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[in Japanese]
1985 Volume 14 Issue 6 Pages
1873
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1985 Volume 14 Issue 6 Pages
1875-1881
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1985 Volume 14 Issue 6 Pages
1882-1889
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1985 Volume 14 Issue 6 Pages
1890-1901
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1985 Volume 14 Issue 6 Pages
1902-1910
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1985 Volume 14 Issue 6 Pages
1911-1912
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1985 Volume 14 Issue 6 Pages
1912-1913
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1985 Volume 14 Issue 6 Pages
1913-1914
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1985 Volume 14 Issue 6 Pages
1914-1915
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1985 Volume 14 Issue 6 Pages
1915-1916
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1985 Volume 14 Issue 6 Pages
1916-1917
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1985 Volume 14 Issue 6 Pages
1917-1918
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1985 Volume 14 Issue 6 Pages
1918-1920
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1985 Volume 14 Issue 6 Pages
1920-1921
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1985 Volume 14 Issue 6 Pages
1921
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1985 Volume 14 Issue 6 Pages
1921a-1922
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1985 Volume 14 Issue 6 Pages
1922-1923
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1985 Volume 14 Issue 6 Pages
1924-1926
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1985 Volume 14 Issue 6 Pages
1926-1927
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1985 Volume 14 Issue 6 Pages
1927-1928
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1985 Volume 14 Issue 6 Pages
1928-1930
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1985 Volume 14 Issue 6 Pages
1930-1931
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1985 Volume 14 Issue 6 Pages
1931-1933
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1985 Volume 14 Issue 6 Pages
1934-1940
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1985 Volume 14 Issue 6 Pages
1941-1946
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Bilirubin adsorption by polyamine-triglycidylisocyanulate (PAT) resin
Y. SHIMAHARA, R. NAKURA, A. JIKKO, K. YASUDA, M. MATSUSHIMA, H. NODA, ...
1985 Volume 14 Issue 6 Pages
1947-1952
Published: December 15, 1985
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Bilirubin adsorption capacity of PAT resin was examined, using icteric human serum obtained by plasmapheresis. PAT resin adsorbs markedly direct and indirect bilirubin, and uric acid from the serum. Ca
2+, creatinine, and BUN were also adsorbed relatively well. Little change was observed in the levels of serum albumin, globulin, glucose, amino acids, cholesterol, free fatty acid, trigyceride, Na
+, K
+, and Cl
-. The amount of bilirubin adsorbed by PAT correlates positively with the initial bilirubin concentration of the serum. However, no relation was found between the removal rate and the bilirubin levels of the serum. The ability of bilirubin adsorption of PAT deteriorates gradually according to the time courses. A possibility was suggested to apply the PAT resin to clinical use, if the optimal conditions in temperature, flow rate, volume and shape of the column etc. are determined, and an adequate combination with other hemopurification procedures such as plasmapheresis is established.
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J. MIYA, H. MAETA, M. HORI
1985 Volume 14 Issue 6 Pages
1953-1958
Published: December 15, 1985
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For relief of aortic regurgitation (AR), we have developed a new style umbrella-shaped catheter-mounted aortic valve (CAV). This CAV is composed of a catheter, a main shaft which slides in the catheter, three flexible wires, which distal ends are fixed to the main shaft and proximal ones fixed to the catheter, and a valve sheet sutured to these flexible wires. Following insertion into the aortic annulus, the CAV is opened by means of pulling the main shaft to form an umbrella-like shape, so that the mid portions of each flexible wire make an arch and are fixed into Valsalva's sinuses (where the flexible wires are designed to form an outward protruded arch to fix the CAV satisfactory and not to obstruct coronary orifices.) The efficacy of this CAV was experimentally evaluated using 7 mongrel dogs with destroyed aortic valves. Formation of AR decreased diastolic and mean aortic pressure by 42.0mmHg and 30.3mmHg respectively, increased left atrial pressure by 8.7mmHg and decreased cardiac output by 46.4%. Under these conditions, insertion and application of the CAV increased diastolic and mean aortic pressure by 22.9mmHg and 16.2mmHg, respectively, decreased left atrial pressure by 3.1mmHg and increased cardiac output by 50.9%. Comparing with CAVs developed previously, the most remarkable advantage of this new style CAV is its stable fixation in the aorta brought about by three arched wires. This stability insured the prevention of regurgitation in diastole and decreased the risk of coronary orifice obstruction by the valve sheet. Accompanied with these considerable improvements of hemodynamics for AR, the advantages would bring a possibility of actual clinical use of this CAV.
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T. OGAWA, T. SUZUKI, M. TAGUCHI, T. MATSUBARA, Y. HIROFUJI, Y. FUJII, ...
