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Volume 51 (1989)
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Volume 51, Issue 1
Displaying 1-21 of 21 articles from this issue
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Yukihiko HAGIWARA, Yukiko SUZUKI1989 Volume 51 Issue 1 Pages 1-9
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSIn the experiments reported here, we investigated chlorpromazine (CPZ)-induced enhancement of the cat cerebellar potentials evoked by peripheral nerve stimulation, with regard to the subtypes of adrenoceptor in the nucleus reticularis lateralis (LRN). Electrical stimulus of the locus coeruleus (LC) at high frequencies enhanced cerebellar potentials evoked by peripheral nerve stimulation. Although similar stimulus increased them after pretreatment with an α2-antagonist, yohimbine, these enhancements were not recognized by pretreatment with an α1-antagonist, prazosin. Microinjection of norepinephrine (NE: 10 μg) into LRN decreased cerebellar potentials, and conversely, 30 μg of NE significantly increased them. Although microinjection of an α2-adrenoceptor agonist, clonidine, into the LRN depressed cerebellar potentials, clonidine-induced decrease was obviously antagonized by pretreatment with CPZ. Furthermore, an α1-adrenoceptor agonist, phenylephrine, into the LRN increased cerebellar potentials. Pretreatment with CPZ hardly changed phenylephrine-induced enhancement. We thought that CPZ blocked α2-autoreceptors in adrenergic terminals from the LC rather than α1-adrenoceptors within the LRN. As a result, NE released from the LC terminals may act on α1-adrenoceptors in the LRN and may attenuate activities of the LRN. Therefore, it was clear that previous CPZ-induced enhancement may be due to depression of the descending inhibitory adrenergic system via CPZ-induced blockade of α2-autoreceptors.View full abstractDownload PDF (481K) -
Takeshi MIYATA, Nobuteru MATSUMOTO, Hidenobu YUKI, Yoshiaki ODA, Kazuo ...1989 Volume 51 Issue 1 Pages 11-15
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effects of atropine, ipratropium and oxitropium on the mucociliary clearance were studied in pigeons and rabbits. The normal mucociliary transport (MCT) in pigeons was inhibited after the treatment by any of the three drugs at concentrations of 10-4 to 10-3 g/ml. These three drugs markedly inhibited eserine-induced MCT acceleration at a lower concentration than ACh-induced acceleration. The normal airway secretion was inhibited only by atropine in rabbits. The results indicate that neither oxitropium nor ipratropium depress the normal mucociliary clearance, but atropine may depress it under some conditions. Additionally, we suggest that these anticholinergic drugs might selectively affect the mucociliary transport modulated by endogenous ACh.View full abstractDownload PDF (277K) -
Hideki TAKASE, Katsue IMANISHI, Osamu MIURA, Eizaburou YUMIOKA1989 Volume 51 Issue 1 Pages 17-23
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSWe investigated the involvement of sulfhydryl-compounds in the cytoprotective effect of Oren-gedoku-to (OGT) against ethanol-induced gastric lesions and potential difference (PD) reduction in comparison with those of sucralfate and glutathione in rats. Pretreatment with indomethacin (IND) had little influence on the cytoprotective effects of OGT and glutathione, but attenuated the effect of sucralfate. Pretreatment with N-ethylmaleimide (NEM) blocked the cytoprotective effects of these three drugs. Pretreatment with iodoacetamide diminished the cytoprotection of OGT and glutathione, but had little effect on that of sucralfate. The cytoprotective activities of OGT, glutathione and sucralfate were little affected by pretreatment with 6, 6'-dithiodinicotinic acid. The inhibitory effects of OGT and glutathione against the PD reduction were completely blocked by pretreatment with NEM, while they were not influenced by pretreatment with IND. On the other hand, the inhibitory effect of sucralfate disappeared both by IND and NEM. These results suggest that the cytoprotective effect of OGT may be mediated by endogenous sulfhydryl compounds, but not by endogenous prostaglandins in the gastric mucosa.View full abstractDownload PDF (442K) -
