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Volume 20, Issue 5
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1979 Volume 20 Issue 5 Pages 457-461
Published: 1979
Released on J-STAGE: January 19, 2009
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[in Japanese]1979 Volume 20 Issue 5 Pages 462-475
Published: 1979
Released on J-STAGE: January 19, 2009
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]1979 Volume 20 Issue 5 Pages 476-484
Published: 1979
Released on J-STAGE: January 19, 2009
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Hajime NASU, Haruaki WARABI1979 Volume 20 Issue 5 Pages 485-490
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSImmunochemical properties of pyroglobulin in a myeloma patient were analyzed by the following procedures; immunoelectrophoresis, gel fractionation and ultracentrifugation. IgG (L) pyroglobulin was found in a male patient, 54-year-old with plasma cell leukemia.
After centrifugation with 14,000g at 4°C for 30 minutes, the amount of immunoglobulins in the supernatants of both heated and unheated serum was measured by radial immunodiffusion. The amount of pyroglobulin was defined as deducted value of immunoglobulin in the supernatant of the heated serum from that of the unheated. A large amount of IgA and IgM was precipitated with IgG myeloma protein at 56°C. (Table)
By the fractionation procedure with Sephadex G 200 column and ultracentrifugation it was determined that IgG myeloma protein was composed of IgG monomers with sedimentation coefficient of 8.5 S. (peak-I, Figs. 2a, 4 and 5)
Turbidity of the fractions after heating was measured by a spectrophotometer at 400 nm in optical density which was a proper wave length for turbidimetry (Figs. 2b and 3). These data revealed that peak-I had the characteristic of forming precipitates at 56°C for 30 min. and peak-II formed precipitates at 60°C for 30 min. Large molecular IgG (peak-I) could form pyrogel easier than monomer IgG (peak-II).
This was the first report that a least two types of pyroglobulin, precipitating at different temperatures, were detected in a single case.View full abstractDownload PDF (569K) -
Yasuyuki ENDO, Keiko TAKAHASHI, Maki SATO, Shigeo MAMIYA1979 Volume 20 Issue 5 Pages 491-499
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSAn investigation was made of the effect of Diltiazem, a drug used for ischemic heart diseases, on platelet function and the following results have been obtained:
1. Diltiazem suppressed platelet adhesiveness and aggregation in vitro at concentrations greater than 100 μg/ml, but in vivo this effect was not pronounced at the normal doses investigated here. It was thought that this discrepancy was due to the difference in concentration of the drug in blood.
2. Doses of Diltiazem greater than 100 μg/ml were capable of suppressing aggregation even with the addition of various inducers, including ADP, collagen, adrenalin, thrombin, bovine fibrinogen, arachidonic acid and CaCl2.
3. The suppression of aggregation by this drug was due to its blocking action on phosphodiesterase, which caused an increase in cyclic AMP.
4. There was a discrepancy between the concentration of this drug needed for a suppression of Aa-induced platelet aggregation and a decrease of malondialdehyde synthesis. Aa aggregation suppression was not caused solely by the inhibition of the production of endoperoxide, but rather through the action of cyclic AMP.
5. Diltiazem had no effect on platelet aggregation through extracellular Ca concentrations.View full abstractDownload PDF (574K) -
Shin ISHIMARU, Masaki KONISHI, Kinichi FURUKAWA, Masatoshi TAKAHASHI, ...1979 Volume 20 Issue 5 Pages 500-509
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSChanges of blood coagulation system during defibrinogenation therapy with batroxobin were investigated on 18 patients suffered from thrombo-embolic disorders (DVT, ASO, TAO, CAT, etc.).
Five patients were treated with Bothrops atrox marajoensis and the other 13 patients were treated with B. atrox moojeni. Batroxobin was given in doses of 0.6 to 2.3 PCU/kg as intravenous infusion for 2 to 4 hours. Nine out of 18 patients were treated with batroxobin and urokinase. On 7 out of the other 9 patients, surgical procedure was performed during defibrinogenation therapy.
Red blood cell, hematocrit, platelet counts and coagulation factors (II, V, VII-X, VIII, IX) were unchanged. Plasma fibrinogen concentration decreased to 133±46 mg/dl in B. marajoensis treated patients, and to 55±28 mg/dl in B. moojeni treated patients. Prothrombin time was prolonged at a fibrinogen level of below 100 mg/dl. Platelet adhesion to glass and ADP induced platelet aggregation were not changed.
It was concluded from these results as follows:
1) Batroxobin from B. moojeni induced longer lasting defibrinogenation than B. marajoensis. And approximately 400 mg/dl of fibrinogen could be broken down per 1 PCU/kg of B. moojeni.
2) Decreased fibrinogen concentration returned to normal limits 6 to 8 days after termination of the treatment.
3) Platelet function was not influenced by the decreased fibrinogen concentration.
