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Volume 3, Issue 4
Displaying 1-4 of 4 articles from this issue
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MASAKATSU IZAKI, TOSHIKO HORIUCHI, HIDEO HOZAKI1954 Volume 3 Issue 4 Pages 163-181
Published: 1954
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSDownload PDF (4361K) -
TAKASHI HAYASHI1954 Volume 3 Issue 4 Pages 183-192
Published: 1954
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) High concentration of sodium glutamate (as well as sodium aspartate) which is applied into grey matters of motor cortex in dogs, monkeys and men, generates clonic convulsions with very short latent periods.
2) Small dose of sodium glutamate which is introduced into circulation in dogs improves the differentiation of conditioned salivary reflexes during 20 minutes after its administration, and continues its action for some hours.
3) The above two aspects of the effect of sodium glutamate must be attributable to the direct physiological action of the chemicals on the central nervoos system in higher animals.View full abstractDownload PDF (559K) -
TSUTOMU WATANABE1954 Volume 3 Issue 4 Pages 193-213
Published: 1954
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSIn studying the effect of SM on the resting cells of bacteria, no evidence was obtained which supports the specific induction of resistance by SM, because neither zero-point mutants nor end-point mutants were induced. Various facts which were thought to be explained only with the mutagenic action of this antibiotic have been shown to be more naturally explained by the spontaneous mutation with selection theory. “Relative selection” due to “relative inhibition” was emphasized in elucidating the emergence of SM-resistance in the wild population.
The experiment on the development of SM-resistance in the minimal medium made it likely that the mutagenic action of SM does not operate but that the spontaneous mutation with selection would be a sole factor.
In relation to the development of SM-resistance, the so-called, SM-resistance was classified into “SM-resistance” and “SM-indifference”, and “SM-resistant” cells were further subdivided into “dysgonic resistant” and “eugonic resistant” cells. “SM-indifference” was considered to be a specific phenomenon for SM, while “SM-resistance” was thought to correspond to the other drug-resistance. The genetic characters of these 3 types of mutants are discussed.
The author is greatly indebted to Prof. Dr. D. Ushiba for his kind sugges tions in conducting this study and for reading the manuscript of this paper.View full abstractDownload PDF (1770K) -
KENYA HORIE1954 Volume 3 Issue 4 Pages 215-228
Published: 1954
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSFrom the histologic studies in seventeen cases of lipogranuloma, two types, the typical and the atypical type, were differentiated. Among the seventeen cases, twelve cases were typical lipogranuloma cases, while five were atypical cases. The atypical lipogranuloma is characterized by its cyst formation. Some observers have the opinion that the cyst formation occur in later stages, however, in my cases, cyst formation was even found in early stages. It is considered, to the author's opinion, that the lipogranuloma with cysts should be differentiated from the typical type. Further, between these two types of lypogranuloma tinctorial differences were noticed by the lipide staining method.
The causative mechanism of the formation of lipogranuloma was considered to be not a simple one. When a certain cause, either traumatic or inflammatory, etc., happen to act in an individual with the disposition, first lesion occurs in the vessel, which leads the degeneration and necrosis of the fat tissue. The liberated fat also degenrates, however, in this case whether lipase is closely connected with this degeneration or not is not clear. Around this degenerated fat arises the productive reaction chiefly consisted of giant cells, epitheloid cells and histiocytes, and finally fibrosis occurs.
In one case bone formation was found in the wall of the cyst.
The author wish to express his gratitude to Prof. Tadayoshi Kobayashi for suggesting this investigation as well as for constant guidance in the course of the work. Thanks are also due to Prof. Yoshio Kusama for reading and revising the manuscript.View full abstractDownload PDF (3566K)
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