Akinobu NAGAOKA, Masaki SHIBOTA, Kazuhiro HAMAJO1989 Volume 51 Issue 1 Pages 25-35
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effects of a new calcium antagonist, CV-4093·2HCl, on renal hemodynamics were examined in anesthetized and conscious spontaneously hypertensive rats (SHR). In the anesthetized rats, CV-4093·2HCl (5 and 10 μg/ kg, i.v.) showed a long-lasting hypotensive action, dilated renal vasculature, and increased renal blood flow. These renal hemodynamic actions of CV-4093·2HCl were more prominent than those of nicardipine (5 and 10 μg/kg). Moreover, CV-4093·2HCl (10 μg/kg, i.v.) inhibited renal vascular contractions induced by intra venous norepinephrine and angiotensin II. The inhibitory effect of CV-4093·2HCl was much more marked than that of nicardipine, although the inhibitory effects of both calcium antagonists on systemic pressor responses induced by the vasoactive substances were almost the same. In addition, CV-4093·2HCl (1 and 3 mg/kg, p.o.) increased blood flow in the kidneys but not in the other organs except for the small intestine in conscious SHR. These results suggest that CV-4093·2HCl has a relatively higher affinity for the renal vascular bed (renal resistance vessels), and its effect on renal hemodynamics seems to be beneficial for treating hypertension.View full abstractDownload PDF (581K) -
Yukiko GOTOH, Sayo KUMADANI, Tomoyuki KAWAI, Yuji IMAIZUMI, Minoru WAT ...1989 Volume 51 Issue 1 Pages 37-45
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEffects of benidipine, a newly developed 1, 4-dihydropyridine derivative, on the high K+-induced contraction in aorta and the spontaneous contraction in portal vein of the rat were examined. When either tissue was treated with a low concentration (0.1-10 nM) of benidipine for 90, 180 min or a longer period, the evoked or spontaneous contraction was reduced in a time and concentration-dependent manner. The time required for 50% inhibition by 1 nM benidipine was approximately 60 and 120 min in the portal vein and aorta, respectively. Although the exact IC50 of benidipine was not determined because of the unexpectedly slow onset of the effect, it might have been overestimated previously and is apparently lower than 1 nM. After the withdrawal of 1 nM benidipine, its inhibitory action was not removed significantly even by washing for 5 hr. A partial or full recovery from the inhibition was observed in tissues pretreated with 0.3 nM benidipine. The persistent inhibition after withdrawal of 1 nM benidipine was not removed by Bay K 8644 treatment. The results strongly suggest that the slow recovery from the benidipine-induced inhibition is, at least in part, responsible for the long-lasting antihypertensive effects of benidipine.View full abstractDownload PDF (506K) -
Mohsin Md. SYED, Hiroyuki TOKUNO, Tadao TOMITA1989 Volume 51 Issue 1 Pages 47-56
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEffects of cisapride were studied on the whole segments and muscle strips isolated from the guinea pig ascending colon. In whole segment preparations, external application of cisapride (0.4-10 μM) produced relaxation and inhibited spontaneous and evoked intraluminal pressure changes. Intraluminal application (1-10 μM) increased the pressure response. In many circular muscle strips (18 preparations out of 20), cisapride (0.3-1 μM) increased the mechanical activity, particularly when the pH was lowered, associated with an increased spike activity. However, this action was relatively weak, and in some preparations (2 preparations out of 20), almost no effect was observed. At higher concentrations (more than 1-5 μM), cisapride reduced the muscle tone and nerve-mediated contractions. The cisapride effect could be demonstrated in the presence of atropine (0.5 μM) and serotonin (5 μM). It was concluded that cisapride has direct inhibitory as well as excitatory actions. There was a tendency for the excitatory action to appear at a lower concentration than for the inhibitory action.View full abstractDownload PDF (437K) -
