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Volume 19, Issue 9
Displaying 1-14 of 14 articles from this issue
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[in Japanese]1978 Volume 19 Issue 9 Pages 1171-1178
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (652K)
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Kozo NISHIMURA, Aki HIBI, Yukio SAITO, Kiyotaka NAKAJIMA, Ryota HOSOYA ...1978 Volume 19 Issue 9 Pages 1179-1185
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThis is to report the results of granulocyte transfusion by continuous flow filtration leukapheresis (CFFL) using Japanese-made pump and filter performed at our department. About 3,000 to 5,000ml of donor blood was filtered for a period of 2 hours. Average number of granulocytes collected was 0.81×1010, and the recovery rate was 49.1%. When transfused to leukemic children with intractable infection, average increment of granulocyte was 687/mm3 and defervescence was noted as an effect. Complaints of note were seen in neither recipients nor donors. When plasma content in eluting fluid was raised from 15% to 30%, vacuolar degeneration of granulocytes was decreased. Shortening of granulocyte adherence to the filter and improving the quality of filter are needed in order to improve function of collected granulocytes.View full abstractDownload PDF (846K) -
Part 2 Serial Transplantation of a Japanese Burkitt Lymphoma Cell Line in HamstersHirofumi KISHIMOTO1978 Volume 19 Issue 9 Pages 1186-1191
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSAn EB virus genome-free Japanese Burkitt lymphoma line (JBL) was intraperitoneally transplanted for ten serial passages in newborn Syrian hamsters treated with antilymphocyte serum. All the recipient hamsters developed invasive tumors and massive ascites. This hamster-passaged line maintained a characteristic starry sky pattern closely resembling that of the human biopsy material. Some of these animals developed not only bone marrow invasion but also a leukemic blood picture. Since the JBL line was converted to an ascitic form, its serial passage was greatly facilitated.View full abstractDownload PDF (784K) -
Yasunari NAKATA, Taisuke ONOSHI, Kenta TAKASUGI, Akira MIYATA, Osami K ...1978 Volume 19 Issue 9 Pages 1192-1197
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSEmploying a mixed rosette method, the proportion of peripheral lymphocytes, which bear both complement receptor and capacity of binding to sheep erythrocytes (D-lymphocytes), was determined in healthy persons and patients with various disorders.
The mean percentage value and the number for D-lymphocytes in peripheral blood of healthy persons were 1.3±0.4% (M±SD), 25.5±11.3/cmm, respectively. An increased percentage of D-lymphocytes was observed in 9 of 24 patients (37%) with bronchogenic carcinoma, 1 of 7 sarcoidosis (14%), 1 of 5 idiopathic thrombocytopenic purpura (20%), 11 of 29 malignant lymphoma (38%), and 2 of 3 thymoma (66%). D-lymphocytes in atypical pneumonia, Crohn's disease and chronic lymphocytic leukemia were within normal range as compared to normal subjects. An increased absolute number of D-lymphocytes was found in 4 of 24 patients (16%) with bronchogenic carcinoma, 5 of 29 malignant lymphoma (17%), 2 of 3 thymoma (66%), and 1 of 2 chronic lymphocytic leukemia (50%).
There was no significant correlation between the number of D-lymphocytes and the clinical stage, or the histological type of these diseases. No effect of anticancer combination chemotherapy on the absolute number of D-lymphocytes was found in the patients with bronchogenic carcinoma.View full abstractDownload PDF (468K)
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Haruya YOSHIKAWA1978 Volume 19 Issue 9 Pages 1198-1203
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA case of acute erythroblastopenia with vascular purpura and neutropenia is presented.
The 11-year-old boy was consulted to the hospital with purpura and persisted fever by upper respiratory infection, for which he had received no known potentially toxic drugs. He was a well-developed, well-nourished boy in rather good health. Petechiae and purpuric spots were present over the body, which were attributable to vascular fragility by hemostatic tests. The initial hematological examination showed hemoglobin, 14.5g/dl; red blood cell count, 519×104/cmm; reticulocyte, 0.1%; platelet count, 18.1×104/cmm; white blood cell count, 2,800/cmm with 22% neutrophils. Sternal marrow aspiration revealed decreased cellularity with almost complete absence of all erythroid elements, the presence of rare giant proerythroblasts and maturation arrest of granulopoiesis. X-ray films of the chest showed no abnormalities. Oral penicillin was instituted and fever dropped immediately. Then, purpura dissappeared and the white blood cell count increased gradually. On the other hand, anemia was not so accenturated. On the eighth day, the bone marrow revealed erythroid hyperplasia.
