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Volume 19, Issue 6
Displaying 1-9 of 9 articles from this issue
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[in Japanese], [in Japanese]1978 Volume 19 Issue 6 Pages 761-776
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (3052K)
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[in Japanese]1978 Volume 19 Issue 6 Pages 777-784
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (747K) -
[in Japanese]1978 Volume 19 Issue 6 Pages 785-791
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (577K)
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Yasuhiko MIYASAKA, Makoto NISHINOBU, Kunio KANAMORI, Shoji ZAKOJI, Yum ...1978 Volume 19 Issue 6 Pages 829-835
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA new aspiration-biopsy instrument for bone marrow was devised and experiences of clinical application were reported. 35 cases of bone marrow examination in hematological and nonhematological disorders involving 12 “dry tap” cases were studied. 68 trials of bone marrow biopsy on 35 cases were performed. Sufficient specimens were obtained in all cases. They were 2 mm in diameter and ranged from 0.3∼2.5 cm in length. (average length 1.2 cm). 66 out of 68 specimens (97%) were considered as good materials for histological evaluation except 2 specimens which were moderately crushed. The merits of a new aspiration-biopsy instrument were as follows:
1. This needle were well evaluated not only for diagnosis of hematological and nonhematological disorders, but also for the study of haematopoietic activity and the staging of malignant lymphoma. By this method, cell and tissue examination could be performed simultaneously.
2. As this method was being used for biopsy in the case of “dry tap”, there was few damage on the patient's side.
3. Having the stopper and the graduation attached to the complementary tube, this instrument could be used with safety.
4. The outer needle was modeled according to the volume of old aspiration instrument.
5. The outer needle was so easily removed that we could change it for another one, when damage of tip was found.
6. The outer needle was able to being attached to the transfusion set, so that both infusions and blood transfusions could be carried out.View full abstractDownload PDF (1018K)
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Katsuo KOIE, Kanzi OGATA, Junzo ISHIGURO, Tadashi KAMIYA, Kiichi ASAI1978 Volume 19 Issue 6 Pages 836-843
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSCase 1: A boy, born in 1960, was referred to us in 1969 because of a painful swelling of the left thigh due to intramuscular bleeding. The first bleeding episode was umbilical bleeding at 7 days of age. The family history was negative for bleeding tendency, although the maternal grandfather and grandmother were first cousins. Routine hemostatic tests revealed no abnormalities except moderately shortened plasma euglobulin lysis time and mildly abnormal “ma” and “k” values in thrombelastogram. The plasma clot solubility test both in 5M urea and in 1% MCA was positive and the level of plasma FSF was less than 1% of normal. These levels of the elder brother, parents and the maternal grandmother were from 25 to 50% of normal. In 1970 he was hospitalized because of subarachnoidal bleeding, when the plasma FSF level was maintained with plasma infusion in from 3 to 12% of normal for the following one month, and he was recovered without any neurological sequelae.
Case 2: A girl, born in 1966, was first seen by us in 1972 because of repeated episodes of hematoma and ecchymosis following minor traumas. Although her elder sister died at the age of 8 months from subdural hemorrhage, the other members of the family were non bleeders. The umbilical bleeding was the first episode of bleeding and she was operated for subdural hematoma at the age of 10 months. The plasma clot solved completely in a few minutes both in 5M urea and in 1% MCA and the level of plasma FSF was less than 1% of normal in the patient and from 30 to 50% in the parents.
In the solid phase immunoradiometric assay using anti-F. XIII subunit A serum, nearly normal level of FSF-like substance was measured in case 1 and 20% in case 2.
The concentrated F. XIII preparation (Factor-XIII-Konzentrat, Behringwerke, AG) was infused and evaluated in each patient. The infusion of the preparation (25 units/kg of body weight) yielded the rise of about 40% in plasma FSF activity and the half-life in vivo was estimated to be 7 days. The clinical hemostatic effect seemed to continue much longer.View full abstractDownload PDF (666K) -
Kazuo DAN, Shinichiro KURIYA, Yoshiki MATSUI, Hideki KUDO, Kenichi KAW ...1978 Volume 19 Issue 6 Pages 844-849
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA rare family was reported where acute leukemia developed in three members over a period of 7 years. Case 1, a 59-year-old man, was diagnosed to have acute myeloblastic leukemia in June, 1959. Case 2, a daughter of the patient in case 1, was hospitalized with complaints of fever, malaise and petechiae at the age of 29 years, and the diagnosis of acute lymphoblastic leukemia was made in January, 1976. A thorough taking of the family history disclosed another case of leukemia in a distant relative, a son of the niece of case 1, where acute myeloblastic leukemia occurred in December, 1970. There existed no evidence of consanguinity in this family. Cases 1 and 2 had lived in the same house until the occurrence of leukemia in case 1, while case 3 lived in a different location. Common environmental factors such as ionizing radiations and toxic chemicals could not be detected among the three cases. The occurrence and significance of familial leukemia in relation to pathogenesis of leukemia were discussed.View full abstractDownload PDF (550K) -
1st Report—120,000 I. U. Administrated—Senji FUJITA, Takashi ITOGA, Tadaharu SHOU, Hidemitsu YAMAMOTO, Hisash ...1978 Volume 19 Issue 6 Pages 850-858
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThree patients with cerebral infarction were admitted to Municipal Nagasaki Hospital during December 1, 1976 to February 21, 1977 and treated with urokinase starting within 72 hours after first symptoms. Each case was administrated 120,000 international units of urokinase over two to six hours by means of dripping infusion and this therapy was performed for three to seven days. Two of them were administrated heparin for two or three days after urokinase therapy. This therapy induced shortened Euglobulin Clot Lysis Time, increase of fibrinolytic activities, decrease of plasminogen, plasmin inhibitor and antithrombin III during urokinase therapy. After stopping urokinase therapy, significant increase of plasma fibrinogen, delayed Euglobulin Clot Lysis Time and increase of α1-Antitrypsin were revealed comparing with prior tests to therapy. Clinically, disturbance of consciousness disappeared in all cases, but motor paralysis continued for thirty-one hospital days.