Kiyoshi OIZUMI, Hiroshi NISHINO, Hiroyuki KOIKE, Toshio SADA, Masaaki ...1989 Volume 51 Issue 1 Pages 57-64
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSCS-905 is a novel dihydropyridine calcium blocker. A single oral administration of CS-905 or nicardipine at doses of 0.3-3.0 mg/kg produced a dosedependent reduction of blood pressure in conscious SHR. CS-905, when administered orally in conscious SHR, was more than 3 times as potent as nicardipine. Unlike the hypotensive effect of nicardipine, that of CS-905 has a gradual onset and is long-lasting, with little increase in heart rate. An intravenous administration of CS-905 also produced a hypotension with a slow onset and long duration in SHR, but CS-905 was 3 times less potent than nicardipine by intravenous administration. This difference may be attributed to the first pass effect, which was associated with nicardipine but not with CS-905. The blood pressure lowering effects of CS-905 was most potent in DOCA-salt hypertensive rats, followed by SHR, RHR and normotensive rats, in this order. CS-905 is expected to be an antihypertensive agent that is effective on a once a day regimen in clinical settings.View full abstractDownload PDF (409K) -
Yuichi ONODA, Tetsuo MAGARIBUCHI, Hajime TAMAKI1989 Volume 51 Issue 1 Pages 65-73
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEffects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers were investigated in rats. Oral administration of TA-2711 at doses of 25 to 100 mg/kg immediately after pyloric ligation markedly reduced pepsin activity and slightly lowered acid concentration without affecting the volume of gastric juice. Addition of TA-2711 (0.25-16 mg/ml) directly to gastric juice also reduced pepsin activity in vitro. Oral TA-2711 dose-relatedly inhibited the formation of pylorus-ligated ulcers (50-200 mg/kg), aspirin-induced gastric erosions (25-100 mg/kg) and cysteamine-induced duodenal ulcers (100-800 mg/kg). In addition, this drug prevented both the formation of gastric lesions (6.3-100 mg/kg, p.o.) and the fall in gastric potential difference (100 mg/kg, p.o.) induced by ethanol. The preventive effect against ethanol-induced lesions was suppressed by pretreatment with indomethacin (10 mg/kg, s.c.). Intravenous dosing of TA-2711 (10-100 mg/kg) never produced such effects on ethanol-induced lesions and pepsin activity as observed by oral administration. These results indicate that TA-2711 exerts its anti-ulcer effect by a local action, and it is suggested that both reduction of pepsin activity and a mucosal prostaglandin-mediated process are involved in the anti-ulcer action of TA-2711.View full abstractDownload PDF (473K) -
Hiroshi WATANABE, Hiroko SHIMIZU1989 Volume 51 Issue 1 Pages 75-82
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSWe have studied effects of intraperitoneal administration of anticholinergic drugs on striatal acetylcholine release in association with motor activity in freely moving rats using brain microdialysis. A low dose of atropine (2.5 mg/kg) increased striatal acetylcholine release. A high dose of atropine (5 mg/kg) or scopolamine (2.5, 5 and 10 mg/kg) increased both striatal acetylcholine release and motor activity, while its quaternary ammonium compounds, atropine methylbromide (5 and 10 mg/kg) and methscopolamine bromide (5 and 10 mg/kg), increased striatal acetylcholine release without motor excitation. Scopolamine (2.5 mg/kg) produced no significant change in striatal acetylcholine content 4 hr after the injection followed by perfusion. These results suggest that anticholinergic drugs cause an increase in striatal acetylcholine release which does not always result in the increase of motor activity.View full abstractDownload PDF (381K) -
Yukiyoshi YANAGIHARA, Hiroshi KASAI, Shizuo MATSUI, Kenji NINOMIYA1989 Volume 51 Issue 1 Pages 83-92
