The intensity of exercise in the therapy of diabetics is usually moderate, but from the viewpoints of ease of education and establishment of safety we are experimenting with low intensity exercise (50% anaerobic threshold: 50% AT). The purpose of this study was to investigate whether or not body fat reduction leading to improvement in insulin resistance could be realized by continuance of low intensity exercise among non-insulin-dependent diabetes mellitus (NIDDM) patients. The subjects were seven NIDDM patients. At the start of exercise an exercise tolerance test was performed on a bicycle ergometer, and after the AT value was found, a load of 50% of the AT value was computed. Then, the heart rate of steady state of 50% AT intensity exercise was found and this value was used as an intensity index in the exercise prescription. The heart rate of the subjects in 50% AT exercise was 97.9 ± 11.6 bpm. Exercise was performed twice daily at 50% AT intensity for 30 minutes, at a frequency of 5 days a week, and was continued for 4 months. In examinations before and after the 4 months exercise period %Fat and lean body mass (LBM) were measured by dual energy X-ray absorptiometry, and at the same time fasting plasma glucose, glycohemoglobinA
1C (HbA
1C), and serum lipids were also measured. As a result, after exercise the %Fat of whole body, and that of the separate regions, upper, lower extremity and trunk, were all significantly lowered in comparison with before exercise, but no significant changes in LBM were found. Fasting plasma glucose, HbA
1C and plasma free fatty acid were significantly reduced, and a significant rise in HDL-cholesterol was observed. It is thought that these facts suggest plasma glucose control was improved through insulin resistance being relieved. We have shown that low intensity exercise preserves LBM, and has the effect of reducing body fat in NIDDM patients, and have confirmed its very high effectiveness in improving insulin resistance.
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