In this patient, infection by beta-hemolytic streptococci or viruses was not revealed and autoimmune-disturbarnce was also not showed by laboratory examinations.View full abstractDownload PDF (881K) -
Masayoshi NISHIDA, Takayuki IWANAGA, Kiyohiro IRIMAJIRI, Atsushi HORIU ...1978 Volume 19 Issue 9 Pages 1204-1210
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 36-year-old man was transfered to Kinki University Hospital with complaints of splenomegaly, motor and sensory dysfunction of lower extremities.
The leukocytosis of this patient was pointed out five years previously in another hospital when he was treated with duodenal ulcer. The diagnosis of CML with Ph1 positive chromosome was made and he was treated with Busulfan intermittently. Two years before admission a gastrojejunostomy was performed because of the perforation of duodenal ulcer. Five months before entry motor and sensory disturbance of lower extremities and incontinence developed abruptly and he was readmitted to the Kansai Denryoku Hospital. Partial obstruction of the Th6 myeloid cavity on myelography and marked splenomegaly were observed. He was treated with VEMP to the blast crisis of CML. Thereafter neurologic findings disappered gradually and he was transfered to our hospital on March 25, 1977. Patient was chronically ill and splenomegaly was presented. Hematological findings were as follows; Hb 5.1g/dl, WBC 19,500 with 37% myeloblast, and 1.5% eosinophils, erythroblast 31/200, platelet 4.0×104, NAP score 206. Bone marrow; cc 22.1×104, myeloblast 14%, erythroblast 63.4% with 37.6% immature erythroblast in Wright-Giemsa staining, Peroxidase (-), PAS (+). The patient was treated with MTX and blood transfusions, subsequently immature erythroblast in bone marrow decreased to 6%, but rose to 42.5% thereafter. Patient died on 33th hospital day inspite of intensive chemotherapy and supportive therapy.
At autopsy, bone marrow and lymph nodes were extremely infiltrated with blast cells and eosinophils. Spleen was markedly enlarged (1,500g) due to moderate cell infiltration. Spinal cord showed no infiltration of blast cells.View full abstractDownload PDF (799K) -
Kazumi MATSUMOTO, Toshimitsu TAYA, Kenichi KAWADA, Nozomu AOKI1978 Volume 19 Issue 9 Pages 1211-1216
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 21-year-old housewife was admitted to the hospital with complaints of fever, petechiae and gingival bleeding and swelling on 17 July 1975. The diagnosis of acute promyelocytic leukemia was made based on the proliferation of atypical promyelocytes in the peripheral blood and bone-marrow, severe hemorrhage and mild hypofibrinogenemia. A complete remission was obtained by daunorubicin 6 weeks after the start of the chemotherapy. The remission was maintained by oral 6-mercaptopurine. In December 1975, multiple greenish-brown nodules developed on her anterior chest wall, and gradually spread to the back and head. In addition, indurations were noted in both breasts. Biopsy of a skin nodule showed a massive infiltration of leukemic cells. There was no evidence of relapse either in the peripheral blood or bone marrow at this stage of the disease. The extramedullary infiltration responded excellently to the daunorubicin therapy to leave only skin pigmentation and dysfiguration of the breasts. In August 1976, hematologic relapse occurred, and the patient died of massive gastrointestinal hemorrhages despite intensive chemotherapy on 21 September, 1976.View full abstractDownload PDF (635K) -
Jun OKAMURA, Yoshiko IKUNO, Hideko TASAKA, Yasunori KOTOO, Kunihiro NI ...1978 Volume 19 Issue 9 Pages 1217-1225
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA case of T-cell type lymphoma in a 14-year-old Japanese boy, born in Kyushu, is reported. The patient had chief complaints of cough and fever of unknown origin for 5 weeks and developed dyspnea.
On admission, he was found to have splenomegaly and one metastatic skin nodule on the abdomen. Chest x-ray showed a huge mediastinal mass with pleural effusion, bilaterally. Microscopically, tumor cells in the pleural fluid were lymphoblastic and some of them had convoluted nucleus. They showed strong focal acid phosphatase reactivity.
Diagnosis of malignant lymphoma, lymphoblastic was established by the biopsy of the skin nodule. He obtained complete remission with radiation therapy and combination chemotherapy. However, he became leukemic in 3 months, developed CNS involvement in 7 months and died in 7 1/2 months after diagnosis in spite of various kinds of combination chemotherapy.