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effects of 9-methyl-3-(lH-tetrazol-5-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one potassium salt (TBX), a new antiallergic drug, on histamine release from lung fragments, experimental asthma and isolated tracheal muscle were investigated in guinea pigs. TBX (10-7 to 10-4 g/ml) dose-dependently inhibited antigen-induced histamine release from lung fragments of guinea pigs passively sensitized with homologous IgE serum. Antigen inhalation-induced experimental asthma in passively sensitized animals was inhibited in a dose-dependent fashion by i.v. (1 to 5 mg/kg) and p.o. (10 to 100 mg/kg) administrations of TBX. In vivo bronchoconstriction by platelet-activating factor (PAF, i.v.) was also inhibited by TBX (0.3 to 10 mg/kg, i.v.). However, high concentrations of TBX (more than 3 x 10-4 g/ml) were needed to inhibit PAF-induced platelet aggregation in vitro. With regard to the effect on isolated tracheal muscle, TBX itself at concentrations higher than 10-5 g/ml induced dose-dependent reduction in the resting tonus, which was not affected by pretreatment with propranolol. Neither the leukotriene D4-induced contraction nor the prostaglandin F2α-Induced one was specifically antagonized by TBX. The results obtained indicate that TBX is an antiasthmatic agent effective in inhibiting both IgE- and PAF-induced bronchoconstriction, possibly by interfering with mediator release.View full abstractDownload PDF (500K) -
Yukiyoshi YANAGIHARA, Hiroshi KASAI, Toshio KAWASHIMA, Kenji NINOMIYA1989 Volume 51 Issue 1 Pages 93-100
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effects of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one potassium salt (TBX) on type II to IV allergic reactions and immunological functions were investigated in animal models. Types II to IV allergic reactions in rodents were unaffected in vivo by TBX, even at higher doses than those capable of completely inhibiting the type I allergic reaction. However, both complement-mediated hemolysis via the classical pathway and hypotonic shock-induced hemolysis were slightly inhibited in vitro only by a high concentration of the drug (10-4 g/ml). In the mouse system, TBX had no ability to suppress anti-hapten IgE anti-body formation as well as hemagglutinin formation and to inhibit the proliferation of spleen cells induced by non-specific T and B cell mitogens. The results obtained indicate that TBX is an antiallergic drug essentially devoid of inhibitory actions on types II to IV allergic reactions and immunological functions, thus indicating that it is a specific inhibitor of type I allergic reactions.View full abstractDownload PDF (435K) -
Masaharu DOZEN, Kohji YAMAKI, Sachiko OH-ISHI1989 Volume 51 Issue 1 Pages 101-105
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSAs previously reported, pretreatment with captopril significantly enhanced pleural exudation of rat carrageenin-induced pleurisy. However, in high molecular weight kininogen-deficient rats (B/N-Katholiek), the pleural exudate volume was significantly less than that of the normal strain (B/N-Kitasato), and captopril pretreatment did not enhance exudation. In the present study, the following additional evidences were demonstrated: 1) Captopril did not increase 6-keto-PGF1α level in the deficient strain, but it was significantly increased in the normal strain after captopril treatment; 2) simultaneous administration of soybean trypsin inhibitor with carrageenin markedly suppressed the exudate volume and levels of 6-keto-PGF1α in the normal strain; and 3) indomethacin also suppressed pleural fluid accumulation and the production of arachidonate metabolites. These data suggest that carrageenin causes intrinsic kinin-release through the activation of plasma kallikrein and then in turn, the kinin stimulates the production of arachidonic acid metabolites. Thus these products and kinin may interact to induce more plasma exudation in carrageenin inflammation. The results also indicate that captopril uncovers the effects of bradykinin on exudation and stimulation of arachidonate metabolite production; otherwise, the biological effect of kinin is too slight to produce a clear effect at the initial phase of the inflammation.View full abstractDownload PDF (256K) -