4) No bleeding and thrombo-embolic complications were observed in all patients.View full abstractDownload PDF (640K) -
Michio TAKI, Shin SHIMIZU, Shin OHASHI, Keiko IGUCHI, Yasuo TANIMOTO, ...1979 Volume 20 Issue 5 Pages 510-518
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSLeukoencephalopathy is one of the most ominous complications of acute lymphoblastic leukemia in children under modern intensive treatments. During past 3 years, two of 31 children with ALL had developed typical leukoencephalopathy. The first case was seen in a 12-year-old boy, and 2nd case in a 4-year-old boy. The first one had died and the diagnosis was confirmed by autopsy. The extensive demyelinization, obliteration of axon, and necrotic areas were observed in the entire white matter. The calcification was also noted. The 2nd patient is now in the debilitated condition. The initial symptoms of leukoencephalopathy in those two cases appeared rather suddenly, after serial intrathecal instillation of MTX, CA and steroid, which was given in the combination for the second burst of CNS leukemia. Therapeutic cranial irradiation was also given in both cases for the first CNS leukemia. On CT scan, a distinct low density was seen over the area of white matter, when symptoms appeared.
As compared with 7 children, who had developed CNS leukemia, the intrathecal administration of MTX was carried out more frequently during shorter period, 25 times during 11 months in the first case and 24 times during 20 months in the second case.
From our limited experience, it was concluded that the dose and interval of intrathecal MTX administration might hold a major key for the development of leukoencephalopathy. The pharmacokinetic studies of MTX was thought to be mandatory, especially when it was administered intrathecally to the children at the time of cranial irradiation. It was also recommended to carry out periodical CT scan survey for the early diagnosis of leukoencephalopathy.View full abstractDownload PDF (1214K)
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S. ARAKAWA, S. IMASHUKU, S. TODO, T. TAKAMATSU, T. SAWADA, M. MIYAKE, ...1979 Volume 20 Issue 5 Pages 519-527
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSWe report a 5 year-old-boy with neurofibromatosis who developed juvenile chronic myelocytic leukemia (CML). Blastic transformation to acute erythroleukemia was seen after 3 months' busulfan therapy and he died 2 weeks later.
This case is interesting in two points. First, missing Y chromosome was found in his bone marrow cells. Like some reported cases of Ph1-positive CML with missing Y chromosome, blastic crisis of this case could not be prevented with busulfan. We assume, therefore, that missing Y chromosome does not indicate a good prognosis in juvenile CML as in Ph1-positive CML. Second, he had many café-au-lait spots in various sizes and a family history of neurofibromatosis in his father.
We await evaluable numbers of concomitant occurrences of neurofibromatosis and leukemia to make sure whether neurofibromatosis has a high risk for leukemia.View full abstractDownload PDF (1380K) -
Hajime NAKAZAWA, Keisuke TOYAMA, Tetsuhei OGAWA, Masayoshi NEGISHI1979 Volume 20 Issue 5 Pages 528-534
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 69-year-old woman first admitted to the Keio University Hospital on May 1, 1975, for the further examination of leukocytosis. On admission, her hemoglobin was 11.3 gm/dl, reticulocytes 8‰, platelets 19.2×104/mm3, WBC 27,700/mm3 with 88.5% of lymphocytes. Her bone marrow smear revealed 47.4% of lymphocytes. From these data the diagnosis of CLL was made. During the examination without treatment severe anemia of hemoglobin 6.1 gm/dl suddenly appeared. Positive direct Coombs test, elevated reticulocytes (74‰), increased serum bilirubin, markedly decreased haptoglobin, and increased LDH (especially LDH1) led to make the diagnosis of AIHA. Anemia was improved by the administration of prednisolone. Although she developed the second and the third attacks of hemolysis in June, 1976, and in April, 1977, anemia was ameliorated with an increase of prednisolone and an addition of azathioprine. To our knowledge, our case was the fourth case of CLL complicated with AIHA in Japan. It is also very interesting in the view point of genetic predisposition of lymphocytic malignancy that her sister died of malignant lymphoma.View full abstractDownload PDF (466K) -
Michiyo IKEDA, Kazuo KUBOTA, Yoshitomo MUTO, Hideaki MIZOGUCHI, Shinob ...1979 Volume 20 Issue 5 Pages 535-540
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA 27 year-old female patient was admitted to our hospital because of right cervical tumor. Physical examinations revealed right and left cervical lymphadenopathy. A roentgenogram of the chest disclosed a right anterior superior mediastinal mass. From the histological examination of right cervical lymph node biopsy specimen, she was diagnosed as having Hodgkin's disease of nodular sclerosis. From the findings of 67Ga-scintigram, 201Tl-scintigram and lymphangiography, she was considered to be at the clinical stage II-A. Thirty nine days after initiation of mantle field radiation therapy, when 3,060 rad had been delivered to the tumor area, she had an episode consisting of disturbance of consciousness, precordial oppression, cyanosis, tremor and weakness of extremities. ECG revealed T wave inversions in leads V3 and V4 and depressions of ST segment in leads I, II, aVF, V5 and V6. Other examinations revealed no abnormalities. The symptoms disappeared about three weeks later and the radiation therapy was completed without the recurrence of the cardiovascular symptoms. The deeply inverted T waves in leads V1 and V2, however, remained even at the termination of the radiation therapy. The symptoms and ECG changes were thought to have been induced by the irradiation.View full abstractDownload PDF (572K)
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1979 Volume 20 Issue 5 Pages 541-560
Published: 1979
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (1969K)
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