The surface marker study of tumor cells in the pleural fluid, bone marrow and CSF revealed that they had receptors for both sheep erythrocytes (sE) and mouse complement (C3b). Surface immunoglobulin was negative. Adenosine deaminase level in tumor cells was elevated.View full abstractDownload PDF (1451K) -
Naokazu NUNOUE, Kimihiro KITAMURA, Shigeru TOMOYASU, Yoji ASANO, Shini ...1978 Volume 19 Issue 9 Pages 1226-1233
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSMany cases of acute myelogenous leukemia (AML) antedated the preleukemic phase have been reported in the literatures. We happened to experience a case of AML preceded by preleukemic phase, which developed during admission because of fibrinous bronchitis. A 41 year-old man was admitted to our hospital because of fever and recurrent attack of dyspnea with expulsion of bronchial casts, that lasted for several months. A diagnosis of fibrinous bronchitis was made. About a month after admission, a few abnormal leukocytes appeared in the blood smear. Bone marrow aspirates revealed as follows: NCC 17.3×104/cmm, Mbl 45.4%, ProM 12.8%.
Finally, a diagnosis of AML was confirmed. Careful review of the blood count from the onset of fibrinous bronchitis to the clinical manifestation of AML revealed progressive anemia with anisopoikilocytosis, and an episode of thrombocytosis, monocytosis and reticulocytosis of unknown cause.
The hematologic abnormalities antedated the development of AML were considered to be preleukemia as compared with the reported cases in the literatures. This paper, also, dealed with fibrinous bronchitis, a rare disease, of one case.View full abstractDownload PDF (722K) -
Nobuaki IWATA, Mitsuhiro OMINE, Jun TSUCHIYA, Tadashi MAEKAWA1978 Volume 19 Issue 9 Pages 1234-1240
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 27 year-old man who had been exposed to benzene for 8 years, was admitted with a diagnosis of aplastic anemia. The treatment with testosterone and oxymetholone achieved the hematological remission 6 months later. He resumed to use benzene because of occupation. Anemia and hemorrhagic diathesis recurred three years afterwards. On readmission mild lymphadenopathy, but no hepatosplenomegaly was noted. In addition to severe anemia and thrombocytopenia, a small number of myeloblasts and atypical monocytes were observed in the peripheral blood smear. Biopsy specimen of the bone marrow, which could not be aspirated, demonstrated a marked increase of fibrous tissue. A diagnosis of AML with bone marrow fibrosis or acute myelofibrosis was suspected at that time. In the later course, hepatosplenomegaly appeared gradually and the atypical immature granulocytes increased in the peripheral blood, terminating in an overt AML 1 year after the second admission. Autopsy revealed the hypercellular bone marrow infiltrated with leukemic cells. It is suggested that the prolonged exposure to benzene may play some causal role in the development of aplastic anemia and the subsequent transformation into AML associated with myelofibrosis.View full abstractDownload PDF (1104K) -
Tadako NAKATSUJI, Susumu ODA, Hiroshi FUJITA, Noboru MATSUMOTO, Shiro ...1978 Volume 19 Issue 9 Pages 1241-1246
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSTwo cases of so-called march hemoglobinuria caused by “kendo” exercise were described and the mechanism of hemolysis was discussed. Two 15-year-old high schoolboys had episodes of passing dark brown urine in April 1977 after an exercise of “Kendo.” They had further attacks of hemoglobinuria during these two or five months.
They showed no abnormalities in physical and laboratory examinations. A hemoglobinuria was proved after an exercise of “fumikomi” for one or one and a half hours, and an increase in serum hemoglobin level was observed prior to hemoglobinuria.
The medical students, who belong to “kendo” club and had noticed hemoglobinuria by themselves, played “kendo” for one hour, and mild hemoglobinemia was found in these students.
It is suggested that “kendo” exercise can produce traumatic damage to erythrocytes to a certain extent even in normal individuals.View full abstractDownload PDF (625K) -
—The Clinical and Laboratory Studies of Sixteen Cases—Akira KANETO, Teruhito KOGA, Yutaka SHIMOKAWA, Kyuichi TANIKAWA1978 Volume 19 Issue 9 Pages 1247-1255
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThe clinical and laboratory studies were made in 16 cases with pernicious anemia, which were diagnosed during recent 9 years at Kurume University Hospital and affiliated hospitals.
The average age of onset was 60.0 year-old, ranged from 36 to 71, and sex distribution was equal.
Soreness of the tongue and graying and whitening of the hair appeared in the early stage before anemia was present and were most frequent physical findings.
The serum parietal cell antibody was positive except one and IF blocking antibody was present in 12 to 15 patients (80%).
Family study in one of these 16 cases revealed that the patient's mother was positive for antibodies to parietal cell, intrinsic factor and thyroid microsome with achlorhydria but not anemic, and one of the patient's brothers positive for parietal cell antibody with achlorhydria. These results were suggestive of familial associations and importance of genetic factors in pernicious anemia.View full abstractDownload PDF (635K)
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1978 Volume 19 Issue 9 Pages 1256-1263
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (704K) -
1978 Volume 19 Issue 9 Pages 1264-1289
Published: 1978
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (2532K)
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