The detection system (DS) to shoplifter might affect to the patient with implantable cardiac pacemaker (PM). Two types of DS, detectors using magnet or high frequency, were used to test the influence on the PMs. Total of 57 PMs (VVI 37, DDD 17 and VVIR 3) were tested. Check list was made from our previous experience of radiation, MRI, electrocoagulator, and shock wave lithotripsy which influenced on PMs. Test of the PMs against DS were made accordingly to check list, (1) false inhibition, (2) EMI protection, (3) program and telemetry malfunction, (4) back-up pacing, and (5) damage to the LSI or microcomputer system. There was no PMs affected by the DS tested. Thus, we concluded that detection system to shoplifter do not influence on PMs.

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Although a variety of physiologic and pathologic factors have been implicated in vascular endothelial regeneration, details of this process remain to be clarified. We studied the relation between endothelial regeneration and alternately aligned static magnetic fields. Thirty-two carotid arteries from 16 mongrel dogs were used in this study. Five-centimeter-long segments of bilateral carotid arteries were mechanically denuded of endothelium. As a general rule, one of each pair of denuded arteries was wrapped in a 5 cm plastic film with alternately aligned static magnetic fields with a magnetic flux density of 280 Gauss (Gr. E). The other artery was not wrapped (Gr.C). The arteries were excised immediately and 1, 2, 4, 5, 6 and 8 weeks after endothelial denudation. Each specimen was divided into proximal, middle and distal portions and examined by light and scanning electron microscopy to determine how fast the endothelium regenerated. Two weeks after denudation, endothelial regeneration had reached the middle portion in Gr. E while endothelial regeneration remained in the proximal and distal portions in Gr.C. This study suggested that alternately aligned static magnetic fields can promote arterial endothelial regeneration. We considered that the interaction between the magnetic fields and flowing negatively charged particles might cause a micropotential that promotes the proliferation of endothelial cells.

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The binding and mode of internalization of conventional
sodium heparin and a low molecular weight heparin (LHG) by human umbilical vein endothelial cells (HUVEC) in culture were studied. The binding and/or internalization of [³⁵S] LHG to HUVEC was lower than those of [³⁵S] heparin when incubation was carried out at 37°C, whereas at 4°C both ³⁵S labeled ligands bound to HUVEC similarly. When HUVEC were exposed to fluoresceinated heparin, the staining pattern suggested that heparin enters HUVEC by receptor-mediated pathway. But intracellular fluorescent punctate vesicles were relatively few when exposed to fluoresceinated LHG. The
reduction of anti-Xa activity in culture medium when LHG was added was smaller than that of heparin. Thus, the uptake by cellular compartments such as endothelial cells was suggested to contribute to the pharmacokinetics of both LHG and heparin.

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We have been developing the artificial heart using the vibrating flow pump (VFP), which can generate the high frequency blood flow about 10Hz/s. To determine the effect of high frequency blood flow on autonomic nervous system under general anestesia, fluctuations in hemodynamics was analyzed by the spectral analysing method. Our newly developped VFP was utilized as the total left heart bypass in acute experiments using adult goats. During VFP pumping, respiratory waves were
not significantly changed (N.S.), though Mayer waves were significantly decreased (p<0.05). These results suggest that high frequency blood flow affects the autonomic nervous system, even during anesthesia.

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