The incremental shuttle walking test (ISWT) was developed for the evaluation of exercise capacity in patients with chronic obstructive pulmonary disease. A previous study reported that peak oxygen consumption (VO
2) was predictable using single regression line against the total walking distance of ISWT. However, it is still unclear whether VO
2 really increases continuously and straight linearly during ISWT since no study has measured changes in VO
2 continuously using breath-by-breath method. The purpose of this study is to determine whether peak VO
2 is predictable according to the total walking distance of ISWT. Twelve healthy men participated in this study. The ISWT and treadmill-walking test using same protocol of ISWT were performed at random. The VO
2 was continuously measured using breath-by-breath method with a portable gas analyzer (AT-1100, Anima, Co., Japan) during ISWT. Straight linear increase in VO
2 both against the total walking distance of ISWT and against the total walking time of ISWT were evaluated using a single regression analysis, and predicted peak VO
2 was calculated. Finally, the measured peak VO
2 was compared with the calculated values. Measured peak VO
2 showed only 1 ml/kg/min difference from the predicted peak VO
2 against the total walking distance. Measured peak VO
2 was 1 Met or significantly higher than the predicted peak VO
2 against the total walking time. In conclusion, peak VO
2 of ISWT was predictable using single regression line against the total walking distance of ISWT in normal subjects. Further study to determine the predictability of peak VO
2 of the ISWT is necessary before implementation to patient population.
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