The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 49, Issue 3
Displaying 1-3 of 3 articles from this issue
  • Shinya Yoshikawa
    2000 Volume 49 Issue 3 Pages 99-105
    Published: 2000
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • Juanita L. Merchant
    2000 Volume 49 Issue 3 Pages 106-110
    Published: 2000
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Gastrin is one of the oldest and most actively studied of the gastrointestinal peptides. Adult expression of the mature peptide is restricted to the stomach and duodenum. However, it is antral gastrin that is subject to feedback regulation from the counter-regulatory peptide somatostatin as a function of gastric pH. Yet little is known about the molecular steps required to modulate the synthesis of this peptide. Using cell culture models, a GC-rich regulatory element called gERE has been identi-fied that binds two families of zinc finger transcription factors - Sp and ZBP. Competitive binding of these two transcription factor families in association with changes in their phosphorylation state appears to mediate the positive and negative activation of this gene in response to EGF receptor ligands. These findings contribute to our understanding of gastrin gene expression in the presence of the activated ras oncogene, e.g., during colonic transformation.
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  • Yousuke Takemura, Shogo Kikuchi, Kenichi Oba, Yutaka Inaba, Katsuya Na ...
    2000 Volume 49 Issue 3 Pages 111-116
    Published: 2000
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    This case-control study examined the relationship between the occurrence of colonic polyps in men in their fifties and the level of their physical fitness while in their thirties. The subjects consisted of 51 male Japan Self-Defense Forces officials in their fifties who had colonic polyps, as diagnosed by colonoscopic examination, and 46 control individuals. As an indicator of physical fitness between 30 and 39, we selected the best time recorded for each individual during that decade of life for the 1, 500 meter Physical Fitness Test run. We calculated the odds ratio for polyps according to selected risk factors (including physical fitness), and a logistic regression analysis was used to adjust for possible confounding variables. Odds ratio (95% confidence interval, p value) for colonic polyps with physical fitness in the thirties was 0.36 (0.16-0.82, p<0.05). With adjustment for the subjects' maximum Body Mass Index in both their thirties and fifties, and serum total cholesterol, the odds ratio was 0.39 (0.15-0.99, p<0.05). We suggest that the occurrence of colonic polyps in men in their fifties can be reduced by maintaining a high level of physical fitness while in their thirties.
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