Yoko OMURA, Keiko ASAHINA, Kazue WATANABE, Sadayuki SHO1989 Volume 51 Issue 1 Pages 107-115
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSWe improved the experimental procedure for the measurement of hog kidney histaminase activity using histamine as a substrate on the basis of a spectro-photometric estimation of the 2, 4-dinitrophenylhydrazone of imidazole acetaldehyde and studied the steady-state kinetics to obtain the basic data for further investigations of the oxidative deamination of histamine. The initial and mean velocities of the enzymatic reaction were calculated and plotted against the amount of enzyme. It was found that the initial velocity increased linearly. The time tα necessary to reach the extent of reaction α was calculated and plotted against the reciprocal of the enzyme concentration eo. It was found that tα was linearly proportional to 1/eo. From Lineweaver-Burk plots, inhibition by high concentration of substrate was evident, and the v-pS curve was bell-shaped, with a pS maximum at 3.2. Km and V were obtained: Km=7.7×10-5 M, V=0.0026, μmol/min (0.00075 μmol/min/mg protein). It was concluded that our DNP method was useful for the measurement of hog kidney histaminase activity using histamine as a substrate, basic steady-state kinetic studies and further investigations of substrate inhibition and inhibitory effect.View full abstractDownload PDF (456K) -
Tomohisa HATTORI, Tadashi NAGAMATSU, Mikio ITO, Yoshio SUZUKI1989 Volume 51 Issue 1 Pages 117-124
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSIn order to elucidate the mechanisms of the antinephritic action of TJ-8014, the effect of this drug on corticosterone release from the adrenal cortex was investigated by using normal rats and rats with original-type anti-GBM nephritis. When the serum corticosterone level was determined 5 hr after test drugs were given p.o. to normal rats, TJ-8014 at 0.5 and 2.0 g/kg significantly elevated the hormone level by 48% and 74%, respectively. Of the crude drugs that constitute TJ-8014, Bupleuri radix (SAIKO) and Glycyrrhizae radix (KANZOU) at 1.0 g/kg also significantly elevated the serum level. When TJ-8014 was given p.o. daily from the next day of anti-GBM serum injection to the 15th day, 2.0 g/kg/day of the drug inhibited the urinary protein excretion. In addition, TJ-8014 (2.0 g/kg/day) inhibited the decrease in the serum and adrenal corticosterone levels induced by nephritis. When corticosterone at 10 mg/kg was given s.c. daily from the next day of the anti-serum injection to the 10th day, it not only reduced proteinuria, but also inhibited glomerular histopathological changes. In contrast, metyrapone, a corticosterone synthetase inhibitor, at 100 mg/kg × 2/day, p.o., aggravated the nephritis. These results suggest that the antinephritic action of TJ-8014 may be partly due to the enhancement of the synthesis or release of corticosterone from the adrenal cortex.View full abstractDownload PDF (396K) -
Tohru MASUKAWA, Midori SAI, Yoshihiro TOCHINO1989 Volume 51 Issue 1 Pages 125-127
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe anti-hypoxic effect (assessed by a standard hypoxia survival test) 3 hr after 2-cyclohexene-1-one (CHX) was completely abolished by injections of L-cysteine after CHX. Under these conditions, brain GSH was depleted to about 50% of the control level in CHX-treated mice and recovered to about 80% of control level following L-cysteine post-treatment. However, D-cysteine could not cause such effects. Intracerebroventricular injection of CHX, which caused a selective depletion of brain GSH, produced an anti-hypoxic effect. Thus, the anti-hypoxic effect may be related to the decrease of brain GSH levels.View full abstractDownload PDF (150K) -
Kayoko MOROI, Tetsuro KUGA, Ken KADOTA1989 Volume 51 Issue 1 Pages 128-131
