with cerebral infarction, plasmin activity was infrequently elevated even within 24 hours after the attack.
3) In cases who died from massive cerevral hemorrhage in a short time, plasmin activation was especially remarkable.
4) In cases surviving relatively long after the attack of cerebral hemo-rrhage, plasmin activity showed fluctuation.
5) In cases of cerebral hemorrhage taking a favorable turn, plasmin; value was frequently elevated within 24 hours after the attack, but restored to the normal level in about 2 weeks.
6) In cases of angiospastic encephalopathy, plasmin value was not elevated at all within 24 hours after the attack.
The mechanism of plasmin activation in cerebral apoplexy remains in obscurity in many respects on account of rapid reaction of the plasmin system, complexity of factors concerned, as well as difficulty in their assay, and must be further investigated for the elucidation. However, the results of our present study revealed that there was evident relation between cerebral hemorrhage and plasmin system, and it is considered that they will give important suggestions for the diagnosis, prognosis and treatment of cerebral apoplexy.View full abstractDownload PDF (2813K) -
GENJU OONEDA, YOJI YOSHIDA, MASAMITSU TAKATAMA, MORIE SEKIGUCHI, MAKOT ...1962 Volume 11 Issue 3 Pages 157-166
Published: 1962
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1. Hypertensive rats with surgically constricted renal arteries were sub-cutaneously given 0.5 cc of isotonic saline solution containing 1 M epsilon-aminocaproic acid (ε-ACA; an antifibrinolytic agent) daily for 7 weeks, and it was found that the development of fibrinoid degeneration in arterial wall was considerably inhibited.
2. In the ε-ACA-administered group, though the arterial intima occasionally showed severe fibrinoid degeneration, the adventitia of the arteries showed only slight cellular reaction and conspicuous fibrosis and cicatrization. Further in this group there was sometimes intimal thickening with proliferating fibroblasts and smooth muscle cells and deposited fibrinoid substance. In short, ε-ACA demon-strated an accelerating effect on the healing of arterial lesions in hypertensive rats.
3. The administration of ε-ACA remarkably depressed plasmin activity of hypertensive rats, but did not exert evident effect on blood pressure. It is consequently assumed that the inhibition of the development of arterial lesions and the acceleration of those healing by the administration of ε-ACA would be ascribed to its depressive effect on the fibrinolytic activity of blood plasma (the plasmin activity), which was considered to be one of the causes of the increased vascular permeability leading to the development of the arterial lesions.View full abstractDownload PDF (1565K) -
HITOSHI HATANO, KAZUYA YAMAMOTO, NAMIO KON1962 Volume 11 Issue 3 Pages 167-172
Published: 1962
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSIn the studies herein reported, an attempt has been made to clarify the pathological physiology of local fibrinolytic enzyme system of the skin in patients suffered from several skin diseases. The investigation was performed by the examination of antifibrinolytic activity in the extract of skin of affected area, adopting modified Sasaki's method to measure the inhibitory activity of skin extract upon the fibrinolytic activity in the extract of human maxillary sinus mucous membrane.
The experimental dermatitis, resulted from broth culture of staphylococcus aureus and sterile filtrate of staph. broth culture, in guinea pig was also examined.
The results of experiments showed the existence of anti-fibrinolytic activity in the extract of affected skin of chronic eczema, erythema exsudativum multi-forme, psoriasis vulgaris, pityriasis rosea Gibert and experimental dermatitis.
Grateful acknowledgement is made to Prof. Dr. Okamoto, Director of Department of Physiology, Division I, Kobe Medical, Colledge. The assistance of the staff of Department of Physiology, School of Medicine, Keio University, is also gratefully acknowledged.View full abstractDownload PDF (277K) -
HAJIME TAMURA, HIDEYUKI TOFUKUJI, MASAMI OGAWA, NAMIO KONO1962 Volume 11 Issue 3 Pages 173-184
Published: 1962
Released on J-STAGE: March 27, 2009
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ITTAKU MIKATA, MITSUTO HASEGAWA, TADAHIRA IGARASHI, YASUO MATSUKI1962 Volume 11 Issue 3 Pages 185-196
Published: 1962
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) Whole plasmin level in the plasma with all plasminogen activated by streptokinase was determined by measuring minimum effective dose of ε-ACA necessary to inhibit fibrinolysis.
2) Twenty five mg was determined to be M.E.D. of ε-ACA necessary to inhibit whole plasmin activity in 100 ml of plasma in normal individuals. No difference between sexes was observed.
3) The material must be examined on the day it is collected because an elevation of whole plasmin activity due to unknown cause was noted in the stored plasma.
4) The effect of ε-ACA in the plasma was immediate and sure but short acting when given intravenously, on the other hand when orally given the effect was slow but long acting (more than 3 hours).
5) The fibrinogen level decrease following administration of ε-ACA, although an increase of fibrinogen level along with decreased plasmin activity was theoretically expected.
This rather puzzling, unexpected phenomenon may indicate some dynamic and complicated relationship among plasmin, antiplasmin and fibrinogen, which is of great interest and awaits further investigation.View full abstractDownload PDF (603K)
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