However, urokinase therapy could not invite significant effectiveness for cerebral infarction clinically, although laboratory data showed enhanced fibrinolytic activity, no bleeding tendency was found during urokinase therapy in all cases.
Further trials with urokinase on cerebral infarction are expected to bring more information for promoting its effectiveness on cerebral vascular disturbance.View full abstractDownload PDF (657K) -
Masahide KOBAYASHI, Hisamitsu SUZUKI, Yukio KATO, Yasuo MORISHIMA, Kan ...1978 Volume 19 Issue 6 Pages 859-866
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSTwo young female patients with severe anorexia nervosa (cases K. O. and T. U.) who had moderate pancytopenia were studied.
The peripheral hematological examination revealed normochromic anemia (248x104/cmm, 277x104/cmm), granulocytopenia (1071/cmm, 1255/cmm), lymphopenia (1071/cmm, 1225/cmm) and moderate thrombocytopenia (12.4x104/cmm, 15x104/cmm). In case K. O. a large number of spur-shaped erythrocytes were observed on the smears of the peripheral blood.
In both cases bone marrow aspiration and biopsy revealed a large amount of sticky gelatinous material. It was suggested to be acid mucopolysaccharide histochemically as described by H. A. Pearson.
The hematopoietic cells were scattered in clusters and histiocytes containing ceroidlike pigments were also seen. Bone marrow differentials showed a decrease in myeloid series and megakaryocytes but erythropoiesis did not seem to be so suppressed as other cell series.
In hemostatic tests euglobulin lysis time was shortened and a slight decrease in factor VIII and prothrombin was observed.
The more detailed studies performed in case K. O. were as follows: 1) Mean red cell survival studied with DF32P was reduced (61 days). 2) A normal total red cell volume expressed in terms of body weight was seen with an increase in total plasma volume. 3) Plasma iron disappearance time and red cell utilization were normal and plasma iron turnover was accentuated. 4) Whole body scan at 5 to 24 hours after injection of 59Fe, which reflects the erythropoietic marrow distribution, demonstrated normal peaks in the sternum and pelvis and an increased uptake in the mid vertebrae. An increased uptake in the spleen at 10 days suggested hemolysis in the circulation.
In case T. U. the pripheral blood picture recovered to the almost normal level along with the improvement of appetite four months later.
The pathogenesis of these various hematological abnormalities in patients with anorexia nervosa remains to be elucidated.View full abstractDownload PDF (735K) -
Kanji SATO, Yasuo IMAI, Muneaki TAKAYASU, Takeshi TANGE, Yukio IMAMURA1978 Volume 19 Issue 6 Pages 867-874
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 74-year-old male with multiple myeloma (Ig G, κ-type) was treated with cyclophosphomide and prednisolone with a good clinical response. Fourteen months later the same treatment was repeated with moderate response. Sixteen months after the initial therapy, the patient developed cramping abdominal pain, nausea and vomiting. Physical examination revealed a hard, tender mass in the right costal margin which developed rapidly in size. The patient developed severe jaundice and died of massive hematemesis seventeen months after the initial presentation.
At autopsy, there was a huge tumour mass around the omentum (18×13×9cm), which extended directly to the duodenum, pancreas, bile ducts, gallbladder, and stomach. The common bile duct was encased and compressed by the surrounding tumour, causing complete obstructive jaundice, although the duct was anatomically patent. In the stomach there wer two ulcers (2×2cm, 3×4cm), the basis of which was infiltrated by plasma cells.
Histologically, the myeloma cells were characterized by small and middle-sized plasma cells which showed considerable pleomorphism with many atypical and giantnucleated cells, especially in the extraskeletal lesion.View full abstractDownload PDF (1163K)
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