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe binding of 3H-clonidine to bovine brain coated vesicles was studied. The binding was reversible and saturable. Saturation studies revealed a one-site interaction: Kd was 8.7 nM and Bmax was 24.5 fmol/mg protein. Noradrenaline, yohimbine and phenoxybenzamine displaced 3H-clonidine binding from the binding sites at concentrations of 10-7-10-4 M. The results indicate that the coated vesicles from the bovine cerebral cortex contain 3H-clonidine binding sites comparable to the low affinity sites of α2-adrenergic receptors in bovine brain membranes.View full abstractDownload PDF (219K) -
Yutaka GOMITA, Katsushi FURUNO, Yasunori ARAKI1989 Volume 51 Issue 1 Pages 132-135
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe influence of emotional stress on the pharmacokinetics of isosorbide dinitrate (ISDN) administered s.c. to rats was studied. The plasma level of ISDN in emotionally stressed (ES) rats was the same as that in non-stressed control rats. However, the levels of its metabolites, 5-isosorbide mononitrate (5-ISMN) and 2-isosorbide mononitrate (2-ISMN), were markedly lower in ES rats than in the control rats. On the other hand, urine ISDN and 2-ISMN excretion rates were lower in ES rats than in the control rats. These observations suggest that the pharmacokinetics of ISDN administered s.c. is influenced by emotional stress such as foot shock.View full abstractDownload PDF (237K) -
Kouichi HIROTA, Toru KAWANISHI, Momoko SUNOUCHI, Yasuo OHNO, Akira TAK ...1989 Volume 51 Issue 1 Pages 136-139
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effects of metyrapone on qualitative changes in cytochrome P-450-dependent drug metabolizing activities in primary cultures of rat hepatocytes were investigated. Metyrapone apparently increased benzo(a)pyrene hydroxylation and maintained both ethoxycoumarin-O-deethylation and propoxycoumarin-O-depropylation, whereas it had little effect on methoxycoumarin-0-demethylation. Furthermore, P-450d (high spin type of P-448) as well as P-450c (low spin type of P-448) were induced by metyrapone, while P-450b and P-450e were not. In conclusion, metyrapone act as a 3-methylcholanthrene-like inducer in the primary cultures of rat hepatocytes.View full abstractDownload PDF (240K) -
Toshihiro OKAMOTO, Kazuyoshi KURAHASHI, Motohatsu FUJIWARA1989 Volume 51 Issue 1 Pages 140-142
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSStimulation of the vagal trunk in cats anesthetized with pentobarbital sodium produced a contractile response of the stomach during stimulation (initial contraction). Pretreatment with either hexamethonium (0.3 to 30 mg/kg, i.v.) or gallamine (1 to 100 mg/kg, i.v.) dose-dependently produced a delayed contraction, following the initial contraction after stimulation. After the administration of either hexamethonium or gallamine produced a maximum delayed contraction, then an additional dose of gallamine or hexamethonium was administered. The subsequent treatment further augmented the delayed contraction. The results indicate that gallamine induced the delayed contraction by a mechanism different from hexamethonium.View full abstractDownload PDF (148K) -
Masao SEIKI, Motonobu MURAKAMI, Jung Keun YOO, Sanae TERANUMA, Hiroshi ...1989 Volume 51 Issue 1 Pages 143-145
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSWe examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ influxes into the lumen. In dogs, in an exactly similar manner to rats, ammonia at concentrations of 0.1 to 0.5% increased H+ loss, and ammonia at concentration of 0.5% increased both Na+ and K+ influxes into the lumen. These results suggest that ammonia breaks the gastric mucosal barrier.View full abstractDownload PDF (168K) -
Masaaki ISHIKAWA, Ken-ichi SASAKI, Yoshio TAKAYANAGI1989 Volume 51 Issue 1 Pages 146-149
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effect of buthionine sulfoximine (BSO), a glutathione biosynthesis inhibitor, on the acute lethal toxicity and urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/ kg, i.p.) 5 hr prior to CPA resulted in enhanced lethality and urotoxicity of CPA. In contrast, administration of cysteamine decreased the lethality and urotoxicity of CPA.View full abstractDownload PDF (208K)
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