1985 Volume 14 Issue 6 Pages
1959-1963
Published: December 15, 1985
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We performed plasma exchange (PEx) and double filtration plasmapheresis (DFPP) on 4 patients, 2 HB-nephropathy, 1 amyotrophic lateral sclerosis (ALS) and 1 progressive systemic sclerosis (PSS). And we investigated various cardiovascular parameters via Swan-Ganz catheter on four occasions in each case: before and at 1 hour and 2 hours after initiation of PEx and DFPP and at 30 minutes after completion of them. In 2 HB-nephropathy and 1 ALS, all cardiovascular parameters were within normal limits. But in PSS, systemic vascular resistance (
SVR) increased significantly before PEx and DFPP. In the patients except PSS, mean pulmonary -arterial pressure (
PAP), cardiac index (
CI) and stroke work index (
SWI) decreased significantly -during DFPP than PEx, but SVR increased significantly during DFPP. And so mean arterial pressure (
MAP) did not decrease significantly at 2 hours after initiation of DFPP and at 30 minutes after the completion. In PSS,
PAP,
CI and
SWI decreased significantly during DFPP than PEx, but
SVR did not increase, so that
MAP decreased during DFPP significantly. These facts suggested that DFPP has more influence upon the hemodynamics than PEx, because of decreased plasma refilling rate during DFPP. It is important of grasp sufficient information on the cardiovascular dynamic status at the time of DFPP on the patients with systemic vascular disease.
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Y. TABATA
1985 Volume 14 Issue 6 Pages
1964-1975
Published: December 15, 1985
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The present study was undertaken to investigate the efficacy of charcoal hemoadsorption (HA) in the treatment of acute hepatic failure (AHF). The effect of HA on the survival of AHF rats and the reticuloendothelial system (RES) function were studied experimentally. The survival of HA treatment group was significantly improved compared to the control. The EC, AKBR and RES function were significantly improved among HA treatment group compared to those among the control. In clinical study, since 1975 to 1983, 28 AHF patients were hemoadsorbed. The study period was divided into three terms according to the treatments. During the third term, HA and plasma exchange were performed alternatively in the AHF patients even though they were in grade II coma. The survival among patients treated during the third term was significantly improved compared to those treated during the first and second term. The hepatic cellular energy metabolism, studied using AKBR, was improved following HA. These data indicate that HA has the beneficial effect on the survival of AHF and that the mechanism of the beneficial effect could be through the improvement of hepatic energy metabolism. The data also indicate that HA is more effective when it is applied to the patients who are still in early stage of AHF.
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Y. ONDA
1985 Volume 14 Issue 6 Pages
1976-1984
Published: December 15, 1985
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The glutaraldehyde-tanned equine umbilical cord vessels (EUCV) were investigated as a venous substitute. After glutaraldehyde treatment, quality of the EUCV wass improved as follows; 1) high tolerance against the internal pressure. 2) adequate rigidity withh elasticity. 3) high antithrombogenicity. 4) good disinfectant effect. 5) marked supression of antigenicity. 6) high tolerance in a living body. 7) easy in handling and preservation. The glutaraldehydetanned EUCV were transplanted in the infrarenal vena cave of mongrel dogs. The patency rate was 83% after 7 days but 60% after 4 weeks. However no further obstruction was observed after 4 weeks up to over one year. The main cause of the obstruction was constriction at the anastomotic region. The patency rate could be improved with some adjuvant treatments in this period. In conclusion, the glutaraldehyde-tanned EUCV could be regarded as a useful venous substitute for human.
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An experimental study
C. NOJICI
1985 Volume 14 Issue 6 Pages
1985-1997
Published: December 15, 1985
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The use of temporary shunt tube has been a very useful and easy method in descending thoracic aneurysmectomy. I developed an originally designed heparinless shunt tube coated with TM3, which is a new antithrombogenic polymer. The purpose of this study is to evaluate the antithrombogenicity as well as the hemodynamic performance in dogs. All underwent a five hour period of aorto-femoral bypass without systemic heparinization. After bypass all tubes were clear without detectable thrombi and SEM study demonstrated no platelet aggregation nor fibrin strunds. And hemodynamically this tube showed excellent results. Because the shape of TM3-coated shunt tube can afford excellent anti-thrombogenicity and performance without systemic heparinization, this shunt tube is worthy of clinical trials.
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S. SEKIGUCHI, K. ITO, N. OTOTAKE, H. IKEDA, S. SASAKAWA
1985 Volume 14 Issue 6 Pages
1998-1999
Published: December 15, 1985
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Stroma-free hemoglobin (SFH) solutions are potential oxygen carriers as red blood cell substitutes, but they have two major defects which are high oxygen binding and short life span. In order to improve these defects, we modified the SFH solutions with pyridoxal 5'-phosphate. But the modified SFH solutions contain non-reactive SFH and pyridoxylated hemoglobin (PLP-Hb). Then we separated completely non-reactive SFH from PLP-Hb used with ion exchanger, DEAE Sephadex A-50. Moreover separated PLP-Hb solutions have two different derivatives, and the P
50 values are respectively 17.5mmHg, 24.5mmHg (P
50 value of SFH and red blood cells are 10.5mmHg and 25-26mmHg respectively). When those two PLP-Hb derivatives are stored at 4°C, they are very stable at least until 4 weeks. Therefore it is evident that PLP-Hb separated from SFH using DEAE Sephadex A-50 are valuable materials as red blood cell substitutes.
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[in Japanese]
1985 Volume 14 Issue 6 Pages
2000
Published: December 15, 1985
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