This study examined the effect of varying upper body inclination on cerebral blood circulation in patients with acute cerebral infarction using non-invasive, near-infrared spectroscopy (NIRS) of cerebral regional oxygen saturation. The patients' results were compared to those of normal, healthy controls. The patient group included 35 acute stroke patients (mean ± SD age, 72.2 ± 10.2 years) who were admitted to the neurological department of Yokkaichi Municipal Hospital. They were selected based on the following criteria: 1) a lesion in the middle cerebral artery region; 2) a Japan Coma Scale I consciousness level. Subjects in the patient group were classified into three subgroups: 1) lacunar infarction subgroup, 12 cases; 2) atherothrombotic brain infarction subgroup, 12 cases; and 3) cardiogenic brain infarction subgroup, 11 cases. The control group consisted of 10 healthy adult volunteers (age, 71.0 ± 4.7 years) who were not using any medications. With the NIRS sensor pasted on their forehead, the subjects were placed face up on the reclining bed quietly for more than 10 minutes. Then, the reclining bed was lifted up to a 30-degree angle, then a 60-degree angle, and then finally to the upright sitting position. The NIRS data were recorded 9 times in total: immediately after each position change, 3 minutes after each position change, and 5 minutes after each position change. Differences in the cerebral oxygen saturation values between the resting state and these 9 values were then calculated. One-way ANOVA and a multiple comparison test (Dunnett's method) were used to test the statistical significance of the mean difference between the control group and the three patient subgroups. The mean NIRS value was significantly lower in the atherothrombotic brain infarction patient subgroup than in the control group. These results suggest that patients with atherothrombotic brain infarction require more careful observation than patients with other types of stroke in the acute phase.
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